Uyaranlara Duyarlı Nanotaşıyıcılar
Özet
Nanoteknolojinin ilaç uygulamaları üzerinde gittikçe artan etkisiyle birlikte, uyaranlara duyarlı nanotaşıyıcıların geliştirilmesi, terapötik ajanların özellikle istenen etki bölgesine hedeflendirilerek salımını kontrol etmede çeşitli üstünlükleri de beraberinde getiren bir strateji olarak kullanılmaya başlanmıştır. Bu yaklaşım ile nanotaşıyıcının bölgesel, zamansal ve dozaj kontrollü özellikler kazanması mümkün hale getirilmiştir. Optimize edilmiş bir sistem tasarlamak için, endojen (pH, redoks, enzim) veya eksojen (sıcaklık, manyetik alan, ultrason, ışık, elektrik alan) veya çoklu uyaranlar gibi farklı uyaran mekanizmalarını kavramak gerekmektedir. Bu bölüm, endojen ve eksojen uyaranlara duyarlı nanotaşıyıcı sistemlerin kontrollü ve hedeflendirilmiş ilaç uygulamasındaki mevcut güncel yaklaşımlara genel bir bakış sunmaktadır.
Referanslar
Mura S, Nicolas J, Couvreur P. Stimuli-responsive nanocarriers for drug delivery. Nature Materials. 2013;12(11):991-1003.
Farokhzad OC, Langer R. Impact of nanotechnology on drug delivery. ACS Nano. 2009;3(1):16-20.
Hamidi M, Azadi A, Rafiei P, Ashrafi H. A pharmacokinetic overview of nanotechnology-based drug delivery systems: an ADME-oriented approach. Critical Reviews in Therapeutic Drug Carrier Systems. 2013;30(5).
Bobo D, Robinson KJ, Islam J, Thurecht KJ, Corrie SR. Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. Pharmaceutical Research. 2016;33:2373-87.
Raza A, Rasheed T, Nabeel F, Hayat U, Bilal M, Iqbal HM. Endogenous and exogenous stimuli-responsive drug delivery systems for programmed site-specific release. Molecules. 2019;24(6):1117.
Yatvin MB, Weinstein JN, Dennis WH, Blumenthal R. Design of liposomes for enhanced local release of drugs by hyperthermia. Science. 1978;202(4374):1290-3.
Rasheed T, Bilal M, Abu-Thabit NY, Iqbal HM. The smart chemistry of stimuli-responsive polymeric carriers for target drug delivery applications. Makhlouf, A. S. H., & Abu-Thabit, N. Y. (Eds.), Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications, Volume 1 içinde. Woodhead Publishing; 2018. p. 61-99.
Ghaffar A, Yameen B, Latif M, Malik MI. pH-sensitive drug delivery systems. Shah, M. R., Imran, M., & Ullah, S. (Eds.), Metal Nanoparticles for Drug Delivery and Diagnostic Applications içinde. Elsevier; 2020. p. 259-78.
Ahmed M, Narain R. Intracellular delivery of DNA and enzyme in active form using degradable carbohydrate-based nanogels. Molecular Pharmaceutics. 2012;9(11):3160-70.
Yan Y, Ding H. pH-responsive nanoparticles for cancer immunotherapy: a brief review. Nanomaterials. 2020;10(8):1613.
Colson YL, Grinstaff MW. Biologically responsive polymeric nanoparticles for drug delivery. Advanced Materials. 2012;24(28):3878-86.
Deng Z, Zhen Z, Hu X, Wu S, Xu Z, Chu PK. Hollow chitosan–silica nanospheres as pH-sensitive targeted delivery carriers in breast cancer therapy. Biomaterials. 2011;32(21):4976-86.
Gao GH, Park MJ, Li Y, Im GH, Kim J-H, Kim HN, et al. The use of pH-sensitive positively charged polymeric micelles for protein delivery. Biomaterials. 2012;33(35):9157-64.
Zhang K, Luo Y, Li Z. Synthesis and characterization of a pH‐and ionic strength‐responsive hydrogel. Soft Materials. 2007;5(4):183-95.
Chen W, Meng F, Cheng R, Zhong Z. pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: a comparative study with micelles. Journal of Controlled Release. 2010;142(1):40-6.
Wang J, Byrne JD, Napier ME, DeSimone JM. More effective nanomedicines through particle design. Small. 2011;7(14):1919-31.
Abed HF, Abuwatfa WH, Husseini GA. Redox-responsive drug delivery systems: a chemical perspective. Nanomaterials. 2022;12(18):3183.
Sun Y, Yan X, Yuan T, Liang J, Fan Y, Gu Z, et al. Disassemblable micelles based on reduction-degradable amphiphilic graft copolymers for intracellular delivery of doxorubicin. Biomaterials. 2010;31(27):7124-31.
Li J, Huo M, Wang J, Zhou J, Mohammad JM, Zhang Y, et al. Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel. Biomaterials. 2012;33(7):2310-20.
Wang Y-C, Wang F, Sun T-M, Wang J. Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells. Bioconjugate Chemistry. 2011;22(10):1939-45.
Kurtoglu YE, Navath RS, Wang B, Kannan S, Romero R, Kannan RM. Poly (amidoamine) dendrimer–drug conjugates with disulfide linkages for intracellular drug delivery. Biomaterials. 2009;30(11):2112-21.
Ong W, Yang Y, Cruciano AC, McCarley RL. Redox-triggered contents release from liposomes. Journal of the American Chemical Society. 2008;130(44):14739-44.
Ryu J-H, Chacko RT, Jiwpanich S, Bickerton S, Babu RP, Thayumanavan S. Self-cross-linked polymer nanogels: a versatile nanoscopic drug delivery platform. Journal of the American Chemical Society. 2010;132(48):17227-35.
Türkiye İlaç ve Tıbbi Cihaz Kurumu. Mylotarg 5 mg 2023. (02/07/2023 tarihinde https://titck.gov.tr/storage/Archive/2021/kubKtAttachments/mylotargonaylkt_a7c84889-bd11-4245-b90f-b9add41378af.pdf. adresinden ulaşılmıştır).
Eskandari P, Bigdeli B, Porgham Daryasari M, Baharifar H, Bazri B, Shourian M, et al. Gold-capped mesoporous silica nanoparticles as an excellent enzyme-responsive nanocarrier for controlled doxorubicin delivery. Journal of Drug Targeting. 2019;27(10):1084-93.
Hu Q, Katti PS, Gu Z. Enzyme-responsive nanomaterials for controlled drug delivery. Nanoscale. 2014;6(21):12273-86.
Hu X, Tian J, Liu T, Zhang G, Liu S. Photo-triggered release of caged camptothecin prodrugs from dually responsive shell cross-linked micelles. Macromolecules. 2013;46(15):6243-56.
Basel MT, Shrestha TB, Troyer DL, Bossmann SH. Protease-sensitive, polymer-caged liposomes: a method for making highly targeted liposomes using triggered release. ACS Nano. 2011;5(3):2162-75.
Radhakrishnan K, Tripathy J, Gnanadhas DP, Chakravortty D, Raichur AM. Dual enzyme responsive and targeted nanocapsules for intracellular delivery of anticancer agents. RSC Advances. 2014;4(86):45961-8.
Kundu JK, Surh Y-J. Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis. Pharmaceutical Research. 2010;27:999-1013.
Wang Y, Li Z, Hu Q. Emerging self-regulated micro/nano drug delivery devices: a step forward towards intelligent diagnosis and therapy. Nano Today. 2021;38:101127.
Wang B, Ma R, Liu G, Li Y, Liu X, An Y, et al. Glucose-responsive micelles from self-assembly of poly (ethylene glycol)-b-poly (acrylic acid-co-acrylamidophenylboronic acid) and the controlled release of insulin. Langmuir. 2009;25(21):12522-8.
Kim H, Kang YJ, Kang S, Kim KT. Monosaccharide-responsive release of insulin from polymersomes of polyboroxole block copolymers at neutral pH. Journal of the American Chemical Society. 2012;134(9):4030-3.
Kim H, Kang YJ, Jeong ES, Kang S, Kim KT. Glucose-responsive disassembly of polymersomes of sequence-specific boroxole-containing block copolymers under physiologically relevant conditions. ACS Macro Letters. 2012;1(10):1194-8.
Yao Y, Zhao L, Yang J, Yang J. Glucose-responsive vehicles containing phenylborate ester for controlled insulin release at neutral pH. Biomacromolecules. 2012;13(6):1837-44.
Jin X, Zhang X, Wu Z, Teng D, Zhang X, Wang Y, et al. Amphiphilic random glycopolymer based on phenylboronic acid: synthesis, characterization, and potential as glucose-sensitive matrix. Biomacromolecules. 2009;10(6):1337-45.
ABD Gıda ve İlaç Dairesi. t:slim X2 Insulin Pump. (01/07/2023 tarihinde https://www.fda.gov/news-events/press-announcements/fda-authorizes-first-interoperable-insulin-pump-intended-allow-patients-customize-treatment-through. adresinden ulaşılmıştır).
Joshi N, Shirsath N, Singh A, Joshi KS, Banerjee R. Endogenous lung surfactant inspired pH responsive nanovesicle aerosols: Pulmonary compatible and site-specific drug delivery in lung metastases. Scientific Reports. 2014;4(1):7085.
Li J, Ke W, Li H, Zha Z, Han Y, Ge Z. Endogenous stimuli‐sensitive multistage polymeric micelleplex anticancer drug delivery system for efficient tumor penetration and cellular internalization. Advanced Healthcare Materials. 2015;4(15):2206-19.
Lu H, Xu S, Guo Z, Zhao M, Liu Z. Redox-responsive molecularly imprinted nanoparticles for targeted intracellular delivery of protein toward cancer therapy. ACS Nano. 2021;15(11):18214-25.
Vicent MJ, Greco F, Nicholson RI, Paul A, Griffiths PC, Duncan R. Polymer therapeutics designed for a combination therapy of hormone‐dependent cancer. Angewandte Chemie. 2005;117(26):4129-34.
Xiong M-H, Bao Y, Yang X-Z, Wang Y-C, Sun B, Wang J. Lipase-sensitive polymeric triple-layered nanogel for “on-demand” drug delivery. Journal of the American Chemical Society. 2012;134(9):4355-62.
Liu D, Yang F, Xiong F, Gu N. The smart drug delivery system and its clinical potential. Theranostics. 2016;6(9):1306.
Bikram M, West JL. Thermo-responsive systems for controlled drug delivery. Expert Opinion on Drug Delivery. 2008;5(10):1077-91.
Mazzotta E, Tavano L, Muzzalupo R. Thermo-sensitive vesicles in controlled drug delivery for chemotherapy. Pharmaceutics. 2018;10(3):150.
Tagami T, Foltz WD, Ernsting MJ, Lee CM, Tannock IF, May JP, et al. MRI monitoring of intratumoral drug delivery and prediction of the therapeutic effect with a multifunctional thermosensitive liposome. Biomaterials. 2011;32(27):6570-8.
Chen K-J, Liang H-F, Chen H-L, Wang Y, Cheng P-Y, Liu H-L, et al. A thermoresponsive bubble-generating liposomal system for triggering localized extracellular drug delivery. ACS Nano. 2013;7(1):438-46.
Price PM, Mahmoud WE, Al-Ghamdi AA, Bronstein LM. Magnetic drug delivery: where the field is going. Frontiers in Chemistry. 2018;6:619.
Yang H-W, Hua M-Y, Liu H-L, Huang C-Y, Tsai R-Y, Lu Y-J, et al. Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas. Biomaterials. 2011;32(27):6523-32.
Tian B, Liu Y, Liu J. Smart stimuli-responsive drug delivery systems based on cyclodextrin: A review. Carbohydrate Polymers. 2021;251:116871.
Zhang L, Wang T, Yang L, Liu C, Wang C, Liu H, et al. General route to multifunctional uniform yolk/mesoporous silica shell nanocapsules: a platform for simultaneous cancer‐targeted imaging and magnetically guided drug delivery. Chemistry–A European Journal. 2012;18(39):12512-21.
Hua M-Y, Liu H-L, Yang H-W, Chen P-Y, Tsai R-Y, Huang C-Y, et al. The effectiveness of a magnetic nanoparticle-based delivery system for BCNU in the treatment of gliomas. Biomaterials. 2011;32(2):516-27.
Plassat V, Wilhelm C, Marsaud V, Ménager C, Gazeau F, Renoir JM, et al. Anti‐estrogen‐loaded superparamagnetic liposomes for intracellular magnetic targeting and treatment of breast cancer tumors. Advanced Functional Materials. 2011;21(1):83-92.
Zhang F, Braun GB, Pallaoro A, Zhang Y, Shi Y, Cui D, et al. Mesoporous multifunctional upconversion luminescent and magnetic “nanorattle” materials for targeted chemotherapy. Nano Letters. 2012;12(1):61-7.
Arias JL, Reddy LH, Othman M, Gillet B, Desmaele D, Zouhiri F, et al. Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics. ACS Nano. 2011;5(2):1513-21.
Qin J, Asempah I, Laurent S, Fornara A, Muller RN, Muhammed M. Injectable superparamagnetic ferrogels for controlled release of hydrophobic drugs. Advanced Materials. 2009;21(13):1354-7.
Luo Z, Jin K, Pang Q, Shen S, Yan Z, Jiang T, et al. On-demand drug release from dual-targeting small nanoparticles triggered by high-intensity focused ultrasound enhanced glioblastoma-targeting therapy. ACS Applied Materials & Interfaces. 2017;9(37):31612-25.
Delaney LJ, Isguven S, Eisenbrey JR, Hickok NJ, Forsberg F. Making waves: how ultrasound-targeted drug delivery is changing pharmaceutical approaches. Materials Advances. 2022;3(7):3023-40.
Schroeder A, Honen R, Turjeman K, Gabizon A, Kost J, Barenholz YJ. Ultrasound triggered release of cisplatin from liposomes in murine tumors. Journal of Controlled Release. 2009;137(1):63-8.
Kheirolomoom A, Mahakian LM, Lai C-Y, Lindfors HA, Seo JW, Paoli EE, et al. Copper− doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicity. Molecular Pharmaceutics. 2010;7(6):1948-58.
Rapoport NY, Kennedy AM, Shea JE, Scaife CL, Nam K-H. Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles. Journal of Controlled Release. 2009;138(3):268-76.
Ranjan A, Jacobs GC, Woods DL, Negussie AH, Partanen A, Yarmolenko PS, et al. Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model. Journal of Controlled Release. 2012;158(3):487-94.
Lino MM, Ferreira L. Light-triggerable formulations for the intracellular controlled release of biomolecules. Drug Discovery Today. 2018;23(5):1062-70.
Brown AA, Azzaroni O, Huck WT. Photoresponsive polymer brushes for hydrophilic patterning. Langmuir. 2009;25(3):1744-9.
Hossion AM, Bio M, Nkepang G, Awuah SG, You Y. Visible light controlled release of anticancer drug through double activation of prodrug. ACS Medicinal Chemistry Letters. 2013;4(1):124-7.
Liu C, Zhang Y, Liu M, Chen Z, Lin Y, Li W, et al. A NIR-controlled cage mimicking system for hydrophobic drug mediated cancer therapy. Biomaterials. 2017;139:151-62.
Xiang J, Tong X, Shi F, Yan Q, Yu B, Zhao Y. Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity. Journal of Materials Chemistry B. 2018;6(21):3531-40.
Yang J, Lee J, Kang J, Oh SJ, Ko HJ, Son JH, et al. Smart drug‐loaded polymer gold nanoshells for systemic and localized therapy of human epithelial cancer. Advanced Materials. 2009;21(43):4339-42.
Jeon G, Yang SY, Byun J, Kim JK. Electrically actuatable smart nanoporous membrane for pulsatile drug release. Nano Letters. 2011;11(3):1284-8.
Servant A, Bussy C, Al-Jamal K, Kostarelos K. Design, engineering and structural integrity of electro-responsive carbon nanotube-based hydrogels for pulsatile drug release. Journal of Materials Chemistry B. 2013;1(36):4593-600.
Ge J, Neofytou E, Cahill III TJ, Beygui RE, Zare RN. Drug release from electric-field-responsive nanoparticles. ACS Nano. 2012;6(1):227-33.
Olvera D, Monaghan MG. Electroactive material-based biosensors for detection and drug delivery. Advanced Drug Delivery Reviews. 2021;170:396-424.
Im JS, Bai BC, Lee Y-S. The effect of carbon nanotubes on drug delivery in an electro-sensitive transdermal drug delivery system. Biomaterials. 2010;31(6):1414-9.
Liu K-H, Liu T-Y, Chen S-Y, Liu D-M. Drug release behavior of chitosan–montmorillonite nanocomposite hydrogels following electrostimulation. Acta Biomaterialia. 2008;4(4):1038-45.
Hosseini-Nassab N, Samanta D, Abdolazimi Y, Annes JP, Zare RN. Electrically controlled release of insulin using polypyrrole nanoparticles. Nanoscale 2017;9(1):143-9.
An X, Zhu A, Luo H, Ke H, Chen H, Zhao Y. Rational design of multi-stimuli-responsive nanoparticles for precise cancer therapy. ACS Nano. 2016;10(6):5947-58.
Yoon S, Kim WJ, Yoo HS. Dual‐responsive breakdown of nanostructures with high doxorubicin payload for apoptotic anticancer therapy. Small. 2013;9(2):284-93.
Zhang L, Qin Y, Zhang Z, Fan F, Huang C, Lu L, et al. Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination therapy. Acta Biomaterialia. 2018;75:371-85.
You C, Wu H, Wang M, Gao Z, Sun B, Zhang X, et al. Synthesis and biological evaluation of redox/NIR dual stimulus-responsive polymeric nanoparticles for targeted delivery of cisplatin. Materials Science. 2018;92:453-62.
Hegazy M, Zhou P, Wu G, Wang L, Rahoui N, Taloub N, et al. Construction of polymer coated core–shell magnetic mesoporous silica nanoparticles with triple responsive drug delivery. Polymer Chemistry. 2017;8(38):5852-64.
Jia R, Teng L, Gao L, Su T, Fu L, Qiu Z, et al. Advances in multiple stimuli-responsive drug-delivery systems for cancer therapy. International Journal of Nanomedicine. 2021:1525-51.
Wei H, Zhang X-Z, Zhou Y, Cheng S-X, Zhuo R-X. Self-assembled thermoresponsive micelles of poly (N-isopropylacrylamide-b-methyl methacrylate). Biomaterials. 2006;27(9):2028-34.
Yang Z, Cheng Q, Jiang Q, Deng L, Liang Z, Dong A. Thermo-sensitive nanoparticles for triggered release of siRNA. Journal of Biomaterials Science, Polymer Edition. 2015;26(4):264-76.
Hardiansyah A, Yang M-C, Liu T-Y, Kuo C-Y, Huang L-Y, Chan T-Y. Hydrophobic drug-loaded PEGylated magnetic liposomes for drug-controlled release. Nanoscale Research Letters. 2017;12:1-11.
Yavlovich A, Singh A, Blumenthal R, Puri A. A novel class of photo-triggerable liposomes containing DPPC: DC8, 9PC as vehicles for delivery of doxorubcin to cells. Biochimica et Biophysica Acta -Biomembranes. 2011;1808(1):117-26.
Kim KN, Oh KS, Shim J, Schlaepfer IR, Karam SD, Lee J-J. Light-responsive polymeric micellar nanoparticles with enhanced formulation stability. Polymers. 2021;13(3):377.
Papa A-L, Korin N, Kanapathipillai M, Mammoto A, Mammoto T, Jiang A, et al. Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery. Biomaterials. 2017;139:187-94.
Liu K-H, Liu T-Y, Liu D-M, Chen S-Y, Nanotechnology. Electrical-sensitive nanoparticle composed of chitosan and tetraethyl orthosilicate for controlled drug release. Journal of Nanoscience. 2009;9(2):1198-203.
Referanslar
Mura S, Nicolas J, Couvreur P. Stimuli-responsive nanocarriers for drug delivery. Nature Materials. 2013;12(11):991-1003.
Farokhzad OC, Langer R. Impact of nanotechnology on drug delivery. ACS Nano. 2009;3(1):16-20.
Hamidi M, Azadi A, Rafiei P, Ashrafi H. A pharmacokinetic overview of nanotechnology-based drug delivery systems: an ADME-oriented approach. Critical Reviews in Therapeutic Drug Carrier Systems. 2013;30(5).
Bobo D, Robinson KJ, Islam J, Thurecht KJ, Corrie SR. Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. Pharmaceutical Research. 2016;33:2373-87.
Raza A, Rasheed T, Nabeel F, Hayat U, Bilal M, Iqbal HM. Endogenous and exogenous stimuli-responsive drug delivery systems for programmed site-specific release. Molecules. 2019;24(6):1117.
Yatvin MB, Weinstein JN, Dennis WH, Blumenthal R. Design of liposomes for enhanced local release of drugs by hyperthermia. Science. 1978;202(4374):1290-3.
Rasheed T, Bilal M, Abu-Thabit NY, Iqbal HM. The smart chemistry of stimuli-responsive polymeric carriers for target drug delivery applications. Makhlouf, A. S. H., & Abu-Thabit, N. Y. (Eds.), Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications, Volume 1 içinde. Woodhead Publishing; 2018. p. 61-99.
Ghaffar A, Yameen B, Latif M, Malik MI. pH-sensitive drug delivery systems. Shah, M. R., Imran, M., & Ullah, S. (Eds.), Metal Nanoparticles for Drug Delivery and Diagnostic Applications içinde. Elsevier; 2020. p. 259-78.
Ahmed M, Narain R. Intracellular delivery of DNA and enzyme in active form using degradable carbohydrate-based nanogels. Molecular Pharmaceutics. 2012;9(11):3160-70.
Yan Y, Ding H. pH-responsive nanoparticles for cancer immunotherapy: a brief review. Nanomaterials. 2020;10(8):1613.
Colson YL, Grinstaff MW. Biologically responsive polymeric nanoparticles for drug delivery. Advanced Materials. 2012;24(28):3878-86.
Deng Z, Zhen Z, Hu X, Wu S, Xu Z, Chu PK. Hollow chitosan–silica nanospheres as pH-sensitive targeted delivery carriers in breast cancer therapy. Biomaterials. 2011;32(21):4976-86.
Gao GH, Park MJ, Li Y, Im GH, Kim J-H, Kim HN, et al. The use of pH-sensitive positively charged polymeric micelles for protein delivery. Biomaterials. 2012;33(35):9157-64.
Zhang K, Luo Y, Li Z. Synthesis and characterization of a pH‐and ionic strength‐responsive hydrogel. Soft Materials. 2007;5(4):183-95.
Chen W, Meng F, Cheng R, Zhong Z. pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: a comparative study with micelles. Journal of Controlled Release. 2010;142(1):40-6.
Wang J, Byrne JD, Napier ME, DeSimone JM. More effective nanomedicines through particle design. Small. 2011;7(14):1919-31.
Abed HF, Abuwatfa WH, Husseini GA. Redox-responsive drug delivery systems: a chemical perspective. Nanomaterials. 2022;12(18):3183.
Sun Y, Yan X, Yuan T, Liang J, Fan Y, Gu Z, et al. Disassemblable micelles based on reduction-degradable amphiphilic graft copolymers for intracellular delivery of doxorubicin. Biomaterials. 2010;31(27):7124-31.
Li J, Huo M, Wang J, Zhou J, Mohammad JM, Zhang Y, et al. Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel. Biomaterials. 2012;33(7):2310-20.
Wang Y-C, Wang F, Sun T-M, Wang J. Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells. Bioconjugate Chemistry. 2011;22(10):1939-45.
Kurtoglu YE, Navath RS, Wang B, Kannan S, Romero R, Kannan RM. Poly (amidoamine) dendrimer–drug conjugates with disulfide linkages for intracellular drug delivery. Biomaterials. 2009;30(11):2112-21.
Ong W, Yang Y, Cruciano AC, McCarley RL. Redox-triggered contents release from liposomes. Journal of the American Chemical Society. 2008;130(44):14739-44.
Ryu J-H, Chacko RT, Jiwpanich S, Bickerton S, Babu RP, Thayumanavan S. Self-cross-linked polymer nanogels: a versatile nanoscopic drug delivery platform. Journal of the American Chemical Society. 2010;132(48):17227-35.
Türkiye İlaç ve Tıbbi Cihaz Kurumu. Mylotarg 5 mg 2023. (02/07/2023 tarihinde https://titck.gov.tr/storage/Archive/2021/kubKtAttachments/mylotargonaylkt_a7c84889-bd11-4245-b90f-b9add41378af.pdf. adresinden ulaşılmıştır).
Eskandari P, Bigdeli B, Porgham Daryasari M, Baharifar H, Bazri B, Shourian M, et al. Gold-capped mesoporous silica nanoparticles as an excellent enzyme-responsive nanocarrier for controlled doxorubicin delivery. Journal of Drug Targeting. 2019;27(10):1084-93.
Hu Q, Katti PS, Gu Z. Enzyme-responsive nanomaterials for controlled drug delivery. Nanoscale. 2014;6(21):12273-86.
Hu X, Tian J, Liu T, Zhang G, Liu S. Photo-triggered release of caged camptothecin prodrugs from dually responsive shell cross-linked micelles. Macromolecules. 2013;46(15):6243-56.
Basel MT, Shrestha TB, Troyer DL, Bossmann SH. Protease-sensitive, polymer-caged liposomes: a method for making highly targeted liposomes using triggered release. ACS Nano. 2011;5(3):2162-75.
Radhakrishnan K, Tripathy J, Gnanadhas DP, Chakravortty D, Raichur AM. Dual enzyme responsive and targeted nanocapsules for intracellular delivery of anticancer agents. RSC Advances. 2014;4(86):45961-8.
Kundu JK, Surh Y-J. Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis. Pharmaceutical Research. 2010;27:999-1013.
Wang Y, Li Z, Hu Q. Emerging self-regulated micro/nano drug delivery devices: a step forward towards intelligent diagnosis and therapy. Nano Today. 2021;38:101127.
Wang B, Ma R, Liu G, Li Y, Liu X, An Y, et al. Glucose-responsive micelles from self-assembly of poly (ethylene glycol)-b-poly (acrylic acid-co-acrylamidophenylboronic acid) and the controlled release of insulin. Langmuir. 2009;25(21):12522-8.
Kim H, Kang YJ, Kang S, Kim KT. Monosaccharide-responsive release of insulin from polymersomes of polyboroxole block copolymers at neutral pH. Journal of the American Chemical Society. 2012;134(9):4030-3.
Kim H, Kang YJ, Jeong ES, Kang S, Kim KT. Glucose-responsive disassembly of polymersomes of sequence-specific boroxole-containing block copolymers under physiologically relevant conditions. ACS Macro Letters. 2012;1(10):1194-8.
Yao Y, Zhao L, Yang J, Yang J. Glucose-responsive vehicles containing phenylborate ester for controlled insulin release at neutral pH. Biomacromolecules. 2012;13(6):1837-44.
Jin X, Zhang X, Wu Z, Teng D, Zhang X, Wang Y, et al. Amphiphilic random glycopolymer based on phenylboronic acid: synthesis, characterization, and potential as glucose-sensitive matrix. Biomacromolecules. 2009;10(6):1337-45.
ABD Gıda ve İlaç Dairesi. t:slim X2 Insulin Pump. (01/07/2023 tarihinde https://www.fda.gov/news-events/press-announcements/fda-authorizes-first-interoperable-insulin-pump-intended-allow-patients-customize-treatment-through. adresinden ulaşılmıştır).
Joshi N, Shirsath N, Singh A, Joshi KS, Banerjee R. Endogenous lung surfactant inspired pH responsive nanovesicle aerosols: Pulmonary compatible and site-specific drug delivery in lung metastases. Scientific Reports. 2014;4(1):7085.
Li J, Ke W, Li H, Zha Z, Han Y, Ge Z. Endogenous stimuli‐sensitive multistage polymeric micelleplex anticancer drug delivery system for efficient tumor penetration and cellular internalization. Advanced Healthcare Materials. 2015;4(15):2206-19.
Lu H, Xu S, Guo Z, Zhao M, Liu Z. Redox-responsive molecularly imprinted nanoparticles for targeted intracellular delivery of protein toward cancer therapy. ACS Nano. 2021;15(11):18214-25.
Vicent MJ, Greco F, Nicholson RI, Paul A, Griffiths PC, Duncan R. Polymer therapeutics designed for a combination therapy of hormone‐dependent cancer. Angewandte Chemie. 2005;117(26):4129-34.
Xiong M-H, Bao Y, Yang X-Z, Wang Y-C, Sun B, Wang J. Lipase-sensitive polymeric triple-layered nanogel for “on-demand” drug delivery. Journal of the American Chemical Society. 2012;134(9):4355-62.
Liu D, Yang F, Xiong F, Gu N. The smart drug delivery system and its clinical potential. Theranostics. 2016;6(9):1306.
Bikram M, West JL. Thermo-responsive systems for controlled drug delivery. Expert Opinion on Drug Delivery. 2008;5(10):1077-91.
Mazzotta E, Tavano L, Muzzalupo R. Thermo-sensitive vesicles in controlled drug delivery for chemotherapy. Pharmaceutics. 2018;10(3):150.
Tagami T, Foltz WD, Ernsting MJ, Lee CM, Tannock IF, May JP, et al. MRI monitoring of intratumoral drug delivery and prediction of the therapeutic effect with a multifunctional thermosensitive liposome. Biomaterials. 2011;32(27):6570-8.
Chen K-J, Liang H-F, Chen H-L, Wang Y, Cheng P-Y, Liu H-L, et al. A thermoresponsive bubble-generating liposomal system for triggering localized extracellular drug delivery. ACS Nano. 2013;7(1):438-46.
Price PM, Mahmoud WE, Al-Ghamdi AA, Bronstein LM. Magnetic drug delivery: where the field is going. Frontiers in Chemistry. 2018;6:619.
Yang H-W, Hua M-Y, Liu H-L, Huang C-Y, Tsai R-Y, Lu Y-J, et al. Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas. Biomaterials. 2011;32(27):6523-32.
Tian B, Liu Y, Liu J. Smart stimuli-responsive drug delivery systems based on cyclodextrin: A review. Carbohydrate Polymers. 2021;251:116871.
Zhang L, Wang T, Yang L, Liu C, Wang C, Liu H, et al. General route to multifunctional uniform yolk/mesoporous silica shell nanocapsules: a platform for simultaneous cancer‐targeted imaging and magnetically guided drug delivery. Chemistry–A European Journal. 2012;18(39):12512-21.
Hua M-Y, Liu H-L, Yang H-W, Chen P-Y, Tsai R-Y, Huang C-Y, et al. The effectiveness of a magnetic nanoparticle-based delivery system for BCNU in the treatment of gliomas. Biomaterials. 2011;32(2):516-27.
Plassat V, Wilhelm C, Marsaud V, Ménager C, Gazeau F, Renoir JM, et al. Anti‐estrogen‐loaded superparamagnetic liposomes for intracellular magnetic targeting and treatment of breast cancer tumors. Advanced Functional Materials. 2011;21(1):83-92.
Zhang F, Braun GB, Pallaoro A, Zhang Y, Shi Y, Cui D, et al. Mesoporous multifunctional upconversion luminescent and magnetic “nanorattle” materials for targeted chemotherapy. Nano Letters. 2012;12(1):61-7.
Arias JL, Reddy LH, Othman M, Gillet B, Desmaele D, Zouhiri F, et al. Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics. ACS Nano. 2011;5(2):1513-21.
Qin J, Asempah I, Laurent S, Fornara A, Muller RN, Muhammed M. Injectable superparamagnetic ferrogels for controlled release of hydrophobic drugs. Advanced Materials. 2009;21(13):1354-7.
Luo Z, Jin K, Pang Q, Shen S, Yan Z, Jiang T, et al. On-demand drug release from dual-targeting small nanoparticles triggered by high-intensity focused ultrasound enhanced glioblastoma-targeting therapy. ACS Applied Materials & Interfaces. 2017;9(37):31612-25.
Delaney LJ, Isguven S, Eisenbrey JR, Hickok NJ, Forsberg F. Making waves: how ultrasound-targeted drug delivery is changing pharmaceutical approaches. Materials Advances. 2022;3(7):3023-40.
Schroeder A, Honen R, Turjeman K, Gabizon A, Kost J, Barenholz YJ. Ultrasound triggered release of cisplatin from liposomes in murine tumors. Journal of Controlled Release. 2009;137(1):63-8.
Kheirolomoom A, Mahakian LM, Lai C-Y, Lindfors HA, Seo JW, Paoli EE, et al. Copper− doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicity. Molecular Pharmaceutics. 2010;7(6):1948-58.
Rapoport NY, Kennedy AM, Shea JE, Scaife CL, Nam K-H. Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles. Journal of Controlled Release. 2009;138(3):268-76.
Ranjan A, Jacobs GC, Woods DL, Negussie AH, Partanen A, Yarmolenko PS, et al. Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model. Journal of Controlled Release. 2012;158(3):487-94.
Lino MM, Ferreira L. Light-triggerable formulations for the intracellular controlled release of biomolecules. Drug Discovery Today. 2018;23(5):1062-70.
Brown AA, Azzaroni O, Huck WT. Photoresponsive polymer brushes for hydrophilic patterning. Langmuir. 2009;25(3):1744-9.
Hossion AM, Bio M, Nkepang G, Awuah SG, You Y. Visible light controlled release of anticancer drug through double activation of prodrug. ACS Medicinal Chemistry Letters. 2013;4(1):124-7.
Liu C, Zhang Y, Liu M, Chen Z, Lin Y, Li W, et al. A NIR-controlled cage mimicking system for hydrophobic drug mediated cancer therapy. Biomaterials. 2017;139:151-62.
Xiang J, Tong X, Shi F, Yan Q, Yu B, Zhao Y. Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity. Journal of Materials Chemistry B. 2018;6(21):3531-40.
Yang J, Lee J, Kang J, Oh SJ, Ko HJ, Son JH, et al. Smart drug‐loaded polymer gold nanoshells for systemic and localized therapy of human epithelial cancer. Advanced Materials. 2009;21(43):4339-42.
Jeon G, Yang SY, Byun J, Kim JK. Electrically actuatable smart nanoporous membrane for pulsatile drug release. Nano Letters. 2011;11(3):1284-8.
Servant A, Bussy C, Al-Jamal K, Kostarelos K. Design, engineering and structural integrity of electro-responsive carbon nanotube-based hydrogels for pulsatile drug release. Journal of Materials Chemistry B. 2013;1(36):4593-600.
Ge J, Neofytou E, Cahill III TJ, Beygui RE, Zare RN. Drug release from electric-field-responsive nanoparticles. ACS Nano. 2012;6(1):227-33.
Olvera D, Monaghan MG. Electroactive material-based biosensors for detection and drug delivery. Advanced Drug Delivery Reviews. 2021;170:396-424.
Im JS, Bai BC, Lee Y-S. The effect of carbon nanotubes on drug delivery in an electro-sensitive transdermal drug delivery system. Biomaterials. 2010;31(6):1414-9.
Liu K-H, Liu T-Y, Chen S-Y, Liu D-M. Drug release behavior of chitosan–montmorillonite nanocomposite hydrogels following electrostimulation. Acta Biomaterialia. 2008;4(4):1038-45.
Hosseini-Nassab N, Samanta D, Abdolazimi Y, Annes JP, Zare RN. Electrically controlled release of insulin using polypyrrole nanoparticles. Nanoscale 2017;9(1):143-9.
An X, Zhu A, Luo H, Ke H, Chen H, Zhao Y. Rational design of multi-stimuli-responsive nanoparticles for precise cancer therapy. ACS Nano. 2016;10(6):5947-58.
Yoon S, Kim WJ, Yoo HS. Dual‐responsive breakdown of nanostructures with high doxorubicin payload for apoptotic anticancer therapy. Small. 2013;9(2):284-93.
Zhang L, Qin Y, Zhang Z, Fan F, Huang C, Lu L, et al. Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination therapy. Acta Biomaterialia. 2018;75:371-85.
You C, Wu H, Wang M, Gao Z, Sun B, Zhang X, et al. Synthesis and biological evaluation of redox/NIR dual stimulus-responsive polymeric nanoparticles for targeted delivery of cisplatin. Materials Science. 2018;92:453-62.
Hegazy M, Zhou P, Wu G, Wang L, Rahoui N, Taloub N, et al. Construction of polymer coated core–shell magnetic mesoporous silica nanoparticles with triple responsive drug delivery. Polymer Chemistry. 2017;8(38):5852-64.
Jia R, Teng L, Gao L, Su T, Fu L, Qiu Z, et al. Advances in multiple stimuli-responsive drug-delivery systems for cancer therapy. International Journal of Nanomedicine. 2021:1525-51.
Wei H, Zhang X-Z, Zhou Y, Cheng S-X, Zhuo R-X. Self-assembled thermoresponsive micelles of poly (N-isopropylacrylamide-b-methyl methacrylate). Biomaterials. 2006;27(9):2028-34.
Yang Z, Cheng Q, Jiang Q, Deng L, Liang Z, Dong A. Thermo-sensitive nanoparticles for triggered release of siRNA. Journal of Biomaterials Science, Polymer Edition. 2015;26(4):264-76.
Hardiansyah A, Yang M-C, Liu T-Y, Kuo C-Y, Huang L-Y, Chan T-Y. Hydrophobic drug-loaded PEGylated magnetic liposomes for drug-controlled release. Nanoscale Research Letters. 2017;12:1-11.
Yavlovich A, Singh A, Blumenthal R, Puri A. A novel class of photo-triggerable liposomes containing DPPC: DC8, 9PC as vehicles for delivery of doxorubcin to cells. Biochimica et Biophysica Acta -Biomembranes. 2011;1808(1):117-26.
Kim KN, Oh KS, Shim J, Schlaepfer IR, Karam SD, Lee J-J. Light-responsive polymeric micellar nanoparticles with enhanced formulation stability. Polymers. 2021;13(3):377.
Papa A-L, Korin N, Kanapathipillai M, Mammoto A, Mammoto T, Jiang A, et al. Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery. Biomaterials. 2017;139:187-94.
Liu K-H, Liu T-Y, Liu D-M, Chen S-Y, Nanotechnology. Electrical-sensitive nanoparticle composed of chitosan and tetraethyl orthosilicate for controlled drug release. Journal of Nanoscience. 2009;9(2):1198-203.
