Epilepsi Cerrahisine Hazırlıkta İlk Aşama ve Non-İnvazif Tetkiklerle Değerlendirme-Nükleer Tıp
Özet
Bu kitap bölümünde ilaca dirençli epilepsi hastalarının epilepsi cerrahisine hazırlanması aşamasında işlevsel Nükleer Tıp görüntüleme yöntemleri [Beyin perfüzyon SPECT (“Single Photon Emission Computed Tomography”) ve Floro Deoksi Glukoz (FDG) ile yapılan Pozitron Emiston Tomografisi (PET)] hakkında bilgi verilmeye çalışılmıştır. İşlevsel görüntüleme yöntemlerinin endikasyonları, tetkiklerin avantajları ve bu süreçte verdikleri bilgilerin çocuklardaki cerrahi planlamasındaki rolü anlatılmaya çalışılmıştır.
Referanslar
Thomsen, G. & Knudsen, G.M.: Procedure guideline for brain perfusion SPECT using 99mTc radiopharmaceuticals 3.0. J Nucl Med Technol. 2010; 38: 209.
Technetium Tc 99m Bicisate. (2006) in Drugs and Lactation Database (LactMed(R)) (Bethesda (MD).
Goffin, K. & van Laere, K.: Single-photon emission tomography. Handb Clin Neurol. 2016; 135: 241-250.
Grunwald, F., Menzel, C., Pavics, L. et al: Ictal and interictal brain SPECT imaging in epilepsy using technetium-99m-ECD. J Nucl Med. 1994; 35: 1896-1901.
Newton, M.R., Berkovic, S.F., Austin, M.C., Rowe, C.C., McKay, W.J. & Bladin, P.F.: Postictal switch in blood flow distribution and temporal lobe seizures. J Neurol Neurosurg Psychiatry. 1992; 55: 891-894.
Vander Borght, T., Laloux, P., Maes, A. et al: Guidelines for brain radionuclide imaging. Perfusion single photon computed tomography (SPECT) using Tc-99m radiopharmaceuticals and brain metabolism positron emission tomography (PET) using F-18 fluorodeoxyglucose. The Belgian Society for Nuclear Medicine. Acta Neurol Belg. 2001; 101: 196-209.
Chassagnon, S., Namer, I.J., Armspach, J.P. et al: SPM analysis of ictal-interictal SPECT in mesial temporal lobe epilepsy: relationships between ictal semiology and perfusion changes. Epilepsy Res. 2009; 85: 252-260.
la Fougere, C., Rominger, A., Forster, S., Geisler, J. & Bartenstein, P.: PET and SPECT in epilepsy: a critical review. Epilepsy Behav. 2009; 15: 50-55.
Velasco, T.R., Wichert-Ana, L., Mathern, G.W. et al: Utility of ictal single photon emission computed tomography in mesial temporal lobe epilepsy with hippocampal atrophy: a randomized trial. Neurosurgery. 2011; 68: 431-436; discussion 436.
Wichert-Ana, L., Velasco, T.R., Terra-Bustamante, V.C. et al: Typical and atypical perfusion patterns in periictal SPECT of patients with unilateral temporal lobe epilepsy. Epilepsia. 2001; 42: 660-666.
von Oertzen, T.J., Mormann, F., Urbach, H. et al: Prospective use of subtraction ictal SPECT coregistered to MRI (SISCOM) in presurgical evaluation of epilepsy. Epilepsia. 2011; 52: 2239-2248.
O'Brien, T.J., So, E.L., Cascino, G.D. et al: Subtraction SPECT coregistered to MRI in focal malformations of cortical development: localization of the epileptogenic zone in epilepsy surgery candidates. Epilepsia. 2004; 45: 367-376.
Kudr, M., Krsek, P., Marusic, P. et al: SISCOM and FDG-PET in patients with non-lesional extratemporal epilepsy: correlation with intracranial EEG, histology, and seizure outcome. Epileptic Disord. 2013; 15: 3-13.
Wetjen, N.M., Cascino, G.D., Fessler, A.J. et al: Subtraction ictal single-photon emission computed tomography coregistered to magnetic resonance imaging in evaluating the need for repeated epilepsy surgery. J Neurosurg. 2006; 105: 71-76.
Haemels, M., Van Weehaeghe, D., Cleeren, E. et al: Predictive value of metabolic and perfusion changes outside the seizure onset zone for postoperative outcome in patients with refractory focal epilepsy. Acta Neurol Belg. 2022; 122: 325-335.
Ergun, E.L., Saygi, S., Yalnizoglu, D., Oguz, K.K. & Erbas, B.: SPECT-PET in Epilepsy and Clinical Approach in Evaluation. Semin Nucl Med. 2016; 46: 294-307.
Kim, Y.K., Lee, D.S., Lee, S.K., Chung, C.K., Chung, J.K. & Lee, M.C.: (18)F-FDG PET in localization of frontal lobe epilepsy: comparison of visual and SPM analysis. J Nucl Med. 2002; 43: 1167-1174.
Muzik, O., da Silva, E.A., Juhasz, C. et al: Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology. 2000; 54: 171-179.
Juhasz, C., Chugani, D.C., Muzik, O. et al: Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. Neurology. 2000; 55: 825-835.
Juhasz, C., Nagy, F., Muzik, O., Watson, C., Shah, J. & Chugani, H.T.: [11C]Flumazenil PET in patients with epilepsy with dual pathology. Epilepsia. 1999; 40: 566-574.
Juhasz, C., Chugani, D.C., Muzik, O. et al: Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology. 2003; 60: 960-968.
Ergün EL, E.B.: Çocukluk çağında epilepsi ve Nükleer tip. Katki Pediatri Dergisi. 2005; 27: 228-246.
Oguz KK, Ergün.EL. (2008) Epilepsi ve Fonksiyonel-Metabolik Görüntüleme. in Epilepsi. , Vol. 1 (ed. Bora İ, Y.S., Gürses C) (Nobel TİP Kitabevleri, Ankara.
Ergün EL (2011). Hareket bozuklukları, inme, epilepsi. in PET ve PET/BT Prensipler ve Uygulamalar.; (ed. Caner B, U.Ö., Bozkurt MF, ) ( Öncü Basimevi, Rotatip Kitabevi, Ankara.
Kumar, A. & Chugani, H.T.: The Role of Radionuclide Imaging in Epilepsy, Part 2: Epilepsy Syndromes. J Nucl Med Technol. 2017; 45: 22-29.
Pavone, P., Striano, P., Falsaperla, R., Pavone, L. & Ruggieri, M.: Infantile spasms syndrome, West syndrome and related phenotypes: what we know in 2013. Brain Dev. 2014; 36: 739-751.
Chugani, H.T., Shields, W.D., Shewmon, D.A., Olson, D.M., Phelps, M.E. & Peacock, W.J.: Infantile spasms: I. PET identifies focal cortical dysgenesis in cryptogenic cases for surgical treatment. Ann Neurol. 1990; 27: 406-413.
Lee, J.S., Asano, E., Muzik, O. et al: Sturge-Weber syndrome: correlation between clinical course and FDG PET findings. Neurology. 2001; 57: 189-195.
De la Torre, A.J., Luat, A.F., Juhasz, C. et al: A Multidisciplinary Consensus for Clinical Care and Research Needs for Sturge-Weber Syndrome. Pediatr Neurol. 2018; 84: 11-20.
Alkonyi, B., Chugani, H.T. & Juhasz, C.: Transient focal cortical increase of interictal glucose metabolism in Sturge-Weber syndrome: implications for epileptogenesis. Epilepsia. 2011; 52: 1265-1272.
Kagawa, K., Chugani, D.C., Asano, E. et al: Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET). J Child Neurol. 2005; 20: 429-438.
Ferrendelli, J.A.: Lennox-Gastaut syndrome and positron emission tomography. Ann Neurol. 1987; 21: 3.
Ostendorf, A.P. & Ng, Y.T.: Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions. Neuropsychiatr Dis Treat. 2017; 13: 1131-1140.
Archer, J.S., Warren, A.E., Stagnitti, M.R., Masterton, R.A., Abbott, D.F. & Jackson, G.D.: Lennox-Gastaut syndrome and phenotype: secondary network epilepsies. Epilepsia. 2014; 55: 1245-1254.
Bordonne, M., Chawki, M.B., Doyen, M. et al: Brain (18)F-FDG PET for the diagnosis of autoimmune encephalitis: a systematic review and a meta-analysis. Eur J Nucl Med Mol Imaging. 2021; 48: 3847-3858.
Referanslar
Thomsen, G. & Knudsen, G.M.: Procedure guideline for brain perfusion SPECT using 99mTc radiopharmaceuticals 3.0. J Nucl Med Technol. 2010; 38: 209.
Technetium Tc 99m Bicisate. (2006) in Drugs and Lactation Database (LactMed(R)) (Bethesda (MD).
Goffin, K. & van Laere, K.: Single-photon emission tomography. Handb Clin Neurol. 2016; 135: 241-250.
Grunwald, F., Menzel, C., Pavics, L. et al: Ictal and interictal brain SPECT imaging in epilepsy using technetium-99m-ECD. J Nucl Med. 1994; 35: 1896-1901.
Newton, M.R., Berkovic, S.F., Austin, M.C., Rowe, C.C., McKay, W.J. & Bladin, P.F.: Postictal switch in blood flow distribution and temporal lobe seizures. J Neurol Neurosurg Psychiatry. 1992; 55: 891-894.
Vander Borght, T., Laloux, P., Maes, A. et al: Guidelines for brain radionuclide imaging. Perfusion single photon computed tomography (SPECT) using Tc-99m radiopharmaceuticals and brain metabolism positron emission tomography (PET) using F-18 fluorodeoxyglucose. The Belgian Society for Nuclear Medicine. Acta Neurol Belg. 2001; 101: 196-209.
Chassagnon, S., Namer, I.J., Armspach, J.P. et al: SPM analysis of ictal-interictal SPECT in mesial temporal lobe epilepsy: relationships between ictal semiology and perfusion changes. Epilepsy Res. 2009; 85: 252-260.
la Fougere, C., Rominger, A., Forster, S., Geisler, J. & Bartenstein, P.: PET and SPECT in epilepsy: a critical review. Epilepsy Behav. 2009; 15: 50-55.
Velasco, T.R., Wichert-Ana, L., Mathern, G.W. et al: Utility of ictal single photon emission computed tomography in mesial temporal lobe epilepsy with hippocampal atrophy: a randomized trial. Neurosurgery. 2011; 68: 431-436; discussion 436.
Wichert-Ana, L., Velasco, T.R., Terra-Bustamante, V.C. et al: Typical and atypical perfusion patterns in periictal SPECT of patients with unilateral temporal lobe epilepsy. Epilepsia. 2001; 42: 660-666.
von Oertzen, T.J., Mormann, F., Urbach, H. et al: Prospective use of subtraction ictal SPECT coregistered to MRI (SISCOM) in presurgical evaluation of epilepsy. Epilepsia. 2011; 52: 2239-2248.
O'Brien, T.J., So, E.L., Cascino, G.D. et al: Subtraction SPECT coregistered to MRI in focal malformations of cortical development: localization of the epileptogenic zone in epilepsy surgery candidates. Epilepsia. 2004; 45: 367-376.
Kudr, M., Krsek, P., Marusic, P. et al: SISCOM and FDG-PET in patients with non-lesional extratemporal epilepsy: correlation with intracranial EEG, histology, and seizure outcome. Epileptic Disord. 2013; 15: 3-13.
Wetjen, N.M., Cascino, G.D., Fessler, A.J. et al: Subtraction ictal single-photon emission computed tomography coregistered to magnetic resonance imaging in evaluating the need for repeated epilepsy surgery. J Neurosurg. 2006; 105: 71-76.
Haemels, M., Van Weehaeghe, D., Cleeren, E. et al: Predictive value of metabolic and perfusion changes outside the seizure onset zone for postoperative outcome in patients with refractory focal epilepsy. Acta Neurol Belg. 2022; 122: 325-335.
Ergun, E.L., Saygi, S., Yalnizoglu, D., Oguz, K.K. & Erbas, B.: SPECT-PET in Epilepsy and Clinical Approach in Evaluation. Semin Nucl Med. 2016; 46: 294-307.
Kim, Y.K., Lee, D.S., Lee, S.K., Chung, C.K., Chung, J.K. & Lee, M.C.: (18)F-FDG PET in localization of frontal lobe epilepsy: comparison of visual and SPM analysis. J Nucl Med. 2002; 43: 1167-1174.
Muzik, O., da Silva, E.A., Juhasz, C. et al: Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology. 2000; 54: 171-179.
Juhasz, C., Chugani, D.C., Muzik, O. et al: Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. Neurology. 2000; 55: 825-835.
Juhasz, C., Nagy, F., Muzik, O., Watson, C., Shah, J. & Chugani, H.T.: [11C]Flumazenil PET in patients with epilepsy with dual pathology. Epilepsia. 1999; 40: 566-574.
Juhasz, C., Chugani, D.C., Muzik, O. et al: Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology. 2003; 60: 960-968.
Ergün EL, E.B.: Çocukluk çağında epilepsi ve Nükleer tip. Katki Pediatri Dergisi. 2005; 27: 228-246.
Oguz KK, Ergün.EL. (2008) Epilepsi ve Fonksiyonel-Metabolik Görüntüleme. in Epilepsi. , Vol. 1 (ed. Bora İ, Y.S., Gürses C) (Nobel TİP Kitabevleri, Ankara.
Ergün EL (2011). Hareket bozuklukları, inme, epilepsi. in PET ve PET/BT Prensipler ve Uygulamalar.; (ed. Caner B, U.Ö., Bozkurt MF, ) ( Öncü Basimevi, Rotatip Kitabevi, Ankara.
Kumar, A. & Chugani, H.T.: The Role of Radionuclide Imaging in Epilepsy, Part 2: Epilepsy Syndromes. J Nucl Med Technol. 2017; 45: 22-29.
Pavone, P., Striano, P., Falsaperla, R., Pavone, L. & Ruggieri, M.: Infantile spasms syndrome, West syndrome and related phenotypes: what we know in 2013. Brain Dev. 2014; 36: 739-751.
Chugani, H.T., Shields, W.D., Shewmon, D.A., Olson, D.M., Phelps, M.E. & Peacock, W.J.: Infantile spasms: I. PET identifies focal cortical dysgenesis in cryptogenic cases for surgical treatment. Ann Neurol. 1990; 27: 406-413.
Lee, J.S., Asano, E., Muzik, O. et al: Sturge-Weber syndrome: correlation between clinical course and FDG PET findings. Neurology. 2001; 57: 189-195.
De la Torre, A.J., Luat, A.F., Juhasz, C. et al: A Multidisciplinary Consensus for Clinical Care and Research Needs for Sturge-Weber Syndrome. Pediatr Neurol. 2018; 84: 11-20.
Alkonyi, B., Chugani, H.T. & Juhasz, C.: Transient focal cortical increase of interictal glucose metabolism in Sturge-Weber syndrome: implications for epileptogenesis. Epilepsia. 2011; 52: 1265-1272.
Kagawa, K., Chugani, D.C., Asano, E. et al: Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET). J Child Neurol. 2005; 20: 429-438.
Ferrendelli, J.A.: Lennox-Gastaut syndrome and positron emission tomography. Ann Neurol. 1987; 21: 3.
Ostendorf, A.P. & Ng, Y.T.: Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions. Neuropsychiatr Dis Treat. 2017; 13: 1131-1140.
Archer, J.S., Warren, A.E., Stagnitti, M.R., Masterton, R.A., Abbott, D.F. & Jackson, G.D.: Lennox-Gastaut syndrome and phenotype: secondary network epilepsies. Epilepsia. 2014; 55: 1245-1254.
Bordonne, M., Chawki, M.B., Doyen, M. et al: Brain (18)F-FDG PET for the diagnosis of autoimmune encephalitis: a systematic review and a meta-analysis. Eur J Nucl Med Mol Imaging. 2021; 48: 3847-3858.
