Bakteri Genetiği
Özet
Tek hücreli mikroorganizma gruplarından olan bakteriler, prokaryotik hücre yapısına sahip olmaları, laboratuvar ortamında kolay üretilmeleri ve deneysel aşamaların diğer canlılara göre genellikle daha kolay olması bakımından moleküler biyolojide önemli model organizmalar olarak kullanılmaktadırlar. Dünyanın hemen hemen her yerinde yaşama uyum sağlamış olan bakteriler, gen transferleri ve metabolik süreçlerini düzenleyebilmeleri sayesinde bu uyumlarını gösterebilmektedirler. “Bakteri Genetiği” bölümünde, bakterilerin genetik yapılarını nasıl şekillendirdiklerinden, gen aktarım yöntemlerine ve metabolik süreçlerin düzenlenmesine kadar olan birçok mekanizma örnekleri ile sunulmuştur.
Referanslar
Toro, Esteban, and Lucy Shapiro. "Bacterial chromosome organization and segregation." Cold Spring Harbor perspectives in biology 2.2 (2010): a000349. doi: 10.1101/cshperspect.a000349
Dame, Remus T., Fatema-Zahra M. Rashid, and David C. Grainger. "Chromosome organization in bacteria: mechanistic insights into genome structure and function." Nature Reviews Genetics 21.4 (2020): 227-242. doi: 10.1038/s41576-019-0185-4
Dubnau, David, and Melanie Blokesch. "Mechanisms of DNA uptake by naturally competent bacteria." Annual review of genetics 53 (2019): 217-237. https://doi.org/10.1146/annurev-genet-112618-043641
Johnsborg, Ola, and Leiv Sigve Håvarstein. "Regulation of natural genetic transformation and acquisition of transforming DNA in Streptococcus pneumoniae." FEMS microbiology reviews 33.3 (2009): 627-642. https://doi.org/10.1111/j.1574-6976.2009.00167.x
Goessweiner-Mohr, Nikolaus, et al. "Conjugation in gram‐positive bacteria." Plasmids: Biology and Impact in Biotechnology and Discovery (2015): 237-256. https://doi.org/10.1128/9781555818982.ch14
Wozniak, Rachel AF, and Matthew K. Waldor. "Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow." Nature Reviews Microbiology 8.8 (2010): 552-563. doi:10.1038/nrmicro2382
Thierauf, Anne, Gerardo Perez, and and Stanley Maloy. "Generalized transduction." Bacteriophages: Methods and Protocols, Volume 1: Isolation, Characterization, and Interactions (2009): 267-286.
Soler, Nicolas, and Patrick Forterre. "Vesiduction: the fourth way of HGT." Environmental Microbiology 22.7 (2020): 2457-2460.
Mitrophanov, Alexander Y., and Eduardo A. Groisman. "Signal integration in bacterial two-component regulatory systems." Genes & development 22.19 (2008): 2601-2611.
Rutherford, Steven T., and Bonnie L. Bassler. "Bacterial quorum sensing: its role in virulence and possibilities for its control." Cold Spring Harbor perspectives in medicine 2.11 (2012): a012427.
Waters, Christopher M., and Bonnie L. Bassler. "Quorum sensing: cell-to-cell communication in bacteria." Annu. Rev. Cell Dev. Biol. 21 (2005): 319-346.
Referanslar
Toro, Esteban, and Lucy Shapiro. "Bacterial chromosome organization and segregation." Cold Spring Harbor perspectives in biology 2.2 (2010): a000349. doi: 10.1101/cshperspect.a000349
Dame, Remus T., Fatema-Zahra M. Rashid, and David C. Grainger. "Chromosome organization in bacteria: mechanistic insights into genome structure and function." Nature Reviews Genetics 21.4 (2020): 227-242. doi: 10.1038/s41576-019-0185-4
Dubnau, David, and Melanie Blokesch. "Mechanisms of DNA uptake by naturally competent bacteria." Annual review of genetics 53 (2019): 217-237. https://doi.org/10.1146/annurev-genet-112618-043641
Johnsborg, Ola, and Leiv Sigve Håvarstein. "Regulation of natural genetic transformation and acquisition of transforming DNA in Streptococcus pneumoniae." FEMS microbiology reviews 33.3 (2009): 627-642. https://doi.org/10.1111/j.1574-6976.2009.00167.x
Goessweiner-Mohr, Nikolaus, et al. "Conjugation in gram‐positive bacteria." Plasmids: Biology and Impact in Biotechnology and Discovery (2015): 237-256. https://doi.org/10.1128/9781555818982.ch14
Wozniak, Rachel AF, and Matthew K. Waldor. "Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow." Nature Reviews Microbiology 8.8 (2010): 552-563. doi:10.1038/nrmicro2382
Thierauf, Anne, Gerardo Perez, and and Stanley Maloy. "Generalized transduction." Bacteriophages: Methods and Protocols, Volume 1: Isolation, Characterization, and Interactions (2009): 267-286.
Soler, Nicolas, and Patrick Forterre. "Vesiduction: the fourth way of HGT." Environmental Microbiology 22.7 (2020): 2457-2460.
Mitrophanov, Alexander Y., and Eduardo A. Groisman. "Signal integration in bacterial two-component regulatory systems." Genes & development 22.19 (2008): 2601-2611.
Rutherford, Steven T., and Bonnie L. Bassler. "Bacterial quorum sensing: its role in virulence and possibilities for its control." Cold Spring Harbor perspectives in medicine 2.11 (2012): a012427.
Waters, Christopher M., and Bonnie L. Bassler. "Quorum sensing: cell-to-cell communication in bacteria." Annu. Rev. Cell Dev. Biol. 21 (2005): 319-346.
