Tonik–Klonik Nöbetlerle Birlikte Olan İdiyopatik Jeneralize Epilepsi Sendromu
Özet
İdiyopatik jeneralize epilepsiler içinde tek başına jeneralize tonik klonik nöbetlerin görüldüğü jeneralize tonik klonik nöbetli epilepsi sendromu sık görülen bir epilepsi sendromudur. Etkilenen bireyler çoğunlukla ikinci veya erken üçüncü on yılda başlayan, değişen sıklıkta görülen jeneralize tonik–klonik nöbetlere sahiptirler. Genellikle nöbetler uykusuzluk nedeniyle tetiklenir ve hastalarda diğer nöbet türleri ile birlikte görülmez. Öncelikle nöbetleri tetikleyen nedenler, yüksek doz alkol alımı, uykusuzluktan kaçınılması gerektiği hastalara anlatılmalıdır. Bazı hastalarda yaşam biçimini değiştirmek bile nöbetlerin tekrarını engelleyebilir. Tedavide, monoterapide valproik asit ve lamotrijin önerilir.
Referanslar
Caraballo R, Silva S, Beltran L, Calvo A, Caballero R. Childhood-only epilepsy with generalized tonic-clonic seizures: A well-defined epileptic syndrome. Epilepsy Res. 2019 ;153:28-33.
Vorderwulbecke BJ, Kowski AB, Kirschbaum A, Merkle H, Senf P, Janz D, et al. Long-term outcome in adolescent-onset generalized genetic epilepsies. Epilepsia 2017;58:1244-1250.
Beghi M, Beghi E, Cornaggia CM, Gobbi G. Idiopathic generalized epilepsies of adolescence. Epilepsia 2006;47:107-110.
Syvertsen M, Nakken KO, Edland A, Hansen G, Hellum MK, Koht J. Prevalence and etiology of epilepsy in a Norwegian county-A population based study. Epilepsia 2015;56:699-70
Holtkamp M, Kowski AB, Merkle H, Janz D. Long-term outcome in epilepsy with grand mal on awakening: forty years of follow-up. Ann Neurol 2014;75:298-302.
Zhang YH, Burgess R, Malone JP, Glubb GC, Helbig KL, Vadlamudi L, et al. Genetic epilepsy with febrile seizures plus: Refining the spectrum. Neurology 2017;89:1210-1219.
Mostacci B, Bisulli F, Alvisi L, Licchetta L, Baruzzi A, Tinuper P. Ictal characteristics of psychogenic nonepileptic seizures: what we have learned from video/EEG recordings--a literature review. Epilepsy Behav 2011;22:144-153.
Hovorka J, Nezadal T, Herman E, Nemcova I, Bajacek M. Psychogenic non-epileptic seizures, prospective clinical experience: diagnosis, clinical features, risk factors, psychiatric comorbidity, treatment outcome. Epileptic Disord 2007;9:52-58.
Shmuely S, Bauer PR, van Zwet EW, van Dijk JG, Thijs RD. Differentiating motor phenomena in tilt-induced syncope and convulsive seizures. Neurology 2018;90:1339-1346.
Referanslar
Caraballo R, Silva S, Beltran L, Calvo A, Caballero R. Childhood-only epilepsy with generalized tonic-clonic seizures: A well-defined epileptic syndrome. Epilepsy Res. 2019 ;153:28-33.
Vorderwulbecke BJ, Kowski AB, Kirschbaum A, Merkle H, Senf P, Janz D, et al. Long-term outcome in adolescent-onset generalized genetic epilepsies. Epilepsia 2017;58:1244-1250.
Beghi M, Beghi E, Cornaggia CM, Gobbi G. Idiopathic generalized epilepsies of adolescence. Epilepsia 2006;47:107-110.
Syvertsen M, Nakken KO, Edland A, Hansen G, Hellum MK, Koht J. Prevalence and etiology of epilepsy in a Norwegian county-A population based study. Epilepsia 2015;56:699-70
Holtkamp M, Kowski AB, Merkle H, Janz D. Long-term outcome in epilepsy with grand mal on awakening: forty years of follow-up. Ann Neurol 2014;75:298-302.
Zhang YH, Burgess R, Malone JP, Glubb GC, Helbig KL, Vadlamudi L, et al. Genetic epilepsy with febrile seizures plus: Refining the spectrum. Neurology 2017;89:1210-1219.
Mostacci B, Bisulli F, Alvisi L, Licchetta L, Baruzzi A, Tinuper P. Ictal characteristics of psychogenic nonepileptic seizures: what we have learned from video/EEG recordings--a literature review. Epilepsy Behav 2011;22:144-153.
Hovorka J, Nezadal T, Herman E, Nemcova I, Bajacek M. Psychogenic non-epileptic seizures, prospective clinical experience: diagnosis, clinical features, risk factors, psychiatric comorbidity, treatment outcome. Epileptic Disord 2007;9:52-58.
Shmuely S, Bauer PR, van Zwet EW, van Dijk JG, Thijs RD. Differentiating motor phenomena in tilt-induced syncope and convulsive seizures. Neurology 2018;90:1339-1346.
