Eş Zamanlı Multipl Miyelom ve Polisitemiya Vera Tanısı Konulan Nadir Bir Olgu
Özet
Polisitemiya vera ve multipl miyelom hematopoetik öncü hücrelerin artmış duyarlılığı sonucunda ortaya çıkan klonal iki ayrı hematolojik hastalıktır.(1) Bu iki hastalığın eş zamanlı aynı hastada ortaya çıkması ise oldukça nadirdir.(1,2,3) Literatür irdelendiğinde; bu iki hematolojik hastalığın eş zamanlı birlikteliğinin oldukça nadir ve sporadik olgu sunumları şeklinde rapor edilmiş olduğu görülmüştür.(2,3) Biz burada; eritrositozla başvuru yapan 53 yaşında, erkek hastamızda; KMPN (kronik miyeloproliferatif neoplazma) ön tanısı ile tetkik ederken yapılan kemik iliği biyopsisi ve aspirasyonu sonucu eş zamanlı multipl miyelom ve JAK-2 pozitif polisitemi vera tanısı koymuş olduğumuz olgumuzu sunduk ve literatür eşliğinde irdeledik.
Referanslar
L Fink, F Bauer, J J Perry. Coincidental polycythemia vera and multiple myeloma: case report and review. Am J Hematol 1993 Nov;44(3):196-200. doi: 10.1002/ajh.2830440311.
P R Kelsey , K Patel. Coexistence of Polycythaemia Vera with Indolent Myeloma in the same Patient. Hematology 1997;2(2):139-42. doi: 10.1080/10245332.1997.11746329.
Hideo Kimura , Miki Furukawa , Hirotaka Mori , et al. Development of multiple myeloma after 15 years of treatment for polycythemia vera and successful treatment using bortezomib: A case report. Case Reports Clin Case Rep 2022 Nov 19;10(11):e6614. doi: 10.1002/ccr3.6614. eCollection 2022 Nov.
Karakuş S. Polisitemiya Vera.,Özcan M (Ed), Hematolog. Ankara: Türk hematoloji derneği; 2012 ;(1): 27-36
Malhotra J, Kremyanskaya M, Schorr E,et al.
Coexistence of myeloproliferative neoplasm and plasma-cell dyscrasia. J.Clin Lymphoma Myeloma Leuk. 2014 Feb;14(1):31-6. doi: 10.1016/j.clml.2013.09.015. Epub 2013 Sep 30.PMID: 24220620 Review.
Kartı SS. Multipıl myelom epidemiyoloji ve etyoloji. Soysal T(Ed), Hematolog. Ankra: Türk hematoloji derneği; 2013; (3:1): 1-7
Elaine J Hutchison, Josephine A Taverna, Qi Yu, et al. Polycythaemia: an unusual presentation of multiple myeloma. Case Report. BMJ Case Rep. 2016; 2016: bcr2016216686.Published online 2016 Sep 20. doi: 10.1136/bcr-2016-216686
R L Krzyzaniak , D H Buss, M R Cooper, et al. Marrow fibrosis and multipl myeloma. Am J Clin Pathol 1988 Jan;89(1):63- 68. doi: 10.1093/ajcp/89.1.63.
Economopoulos T, Economidou J, Papageorgiou E, et al. Monoclonal gammopathy in chronic myeloproliferative disorders. Blut. 1989 Jan;58(1):7-9. doi: 10.1007/BF00320228.
Randi ML, Tison T, Ruzzon E,et al.
Association of monoclonal gammopathy and polycythemia vera or essential thrombocythemia: study of a large cohort of patients. Ann Hematol. 2003 Apr;82(4):214-7. doi: 10.1007/s00277-002-0577
J H Lawrence, R L Rosenthal. Multiple myeloma associated with polycythemia; report of four cases. Am J Med Sci 1949 Aug;218(2):149-54. doi: 10.1097/00000441-194908000-00005.
Holly Lee , Sylvia McCulloch , Etienne Mahe , et al. Anti-myeloma potential of ruxolitinib in co-existing JAK2V617F-positive smouldering myeloma and polycythaemia vera. Case Report. Br J Haematol 2020 May;189(3):e114-e118. doi: 10.1111/bjh.16533. Epub 2020 Feb 20.
Junya Kuroda,Yosuke Matsumoto, Ruriko Tanaka, et al. JAK2V617F-Positive Essential Thrombocythemia and Multiple Myeloma with IGH/CCND1 Gene Translocation Coexist, but Originate from Separate Clones. Acta Haematol (2009) 120 (3): 177-181 .https://doi.org/10.1159/000187645181.
Referanslar
L Fink, F Bauer, J J Perry. Coincidental polycythemia vera and multiple myeloma: case report and review. Am J Hematol 1993 Nov;44(3):196-200. doi: 10.1002/ajh.2830440311.
P R Kelsey , K Patel. Coexistence of Polycythaemia Vera with Indolent Myeloma in the same Patient. Hematology 1997;2(2):139-42. doi: 10.1080/10245332.1997.11746329.
Hideo Kimura , Miki Furukawa , Hirotaka Mori , et al. Development of multiple myeloma after 15 years of treatment for polycythemia vera and successful treatment using bortezomib: A case report. Case Reports Clin Case Rep 2022 Nov 19;10(11):e6614. doi: 10.1002/ccr3.6614. eCollection 2022 Nov.
Karakuş S. Polisitemiya Vera.,Özcan M (Ed), Hematolog. Ankara: Türk hematoloji derneği; 2012 ;(1): 27-36
Malhotra J, Kremyanskaya M, Schorr E,et al.
Coexistence of myeloproliferative neoplasm and plasma-cell dyscrasia. J.Clin Lymphoma Myeloma Leuk. 2014 Feb;14(1):31-6. doi: 10.1016/j.clml.2013.09.015. Epub 2013 Sep 30.PMID: 24220620 Review.
Kartı SS. Multipıl myelom epidemiyoloji ve etyoloji. Soysal T(Ed), Hematolog. Ankra: Türk hematoloji derneği; 2013; (3:1): 1-7
Elaine J Hutchison, Josephine A Taverna, Qi Yu, et al. Polycythaemia: an unusual presentation of multiple myeloma. Case Report. BMJ Case Rep. 2016; 2016: bcr2016216686.Published online 2016 Sep 20. doi: 10.1136/bcr-2016-216686
R L Krzyzaniak , D H Buss, M R Cooper, et al. Marrow fibrosis and multipl myeloma. Am J Clin Pathol 1988 Jan;89(1):63- 68. doi: 10.1093/ajcp/89.1.63.
Economopoulos T, Economidou J, Papageorgiou E, et al. Monoclonal gammopathy in chronic myeloproliferative disorders. Blut. 1989 Jan;58(1):7-9. doi: 10.1007/BF00320228.
Randi ML, Tison T, Ruzzon E,et al.
Association of monoclonal gammopathy and polycythemia vera or essential thrombocythemia: study of a large cohort of patients. Ann Hematol. 2003 Apr;82(4):214-7. doi: 10.1007/s00277-002-0577
J H Lawrence, R L Rosenthal. Multiple myeloma associated with polycythemia; report of four cases. Am J Med Sci 1949 Aug;218(2):149-54. doi: 10.1097/00000441-194908000-00005.
Holly Lee , Sylvia McCulloch , Etienne Mahe , et al. Anti-myeloma potential of ruxolitinib in co-existing JAK2V617F-positive smouldering myeloma and polycythaemia vera. Case Report. Br J Haematol 2020 May;189(3):e114-e118. doi: 10.1111/bjh.16533. Epub 2020 Feb 20.
Junya Kuroda,Yosuke Matsumoto, Ruriko Tanaka, et al. JAK2V617F-Positive Essential Thrombocythemia and Multiple Myeloma with IGH/CCND1 Gene Translocation Coexist, but Originate from Separate Clones. Acta Haematol (2009) 120 (3): 177-181 .https://doi.org/10.1159/000187645181.
