Sentrotemporal Dikenli Kendini Sınırlayan Epilepsi (SeLECTS)

Ekrem Emre Yılmaz; Mutluay Arslan

doi:10.37609/akya.3122

Yazarlar

Ekrem Emre Yılmaz

https://orcid.org/0009-0004-9620-9884

Mutluay Arslan

https://orcid.org/0000-0002-6520-1810

DOI: https://doi.org/10.37609/akya.3122.c12208

Özet

SeLECTS, erken çocukluk döneminde başlayan, önceden iyi huylu Rölandik epilepsi veya sentrotemporal dikenli iyi huylu epilepsi olarak bilinen, kendini sınırlayan bir epilepsi sendromudur. Nöbetler sıklıkla kısadır. Tipik olarak yüzün, ağzın ya da dilin tek taraflı uyuşma ve parestezi sonrası yüzün alt yarısının tonik ya da klonik kasılmasıyla giden orofasiyal motor bulgular görülür. Devamında fokal ya da bilateral tonik-klonik nöbete dönüşebilir. Bu epilepsi sendromu nörolojik ve bilişsel açıdan normal olan çocuklarda ortaya çıkar ve görüntülemede özellik izlenmemektedir. Elektroensefalografide, uyku ve uykuya dalma sırasında artış gösteren normal zemin ritmiyle beraber yüksek amplitüdlü sentrotemporal keskin-yavaş dalga kompleksi izlenir. Nöbetler ergenlik döneminde sona erer.

SeLECTS is a self-limiting epilepsy syndrome with onset in early childhood, formerly known as benign Rolandic epilepsy or benign epilepsy with centrotemporal spikes. Seizures are often short. Typically, orofacial motor findings with tonic or clonic contraction of the lower half of the face are observed after unilateral numbness and paresthesia of the face, mouth or tongue. It may subsequently turn into a focal or bilateral tonic-clonic seizure. This epilepsy syndrome occurs in children who are neurologically and cognitively normal, and there is no feature on imaging. In electroencephalography, a high-amplitude centrotemporal sharp-slow wave complex is observed along with the normal background rhythm that increases during sleep and falling asleep. Seizures end in adolescence.

Referanslar

Loiseau P, Beaussart M. The seizures of benign childhood epilepsy with Rolandic paroxysmal discharges. Epilepsia. 1973;14(4): 381-9.

Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification ofthe epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):512– 21.

Gastaut Y: Un e'lle'ment de' routant de la se'me'iologie e'lectroence'phalographique: Les pointes pre'rolandiques sans signification focale. Rev Neurol 1952;87: 488-490.

Nayrac P, Beaussart M: Les pointes-ondes pre'rolandiques: Expression EEG tre's particulie're: Etude e'lectroclinique de 21 cas. Rev Neurol 1958;99: 201-206.

Gregory DL, Wong PK: Topographical analysis of the centrotemporal discharges in benign rolandic epilepsy of childhood. Epilepsia 1984; 25: 705-711.

Penfield W, Jasper H: Epilepsy and the Functional Anatomy of the Human Brain. Boston, Little Brown & Co, 1954

Dalla Bernardina B, Sgrò V, Caraballo R, et al. Sleep and benign partial epilepsies ofchild-hood: EEG and evoked potentials study. Epilepsy Res Suppl. 1991;2: 83-96.

Pal DK, Ferrie C, Addis L, et al. Idiopathic focal epilepsies: the “lost tribe”. Epileptic Disord. 2016;18(3): 252-88.

Vears DF, Tsai M- H, Sadleir LG, et al. Clinical genetic studies in benign childhood epilepsy with centrotemporal spikes. Epilepsia. 2012;53(2): 319-24.

Wirrell EC, Grossardt BR, Wong- Kisiel LCL, Nickels KC. Incidence and classification ofnew-onset epilepsy and epi-lepsy syndromes in children in Olmsted County, Minnesota from 1980 to 2004: a population- based study. Epilepsy Res. 2011;95(1– 2): 110-8.

Camfield CS, Camfield PR, Gordon K, Wirrell E, Dooley JM. Incidence ofepilepsy in childhood and adolescence: a population- based study in Nova Scotia from 1977 to 1985. Epilepsia. 1996;37(1): 19-23.

Weir E, Gibbs J, Appleton R. Panayiotopoulos syndrome and benign partial epilepsy with centro- temporal spikes: a compar-ative incidence study. Seizure. 2018;57: 66-9.

Astradsson A, Olafsson E, Ludvigsson P, Bjorgvinsson H, Hauser WA. Rolandic Epilepsy: an incidence study in Iceland. Epilepsia. 1998;39(8): 884-6.

Berg AT, Shinnar S, Levy SR, Testa FM. Newly diagnosed epilepsy in children: presentation at diagnosis. Epilepsia. 1999;40(4): 445-52.

Beaussart M. Benign epilepsy ofchildren with Rolandic (centro- temporal) paroxysmal foci. A clinical entity. Study of221 cases. Epilepsia. 1972;13(6): 795-811.

Larsson K, Eeg-Olofsson O. A population based study ofepi-lepsy in children from a Swedish county. Eur J Paediatr Neurol. 2006;10(3): 107-13.

Caraballo R, Cersósimo R, Fejerman N. Panayiotopoulos syndrome: a prospective study of192 patients. Epilepsia. 2007;48(6): 1054-61.

Larson K, Eeg- Olofson O. A population based study of epilepsy in children from a Swedish county. Eur J Paediatr Neurol 2006; 10: 107-13.

Overvliet GM, Aldenkamp AP, Klinkenberg S, Vles JSH, Hendriksen J. Impaired language performance as a pre-cursor or consequence of Rolandic epilepsy? J Neurol Sci. 2011;304(1– 2): 71-4.

Luders HO, Lesser RP, Dinner DS et al. Benign focal epilepsy in childhood. H Luders, RP Lesser, ed. Epilepsy, Electroclinical syndromes. Berlin: Springer- Verlag;1987: 303-346.

Panayiotopoulos CP. Benign childhood epilepsy with centrotemporal spikes or Rolandic seizures and related epileptic syndromes, 1 ed. London: John Libbey and Company; 1999: 33-70.

Wirrell EC, Camfield PR, Gordon KE, Dooley JM, Camfield CS. Benign Rolandic epilepsy: atypical features are very common. J Child Neurol. 1995;10(6): 455-8.

Parmeggiani l, Seri S,Boanni P, Guerrini R. Electrophysiological characterization of spontaneous and carbamazepine-induced epileptic negaitve myoclonus in benign childhood epilepsy with centro-temporal spikes. Clin Neurophysiol 2004; 115: 50-8.

Hirsch LJ, Fong MWK, Leitinger M, LaRoche SM, Beniczky S, Abend NS, et al. American clinical neurophysiology society’s standardized critical care EEG terminology: 2021 version. J Clin Neurophysiol. 2021;38(1): 1-29.

Panayiotopoulos CP. Elementary visual hallucinations, blindness,and headache in idiopathic occipital epilepsy: differentiation frommigraine. J Neurol Neurosurg Psychiatry. 1999;66(4): 536-40.

Deonna TR, Roulet Perez E, de Tiege X, Van Bogaert P. The ep-ilepsy aphasia spectrum: from Landau- Kleffner syndrome to Rolandic epilepsy. Chichester, UK: Wiley; 2017.

De MP, Tassinari CA. Extreme somatosensory evoked potential (ESEP): an EEG sign forecasting the possible occurrence ofsei-zures in children. Epilepsia. 1981;22(5): 569-75.

Scheffer IE, Jones L, Pozzebon M, Howell RA, Saling MM, Berkovic SF. Autosomal dominant rolandic epilepsy and speech dyspraxia: a new syndrome with anticipation. Ann Neurol. 1995;38(4): 633-42.

Capovilla G, Beccaria F, Bianchi A, Canevini MP, Giordano L, Gobbi G, et al. Ictal EEG patterns in epilepsy with centro- temporal spikes. Brain Dev. 2011;33(4): 301-9.

Saint- Martin AD, Carcangiu R, Arzimanoglou A, Massa R, Thomas P, Motte J, et al. Semiology oftypical and atypical Rolandic epilepsy: a video- EEG analysis. Epileptic Disord. 2001;3(4): 173-82.

Otsubo H, Chitoku S, Ochi A, et al. Malignant rolandic- sylvian epilepsy in children: diagnosis, treatment and outcomes. Neurology 2001;28;57: 590-6.

Massa R, de Saint-Martin A, Carcangiu R, Rudolf G, Seegmuller C,Kleitz C, Metz-Lutz MN, Hirsch E, Marescaux C. (2001) EEG criteria predictive of complicated evolution in idiopathic Rolandic epilepsy. Neurology 57: 1071-1079.

Nicolai J, van der Linden I, Arends JB, van Mil SG, Weber JW, Vles JS,Aldenkamp AP. (2007) EEG characteristics related to educationalimpairments in children with benign childhood epilepsy with centro-temporal spikes. Epilepsia48: 2093-2100.

Gelisse P, Corda D, Raybaud C, Dravet C, Bureau M, Genton P. Abnormal neuroimaging in patients with benign epilepsy with centrotemporal spikes. Epilepsia. 2003;44(3): 372-8.

Bray PF, Wiser WC. Evidence for a genetic etiology of temporal- central abnormalities in focal epilepsy. New Engl J Med, 1964, 271: 926-933.

Bray PF, Wiser WC.Hereditary characteristics of familial temporalcentral focal epilepsy. Pediatrics, 1965;36: 207-221.

Verotti A, Matricardi S, Di Giacomo DI, Rapino D, Chiarelli E, Coppola G, Neuropsychological impairment in children with Rolandic epilepsy and in their siblings, Epilepsy Behav 2013; 28: 108-12.

Neubauer BA. The genetics of rolandic epilepsy. Epileptic Disord 2000; 2 Suppl 1: S67.

Bali B, Kull LL, Strug L, et al. Autosomal dominant inheritence of centrotemporal sharp wawes in rolandic epilepsy families. Epilepsia 2007;48: 2266.

Neubauer BA, Waldegger S, Heinzinger J, et al. KCNQ2 and KCNQ3 mutation contribute to different idiopathic epilepsy syndromes . Neurology 2008; 71: 177.

Lemke JR, Lal D, Reinthaler EM, Steiner I, Nothnagel M, Alber M, et al. Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. Nat Genet. 2013;45(9):1067-72.

Lesca G, RudolfG, Bruneau N, et al. GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction. Nat Genet. 2013;45(9):1061-6.

Carvill GL, Regan BM, Yendle SC, et al. GRIN2A mutations cause epilepsy- aphasia spectrum disorders. Nat Genet. 2013;45(9): 1073-6.

Jabbari K, Bobbili DR, Lal D, et al. Rare gene deletions in genetic generalized and Rolandic epilepsies. PLoS One. 2018;13(8):e0202022.

Aicardi J. (2000) Atypical semiology of Rolandic epilepsy in somerelated syndromes.Epileptic disorders2(Suppl 1): S5-S10.

Kramer U, Zelnik N, Lerman-Sagie T, Shahar E. (2002) Benign child-hood epilepsy with centrotemporal spikes: clinical characteristics andidentification of patients at risk of multiple seizures. J Child Neurol17: 17-19.

Saltik S, Uluduz D, Cokar O, Demirbilek V, Dervent A. (2005) A clinical EEG study on idiopathic partial epilepsies with evolution into ESESspectrum disorders. Epilepsia46: 524-533.

You SJ, Kim DS, Ko TS. (2006) Benign childhood epilepsy withcentro-temporal spikes (BCECTS): early onset of seizures is associ-ated with poorer response to initial treatment. Epileptic Disord8: 285-288.

Datta A, Sinclair B. (2007) Benign epilepsy of childhood with Rolandic spikes: typical and atypical variants. Pediatr Neurol36: 141-145.

Verrotti A, Latini G, Trotta D,et al. (2002) Typical and atypical Rolandic epilepsy in child-hood: a follow-up study. Pediatr Neurol26: 26-29.

Metz-Lutz MN, Filippini M. (2006) Neuropsychological findings in Rolandic epilepsy and Landau–Kleffner syndrome. Epilepsia47(Suppl 2):71–75.

Tovia E, Goldberg-Stern H, Ben Zeev B, et al. The prevalence of atypical presentations and comorbidities of benign childhood epilepsy with centrotemporal spikes. Epilepsia 2011;52(8):1483–8.

Pesántez-Ríos G, Martínez-Bermejo A, Arcas J, Merino-Andreu M, Ugalde-Canitrot A. The atypical developments of rolandic epilepsy are predictable complications. Rev Neurol 2015;61(3):106–13.

van Klink NE, van't Klooster MA, Leijten FS, Jacobs J, Braun KP, Zijlmans M. Ripples on rolandic spikes: a marker of epilepsy severity. Epilepsia 2016;57(7): 1179-89.

Kanemura H, Sano F, Aoyagi K, Sugita K, AiHara M. Do sequential EEG changes predicts atypical features in rolandic epilepsy? Dev Med Child Neurol 2012;54(10): 912-7.

Kim H, Yoo IH, Lim BC, Hwang H, Chae JH, Choi J. Averaged EEG spike dipole analysis may predict atypical outcome in benign childhood epilepsy with centrotemporal spikes (BCECTS). Brain Dev 2016;38(10): 903-8.

Berry- Kravis E. Epilepsy in fragile X syndrome. Dev Med Child Neurol. 2002;44(11):724-8.

Musumeci SA, Hagerman RJ, Ferri R, Bosco P, Bernardina BD, Tassinari CA, et al. Epilepsy and EEG findings in males with fragile X syndrome. Epilepsia. 1999;40(8): 1092-9.

Wheless JW, Clarke DF, Arizamanoglou A, Capenter D. Treatment of pediatric epilepsy: European expert opinion. Epileptic Disord 20077353-412.

Millichap J.G. Frequency of rolandic spikes in ADHD. , Pediatr Neurol Briefs. 2003; 17.

Parisi P., Paolino M.C., Raucci U., Ferretti A., Villa M.P., Trenite K.N., Atypical forms" of benign epilepsy with centrotemporal spikes (BECTS): how to diagnose and guide these children. A practical/scientific approach., Epilepsy Behav. 2017; 75: 165-169.

Otsubo H, Chitoku S, Ochi A, et al. Malignant rolandic- sylvian epilepsy in children: diagnosis, treatment, and outcomes. Neurology 2001; 28;57: 590- 6.

The National Institute for Health and Clinical Excellence. The epilepsies: the diagnosis and management of epilepsies in adults and children in primary and secondary care;2012. Retrieved from http://www.nice.org.uk/cg137 (2014).

Scottish Intercollegiate Guidelines Network. The diagnosis and management of the epilepsies in adults and children in primary and secondary care: a national cilinical, guideline; 2005 Retrieved from http://www.sign.ac.uk/guideline70 (2014).

Wei Gu, Jingjing Chen, Wantong T, et al. Outcome analysis of children with rolandic discharges on EEG: A real-world study, Seizure, 2020 Nov:82: 105-108.

Bouma PAD, Bovenkerk AC, Westendorp RGJ, BrouwerOF. The course ofbenign partial epilepsy ofchildhoodwith centrotemporal spikes: a meta- analysis. Neurology.1997;48(2): 430-7.

Goldberg-Stern H, Gonen OM, Sadeh M, Kivity S, Shuper A, Inbar D. Neuropsychological aspects ofbenign childhood epi-lepsy with centrotemporal spikes. Seizure. 2010;19(1): 12-6.

Filippini M, Ardu E, Stefanelli S, Boni A, Gobbi G, Benso F. Neuropsychological profile in new-onset benign epilepsy with centrotemporal spikes (BECTS): focusing on executive functions. Epilepsy Behav. 2016;54: 71-9.

Deonna T. Rolandic epilepsy: neuropsychology ofthe active epilepsy phase. Epileptic Disord. 2000;2(Suppl 1): S59-61.

Ross E.E, Stoyell S.M, Kramer M.A, Berg A.T, Chu C.J, The natural history of seizures and neuropsychiatric symptoms in childhood epilepsy with centrotemporal spikes (CECTS), Epilepsy Behav. 2020; 103106437.

Incecik F, Altunbasak S, Herguner O.M, Mert G, Sahan D, Prognostic significance of failure of the initial antiepileptic drug in children with benign childhood epilepsy with centrotemporal spikes. Brain Dev. 2015; 37: 66-70.

Camfield P, Camfield C. Unprovoked status epilepticus: the prognosis for otherwise normal children with focal epilepsy. Pediatrics. 2012;130(3): 501-6.