DNA Replikasyonu
Özet
DNA replikasyonu, bir orijinal DNA molekülünden iki özdeş DNA kopyası üretme işlemidir. Çift sarmalın yapısının aydınlatılması, DNA'nın nasıl bölündüğü ve kendi kopyalarını oluşturduğu konusunda bir ipucu sağlamıştır. DNA replikasyonu, öncelikle genomun küçük boyutu ve mevcut mutantlar nedeniyle prokaryotlarda son derece iyi çalışılmıştır. Ökaryotik genomlar, prokaryotik genomlar ile karşılaştırıldığında boyutları daha büyük ve yapıları daha karmaşıktır. Replikasyonda rol alan enzimler vardır. Örneğin Helikaz enzimleri tarafından replikasyon çatalının açılması ve ikili sarmalın birbirinden ayrılması DNA’nın diğer bölgelerinde ekstra katlanmaların ve süper dönümlerin oluşmasına yol açar. DNA replikasyonu yarı koruyucudur çünkü her yavru molekül, ana molekülden bir sarmal ve bir yeni tamamlayıcı sarmal içerir.
Referanslar
Berg JM, Tymoczko JL, Stryer L, Clarke ND (2002) Chapter 27, Section 4: DNA Replication of Both Strands Proceeds Rapidly from Specific Start Site. In: Biochemistry. WH Freeman and Company, USA.
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, et al. (2002) Intracellular Control of Cell-Cycle Events: S-Phase Cyclin-Cdk Complexes (S-Cdks) Initiate DNA Replication Once Per Cycle. In: Molecular Biology of the Cell, Garland Science, UK.
Griffiths A.J.F, J.F. Miller, D. T. Suzuki, R.C. Lewontin, W.M. Gelbart, 2000, Introduction to Genetic Analysis, 7Russelth edition, Freeman and Company, USA
Berg JM, Tymoczko JL, Stryer L, Clarke ND (2002) Chapter 27: DNA Replication, Recombination, and Repair. In: Bio-chemistry. WH Freeman and Company, USA.
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, et al. (2002) Chapter 5: DNA Replication, Repair, and Recombination. In: Molecular Biology of the Cell Garland Science, UK. pp. 235-298.
Johnson RE, Klassen R, Prakash L, Prakash S (2015) A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands. Molecular Cell 59(2): 163-175.
Hansen, Barbara (2011) Biochemistry and Medical Genetics: Lecture Notes. Kaplan Medical. p. 21.
James D Watson, Tania A Baker, Stephen P Bell, Alexander Gann, Michael Levine, et al. (2008) Molecular Biology of the gene. Pearson Education: 237.
Brown TA (2002) Termination of replication. In: Genomes. BIOS Scientific Publishers.
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, et al. (2002) DNA Replication Mechanisms: Special Proteins Help to Open Up the DNA Double Helix in Front of the Replication Fork. In: Molecular Biology of the Cell, Garland Science, UK.
Lodish H, Berk A, Zipursky LS, Matsudaira P, Baltimore D, et al. (2000) General Features of Chromosomal Replication: Three Common Features of Replication Origins. In: Molecular Cell Biology. WH Freeman and Company, UK.
Brown TA (2002) Genomes. (2nd edn). Oxford: Wiley-Liss, USA.
Johnson RE, Klassen R, Prakash L, Prakash S (2015) A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands. Molecular Cell 59(2): 163-175.
Referanslar
Berg JM, Tymoczko JL, Stryer L, Clarke ND (2002) Chapter 27, Section 4: DNA Replication of Both Strands Proceeds Rapidly from Specific Start Site. In: Biochemistry. WH Freeman and Company, USA.
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, et al. (2002) Intracellular Control of Cell-Cycle Events: S-Phase Cyclin-Cdk Complexes (S-Cdks) Initiate DNA Replication Once Per Cycle. In: Molecular Biology of the Cell, Garland Science, UK.
Griffiths A.J.F, J.F. Miller, D. T. Suzuki, R.C. Lewontin, W.M. Gelbart, 2000, Introduction to Genetic Analysis, 7Russelth edition, Freeman and Company, USA
Berg JM, Tymoczko JL, Stryer L, Clarke ND (2002) Chapter 27: DNA Replication, Recombination, and Repair. In: Bio-chemistry. WH Freeman and Company, USA.
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, et al. (2002) Chapter 5: DNA Replication, Repair, and Recombination. In: Molecular Biology of the Cell Garland Science, UK. pp. 235-298.
Johnson RE, Klassen R, Prakash L, Prakash S (2015) A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands. Molecular Cell 59(2): 163-175.
Hansen, Barbara (2011) Biochemistry and Medical Genetics: Lecture Notes. Kaplan Medical. p. 21.
James D Watson, Tania A Baker, Stephen P Bell, Alexander Gann, Michael Levine, et al. (2008) Molecular Biology of the gene. Pearson Education: 237.
Brown TA (2002) Termination of replication. In: Genomes. BIOS Scientific Publishers.
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, et al. (2002) DNA Replication Mechanisms: Special Proteins Help to Open Up the DNA Double Helix in Front of the Replication Fork. In: Molecular Biology of the Cell, Garland Science, UK.
Lodish H, Berk A, Zipursky LS, Matsudaira P, Baltimore D, et al. (2000) General Features of Chromosomal Replication: Three Common Features of Replication Origins. In: Molecular Cell Biology. WH Freeman and Company, UK.
Brown TA (2002) Genomes. (2nd edn). Oxford: Wiley-Liss, USA.
Johnson RE, Klassen R, Prakash L, Prakash S (2015) A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands. Molecular Cell 59(2): 163-175.
