Teranostik Nanotaşıyıcılar
Özet
Radyofarmasötikler, farmasötik ve radyoaktif kısımlardan oluşan ve in vivo kullanım için tasarlanan formülasyonladır. Bu formülasyonlar kendilerine has fizikokimyasal ve radyoaktivite özelliklerine bağlı olarak hem teşhis hem de tedavi amaçlı kullanılabilirler. Gama (γ) veya pozitron (β+) yayan radyonüklidlerle hazırlanan radyofarmasötikler görüntüleme amaçlı kullanılırken, beta (β-) veya alfa (α) partikül radyasyonu yayan radyonüklidlerle hazırlanan radyofarmasötikler çoğunlukla tedavi amaçlı kullanılır. Son yıllarda her iki ışımayı da aynı anda yapacak şekilde geliştirilen ve aynı hastalığın görüntülemesinde ve tedavisinde benzer ligandların kullanılması "nanoteranöstik" kavramını gündeme getirmiştir. Bu bölümde nanoteranötik ajanların geliştirilmesine yönelik güncel uygulamalar ve tanı tekniklerinde kullanımları ele alınacaktır.
Referanslar
Wei G, Wang Y, Yang G, Wang Y, Ju R. Recent progress in nanomedicine for enhanced cancer chemotherapy. Theranostics. 2021;11(13):6370-92.
Rong L, Lei Q, Zhang X-Z. Recent advances on peptide-based theranostic nanomaterials. VIEW. 2020;1(4):20200050.
Lindner T, Loktev A, Altmann A, Giesel F, Kratochwil C, Debus J, et al. Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein. Journal of Nuclear Medicine 2018;59(9):1415.
Ji T, Zhao Y, Ding Y, Wang J, Zhao R, Lang J, et al. Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer‐associated fibroblast activation. Angewandte Chemie International Edition 2016;55(3):1050-5.
Ji T, Kohane DS. Nanoscale systems for local drug delivery. Nano Today. 2019;28:100765.
Zhang P, Li Y, Tang W, Zhao J, Jing L, McHugh KJ. Theranostic nanoparticles with disease-specific administration strategies. Nano Today 2022;42:101335.
Han X, Li H, Zhou D, Chen Z, Gu Z. Local and targeted delivery of immune checkpoint blockade therapeutics. Accounts of chemical research 2020;53(11):2521-33.
Abdou P, Wang Z, Chen Q, Chan A, Zhou DR, Gunadhi V, et al. Advances in engineering local drug delivery systems for cancer immunotherapy. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2020;12(5):e1632.
Jin J-f, Zhu L-l, Chen M, Xu H-m, Wang H-f, Feng X-q, et al. The optimal choice of medication administration route regarding intravenous, intramuscular, and subcutaneous injection. Patient preference and adherence 2015:923-42.
Auerbach M, Ballard H. Clinical use of intravenous iron: administration, efficacy, and safety. Hematology 2010, the American Society of Hematology Education Program Book. 2010;2010(1):338-47.
Jain A, Jain S. Advances in tumor targeted liposomes. Current molecular medicine 2018;18(1):44-57.
Fadeel B, Farcal L, Hardy B, Vázquez-Campos S, Hristozov D, Marcomini A, et al. Advanced tools for the safety assessment of nanomaterials. Nature nanotechnology 2018;13(7):537-43.
Peng F, Setyawati MI, Tee JK, Ding X, Wang J, Nga ME, et al. Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness. Nature nanotechnology 2019;14(3):279-86.
Wang H, Su W, Tan M. Endogenous fluorescence carbon dots derived from food items. The innovation 2020;1(1).
Sonavane G, Tomoda K, Makino K. Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size. Colloids and Surfaces B: Biointerfaces 2008;66(2):274-80.
De Jong WH, Hagens WI, Krystek P, Burger MC, Sips AJ, Geertsma RE. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 2008;29(12):1912-9.
Cai R, Chen C. The crown and the scepter: roles of the protein corona in nanomedicine. Advanced Materials 2019;31(45):1805740.
Liu S, Han Y, Qiao R, Zeng J, Jia Q, Wang Y, et al. Investigations on the interactions between plasma proteins and magnetic iron oxide nanoparticles with different surface modifications. The Journal of Physical Chemistry C 2010;114(49):21270-6.
Maeda H. Macromolecular therapeutics in cancer treatment: the EPR effect and beyond. Journal of Controlled Release 2012;164(2):138-44.
Hill LJ, Pinna N, Char K, Pyun J. Colloidal polymers from inorganic nanoparticle monomers. Progress in Polymer Science 2015;40:85-120.
Ma T, Zhang P, Hou Y, Ning H, Wang Z, Huang J, et al. “Smart” nanoprobes for visualization of tumor microenvironments. Advanced Healthcare Materials 2018;7(20):1800391.
Lu Y, Aimetti AA, Langer R, Gu Z. Bioresponsive materials. Nature Reviews Materials 2016;2(1):1-17.
Hou Y, Zhou J, Gao Z, Sun X, Liu C, Shangguan D, et al. Protease-activated ratiometric fluorescent probe for pH mapping of malignant tumors. ACS Nano 2015;9(3):3199-205.
Ma T, Hou Y, Zeng J, Liu C, Zhang P, Jing L, et al. Dual-ratiometric target-triggered fluorescent probe for simultaneous quantitative visualization of tumor microenvironment protease activity and pH in vivo. Journal of the American Chemical Society 2018;140(1):211-8.
Fan Z, Zhao J, Chai X, Li L. A Cooperatively Activatable, DNA‐based Fluorescent Reporter for Imaging of Correlated Enzymatic Activities. Angewandte Chemie International Edition 2021;60(27):14887-91.
Geng Z, Wang L, Liu K, Liu J, Tan W. Enhancing anti‐PD‐1 Immunotherapy by Nanomicelles Self‐Assembled from Multivalent Aptamer Drug Conjugates. Angewandte Chemie 2021;133(28):15587-93.
Crich SG, Terreno E, Aime S. Nano-sized and other improved reporters for magnetic resonance imaging of angiogenesis. Advanced Drug Delivery Reviews 2017;119:61-72.
Kelley WJ, Safari H, Lopez‐Cazares G, Eniola‐Adefeso O. Vascular‐targeted nanocarriers: design considerations and strategies for successful treatment of atherosclerosis and other vascular diseases. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2016;8(6):909-26.
Zhang H, Prince MR. Renal MR angiography. Magnetic Resonance Imaging Clinics. 2004;12(3):487-503.
Chan KW-Y, Wong W-T. Small molecular gadolinium (III) complexes as MRI contrast agents for diagnostic imaging. Coordination Chemistry Reviews 2007;251(17-20):2428-51.
Bogdanov Jr A, Weissleder R, Frank H, Bogdanova A, Nossif N, Schaffer B, et al. A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies. Radiology 1993;187(3):701-6.
Lin Y-H, Hwang R-M, Chen B-B, Hsu C-Y, Yu C-W, Kao J-H, et al. Vascular and hepatic enhancements at MR imaging: comparison of Gd-EOB-DTPA and Gd-DTPA in the same subjects. Clinical Imaging 2014;38(3):287-91.
Peldschus K, Hamdorf M, Robert P, Port M, Adam G, Herborn CU. Comparison of the high relaxivity Gd chelates P1152 and Gd‐BOPTA for contrast‐enhanced MR angiography in rabbits at 1.5 Tesla and 3.0 Tesla. Journal of Magnetic Resonance Imaging 2010;32(2):459-65.
Naccache R, Chevallier P, Lagueux J, Gossuin Y, Laurent S, Vander Elst L, et al. High relaxivities and strong vascular signal enhancement for NaGdF4 nanoparticles designed for dual MR/optical imaging. Advanced Healthcare Materials 2013;2(11):1478-88.
Gupta S, Knowlton AA. HSP60, Bax, Apoptosis and the Heart. Journal of Cellular and Molecular Medicine 2005;9(1):51-8.
Sugimoto T, Yamazaki N, Hayashi T, Yuba E, Harada A, Kotaka A, et al. Preparation of dual-stimuli-responsive liposomes using methacrylate-based copolymers with pH and temperature sensitivities for precisely controlled release. Colloids Surface B Biointerfaces 2017;155:449-58.
Jiao M, Jing L, Wei X, Liu C, Luo X, Gao M. The Yin and Yang of coordinating co-solvents in the size-tuning of Fe3O4 nanocrystals through flow synthesis. Nanoscale 2017;9(47):18609-12.
Tajiri N, De La Peña I, Acosta SA, Kaneko Y, Tamir S, Landesman Y, et al. A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus. CNS Neuroscience Therapy. 2016;22(4):306-15.
Wang T, Hou Y, Bu B, Wang W, Ma T, Liu C, et al. Timely Visualization of the Collaterals Formed during Acute Ischemic Stroke with Fe3O4 Nanoparticle‐based MR Imaging Probe. Small 2018;14(23):1800573.
Kudo S, Nagasaki Y. Facile and Quantitative Synthesis of a Poly(ethylene glycol)-b-Poly(l-arginine) Block Copolymer and Its Use for the Preparation of Polyion Complex Micelles with Polyanions for Biomedical Applications. Macromolecular Rapid Communications. 2015;36(21):1916-22.
Kim BH, Lee N, Kim H, An K, Park YI, Choi Y, et al. Large-scale synthesis of uniform and extremely small-sized iron oxide nanoparticles for high-resolution T 1 magnetic resonance imaging contrast agents. Journal of the American Chemical Society 2011;133(32):12624-31.
Qiao H, Wang Y, Zhang R, Gao Q, Liang X, Gao L, et al. MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles. Biomaterials 2017;112:336-45.
Qiao R, Qiao H, Zhang Y, Wang Y, Chi C, Tian J, et al. Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes. ACS Nano 2017;11(2):1816-25.
Wang Y, Zhang Y, Wang Z, Zhang J, Qiao RR, Xu M, et al. Optical/MRI dual-modality imaging of M1 macrophage polarization in atherosclerotic plaque with MARCO-targeted upconversion luminescence probe. Biomaterials 2019;219:119378.
Choi JY, Ryu J, Kim HJ, Song JW, Jeon JH, Lee D-H, et al. Therapeutic effects of targeted PPARɣ activation on inflamed high-risk plaques assessed by serial optical imaging in vivo. Theranostics 2018;8(1):45.
Hou W, Li J, Cao Z, Lin S, Pan C, Pang Y, et al. Decorating bacteria with a therapeutic nanocoating for synergistically enhanced biotherapy. Small 2021;17(37):2101810.
Zhang Y, Li M, Du G, Chen X, Sun X. Advanced oral vaccine delivery strategies for improving the immunity. Advanced Drug Delivery Reviews 2021;177:113928.
Wang R, Zhou L, Wang W, Li X, Zhang F. In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers. Nature Communications 2017;8(1):14702.
Abramson A, Frederiksen MR, Vegge A, Jensen B, Poulsen M, Mouridsen B, et al. Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors. Nature biotechnology 2022;40(1):103-9.
Yang X, Ma C, Chen Z, Liu J, Liu F, Xie R, et al. Single small molecule-assembled nanoparticles mediate efficient oral drug delivery. Nano research 2019;12:2468-76.
Bernkop-Schnürch A, Schmitz T. Presystemic metabolism of orally administered peptide drugs and strategies to overcome it. Current Drug Metabolism 2007;8(5):509-17.
Zhang Z, Gao F, Jiang S, Ma L, Li Y. Nano-based drug delivery system enhances the oral absorption of lipophilic drugs with extensive presystemic metabolism. Current Drug Metabolism 2012;13(8):1110-8.
Abramson A, Caffarel-Salvador E, Khang M, Dellal D, Silverstein D, Gao Y, et al. An ingestible self-orienting system for oral delivery of macromolecules. Science 2019;363(6427):611-5.
Yeom DW, Chae BR, Son HY, Kim JH, Chae JS, Song SH, et al. Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system. International Journal of Nanomedicine 2017;Volume 12:3533-45.
Naeem M, Bae J, Oshi MA, Kim M-S, Moon HR, Lee BL, et al. Colon-targeted delivery of cyclosporine A using dual-functional Eudragit® FS30D/PLGA nanoparticles ameliorates murine experimental colitis. International journal of nanomedicine 2018:1225-40.
Kang J-H, Hwang J-Y, Seo J-W, Kim H-S, Shin US. Small intestine-and colon-specific smart oral drug delivery system with controlled release characteristic. Materials Science and Engineering: C 2018;91:247-54.
Toffoli G, Corona G, Basso B, Boiocchi M. Pharmacokinetic optimisation of treatment with oral etoposide. Clinical pharmacokinetics 2004;43:441-66.
Wilhelm S, Tavares AJ, Dai Q, Ohta S, Audet J, Dvorak HF, et al. Analysis of nanoparticle delivery to tumours. Nature reviews materials 2016;1(5):1-12.
Weldon C, Ji T, Nguyen MT, Rwei A, Wang W, Hao Y, et al. Nanoscale Bupivacaine Formulations to Enhance the Duration and Safety of Intravenous Regional Anesthesia. ACS Nano. 2019;13(1):18-25.
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Referanslar
Wei G, Wang Y, Yang G, Wang Y, Ju R. Recent progress in nanomedicine for enhanced cancer chemotherapy. Theranostics. 2021;11(13):6370-92.
Rong L, Lei Q, Zhang X-Z. Recent advances on peptide-based theranostic nanomaterials. VIEW. 2020;1(4):20200050.
Lindner T, Loktev A, Altmann A, Giesel F, Kratochwil C, Debus J, et al. Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein. Journal of Nuclear Medicine 2018;59(9):1415.
Ji T, Zhao Y, Ding Y, Wang J, Zhao R, Lang J, et al. Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer‐associated fibroblast activation. Angewandte Chemie International Edition 2016;55(3):1050-5.
Ji T, Kohane DS. Nanoscale systems for local drug delivery. Nano Today. 2019;28:100765.
Zhang P, Li Y, Tang W, Zhao J, Jing L, McHugh KJ. Theranostic nanoparticles with disease-specific administration strategies. Nano Today 2022;42:101335.
Han X, Li H, Zhou D, Chen Z, Gu Z. Local and targeted delivery of immune checkpoint blockade therapeutics. Accounts of chemical research 2020;53(11):2521-33.
Abdou P, Wang Z, Chen Q, Chan A, Zhou DR, Gunadhi V, et al. Advances in engineering local drug delivery systems for cancer immunotherapy. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2020;12(5):e1632.
Jin J-f, Zhu L-l, Chen M, Xu H-m, Wang H-f, Feng X-q, et al. The optimal choice of medication administration route regarding intravenous, intramuscular, and subcutaneous injection. Patient preference and adherence 2015:923-42.
Auerbach M, Ballard H. Clinical use of intravenous iron: administration, efficacy, and safety. Hematology 2010, the American Society of Hematology Education Program Book. 2010;2010(1):338-47.
Jain A, Jain S. Advances in tumor targeted liposomes. Current molecular medicine 2018;18(1):44-57.
Fadeel B, Farcal L, Hardy B, Vázquez-Campos S, Hristozov D, Marcomini A, et al. Advanced tools for the safety assessment of nanomaterials. Nature nanotechnology 2018;13(7):537-43.
Peng F, Setyawati MI, Tee JK, Ding X, Wang J, Nga ME, et al. Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness. Nature nanotechnology 2019;14(3):279-86.
Wang H, Su W, Tan M. Endogenous fluorescence carbon dots derived from food items. The innovation 2020;1(1).
Sonavane G, Tomoda K, Makino K. Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size. Colloids and Surfaces B: Biointerfaces 2008;66(2):274-80.
De Jong WH, Hagens WI, Krystek P, Burger MC, Sips AJ, Geertsma RE. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 2008;29(12):1912-9.
Cai R, Chen C. The crown and the scepter: roles of the protein corona in nanomedicine. Advanced Materials 2019;31(45):1805740.
Liu S, Han Y, Qiao R, Zeng J, Jia Q, Wang Y, et al. Investigations on the interactions between plasma proteins and magnetic iron oxide nanoparticles with different surface modifications. The Journal of Physical Chemistry C 2010;114(49):21270-6.
Maeda H. Macromolecular therapeutics in cancer treatment: the EPR effect and beyond. Journal of Controlled Release 2012;164(2):138-44.
Hill LJ, Pinna N, Char K, Pyun J. Colloidal polymers from inorganic nanoparticle monomers. Progress in Polymer Science 2015;40:85-120.
Ma T, Zhang P, Hou Y, Ning H, Wang Z, Huang J, et al. “Smart” nanoprobes for visualization of tumor microenvironments. Advanced Healthcare Materials 2018;7(20):1800391.
Lu Y, Aimetti AA, Langer R, Gu Z. Bioresponsive materials. Nature Reviews Materials 2016;2(1):1-17.
Hou Y, Zhou J, Gao Z, Sun X, Liu C, Shangguan D, et al. Protease-activated ratiometric fluorescent probe for pH mapping of malignant tumors. ACS Nano 2015;9(3):3199-205.
Ma T, Hou Y, Zeng J, Liu C, Zhang P, Jing L, et al. Dual-ratiometric target-triggered fluorescent probe for simultaneous quantitative visualization of tumor microenvironment protease activity and pH in vivo. Journal of the American Chemical Society 2018;140(1):211-8.
Fan Z, Zhao J, Chai X, Li L. A Cooperatively Activatable, DNA‐based Fluorescent Reporter for Imaging of Correlated Enzymatic Activities. Angewandte Chemie International Edition 2021;60(27):14887-91.
Geng Z, Wang L, Liu K, Liu J, Tan W. Enhancing anti‐PD‐1 Immunotherapy by Nanomicelles Self‐Assembled from Multivalent Aptamer Drug Conjugates. Angewandte Chemie 2021;133(28):15587-93.
Crich SG, Terreno E, Aime S. Nano-sized and other improved reporters for magnetic resonance imaging of angiogenesis. Advanced Drug Delivery Reviews 2017;119:61-72.
Kelley WJ, Safari H, Lopez‐Cazares G, Eniola‐Adefeso O. Vascular‐targeted nanocarriers: design considerations and strategies for successful treatment of atherosclerosis and other vascular diseases. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2016;8(6):909-26.
Zhang H, Prince MR. Renal MR angiography. Magnetic Resonance Imaging Clinics. 2004;12(3):487-503.
Chan KW-Y, Wong W-T. Small molecular gadolinium (III) complexes as MRI contrast agents for diagnostic imaging. Coordination Chemistry Reviews 2007;251(17-20):2428-51.
Bogdanov Jr A, Weissleder R, Frank H, Bogdanova A, Nossif N, Schaffer B, et al. A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies. Radiology 1993;187(3):701-6.
Lin Y-H, Hwang R-M, Chen B-B, Hsu C-Y, Yu C-W, Kao J-H, et al. Vascular and hepatic enhancements at MR imaging: comparison of Gd-EOB-DTPA and Gd-DTPA in the same subjects. Clinical Imaging 2014;38(3):287-91.
Peldschus K, Hamdorf M, Robert P, Port M, Adam G, Herborn CU. Comparison of the high relaxivity Gd chelates P1152 and Gd‐BOPTA for contrast‐enhanced MR angiography in rabbits at 1.5 Tesla and 3.0 Tesla. Journal of Magnetic Resonance Imaging 2010;32(2):459-65.
Naccache R, Chevallier P, Lagueux J, Gossuin Y, Laurent S, Vander Elst L, et al. High relaxivities and strong vascular signal enhancement for NaGdF4 nanoparticles designed for dual MR/optical imaging. Advanced Healthcare Materials 2013;2(11):1478-88.
Gupta S, Knowlton AA. HSP60, Bax, Apoptosis and the Heart. Journal of Cellular and Molecular Medicine 2005;9(1):51-8.
Sugimoto T, Yamazaki N, Hayashi T, Yuba E, Harada A, Kotaka A, et al. Preparation of dual-stimuli-responsive liposomes using methacrylate-based copolymers with pH and temperature sensitivities for precisely controlled release. Colloids Surface B Biointerfaces 2017;155:449-58.
Jiao M, Jing L, Wei X, Liu C, Luo X, Gao M. The Yin and Yang of coordinating co-solvents in the size-tuning of Fe3O4 nanocrystals through flow synthesis. Nanoscale 2017;9(47):18609-12.
Tajiri N, De La Peña I, Acosta SA, Kaneko Y, Tamir S, Landesman Y, et al. A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus. CNS Neuroscience Therapy. 2016;22(4):306-15.
Wang T, Hou Y, Bu B, Wang W, Ma T, Liu C, et al. Timely Visualization of the Collaterals Formed during Acute Ischemic Stroke with Fe3O4 Nanoparticle‐based MR Imaging Probe. Small 2018;14(23):1800573.
Kudo S, Nagasaki Y. Facile and Quantitative Synthesis of a Poly(ethylene glycol)-b-Poly(l-arginine) Block Copolymer and Its Use for the Preparation of Polyion Complex Micelles with Polyanions for Biomedical Applications. Macromolecular Rapid Communications. 2015;36(21):1916-22.
Kim BH, Lee N, Kim H, An K, Park YI, Choi Y, et al. Large-scale synthesis of uniform and extremely small-sized iron oxide nanoparticles for high-resolution T 1 magnetic resonance imaging contrast agents. Journal of the American Chemical Society 2011;133(32):12624-31.
Qiao H, Wang Y, Zhang R, Gao Q, Liang X, Gao L, et al. MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles. Biomaterials 2017;112:336-45.
Qiao R, Qiao H, Zhang Y, Wang Y, Chi C, Tian J, et al. Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes. ACS Nano 2017;11(2):1816-25.
Wang Y, Zhang Y, Wang Z, Zhang J, Qiao RR, Xu M, et al. Optical/MRI dual-modality imaging of M1 macrophage polarization in atherosclerotic plaque with MARCO-targeted upconversion luminescence probe. Biomaterials 2019;219:119378.
Choi JY, Ryu J, Kim HJ, Song JW, Jeon JH, Lee D-H, et al. Therapeutic effects of targeted PPARɣ activation on inflamed high-risk plaques assessed by serial optical imaging in vivo. Theranostics 2018;8(1):45.
Hou W, Li J, Cao Z, Lin S, Pan C, Pang Y, et al. Decorating bacteria with a therapeutic nanocoating for synergistically enhanced biotherapy. Small 2021;17(37):2101810.
Zhang Y, Li M, Du G, Chen X, Sun X. Advanced oral vaccine delivery strategies for improving the immunity. Advanced Drug Delivery Reviews 2021;177:113928.
Wang R, Zhou L, Wang W, Li X, Zhang F. In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers. Nature Communications 2017;8(1):14702.
Abramson A, Frederiksen MR, Vegge A, Jensen B, Poulsen M, Mouridsen B, et al. Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors. Nature biotechnology 2022;40(1):103-9.
Yang X, Ma C, Chen Z, Liu J, Liu F, Xie R, et al. Single small molecule-assembled nanoparticles mediate efficient oral drug delivery. Nano research 2019;12:2468-76.
Bernkop-Schnürch A, Schmitz T. Presystemic metabolism of orally administered peptide drugs and strategies to overcome it. Current Drug Metabolism 2007;8(5):509-17.
Zhang Z, Gao F, Jiang S, Ma L, Li Y. Nano-based drug delivery system enhances the oral absorption of lipophilic drugs with extensive presystemic metabolism. Current Drug Metabolism 2012;13(8):1110-8.
Abramson A, Caffarel-Salvador E, Khang M, Dellal D, Silverstein D, Gao Y, et al. An ingestible self-orienting system for oral delivery of macromolecules. Science 2019;363(6427):611-5.
Yeom DW, Chae BR, Son HY, Kim JH, Chae JS, Song SH, et al. Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system. International Journal of Nanomedicine 2017;Volume 12:3533-45.
Naeem M, Bae J, Oshi MA, Kim M-S, Moon HR, Lee BL, et al. Colon-targeted delivery of cyclosporine A using dual-functional Eudragit® FS30D/PLGA nanoparticles ameliorates murine experimental colitis. International journal of nanomedicine 2018:1225-40.
Kang J-H, Hwang J-Y, Seo J-W, Kim H-S, Shin US. Small intestine-and colon-specific smart oral drug delivery system with controlled release characteristic. Materials Science and Engineering: C 2018;91:247-54.
Toffoli G, Corona G, Basso B, Boiocchi M. Pharmacokinetic optimisation of treatment with oral etoposide. Clinical pharmacokinetics 2004;43:441-66.
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