Adipoz Doku Hormonu: Apelin

Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476. doi:10.1006/bbrc.1998.9489

Mesmin C, Fenaille F, Becher F, et al. Identification and characterization of apelin peptides in bovine colostrum and milk by liquid chromatography-mass spectrometry. J Proteome Res. 2011;10(11):5222-5231. doi:10.1021/pr200725x

Hosoya M, Kawamata Y, Fukusumi S, et al. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem. 2000;275(28):21061-21067. doi:10.1074/jbc.M908417199

Langelaan DN, Bebbington EM, Reddy T, et al. Structural insight into G-protein coupled receptor binding by apelin. Biochemistry. 2009;48(3):537-548. doi:10.1021/bi801864b

Shin K, Kenward C, Rainey JK. Apelinergic System Structure and Function. Compr Physiol. 2017;8(1):407-450. doi:10.1002/cphy.c170028

Mesmin C, Dubois M, Becher F, et al. Liquid chromatography/tandem mass spectrometry assay for the absolute quantification of the expected circulating apelin peptides in human plasma. Rapid Commun Mass Spectrom. 2010;24(19):2875-2884. doi:10.1002/rcm.4718

Castan-Laurell I, Dray C, Attané C, et al. Apelin, diabetes, and obesity. Endocrine. 2011;40(1):1-9. doi:10.1007/s12020-011-9507-9

O'Dowd BF, Heiber M, Chan A, et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene. 1993;136(1-2):355-360. doi:10.1016/0378-1119(93)90495-o

Yu XH, Tang ZB, Liu LJ, et al. Apelin and its receptor APJ in cardiovascular diseases. Clin Chim Acta. 2014;428:1-8. doi:10.1016/j.cca.2013.09.001

Chapman NA, Dupré DJ, Rainey JK. The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR. Biochem Cell Biol. 2014;92(6):431-440. doi:10.1139/bcb-2014-0072

Chaves-Almagro C, Castan-Laurell I, Dray C, et al. Apelin receptors: From signaling to antidiabetic strategy. Eur J Pharmacol. 2015;763(Pt B):149-159. doi:10.1016/j.ejphar.2015.05.017

Guo L, Li Q, Wang W, et al. Apelin inhibits insulin secretion in pancreatic beta-cells by activation of PI3-kinase-phosphodiesterase 3B. Endocr Res. 2009;34(4):142-154. doi:10.3109/07435800903287079

Ringström C, Nitert MD, Bennet H, et al. Apelin is a novel islet peptide. Regul Pept. 2010;162(1-3):44-51. doi:10.1016/j.regpep.2010.03.005

Dray C, Knauf C, Daviaud D, et al. Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab. 2008;8(5):437-445. doi:10.1016/j.cmet.2008.10.003

Sörhede Winzell M, Magnusson C, Ahrén B. The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice. Regul Pept. 2005;131(1-3):12-17. doi:10.1016/j.regpep.2005.05.004

Huang Q, Liu X, Cao C, et al. Apelin-13 induces autophagy in hepatoma HepG2 cells through ERK1/2 signaling pathway-dependent upregulation of Beclin1. Oncol Lett. 2016;11(2):1051-1056. doi:10.3892/ol.2015.3991

Yue P, Jin H, Xu S, et al. Apelin decreases lipolysis via G(q), G(i), and AMPK-Dependent Mechanisms. Endocrinology. 2011;152(1):59-68. doi:10.1210/en.2010-0576

O'Harte FPM, Parthsarathy V, Hogg C, et al. Acylated apelin-13 amide analogues exhibit enzyme resistance and prolonged insulin releasing, glucose lowering and anorexic properties. Biochem Pharmacol. 2017;146:165-173. doi:10.1016/j.bcp.2017.10.002

Chen H, Zheng C, Zhang X, et al. Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice. Peptides. 2011;32(8):1634-1639. doi:10.1016/j.peptides.2011.06.025

Wang W, Zhang D, Yang R, et al. Hepatic and cardiac beneficial effects of a long-acting Fc-apelin fusion protein in diet-induced obese mice. Diabetes Metab Res Rev. 2018;34(5):e2997. doi:10.1002/dmrr.2997

Kleinz MJ, Skepper JN, Davenport AP. Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Regul Pept. 2005;126(3):233-240. doi:10.1016/j.regpep.2004.10.019

Chen MM, Ashley EA, Deng DX, et al. Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation. 2003;108(12):1432-1439. doi:10.1161/01.CIR.0000091235.94914.75

Wang W, McKinnie SM, Patel VB, et al. Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc. 2013;2(4):e000249. doi:10.1161/JAHA.113.000249

Tatin F, Renaud-Gabardos E, Godet AC, et al. Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction. JCI Insight. 2017;2(12):e93887. doi:10.1172/jci.insight.93887

Chagnon F, Coquerel D, Salvail D, et al. Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Crit Care Med. 2017;45(4):e391-e398. doi:10.1097/CCM.0000000000002097

Pan CS, Teng X, Zhang J, et al. Apelin antagonizes myocardial impairment in sepsis. J Card Fail. 2010;16(7):609-617. doi:10.1016/j.cardfail.2010.02.002

Kidoya H, Naito H, Takakura N. Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia. Blood. 2010;115(15):3166-3174. doi:10.1182/blood-2009-07-232306

Tang SY, Xie H, Yuan LQ, et al. Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and PI3-K/Akt signaling pathways. Peptides. 2007;28(3):708-718. doi:10.1016/j.peptides.2006.10.005

Xie H, Tang SY, Cui RR, et al. Apelin and its receptor are expressed in human osteoblasts. Regul Pept. 2006;134(2-3):118-125. doi:10.1016/j.regpep.2006.02.004

Hang K, Ye C, Xu J, et al. Apelin enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly through Wnt/β-catenin signaling pathway. Stem Cell Res Ther. 2019;10(1):189. doi:10.1186/s13287-019-1286-x

Zeng XJ, Yu SP, Zhang L, et al. Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons. Exp Cell Res. 2010;316(11):1773-1783. doi:10.1016/j.yexcr.2010.02.005

Wang K, Ju Z, Yong Y, et al. The Effects of Electroacupuncture on the Apelin/APJ System in the Spinal Cord of Rats With Inflammatory Pain. Anesth Analg. 2016;123(6):1603-1610. doi:10.1213/ANE.0000000000001535

Xiong Q, He W, Wang H, et al. Effect of the spinal apelin APJ system on the pathogenesis of chronic constriction injury induced neuropathic pain in rats. Mol Med Rep. 2017;16(2):1223-1231. doi:10.3892/mmr.2017.6734

Kalantaripour TP, Esmaeili-Mahani S, Sheibani V, et al. Apelin-13 protects rat primary cortical glia-neuron co-culture against pentylenetetrazole-induced toxicity. Biomed Pharmacother. 2017;87:661-668. doi:10.1016/j.biopha.2016.12.131

Bao HJ, Qiu HY, Kuai JX, et al. Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury. Neural Regen Res. 2016;11(7):1128-1133. doi:10.4103/1673-5374.187049

Berta J, Hoda MA, Laszlo V, et al. Apelin promotes lymphangiogenesis and lymph node metastasis. Oncotarget. 2014;5(12):4426-4437. doi:10.18632/oncotarget.2032

Feng M, Yao G, Yu H, et al. Tumor apelin, not serum apelin, is associated with the clinical features and prognosis of gastric cancer. BMC Cancer. 2016;16(1):794. doi:10.1186/s12885-016-2815-y

Zuurbier L, Rahman A, Cordes M, et al. Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer. Oncotarget. 2017;8(26):42949-42961. doi:10.18632/oncotarget.17306

Harford-Wright E, Andre-Gregoire G, Jacobs KA, et al. Pharmacological targeting of apelin impairs glioblastoma growth. Brain. 2017;140(11):2939-2954. doi:10.1093/brain/awx253

Hall C, Ehrlich L, Venter J, et al. Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth. Cancer Lett. 2017;386:179-188. doi:10.1016/j.canlet.2016.11.025

Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476. doi:10.1006/bbrc.1998.9489

Mesmin C, Fenaille F, Becher F, et al. Identification and characterization of apelin peptides in bovine colostrum and milk by liquid chromatography-mass spectrometry. J Proteome Res. 2011;10(11):5222-5231. doi:10.1021/pr200725x

Hosoya M, Kawamata Y, Fukusumi S, et al. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem. 2000;275(28):21061-21067. doi:10.1074/jbc.M908417199

Langelaan DN, Bebbington EM, Reddy T, et al. Structural insight into G-protein coupled receptor binding by apelin. Biochemistry. 2009;48(3):537-548. doi:10.1021/bi801864b

Shin K, Kenward C, Rainey JK. Apelinergic System Structure and Function. Compr Physiol. 2017;8(1):407-450. doi:10.1002/cphy.c170028

Mesmin C, Dubois M, Becher F, et al. Liquid chromatography/tandem mass spectrometry assay for the absolute quantification of the expected circulating apelin peptides in human plasma. Rapid Commun Mass Spectrom. 2010;24(19):2875-2884. doi:10.1002/rcm.4718

Castan-Laurell I, Dray C, Attané C, et al. Apelin, diabetes, and obesity. Endocrine. 2011;40(1):1-9. doi:10.1007/s12020-011-9507-9

O'Dowd BF, Heiber M, Chan A, et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene. 1993;136(1-2):355-360. doi:10.1016/0378-1119(93)90495-o

Yu XH, Tang ZB, Liu LJ, et al. Apelin and its receptor APJ in cardiovascular diseases. Clin Chim Acta. 2014;428:1-8. doi:10.1016/j.cca.2013.09.001

Chapman NA, Dupré DJ, Rainey JK. The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR. Biochem Cell Biol. 2014;92(6):431-440. doi:10.1139/bcb-2014-0072

Chaves-Almagro C, Castan-Laurell I, Dray C, et al. Apelin receptors: From signaling to antidiabetic strategy. Eur J Pharmacol. 2015;763(Pt B):149-159. doi:10.1016/j.ejphar.2015.05.017

Guo L, Li Q, Wang W, et al. Apelin inhibits insulin secretion in pancreatic beta-cells by activation of PI3-kinase-phosphodiesterase 3B. Endocr Res. 2009;34(4):142-154. doi:10.3109/07435800903287079

Ringström C, Nitert MD, Bennet H, et al. Apelin is a novel islet peptide. Regul Pept. 2010;162(1-3):44-51. doi:10.1016/j.regpep.2010.03.005

Dray C, Knauf C, Daviaud D, et al. Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab. 2008;8(5):437-445. doi:10.1016/j.cmet.2008.10.003

Sörhede Winzell M, Magnusson C, Ahrén B. The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice. Regul Pept. 2005;131(1-3):12-17. doi:10.1016/j.regpep.2005.05.004

Huang Q, Liu X, Cao C, et al. Apelin-13 induces autophagy in hepatoma HepG2 cells through ERK1/2 signaling pathway-dependent upregulation of Beclin1. Oncol Lett. 2016;11(2):1051-1056. doi:10.3892/ol.2015.3991

Yue P, Jin H, Xu S, et al. Apelin decreases lipolysis via G(q), G(i), and AMPK-Dependent Mechanisms. Endocrinology. 2011;152(1):59-68. doi:10.1210/en.2010-0576

O'Harte FPM, Parthsarathy V, Hogg C, et al. Acylated apelin-13 amide analogues exhibit enzyme resistance and prolonged insulin releasing, glucose lowering and anorexic properties. Biochem Pharmacol. 2017;146:165-173. doi:10.1016/j.bcp.2017.10.002

Chen H, Zheng C, Zhang X, et al. Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice. Peptides. 2011;32(8):1634-1639. doi:10.1016/j.peptides.2011.06.025

Wang W, Zhang D, Yang R, et al. Hepatic and cardiac beneficial effects of a long-acting Fc-apelin fusion protein in diet-induced obese mice. Diabetes Metab Res Rev. 2018;34(5):e2997. doi:10.1002/dmrr.2997

Kleinz MJ, Skepper JN, Davenport AP. Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Regul Pept. 2005;126(3):233-240. doi:10.1016/j.regpep.2004.10.019

Chen MM, Ashley EA, Deng DX, et al. Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation. 2003;108(12):1432-1439. doi:10.1161/01.CIR.0000091235.94914.75

Wang W, McKinnie SM, Patel VB, et al. Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc. 2013;2(4):e000249. doi:10.1161/JAHA.113.000249

Tatin F, Renaud-Gabardos E, Godet AC, et al. Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction. JCI Insight. 2017;2(12):e93887. doi:10.1172/jci.insight.93887

Chagnon F, Coquerel D, Salvail D, et al. Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Crit Care Med. 2017;45(4):e391-e398. doi:10.1097/CCM.0000000000002097

Pan CS, Teng X, Zhang J, et al. Apelin antagonizes myocardial impairment in sepsis. J Card Fail. 2010;16(7):609-617. doi:10.1016/j.cardfail.2010.02.002

Kidoya H, Naito H, Takakura N. Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia. Blood. 2010;115(15):3166-3174. doi:10.1182/blood-2009-07-232306

Tang SY, Xie H, Yuan LQ, et al. Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and PI3-K/Akt signaling pathways. Peptides. 2007;28(3):708-718. doi:10.1016/j.peptides.2006.10.005

Xie H, Tang SY, Cui RR, et al. Apelin and its receptor are expressed in human osteoblasts. Regul Pept. 2006;134(2-3):118-125. doi:10.1016/j.regpep.2006.02.004

Hang K, Ye C, Xu J, et al. Apelin enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly through Wnt/β-catenin signaling pathway. Stem Cell Res Ther. 2019;10(1):189. doi:10.1186/s13287-019-1286-x

Zeng XJ, Yu SP, Zhang L, et al. Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons. Exp Cell Res. 2010;316(11):1773-1783. doi:10.1016/j.yexcr.2010.02.005

Wang K, Ju Z, Yong Y, et al. The Effects of Electroacupuncture on the Apelin/APJ System in the Spinal Cord of Rats With Inflammatory Pain. Anesth Analg. 2016;123(6):1603-1610. doi:10.1213/ANE.0000000000001535

Xiong Q, He W, Wang H, et al. Effect of the spinal apelin APJ system on the pathogenesis of chronic constriction injury induced neuropathic pain in rats. Mol Med Rep. 2017;16(2):1223-1231. doi:10.3892/mmr.2017.6734

Kalantaripour TP, Esmaeili-Mahani S, Sheibani V, et al. Apelin-13 protects rat primary cortical glia-neuron co-culture against pentylenetetrazole-induced toxicity. Biomed Pharmacother. 2017;87:661-668. doi:10.1016/j.biopha.2016.12.131

Bao HJ, Qiu HY, Kuai JX, et al. Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury. Neural Regen Res. 2016;11(7):1128-1133. doi:10.4103/1673-5374.187049

Berta J, Hoda MA, Laszlo V, et al. Apelin promotes lymphangiogenesis and lymph node metastasis. Oncotarget. 2014;5(12):4426-4437. doi:10.18632/oncotarget.2032

Feng M, Yao G, Yu H, et al. Tumor apelin, not serum apelin, is associated with the clinical features and prognosis of gastric cancer. BMC Cancer. 2016;16(1):794. doi:10.1186/s12885-016-2815-y

Zuurbier L, Rahman A, Cordes M, et al. Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer. Oncotarget. 2017;8(26):42949-42961. doi:10.18632/oncotarget.17306

Harford-Wright E, Andre-Gregoire G, Jacobs KA, et al. Pharmacological targeting of apelin impairs glioblastoma growth. Brain. 2017;140(11):2939-2954. doi:10.1093/brain/awx253

Hall C, Ehrlich L, Venter J, et al. Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth. Cancer Lett. 2017;386:179-188. doi:10.1016/j.canlet.2016.11.025