Akut Promyelositik Lösemi Hastasında Tretinoin Kullanımına Bağlı Papilödem: Olgu Sunumu
Özet
Psödotümör serebri (PTC), normal beyin omurilik sıvısı (BOS) bileşiminin eşlik ettiği artmış kafa içi basıncı ile karakterize edilen bir durumdur. Genellikle birçok tıbbi durum ve ilaçla ilişkilidir. Tretinoinin (all-trans-retinoik asit; ATRA) PTC’yi indükleyebileceği bildirilmiştir. Akut promiyelositik lösemi (APL) tanısı ile takip edilen ve ATRA’ya sekonder intrakranial hipertansiyon ve papilödem gelişen 24 yaşındaki kadın vakamızı sunuyoruz. Hasta 100 mg/gün ATRA ile tedavi edildi. Tedavi protokolünün 14. gününde şiddetli baş ağrısı, çift görme ve bulantı şikâyetleri başladı. Oftalmolojik muayenesinde bilateral papilödem ve sağ gözde görme keskinliğinde azalma saptandı. Diğer fizik muayenelerinde özellik yoktu. Çekilen orbita manyetik rezonans görüntülemesi (MRG), intrakranial hipertansiyon ile uyumlu olduğu düşünülen bilateral optik sinir çevresinde BOS mesafelerinde hafif genişleme, sinir traselerinde hafif tortüozite ve glob arka yüzlerinde minimal düzleşme şeklinde raporlandı. Ayrıca çekilen kontrastlı serebral MRG, serebral diffüzyon MRG ve serebral MRG venografide anormal bulgu tespit edilmedi. Ek olarak lomber ponksiyon uygulandı ve BOS bulgusu yüksek BOS basıncı dışında normaldi. Modifiye Dandy kriterlerine göre tanı PTC’idi. ATRA kesildikten sonra hastanın semptomları azalarak kayboldu.
Referanslar
Lo-Coco F, Avvisati G, Vignetti M et al. Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group. Blood. 2010;116:3171–9.
Sanz MA, Martín G, González M et al. Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group. Blood. 2004;103:1237–43.
Fenaux P, Chastang C, Chevret S et al. A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia. Blood. 1999;94:1192–200.
Friedman DI, Jacobson DM. Diagnostic criteria for idiopathic intracranial hypertension. Neurology. 2002;59:1492–5.
Visani G, Bontempo G, Manfroi S et al. All-trans-retinoic acid and pseudotumor cerebri in a young adult with acute promyelocytic leukemia: A possible disease association. Haematologica. 1996;81:152–4.
Dixon KS, Hassoun A. Pseudotumor cerebri due to the potentiation of all-trans retinoic acid by voriconazole. Journal of the American Pharmacists Association. 2010;50:742–4.
Smith MB, Griffiths EA, Thompson JE et al. High pseudotumor cerebri incidence in tretinoin and arsenic treated acute promyelocytic leukemia and the role of topiramate after acetazolamide failure. Leuk Res Rep [Internet]. 2014 [cited 2023 Jan 2];3:62–Available from: https://pubmed.ncbi.nlm.nih.gov/25180154/
Silberstein S, Lipton R, Dodick D, Freitag F et al. Topiramate Treatment of Chronic Migraine: A Randomized, Placebo-Controlled Trial of Quality of Life and Other Efficacy Measures. Headache: The Journal of Head and Face Pain [Internet]. 2009 [cited 2023 Jan 2];49:1153–62.Availablefrom:https://onlinelibrary.wiley.com/doi/full/10.1111/j.1526-4610.2009.01508.x
Lo-Coco F, Avvisati G, Vignetti M et al. Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia. New England Journal of Medicine. 2013;369:111–21.
Smith MB, Griffiths EA, Thompson JE et al. High pseudotumor cerebri incidence in tretinoin and arsenic treated acute promyelocytic leukemia and the role of topiramate after acetazolamide failure. Leuk Res Rep [Internet]. 2014 [cited 2023 Jan 4];3:62 Available from: https://pubmed.ncbi.nlm.nih.gov/25180154/
Dixon KS, Hassoun A. Pseudotumor cerebri due to the potentiation of all-trans retinoic acid by voriconazole. Journal of the American Pharmacists Association. 2010;50:742–4.
Jindal M, Hiam L, Raman A, Rejali D. Idiopathic intracranial hypertension in otolaryngology. European Archives of Oto-Rhino-Laryngology [Internet]. 2009 [cited 2023 Jan 4];266:803–6. Available from: https://link.springer.com/article/10.1007/s00405-009-0973-0
The Pseudotumor Cerebri Syndrome: Pseudotumor Cerebri, Idiopathic ... - Ian Johnston, Brian Owler, John Pickard - Google Kitaplar [Internet]. [cited 2023 Jan 4]. Available from: https://books.google.com.tr/books?hl=tr&lr=&id=lGCRe8QICS0C&oi=fnd&pg=PA1&ots=7oRfI 1JXTD&sig=pe3PqnLulyZ_ADk4pU-KNCCjSqs&redir_esc=y#v=onepage&q&f=false
Spector RH, Carlisle J. Pseudotumor cerebri caused by a synthetic vitamin A preparation. Neurology. 1984;34:1509–11.
Binder DK, Horton JC, Lawton MT et al. Ideopathic Intracranial Hypertension. Neurosurgery. 2004;54:538–52.
Alore P, Jay W, Macken M. Topiramate, Pseudotumor Cerebri, Weight-Loss and Glaucoma: An Ophthalmologic Perspective. http://dx.doi.org/101080/08820530500509325 [Internet]. 2009 [cited2023 Jan 4];21:15–7. Available from: https://www.tandfonline.com/doi/abs/10.1080/08820530500509325
Wall M, McDermott MP, Kieburtz KD et al. Effect of Acetazolamide on Visual Function in Patients With Idiopathic Intracranial Hypertension and Mild Visual Loss: The Idiopathic Intracranial Hypertension Treatment Trial. JAMA [Internet]. 2014 [cited 2023 Jan 4];311:1641. Available from: /pmc/articles/PMC4362615/
Referanslar
Lo-Coco F, Avvisati G, Vignetti M et al. Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group. Blood. 2010;116:3171–9.
Sanz MA, Martín G, González M et al. Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group. Blood. 2004;103:1237–43.
Fenaux P, Chastang C, Chevret S et al. A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia. Blood. 1999;94:1192–200.
Friedman DI, Jacobson DM. Diagnostic criteria for idiopathic intracranial hypertension. Neurology. 2002;59:1492–5.
Visani G, Bontempo G, Manfroi S et al. All-trans-retinoic acid and pseudotumor cerebri in a young adult with acute promyelocytic leukemia: A possible disease association. Haematologica. 1996;81:152–4.
Dixon KS, Hassoun A. Pseudotumor cerebri due to the potentiation of all-trans retinoic acid by voriconazole. Journal of the American Pharmacists Association. 2010;50:742–4.
Smith MB, Griffiths EA, Thompson JE et al. High pseudotumor cerebri incidence in tretinoin and arsenic treated acute promyelocytic leukemia and the role of topiramate after acetazolamide failure. Leuk Res Rep [Internet]. 2014 [cited 2023 Jan 2];3:62–Available from: https://pubmed.ncbi.nlm.nih.gov/25180154/
Silberstein S, Lipton R, Dodick D, Freitag F et al. Topiramate Treatment of Chronic Migraine: A Randomized, Placebo-Controlled Trial of Quality of Life and Other Efficacy Measures. Headache: The Journal of Head and Face Pain [Internet]. 2009 [cited 2023 Jan 2];49:1153–62.Availablefrom:https://onlinelibrary.wiley.com/doi/full/10.1111/j.1526-4610.2009.01508.x
Lo-Coco F, Avvisati G, Vignetti M et al. Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia. New England Journal of Medicine. 2013;369:111–21.
Smith MB, Griffiths EA, Thompson JE et al. High pseudotumor cerebri incidence in tretinoin and arsenic treated acute promyelocytic leukemia and the role of topiramate after acetazolamide failure. Leuk Res Rep [Internet]. 2014 [cited 2023 Jan 4];3:62 Available from: https://pubmed.ncbi.nlm.nih.gov/25180154/
Dixon KS, Hassoun A. Pseudotumor cerebri due to the potentiation of all-trans retinoic acid by voriconazole. Journal of the American Pharmacists Association. 2010;50:742–4.
Jindal M, Hiam L, Raman A, Rejali D. Idiopathic intracranial hypertension in otolaryngology. European Archives of Oto-Rhino-Laryngology [Internet]. 2009 [cited 2023 Jan 4];266:803–6. Available from: https://link.springer.com/article/10.1007/s00405-009-0973-0
The Pseudotumor Cerebri Syndrome: Pseudotumor Cerebri, Idiopathic ... - Ian Johnston, Brian Owler, John Pickard - Google Kitaplar [Internet]. [cited 2023 Jan 4]. Available from: https://books.google.com.tr/books?hl=tr&lr=&id=lGCRe8QICS0C&oi=fnd&pg=PA1&ots=7oRfI 1JXTD&sig=pe3PqnLulyZ_ADk4pU-KNCCjSqs&redir_esc=y#v=onepage&q&f=false
Spector RH, Carlisle J. Pseudotumor cerebri caused by a synthetic vitamin A preparation. Neurology. 1984;34:1509–11.
Binder DK, Horton JC, Lawton MT et al. Ideopathic Intracranial Hypertension. Neurosurgery. 2004;54:538–52.
Alore P, Jay W, Macken M. Topiramate, Pseudotumor Cerebri, Weight-Loss and Glaucoma: An Ophthalmologic Perspective. http://dx.doi.org/101080/08820530500509325 [Internet]. 2009 [cited2023 Jan 4];21:15–7. Available from: https://www.tandfonline.com/doi/abs/10.1080/08820530500509325
Wall M, McDermott MP, Kieburtz KD et al. Effect of Acetazolamide on Visual Function in Patients With Idiopathic Intracranial Hypertension and Mild Visual Loss: The Idiopathic Intracranial Hypertension Treatment Trial. JAMA [Internet]. 2014 [cited 2023 Jan 4];311:1641. Available from: /pmc/articles/PMC4362615/
