Demir, Oksidatif Stres ve İmmünite

Hentze, M. W., Muckenthaler, M. U., Galy, B. & Camaschella, C. Two to Tango: Regulation of Mammalian Iron Metabolism. Cell 142, 24–38 (2010).

Ganz, T. & Nemeth, E. Iron homeostasis in host defence and inflammation. Nat. Rev. Immunol. 15, 500–510 (2015).

Andrews, N. C. Disorders of Iron Metabolism. N. Engl. J. Med. 341, 1986–1995 (1999).

Ludlow, J. T., Wilkerson, R. G. & Nappe, T. M. Methemoglobinemia. in StatPearls (StatPearls Publishing, Treasure Island (FL), 2025).

Oberdick, S. D. et al. Iron oxide nanoparticles as positive T1 contrast agents for low-field magnetic resonance imaging at 64 mT. Sci. Rep. 13, 11520 (2023).

Hanson, E. S. & Leibold, E. A. Regulation of the Iron Regulatory Proteins by Reactive Nitrogen and Oxygen Species. Gene Expr. 7, 367–376 (2018).

Read, A. D., Bentley, R. ET., Archer, S. L. & Dunham-Snary, K. J. Mitochondrial iron–sulfur clusters: Structure, function, and an emerging role in vascular biology. Redox Biol. 47, 102164 (2021).

Ganz, T. & Nemeth, E. Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harb. Perspect. Med. 2, a011668 (2012).

Andrews, N. C. & Schmidt, P. J. Iron homeostasis. Annu. Rev. Physiol. 69, 69–85 (2007).

Hurrell, R. & Egli, I. Iron bioavailability and dietary reference values. Am. J. Clin. Nutr. 91, 1461S-1467S (2010).

Systemic iron homeostasis - PubMed. https://pubmed.ncbi.nlm.nih.gov/24137020/.

Identification of an intestinal heme transporter - PubMed. https://pubmed.ncbi. nlm.nih.gov/16143108/.

Donovan, A. et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 1, 191–200 (2005).

Hentze, M. W., Muckenthaler, M. U. & Andrews, N. C. Balancing acts: molecular control of mammalian iron metabolism. Cell 117, 285–297 (2004).

Lambert, L. A. Molecular evolution of the transferrin family and associated receptors. Biochim. Biophys. Acta 1820, 244–255 (2012).

Iron metabolism in the reticuloendothelial system - PubMed. https://pubmed.ncbi.nlm. nih.gov/12641343/.

Nemeth, E. & Ganz, T. The role of hepcidin in iron metabolism. Acta Haematol. 122, 78–86 (2009).

Iron Physiology and Pathophysiology in Humans | SpringerLink. https://link.springer.com /book/10.1007/978-1-60327-485-2.

Andrews, N. C. Disorders of iron metabolism. N. Engl. J. Med. 341, 1986–1995 (1999).

Camaschella, C. Iron-Deficiency Anemia. N. Engl. J. Med. 372, 1832–1843 (2015).

Kautz, L. et al. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat. Genet. 46, 678–684 (2014).

Toxicity of iron and hydrogen peroxide: the Fenton reaction - PubMed. https://pubmed. ncbi.nlm.nih.gov/8597169/.

Valko, M., Morris, H. & Cronin, M. T. D. Metals, toxicity and oxidative stress. Curr. Med. Chem. 12, 1161–1208 (2005).

Ferroptosis: an iron-dependent form of nonapoptotic cell death - PubMed. https://pubmed. ncbi.nlm.nih.gov/22632970/.

Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R. & Zecca, L. The role of iron in brain ageing and neurodegenerative disorders. Lancet Neurol. 13, 1045–1060 (2014).

Packer, L., Witt, E. H. & Tritschler, H. J. Alpha-lipoic acid as a biological antioxidant. Free Radic. Biol. Med. 19, 227–250 (1995).

Winterbourn, C. C. Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicol. Lett. 82–83, 969–974 (1995).

Iron sequestration and anemia of inflammation - PubMed. https://pubmed.ncbi. nlm.nih.gov/19786207/.

The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study | Haematologica. https://haematologica.org /article/view/7241.

Hood, M. I. & Skaar, E. P. Nutritional immunity: transition metals at the pathogen-host interface. Nat. Rev. Microbiol. 10, 525–537 (2012).

Nemeth, E. et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 113, 1271–1276 (2004).

Pietrangelo, A. Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology 139, 393–408, 408.e1–2 (2010).

Nemeth, E. & Ganz, T. The role of hepcidin in iron metabolism. Acta Haematol. 122, 78–86 (2009).

Host-pathogen interactions: the role of iron. - Abstract - Europe PMC. https://europepmc. org/article/MED/17449603.

Zou, D.-M. & Sun, W.-L. Relationship between Hepatitis C Virus Infection and Iron Overload. Chin. Med. J. (Engl.) 130, 866–871 (2017).

Nemeth, E. & Ganz, T. Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis. Int. J. Mol. Sci. 22, 6493 (2021).