Porselen Aort ve Aort Kalsifikasyonu
Özet
Aort kalsifikasyonu, kalsiyum birikimi nedeniyle aort duvarında meydana gelen ve kardiyovasküler riskleri artıran bir hastalıktır. Porselen Aorta (PA), aşırı kalsiyum birikimi sonucu aort duvarının diffüz ve çevresel tutulumu ile karakterizedir, genellikle asendan aortta görülür. İntimal kalsifikasyon inme ve emboli riskini artırırken, media kalsifikasyonu cerrahi komplikasyonları artırır. Aterosklerotik ve non-aterosklerotik olmak üzere iki ana tipte görülür ve etiyolojisi buna göre değişir. PA'nın preoperatif tespiti, cerrahi planlamada değişiklikler yapmayı gerektirir. PA, özellikle kardiyak cerrahilerde ciddi komplikasyonlara yol açabilir, bu nedenle tanı ve tedavide dikkatli olunmalıdır. Avrupa ve Amerika kılavuzları, PA varlığında cerrahi yerine transkateter aortik kapak replasmanını önermektedir. PA, yüksek kardiyovasküler mortalite ve morbidite riskine sahip ciddi bir patolojidir.
Aortic calcification is a condition characterized by calcium deposits in the aortic wall, increasing cardiovascular risk. Porcelain Aorta (PA) refers to the diffuse and circumferential calcification of the aortic wall, most commonly seen in the ascending aorta. Intimal calcification raises the risk of stroke and embolism, while medial calcification increases surgical complications. PA occurs in two main types: atherosclerotic and non-atherosclerotic, with varying etiologies. Preoperative detection of PA is crucial for surgical planning. PA can lead to severe complications, especially during cardiac surgeries, making careful diagnosis and treatment essential. European and American guidelines recommend transcatheter aortic valve replacement instead of surgery in the presence of PA. PA is a serious pathology associated with high cardiovascular mortality and morbidity risks.
Referanslar
Boren J, Chapman MJ, Krauss RM, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus state- ment from the European Atherosclerosis Society Consensus Panel. Eur Heart J 2020;41:2313–30. doi: 10.1093/eurheartj/ehz962
Lanzer P, Boehm M, Sorribas V, et al. Medial vascular calcification revisited: review and perspectives. Eur Heart J 2014;35:1515–25. doi: 10.1093/eurheartj/ehu163.
Asenbaum U, Nolz R, Puchner SB, et al. Coronary artery bypass grafting and perioperative stroke: imaging of atherosclerotic plaques in the ascending aorta with ungated high-pitch CT-angiography. Sci Rep 2020;10:13909. doi: 10.1038/s41598-020-70830-4.
Takasu J, Katz R, Nasir K, et al. Relationships of thoracic aortic wall calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J. 2008;155:765–771. doi: 10.1016/j.ahj.2007.11.019.
Kälsch H, Lehmann N, Möhlenkamp S, et al; Investigator Group of the Heinz Nixdorf Recall Study. Prevalence of tho- racic aortic calcification and its relationship to cardiovascular risk factors and coronary calcification in an unselected population-based cohort: the Heinz Nixdorf Recall Study. Int J Cardiovasc Imaging. 2013;29:207–216. doi: 10.1007/s10554-012-0051-3.
Leyh RG, Bartels C, Nötzold A, et al. Management of porcelain aorta during coronary artery bypass grafting. Ann Thorac Surg. 1999 Apr;67(4):986-8. doi: 10.1016/s0003-4975(98)01370-8.
Leon MB, Smith CR, Mack M, et al. PARTNER Trial Investigators. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010 Oct 21;363(17):1597-607. doi: 10.1056/NEJMoa1008232
Gilard M, Eltchaninoff H, Iung B, et al. FRANCE 2 Investigators. Registry of transcatheter aortic-valve implantation in high-risk patients. N Engl J Med. 2012 May 03;366(18):1705-15. doi: 10.1056/NEJMoa1114705.
Zahn R, Schiele R, Gerckens U, et al. German Transcatheter Aortic Valve Interventions Registry Investigators. Transcatheter aortic valve implantation in patients with "porcelain" aorta (from a Multicenter Real World Registry). Am J Cardiol. 2013 Feb 15;111(4):602-8. doi: 10.1016/j.amjcard.2012.11.004.
Lev-Ran O, Ben-Gal Y, Matsa M, et al. 'No touch' techniques for porcelain ascending aorta: comparison between cardiopulmonary bypass with femoral artery cannulation and off-pump myocardial revascularization. J Card Surg. 2002 Sep-Oct;17(5):370-6. doi: 10.1111/j.1540-8191.2001.tb01161.x.
Proudfoot D, Shanahan CM. Biology of calcification in vascular cells: intima versus media. Herz. 2001;26:245–251. doi: 10.1007/pl00002027.
Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995;92:1355–1374. doi: 10.1161/01.cir.92.5.1355.
Shanahan CM, Cary NR, Metcalfe JC, et al. High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. J Clin Invest. 1994;93:2393–2402. doi: 10.1172/JCI117246.
Boström K, Watson KE, Horn S, et al. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest. 1993;91:1800–1809. doi: 10.1172/JCI116391.
Disthabanchong S. Vascular calcification in chronic kidney disease: pathogenesis and clinical implication. World J Nephrol. 2012;1:43–53. doi: 10.5527/wjn.v1.i2.43.
Reynolds JL, Joannides AJ, Skepper JN, et al. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concen- trations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol. 2004;15:2857–2867. doi: 10.1097/01. ASN.0000141960.01035.28.
Santos RD, Rumberger JA, Budoff MJ, et al. Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality. Atherosclerosis. 2010;209:131–135. doi: 10.1016/j.atherosclerosis.2009.08.025.
Vehmas T. Visually scored calcifications in thoracic arteries predict death: follow-up study after lung cancer CT screening. Acta Radiol. 2012;53:643–647. doi: 10.1258/ar.2012.120247.
Gondrie MJ, Mali WP, Jacobs PC, et al; PROVIDI Study Group. Cardiovascular disease: prediction with ancillary aortic find- ings on chest CT scans in routine practice. Radiology. 2010;257:549–559. doi: 10.1148/radiol.10100054.
Jacobs PC, Gondrie MJ, Mali WP, et al. Unrequested information from routine diagnostic chest CT predicts future cardiovascular events. Eur Radiol. 2011;21:1577–1585. doi: 10.1007/s00330-011-2112-8.
Tanne D, Tenenbaum A, Shemesh J, et al. Calcification of the thoracic aorta by spiral computed tomography among hypertensive patients: associations and risk of ischemic cerebrovascular events. Int J Cardiol. 2007;120:32–37. doi: 10.1016/j.ijcard.2006.08.010.
Takeda Y, Hoshiga M, Tatsugami F, et al. Clinical significance of calcification in ascending aorta as a marker for the requirement of coronary revascularization. J Atheroscler Thromb. 2009;16:346–354. doi: 10.5551/jat.no1032
Yamamoto H, Shavelle D, Takasu J, et al. Valvular and thoracic aortic calcium as a marker of the extent and severity of angiographic coronary artery disease. Am Heart J. 2003;146:153–159. doi: 10.1016/S0002-8703(03)00105-4.
Dohmen G, Hatam N, Goetzenich A, et al. PAS-Port® clampless proximal anastomotic device for coronary bypass surgery in porcelain aorta. Eur J Cardiothorac Surg. 2011 Jan;39(1):49- 52. doi: 10.1016/j.ejcts.2010.04.010.
Lev-Ran O, Braunstein R, Sharony R, et al. No-touch aorta off-pump coronary surgery: the effect on stroke. J Thorac Cardiovasc Surg. 2005 Feb;129(2):307-13. doi: 10.1016/j.jtcvs.2004.06.013.
Abramowitz Y, Jilaihawi H, Chakravarty T, et al. Porcelain aorta: a comprehensive review. Circulation. 2015 Mar 03;131(9):827-36. doi: 10.1161/CIRCULATIONAHA.114.011867.
Pascual I, Avanzas P, Muñoz-García AJ, et al. Percutaneous implantation of the CoreValve® self-expanding valve prosthesis in patients with severe aortic stenosis and porcelain aorta: medium- term follow-up. Rev Esp Cardiol (Engl Ed). 2013 Oct;66(10):775-81. doi: 10.1016/j.rec.2013.03.001.
Writing Committee Members, Otto CM, Nishimura RA, et al. ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American heart association Joint committee on clinical Practice guidelines. J Am Coll Cardiol. 2020;77:450–500, 2021. doi: 10.1016/j.jacc.2020.11.035.
Vahanian A, Beyersdorf F, Praz F, et al; ESC/EACTS Scientific Document Group. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022 Feb 12;43(7):561-632. doi: 10.1093/eurheartj/ehab395.
Referanslar
Boren J, Chapman MJ, Krauss RM, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus state- ment from the European Atherosclerosis Society Consensus Panel. Eur Heart J 2020;41:2313–30. doi: 10.1093/eurheartj/ehz962
Lanzer P, Boehm M, Sorribas V, et al. Medial vascular calcification revisited: review and perspectives. Eur Heart J 2014;35:1515–25. doi: 10.1093/eurheartj/ehu163.
Asenbaum U, Nolz R, Puchner SB, et al. Coronary artery bypass grafting and perioperative stroke: imaging of atherosclerotic plaques in the ascending aorta with ungated high-pitch CT-angiography. Sci Rep 2020;10:13909. doi: 10.1038/s41598-020-70830-4.
Takasu J, Katz R, Nasir K, et al. Relationships of thoracic aortic wall calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J. 2008;155:765–771. doi: 10.1016/j.ahj.2007.11.019.
Kälsch H, Lehmann N, Möhlenkamp S, et al; Investigator Group of the Heinz Nixdorf Recall Study. Prevalence of tho- racic aortic calcification and its relationship to cardiovascular risk factors and coronary calcification in an unselected population-based cohort: the Heinz Nixdorf Recall Study. Int J Cardiovasc Imaging. 2013;29:207–216. doi: 10.1007/s10554-012-0051-3.
Leyh RG, Bartels C, Nötzold A, et al. Management of porcelain aorta during coronary artery bypass grafting. Ann Thorac Surg. 1999 Apr;67(4):986-8. doi: 10.1016/s0003-4975(98)01370-8.
Leon MB, Smith CR, Mack M, et al. PARTNER Trial Investigators. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010 Oct 21;363(17):1597-607. doi: 10.1056/NEJMoa1008232
Gilard M, Eltchaninoff H, Iung B, et al. FRANCE 2 Investigators. Registry of transcatheter aortic-valve implantation in high-risk patients. N Engl J Med. 2012 May 03;366(18):1705-15. doi: 10.1056/NEJMoa1114705.
Zahn R, Schiele R, Gerckens U, et al. German Transcatheter Aortic Valve Interventions Registry Investigators. Transcatheter aortic valve implantation in patients with "porcelain" aorta (from a Multicenter Real World Registry). Am J Cardiol. 2013 Feb 15;111(4):602-8. doi: 10.1016/j.amjcard.2012.11.004.
Lev-Ran O, Ben-Gal Y, Matsa M, et al. 'No touch' techniques for porcelain ascending aorta: comparison between cardiopulmonary bypass with femoral artery cannulation and off-pump myocardial revascularization. J Card Surg. 2002 Sep-Oct;17(5):370-6. doi: 10.1111/j.1540-8191.2001.tb01161.x.
Proudfoot D, Shanahan CM. Biology of calcification in vascular cells: intima versus media. Herz. 2001;26:245–251. doi: 10.1007/pl00002027.
Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995;92:1355–1374. doi: 10.1161/01.cir.92.5.1355.
Shanahan CM, Cary NR, Metcalfe JC, et al. High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. J Clin Invest. 1994;93:2393–2402. doi: 10.1172/JCI117246.
Boström K, Watson KE, Horn S, et al. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest. 1993;91:1800–1809. doi: 10.1172/JCI116391.
Disthabanchong S. Vascular calcification in chronic kidney disease: pathogenesis and clinical implication. World J Nephrol. 2012;1:43–53. doi: 10.5527/wjn.v1.i2.43.
Reynolds JL, Joannides AJ, Skepper JN, et al. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concen- trations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol. 2004;15:2857–2867. doi: 10.1097/01. ASN.0000141960.01035.28.
Santos RD, Rumberger JA, Budoff MJ, et al. Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality. Atherosclerosis. 2010;209:131–135. doi: 10.1016/j.atherosclerosis.2009.08.025.
Vehmas T. Visually scored calcifications in thoracic arteries predict death: follow-up study after lung cancer CT screening. Acta Radiol. 2012;53:643–647. doi: 10.1258/ar.2012.120247.
Gondrie MJ, Mali WP, Jacobs PC, et al; PROVIDI Study Group. Cardiovascular disease: prediction with ancillary aortic find- ings on chest CT scans in routine practice. Radiology. 2010;257:549–559. doi: 10.1148/radiol.10100054.
Jacobs PC, Gondrie MJ, Mali WP, et al. Unrequested information from routine diagnostic chest CT predicts future cardiovascular events. Eur Radiol. 2011;21:1577–1585. doi: 10.1007/s00330-011-2112-8.
Tanne D, Tenenbaum A, Shemesh J, et al. Calcification of the thoracic aorta by spiral computed tomography among hypertensive patients: associations and risk of ischemic cerebrovascular events. Int J Cardiol. 2007;120:32–37. doi: 10.1016/j.ijcard.2006.08.010.
Takeda Y, Hoshiga M, Tatsugami F, et al. Clinical significance of calcification in ascending aorta as a marker for the requirement of coronary revascularization. J Atheroscler Thromb. 2009;16:346–354. doi: 10.5551/jat.no1032
Yamamoto H, Shavelle D, Takasu J, et al. Valvular and thoracic aortic calcium as a marker of the extent and severity of angiographic coronary artery disease. Am Heart J. 2003;146:153–159. doi: 10.1016/S0002-8703(03)00105-4.
Dohmen G, Hatam N, Goetzenich A, et al. PAS-Port® clampless proximal anastomotic device for coronary bypass surgery in porcelain aorta. Eur J Cardiothorac Surg. 2011 Jan;39(1):49- 52. doi: 10.1016/j.ejcts.2010.04.010.
Lev-Ran O, Braunstein R, Sharony R, et al. No-touch aorta off-pump coronary surgery: the effect on stroke. J Thorac Cardiovasc Surg. 2005 Feb;129(2):307-13. doi: 10.1016/j.jtcvs.2004.06.013.
Abramowitz Y, Jilaihawi H, Chakravarty T, et al. Porcelain aorta: a comprehensive review. Circulation. 2015 Mar 03;131(9):827-36. doi: 10.1161/CIRCULATIONAHA.114.011867.
Pascual I, Avanzas P, Muñoz-García AJ, et al. Percutaneous implantation of the CoreValve® self-expanding valve prosthesis in patients with severe aortic stenosis and porcelain aorta: medium- term follow-up. Rev Esp Cardiol (Engl Ed). 2013 Oct;66(10):775-81. doi: 10.1016/j.rec.2013.03.001.
Writing Committee Members, Otto CM, Nishimura RA, et al. ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American heart association Joint committee on clinical Practice guidelines. J Am Coll Cardiol. 2020;77:450–500, 2021. doi: 10.1016/j.jacc.2020.11.035.
Vahanian A, Beyersdorf F, Praz F, et al; ESC/EACTS Scientific Document Group. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022 Feb 12;43(7):561-632. doi: 10.1093/eurheartj/ehab395.