Sellüler ve Sistemik Demir Hemostazı
Özet
Bu bölüm, demirin hücresel ve sistemik hemostazdaki temel rolünü kapsamlı biçimde ele almaktadır. Demirin biyolojik önemi; DNA sentezi, enerji üretimi ve oksijen taşınması gibi yaşamsal süreçlerdeki işlevleri üzerinden açıklanmaktadır. Demir metabolizmasının dengesi; enterositler, eritroid öncüller, makrofajlar ve hepatositler arasındaki koordinasyonla sağlanmakta olup, aşırı birikim toksisiteye yol açabilmektedir. Bölümde, demirin emilim mekanizmaları, hücre içi depolanma ve taşınma yolları, ferritinofaji gibi özel süreçler, hepsidin aracılı sistemik regülasyon ve patolojik durumlarla ilişkisi detaylandırılmıştır. Bu kapsamlı yaklaşım, hem temel bilim hem de klinik hematoloji açısından demir homeostazının anlaşılmasına katkı sunmaktadır.
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