Sistemik Hastalıkların Oral Bulguları

Özet

Oral kavite ve orofasiyal bölge birçok fizyolojik süreçte rol oynamakta olup başlıca gastrointestinal, hematolojik, endokrinolojik, otoimmün ve solunum sistemini etkileyen sistemik hastalıklar, enfektif patolojiler ve sistemik tedaviler gibi etiyolojik faktörlerle yakından ilişkilidir. Oral bölgede spesifik bulguları olan sistemik faktörler olabilmekte ve bu spesifik bulgular gerek tanı gerek de tedavi aşamalarında önemli rol oynamaktadır. Nonspesifik bulguları olan sistemik faktörlerde ayırıcı tanılar önemli olup oral bölge bulguları tanısal aşamada yol gösterici olabilmektedir. Oral bölgede genellikle sık ve belirgin olarak saptanabilen bulgulara yol açan sistemik hastalık ve tedaviler bu başlık altında değerlendirilmiş ve ilişkilendirilmiştir.

The oral cavity and orofacial region play a role in many physiological processes and are closely associated with etiologic factors such as systemic diseases affecting the gastrointestinal, hematologic, endocrinologic, autoimmune and respiratory systems, infective pathologies and systemic therapies. There may be systemic factors with specific findings in the oral region and these specific findings play an important role in both diagnosis and treatment. Differential diagnoses are important in systemic factors with nonspecific findings and oral findings may be guiding at the diagnostic stage. Systemic diseases and treatments that cause frequent and prominent findings in the oral region are evaluated and related under this title.

Referanslar

Napeñas JJ, Brennan MT, Elad S. Oral Manifestations of Systemic Diseases. Dermatol Clin. 2020;38(4):495-505.

Wray D. Gastrointestinal and granulomatous diseases. Periodontology 2000. 1998;18(1):95-101.

Fatahzadeh M, Schwartz RA, Kapila R, Rochford C. Orofacial Crohn's disease: an oral enigma. Acta Dermatovenerol Croat. 2009;17(4):289-300.

Islam NM, Bhattacharyya I, Cohen DM. Common oral manifestations of systemic disease. Otolaryngol Clin North Am. 2011;44(1):161-82, vi.

Sciubba JJ, Said-Al-Naief N. Orofacial granulomatosis: presentation, pathology and management of 13 cases. Journal of Oral Pathology & Medicine. 2003;32(10):576-85.

Pittock S, Drumm B, Fleming P, McDermott M, Imrie C, Flint S, et al. The oral cavity in Crohn's disease. J Pediatr. 2001;138(5):767-71.

Bianchi L, Carrozzo AM, Orlandi A, Campione E, Hagman JH, Chimenti S. Pyoderma vegetans and ulcerative colitis. Br J Dermatol. 2001;144(6):1224-7.

Li C, Wu Y, Xie Y, Zhang Y, Jiang S, Wang J, et al. Oral manifestations serve as potential signs of ulcerative colitis: A review. Frontiers in Immunology. 2022;13.

Boirivant M, Cossu A. Inflammatory bowel disease. Oral Dis. 2012;18(1):1-15.

Pazheri F, Alkhouri N, Radhakrishnan K. Pyostomatitis vegetans as an oral manifestation of Crohn's disease in a pediatric patient. Inflamm Bowel Dis. 2010;16(12):2007.

Femiano F, Lanza A, Buonaiuto C, Perillo L, Dell'Ermo A, Cirillo N. Pyostomatitis vegetans: a review of the literature. Med Oral Patol Oral Cir Bucal. 2009;14(3):E114-7.

Al-Zahrani MS, Alhassani AA, Zawawi KH. Clinical manifestations of gastrointestinal diseases in the oral cavity. The Saudi Dental Journal. 2021;33(8):835-41.

Di Fede O, Di Liberto C, Occhipinti G, Vigneri S, Lo Russo L, Fedele S, et al. Oral manifestations in patients with gastro-oesophageal reflux disease: a single-center case-control study. J Oral Pathol Med. 2008;37(6):336-40.

Greenwood M, Meechan J. General medicine and surgery for dental practitioners Part 3: Gastrointestinal system. British dental journal. 2003;194(12):659-63.

McColl K. Clinical practice. Helicobacter pylori infection. The New England journal of medicine. 2010;362(17):1597-604.

Dowsett S, Kowolik M. Oral Helicobacter pylori: can we stomach it? Critical Reviews in Oral Biology & Medicine. 2003;14(3):226-33.

Novacek G. Plummer-vinson syndrome. Orphanet Journal of rare diseases. 2006;1:1-4.

Cheng J, Malahias T, Brar P, Minaya MT, Green PH. The association between celiac disease, dental enamel defects, and aphthous ulcers in a United States cohort. Journal of clinical gastroenterology. 2010;44(3):191-4.

Çekın AH, Çekın Y, Sezer C. Celiac disease prevalence in patients with iron deficiency anemia. The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology. 2012;23(5):490-5.

Zegarelli DJ. Fungal infections of the oral cavity. Otolaryngol Clin North Am. 1993;26(6):1069-89.

Zimmer V, Buecker A, Lammert F. Sideropenic dysphagia. Gastroenterology. 2009;137(6):e1-2.

Toh BH, Alderuccio F. Pernicious anaemia. Autoimmunity. 2004;37(4):357-61.

Dabiri G, Damstetter E, Chang Y, Baiyee Ebot E, Powers JG, Phillips T. Coagulation disorders and their cutaneous presentations: Diagnostic work-up and treatment. J Am Acad Dermatol. 2016;74(5):795-804; quiz 5-6.

James WD, Guiry CC, Grote WR. Acute idiopathic thrombocytopenic purpura. Oral Surg Oral Med Oral Pathol. 1984;57(2):149-51.

Adams PC. Epidemiology and diagnostic testing for hemochromatosis and iron overload. Int J Lab Hematol. 2015;37 Suppl 1:25-30.

Pietrangelo A. Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology. 2010;139(2):393-408, .e1-2.

Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, et al. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med. 2005;352(17):1769-78.

Thoppay JR, Sollecito TP, De Rossi SS. Oral Signs of Endocrine and Metabolic Diseases. In: Fazel N, editor. Oral Signs of Systemic Disease. Cham: Springer International Publishing; 2019. p. 45-61.

Inzucchi SE. Clinical practice. Diagnosis of diabetes. N Engl J Med. 2012;367(6):542-50.

Mealey BL, Oates TW. Diabetes mellitus and periodontal diseases. J Periodontol. 2006;77(8):1289-303.

Mandel L, Patel S. Sialadenosis associated with diabetes mellitus: a case report. J Oral Maxillofac Surg. 2002;60(6):696-8.

Sreebny LM, Yu A, Green A, Valdini A. Xerostomia in diabetes mellitus. Diabetes Care. 1992;15(7):900-4.

Wysocki GP, Daley TD. Benign migratory glossitis in patients with juvenile diabetes. Oral Surg Oral Med Oral Pathol. 1987;63(1):68-70.

Young ER. The thyroid gland and the dental practitioner. J Can Dent Assoc. 1989;55(11):903-7.

Poumpros E, Loberg E, Engström C. Thyroid function and root resorption. The Angle Orthodontist. 1994;64(5):389-93.

Srirangarajan S, Satyanarayan A, Shivamurthy R, Thakur S. Dental manifestation of primary idiopathic hypoparathyroidism. Journal of Indian Society of Periodontology. 2014;18:524-6.

Can Ö, Boynueğri B, Gökçe AM, Özdemir E, Ferhatoğlu F, Canbakan M, et al. Brown tumors: a case report and review of the literature. Case reports in nephrology and dialysis. 2016;6(1):46-52.

Lexomboon D, Tägt M, Nilsson I-L, Buhlin K, Häbel H, Sandborgh-Englund G. Effects of primary hyperparathyroidism on oral health. A longitudinal register-based study. Oral Diseases. 2023;29(7):2954-61.

Findling JW, Raff H. Cushing's Syndrome: important issues in diagnosis and management. J Clin Endocrinol Metab. 2006;91(10):3746-53.

Chakera AJ, Vaidya B. Addison disease in adults: diagnosis and management. Am J Med. 2010;123(5):409-13.

Shah SS, Oh CH, Coffin SE, Yan AC. Addisonian pigmentation of the oral mucosa. Cutis. 2005;76(2):97-9.

Bugălă NM, Carsote M, Stoica LE, Albulescu DM, Ţuculină MJ, Preda SA, et al. New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden. Diagnostics (Basel). 2022;12(9).

Schenberg ME, Zajac JD, Lim-Tio S, Collier NA, Brooks AM, Reade PC. Multiple endocrine neoplasia syndrome--type 2b. Case report and review. Int J Oral Maxillofac Surg. 1992;21(2):110-4.

Hernández-Molina G, Avila-Casado C, Cárdenas-Velázquez F, Hernández-Hernández C, Calderillo ML, Marroquín V, et al. Similarities and differences between primary and secondary Sjögren's syndrome. J Rheumatol. 2010;37(4):800-8.

Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, et al. Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline. Journal of Clinical Oncology. 2021;39(25):2825-43.

Minozzi F, Galli M, Gallottini L, Minozzi M, Unfer V. Stomatological approach to Sjögren's syndrome: diagnosis, management and therapeutical timing. Eur Rev Med Pharmacol Sci. 2009;13(3):201-16.

Nocturne G, Mariette X. Sjögren Syndrome-associated lymphomas: an update on pathogenesis and management. Br J Haematol. 2015;168(3):317-27.

Fischer DJ, Patton LL. Scleroderma: oral manifestations and treatment challenges. Spec Care Dentist. 2000;20(6):240-4.

Gabrielli A, Avvedimento EV, Krieg T. Scleroderma. N Engl J Med. 2009;360(19):1989-2003.

Nagy G, Kovács J, Zeher M, Czirják L. Analysis of the oral manifestations of systemic sclerosis. Oral Surg Oral Med Oral Pathol. 1994;77(2):141-6.

Rout PG, Hamburger J, Potts AJ. Orofacial radiological manifestations of systemic sclerosis. Dentomaxillofac Radiol. 1996;25(4):193-6.

Siegel CH, Sammaritano LR. Systemic Lupus Erythematosus: A Review. JAMA. 2024;331(17):1480-91.

Anía BJ, Suman VJ, Sobell JL, Codd MB, Silverstein MN, Melton LJ, 3rd. Trends in the incidence of polycythemia vera among Olmsted County, Minnesota residents, 1935-1989. Am J Hematol. 1994;47(2):89-93.

Brennan MT, Valerin MA, Napeñas JJ, Lockhart PB. Oral manifestations of patients with lupus erythematosus. Dent Clin North Am. 2005;49(1):127-41, ix.

Grennan DM, Ferguson M, Williamson J, Mavrikakis M, Dick WC, Buchanan WW. Sjogren's syndrome in SLE: Part I. The frequency of the clinical and subclinical features of Sjogren's syndrome in patients with SLE. N Z Med J. 1977;86(598):374-6.

Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023-38.

Voog U, Alstergren P, Eliasson S, Leibur E, Kallikorm R, Kopp S. Progression of radiographic changes in the temporomandibular joints of patients with rheumatoid arthritis in relation to inflammatory markers and mediators in the blood. Acta Odontol Scand. 2004;62(1):7-13.

Hazenberg B. Amyloidosis: A Clinical Overview. Rheumatic diseases clinics of North America. 2013;39:323-45.

Costa JHSM, de Paula AB, de Oliveira Campos L, de Paula RB, Gotardelo DR. Macroglossia and periorbital ecchymoses in a patient with systemic amyloidosis: a case report. International Journal of Case Reports and Images (IJCRI). 2015;6(6):343-7.

Serdar A, Basak D, Sercan G, Ali V. Solitary amyloid tumor of the tongue base. Int J Otolaryngol. 2009;2009:515068.

Saadoun D, Bodaghi B, Cacoub P. Behçet’s Syndrome. New England Journal of Medicine. 2024;390(7):640-51.

Seyahi E. Phenotypes in Behçet’s syndrome. Internal and emergency medicine. 2019;14:677-89.

Altenburg A, El-Haj N, Micheli C, Puttkammer M, Abdel-Naser MB, Zouboulis CC. The treatment of chronic recurrent oral aphthous ulcers. Deutsches Ärzteblatt International. 2014;111(40):665.

Gualtierotti R, Marzano AV, Spadari F, Cugno M. Main Oral Manifestations in Immune-Mediated and Inflammatory Rheumatic Diseases. J Clin Med. 2018;8(1).

JD OD. In: Primer on the Rheumatic Diseases. Arthritis Foundation. 1993;Vol 29:p.206.

Gadiparthi C, Hans A, Potts K, Ismail MK. Gastrointestinal and Hepatic Disease in the Inflammatory Myopathies. Rheum Dis Clin North Am. 2018;44(1):113-29.

Iaccarino L, Ghirardello A, Bettio S, Zen M, Gatto M, Punzi L, et al. The clinical features, diagnosis and classification of dermatomyositis. J Autoimmun. 2014;48-49:122-7.

Mugii N, Hasegawa M, Matsushita T, Hamaguchi Y, Oohata S, Okita H, et al. Oropharyngeal Dysphagia in Dermatomyositis: Associations with Clinical and Laboratory Features Including Autoantibodies. PLoS One. 2016;11(5):e0154746.

Salvarani C, Pipitone N, Versari A, Hunder GG. Clinical features of polymyalgia rheumatica and giant cell arteritis. Nat Rev Rheumatol. 2012;8(9):509-21.

Paraskevas KI, Boumpas DT, Vrentzos GE, Mikhailidis DP. Oral and ocular/orbital manifestations of temporal arteritis: a disease with deceptive clinical symptoms and devastating consequences. Clin Rheumatol. 2007;26(7):1044-8.

Imai K, Iinuma T, Sato S. Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation. Jpn Dent Sci Rev. 2021;57:224-30.

Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11.

Reboll-Ferrer RM, Zapater-Latorre E, Calabuig-Crespo C, Basterra-Alegría J. Wegener's granulomatosis: description of a case with oral manifestation. Med Oral Patol Oral Cir Bucal. 2010;15(4):e601-4.

Ruokonen H, Helve T, Arola J, Hietanen J, Lindqvist C, Hagstrom J. "Strawberry like" gingivitis being the first sign of Wegener's granulomatosis. Eur J Intern Med. 2009;20(6):651-3.

Prasse A. The Diagnosis, Differential Diagnosis, and Treatment of Sarcoidosis. Dtsch Arztebl Int. 2016;113(33-34):565-74.

Brown F, Modi P, Tanner LS. Lofgren Syndrome. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2024, StatPearls Publishing LLC.; 2024.

Fraga RC, Kakizaki P, Valente NYS, Portocarrero LKL, Teixeira MFS, Senise PF. Do you know this syndrome? Heerfordt-Waldenström syndrome. An Bras Dermatol. 2017;92(4):571-2.

Marcoval J, Mañá J. Specific (granulomatous) oral lesions of sarcoidosis: report of two cases. Med Oral Patol Oral Cir Bucal. 2010;15(3):e456-8.

Poate TW, Sharma R, Moutasim KA, Escudier MP, Warnakulasuriya S. Orofacial presentations of sarcoidosis--a case series and review of the literature. Br Dent J. 2008;205(8):437-42.

Referanslar

Napeñas JJ, Brennan MT, Elad S. Oral Manifestations of Systemic Diseases. Dermatol Clin. 2020;38(4):495-505.

Wray D. Gastrointestinal and granulomatous diseases. Periodontology 2000. 1998;18(1):95-101.

Fatahzadeh M, Schwartz RA, Kapila R, Rochford C. Orofacial Crohn's disease: an oral enigma. Acta Dermatovenerol Croat. 2009;17(4):289-300.

Islam NM, Bhattacharyya I, Cohen DM. Common oral manifestations of systemic disease. Otolaryngol Clin North Am. 2011;44(1):161-82, vi.

Sciubba JJ, Said-Al-Naief N. Orofacial granulomatosis: presentation, pathology and management of 13 cases. Journal of Oral Pathology & Medicine. 2003;32(10):576-85.

Pittock S, Drumm B, Fleming P, McDermott M, Imrie C, Flint S, et al. The oral cavity in Crohn's disease. J Pediatr. 2001;138(5):767-71.

Bianchi L, Carrozzo AM, Orlandi A, Campione E, Hagman JH, Chimenti S. Pyoderma vegetans and ulcerative colitis. Br J Dermatol. 2001;144(6):1224-7.

Li C, Wu Y, Xie Y, Zhang Y, Jiang S, Wang J, et al. Oral manifestations serve as potential signs of ulcerative colitis: A review. Frontiers in Immunology. 2022;13.

Boirivant M, Cossu A. Inflammatory bowel disease. Oral Dis. 2012;18(1):1-15.

Pazheri F, Alkhouri N, Radhakrishnan K. Pyostomatitis vegetans as an oral manifestation of Crohn's disease in a pediatric patient. Inflamm Bowel Dis. 2010;16(12):2007.

Femiano F, Lanza A, Buonaiuto C, Perillo L, Dell'Ermo A, Cirillo N. Pyostomatitis vegetans: a review of the literature. Med Oral Patol Oral Cir Bucal. 2009;14(3):E114-7.

Al-Zahrani MS, Alhassani AA, Zawawi KH. Clinical manifestations of gastrointestinal diseases in the oral cavity. The Saudi Dental Journal. 2021;33(8):835-41.

Di Fede O, Di Liberto C, Occhipinti G, Vigneri S, Lo Russo L, Fedele S, et al. Oral manifestations in patients with gastro-oesophageal reflux disease: a single-center case-control study. J Oral Pathol Med. 2008;37(6):336-40.

Greenwood M, Meechan J. General medicine and surgery for dental practitioners Part 3: Gastrointestinal system. British dental journal. 2003;194(12):659-63.

McColl K. Clinical practice. Helicobacter pylori infection. The New England journal of medicine. 2010;362(17):1597-604.

Dowsett S, Kowolik M. Oral Helicobacter pylori: can we stomach it? Critical Reviews in Oral Biology & Medicine. 2003;14(3):226-33.

Novacek G. Plummer-vinson syndrome. Orphanet Journal of rare diseases. 2006;1:1-4.

Cheng J, Malahias T, Brar P, Minaya MT, Green PH. The association between celiac disease, dental enamel defects, and aphthous ulcers in a United States cohort. Journal of clinical gastroenterology. 2010;44(3):191-4.

Çekın AH, Çekın Y, Sezer C. Celiac disease prevalence in patients with iron deficiency anemia. The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology. 2012;23(5):490-5.

Zegarelli DJ. Fungal infections of the oral cavity. Otolaryngol Clin North Am. 1993;26(6):1069-89.

Zimmer V, Buecker A, Lammert F. Sideropenic dysphagia. Gastroenterology. 2009;137(6):e1-2.

Toh BH, Alderuccio F. Pernicious anaemia. Autoimmunity. 2004;37(4):357-61.

Dabiri G, Damstetter E, Chang Y, Baiyee Ebot E, Powers JG, Phillips T. Coagulation disorders and their cutaneous presentations: Diagnostic work-up and treatment. J Am Acad Dermatol. 2016;74(5):795-804; quiz 5-6.

James WD, Guiry CC, Grote WR. Acute idiopathic thrombocytopenic purpura. Oral Surg Oral Med Oral Pathol. 1984;57(2):149-51.

Adams PC. Epidemiology and diagnostic testing for hemochromatosis and iron overload. Int J Lab Hematol. 2015;37 Suppl 1:25-30.

Pietrangelo A. Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology. 2010;139(2):393-408, .e1-2.

Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, et al. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med. 2005;352(17):1769-78.

Thoppay JR, Sollecito TP, De Rossi SS. Oral Signs of Endocrine and Metabolic Diseases. In: Fazel N, editor. Oral Signs of Systemic Disease. Cham: Springer International Publishing; 2019. p. 45-61.

Inzucchi SE. Clinical practice. Diagnosis of diabetes. N Engl J Med. 2012;367(6):542-50.

Mealey BL, Oates TW. Diabetes mellitus and periodontal diseases. J Periodontol. 2006;77(8):1289-303.

Mandel L, Patel S. Sialadenosis associated with diabetes mellitus: a case report. J Oral Maxillofac Surg. 2002;60(6):696-8.

Sreebny LM, Yu A, Green A, Valdini A. Xerostomia in diabetes mellitus. Diabetes Care. 1992;15(7):900-4.

Wysocki GP, Daley TD. Benign migratory glossitis in patients with juvenile diabetes. Oral Surg Oral Med Oral Pathol. 1987;63(1):68-70.

Young ER. The thyroid gland and the dental practitioner. J Can Dent Assoc. 1989;55(11):903-7.

Poumpros E, Loberg E, Engström C. Thyroid function and root resorption. The Angle Orthodontist. 1994;64(5):389-93.

Srirangarajan S, Satyanarayan A, Shivamurthy R, Thakur S. Dental manifestation of primary idiopathic hypoparathyroidism. Journal of Indian Society of Periodontology. 2014;18:524-6.

Can Ö, Boynueğri B, Gökçe AM, Özdemir E, Ferhatoğlu F, Canbakan M, et al. Brown tumors: a case report and review of the literature. Case reports in nephrology and dialysis. 2016;6(1):46-52.

Lexomboon D, Tägt M, Nilsson I-L, Buhlin K, Häbel H, Sandborgh-Englund G. Effects of primary hyperparathyroidism on oral health. A longitudinal register-based study. Oral Diseases. 2023;29(7):2954-61.

Findling JW, Raff H. Cushing's Syndrome: important issues in diagnosis and management. J Clin Endocrinol Metab. 2006;91(10):3746-53.

Chakera AJ, Vaidya B. Addison disease in adults: diagnosis and management. Am J Med. 2010;123(5):409-13.

Shah SS, Oh CH, Coffin SE, Yan AC. Addisonian pigmentation of the oral mucosa. Cutis. 2005;76(2):97-9.

Bugălă NM, Carsote M, Stoica LE, Albulescu DM, Ţuculină MJ, Preda SA, et al. New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden. Diagnostics (Basel). 2022;12(9).

Schenberg ME, Zajac JD, Lim-Tio S, Collier NA, Brooks AM, Reade PC. Multiple endocrine neoplasia syndrome--type 2b. Case report and review. Int J Oral Maxillofac Surg. 1992;21(2):110-4.

Hernández-Molina G, Avila-Casado C, Cárdenas-Velázquez F, Hernández-Hernández C, Calderillo ML, Marroquín V, et al. Similarities and differences between primary and secondary Sjögren's syndrome. J Rheumatol. 2010;37(4):800-8.

Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, et al. Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline. Journal of Clinical Oncology. 2021;39(25):2825-43.

Minozzi F, Galli M, Gallottini L, Minozzi M, Unfer V. Stomatological approach to Sjögren's syndrome: diagnosis, management and therapeutical timing. Eur Rev Med Pharmacol Sci. 2009;13(3):201-16.

Nocturne G, Mariette X. Sjögren Syndrome-associated lymphomas: an update on pathogenesis and management. Br J Haematol. 2015;168(3):317-27.

Fischer DJ, Patton LL. Scleroderma: oral manifestations and treatment challenges. Spec Care Dentist. 2000;20(6):240-4.

Gabrielli A, Avvedimento EV, Krieg T. Scleroderma. N Engl J Med. 2009;360(19):1989-2003.

Nagy G, Kovács J, Zeher M, Czirják L. Analysis of the oral manifestations of systemic sclerosis. Oral Surg Oral Med Oral Pathol. 1994;77(2):141-6.

Rout PG, Hamburger J, Potts AJ. Orofacial radiological manifestations of systemic sclerosis. Dentomaxillofac Radiol. 1996;25(4):193-6.

Siegel CH, Sammaritano LR. Systemic Lupus Erythematosus: A Review. JAMA. 2024;331(17):1480-91.

Anía BJ, Suman VJ, Sobell JL, Codd MB, Silverstein MN, Melton LJ, 3rd. Trends in the incidence of polycythemia vera among Olmsted County, Minnesota residents, 1935-1989. Am J Hematol. 1994;47(2):89-93.

Brennan MT, Valerin MA, Napeñas JJ, Lockhart PB. Oral manifestations of patients with lupus erythematosus. Dent Clin North Am. 2005;49(1):127-41, ix.

Grennan DM, Ferguson M, Williamson J, Mavrikakis M, Dick WC, Buchanan WW. Sjogren's syndrome in SLE: Part I. The frequency of the clinical and subclinical features of Sjogren's syndrome in patients with SLE. N Z Med J. 1977;86(598):374-6.

Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023-38.

Voog U, Alstergren P, Eliasson S, Leibur E, Kallikorm R, Kopp S. Progression of radiographic changes in the temporomandibular joints of patients with rheumatoid arthritis in relation to inflammatory markers and mediators in the blood. Acta Odontol Scand. 2004;62(1):7-13.

Hazenberg B. Amyloidosis: A Clinical Overview. Rheumatic diseases clinics of North America. 2013;39:323-45.

Costa JHSM, de Paula AB, de Oliveira Campos L, de Paula RB, Gotardelo DR. Macroglossia and periorbital ecchymoses in a patient with systemic amyloidosis: a case report. International Journal of Case Reports and Images (IJCRI). 2015;6(6):343-7.

Serdar A, Basak D, Sercan G, Ali V. Solitary amyloid tumor of the tongue base. Int J Otolaryngol. 2009;2009:515068.

Saadoun D, Bodaghi B, Cacoub P. Behçet’s Syndrome. New England Journal of Medicine. 2024;390(7):640-51.

Seyahi E. Phenotypes in Behçet’s syndrome. Internal and emergency medicine. 2019;14:677-89.

Altenburg A, El-Haj N, Micheli C, Puttkammer M, Abdel-Naser MB, Zouboulis CC. The treatment of chronic recurrent oral aphthous ulcers. Deutsches Ärzteblatt International. 2014;111(40):665.

Gualtierotti R, Marzano AV, Spadari F, Cugno M. Main Oral Manifestations in Immune-Mediated and Inflammatory Rheumatic Diseases. J Clin Med. 2018;8(1).

JD OD. In: Primer on the Rheumatic Diseases. Arthritis Foundation. 1993;Vol 29:p.206.

Gadiparthi C, Hans A, Potts K, Ismail MK. Gastrointestinal and Hepatic Disease in the Inflammatory Myopathies. Rheum Dis Clin North Am. 2018;44(1):113-29.

Iaccarino L, Ghirardello A, Bettio S, Zen M, Gatto M, Punzi L, et al. The clinical features, diagnosis and classification of dermatomyositis. J Autoimmun. 2014;48-49:122-7.

Mugii N, Hasegawa M, Matsushita T, Hamaguchi Y, Oohata S, Okita H, et al. Oropharyngeal Dysphagia in Dermatomyositis: Associations with Clinical and Laboratory Features Including Autoantibodies. PLoS One. 2016;11(5):e0154746.

Salvarani C, Pipitone N, Versari A, Hunder GG. Clinical features of polymyalgia rheumatica and giant cell arteritis. Nat Rev Rheumatol. 2012;8(9):509-21.

Paraskevas KI, Boumpas DT, Vrentzos GE, Mikhailidis DP. Oral and ocular/orbital manifestations of temporal arteritis: a disease with deceptive clinical symptoms and devastating consequences. Clin Rheumatol. 2007;26(7):1044-8.

Imai K, Iinuma T, Sato S. Relationship between the oral cavity and respiratory diseases: Aspiration of oral bacteria possibly contributes to the progression of lower airway inflammation. Jpn Dent Sci Rev. 2021;57:224-30.

Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11.

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