Nanobaloncuklar
Özet
Nanobaloncuklar, nanometre çaplarına sahip minik gaz dolu kabarcıklardır. Gıda ve yağ, tıp, çevre, gıda ve içecek gibi birçok alanda kullanılmakta olup son yıllarda ilaç endüstrisinde büyük umutlar vaat etmektedir. Bunlar, hidrofobik ve hidrofilik pek çok etken madde için çok yönlü ilaç taşıyıcıları olarak hizmet ederler, vücut içinde hedeflenmiş ilaç salımını kolaylaştırarak ilaç etkinliğini artırabilirler. Nanobaloncuklar, özellikle ultrasonda, dokuların ve organların daha iyi görselleştirilmesini sağlayarak medikal görüntüleme için değerli kontrast ajanları olarak hizmet ederler. Ayrıca kanser tedavisinde, tanı testlerinde, yara iyileşmesinde, oksijen taşımasında, hücre içi ilaç taşımada, aşı geliştirmede ve diğer tıbbi uygulamalarda fayda sağlarlar. Bu çalışmada nanobaloncukların genel özellikleri, ilaç ve sağlık alanında kullanımları hakkında bilgi verilmektedir.
Referanslar
Thi Phan KK, Truong T, Wang Y, Bhandari B. Nanobubbles: Fundamental characteristics and applications in food processing. Trends in Food Science & Technology. 2020;95:118-30.
Wang Q, Zhao H, Qi N, Qin Y, Zhang X, Li Y. Generation and Stability of Size-Adjustable Bulk Nanobubbles Based on Periodic Pressure Change. Scientific Reports 2019;9(1):1118.
Lohse D., X Z. Surface nanobubbles and nanodroplets. Reviews Of Modern Physics 2018.
Park B, Yoon S, Choi Y, Jang J, Park S, Choi J. Stability of Engineered Micro or Nanobubbles for Biomedical Applications. Pharmaceutics.. 2020;12(11).
Lombard J, Biben T, Merabia S. Threshold for Vapor Nanobubble Generation Around Plasmonic Nanoparticles. The Journal of Physical Chemistry C. 2017;121(28):15402-15.
Johnson BD, Cooke RC. Generation of Stabilized Microbubbles in Seawater. Science 1981;213(4504):209-11.
Attard P. The stability of nanobubbles. The European Physical Journal Special Topics. 2013;223(5):1-22.
Yasui K, Tuziuti T, Kanematsu W. Mysteries of bulk nanobubbles (ultrafine bubbles); stability and radical formation. Ultrason Sonochemistry 2018;48:259-66.
Ljunggren S, Eriksson JC. The lifetime of a colloid-sized gas bubble in water and the cause of the hydrophobic attraction. Colloids and Surfaces A: Physicochemical and Engineering Aspects 1997;129-130:151-5.
Kanematsu W, Tuziuti T, Yasui K. The influence of storage conditions and container materials on the long term stability of bulk nanobubbles — Consideration from a perspective of interactions between bubbles and surroundings. Chemical Engineering Science 2020;219:115594.
Yasui K, Tuziuti T, Kanematsu W, Kato K. Dynamic Equilibrium Model for a Bulk Nanobubble and a Microbubble Partly Covered with Hydrophobic Material. Langmuir. 2016;32(43):11101-10.
Vehmas T, L M. Metastable Nanobubbles. ACS Omega. 2021;6:8021−7.
Degens ET, von Herzen RP, Wong H-K, Deuser WG, Jannasch HW. Lake Kivu: structure, chemistry and biology of an East African rift lake. Geologische Rundschau. 1973;62(1):245-77.
Kyzas GZ, Mitropoulos AC. From Bubbles to Nanobubbles. Nanomaterials (Basel). 2021;11(10).
Theodorakis P, Che Z. Surface nanobubbles: Theory, simulation, and experiment. A review. Advances in Colloid and Interface Science. 2019;272:101995.
Michailidi ED, Bomis G, Varoutoglou A, Efthimiadou EK, Mitropoulos AC, Favvas EP. Fundamentals and applications of nanobubbles. Advanced Low-Cost Separation Techniques in Interface Science. Interface Science and Technology 2019. p. 69-99.
Zargarzadeh L, Elliott JA. Thermodynamics of Surface Nanobubbles. Langmuir. 2016;32(43):11309-20.
Peng H, Birkett GR, Nguyen AV. Progress on the Surface Nanobubble Story: What is in the bubble? Why does it exist? Advance Colloid Interface Science 2015;222:573-80.
Falzarano MS, Argenziano M, Marsollier AC, Mariot V, Rossi D, Selvatici R, et al. Chitosan-Shelled Nanobubbles Irreversibly Encapsulate Morpholino Conjugate Antisense Oligonucleotides and Are Ineffective for Phosphorodiamidate Morpholino-Mediated Gene Silencing of DUX4. Nucleic Acid Therapy. 2021;31(3):201-7.
Fix SM, Borden MA, Dayton PA. Therapeutic gas delivery via microbubbles and liposomes. Journal of Control Release 2015;209:139-49.
Unger EC, Porter T, Culp W, Labell R, Matsunaga T, Zutshi R. Therapeutic applications of lipid-coated microbubbles. Advanced Drug Delivery Reviews 2004;56(9):1291-314.
Yano Y, Hamano N, Haruta K, Kobayashi T, Sato M, Kikkawa Y, et al. Development of an Antibody Delivery Method for Cancer Treatment by Combining Ultrasound with Therapeutic Antibody-Modified Nanobubbles Using Fc-Binding Polypeptide. Pharmaceutics 2022;15(1).
Jugniot N, Massoud TF, Dahl JJ, Paulmurugan R. Biomimetic nanobubbles for triple-negative breast cancer targeted ultrasound molecular imaging. Journal of Nanobiotechnology. 2022;20(1):267.
Azevedo A, Etchepare R, Calgaroto S, Rubio J. Aqueous dispersions of nanobubbles: Generation, properties and features. Minerals Engineering 2016;94:29-37.
Favvas EP, Kyzas GZ, Efthimiadou EK, Mitropoulos AC. Bulk nanobubbles, generation methods and potential applications. Current Opinion in Colloid & Interface Science 2021;54.
Pote AK, et al. State of Art Review on Nanobubbles. Advanced Materials Letters 2021;12:1-9.
Sekine S, Mayama S, Nishijima N, Kojima T, Endo-Takahashi Y, Ishii Y, et al. Development of a Gene and Nucleic Acid Delivery System for Skeletal Muscle Administration via Limb Perfusion Using Nanobubbles and Ultrasound. Pharmaceutics. 2023;15(6).
Banche G, Allizond V, Mandras N, Finesso N, Luganini A, Genova T, et al. Antimicrobial oxygen-loaded nanobubbles as promising tools to promote wound healing in hypoxic human keratinocytes. Toxicology Reports 2022;9:154-62.
Ma Y, Li J, Zhao Y, Hu B, Liu Y, Liu C. Nanobubble-mediated co-delivery of Ce6 and miR-195 for synergized sonodynamic and checkpoint blockade combination therapy with elicitation of robust immune response in hepatocellular carcinoma. European Journal of Pharmaceutics Biopharmaceutics 2022;181:36-48.
Xu J, Salari A, Wang Y, He X, Kerr L, Darbandi A, et al. Microfluidic Generation of Monodisperse Nanobubbles by Selective Gas Dissolution. Small. 2021;17(20):2100345.
Schmidt BJ, Sousa I, van Beek AA, Bohmer MR. Adhesion and ultrasound-induced delivery from monodisperse microbubbles in a parallel plate flow cell. Journal of Control Release. 2008;131(1):19-26.
Ma R, Nai J, Zhang J, Li Z, Xu F, Gao C. Co-delivery of CPP decorated doxorubicin and CPP decorated siRNA by NGR-modified nanobubbles for improving anticancer therapy. Pharmaceutical Development of Technology 2021;26(6):634-46.
Eklund F, Alheshibri M, Swenson J. Differentiating bulk nanobubbles from nanodroplets and nanoparticles. Current Opinion in Colloid & Interface Science 2021;53.
Ishida N, Inoue T, Miyahara M, Higashitani K. Nano Bubbles on a Hydrophobic Surface in Water Observed by Tapping-Mode Atomic Force Microscopy. Langmuir 2000;16:6377-80.
Lou S-T, Ouyang Z-Q, Zhang Y, Li X-J, Hu J, Li M-Q, et al. Nanobubbles on solid surface imaged by atomic force microscopy. Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures 2000;18(5).
Alheshibri M, Qian J, Jehannin M, Craig VS. A History of Nanobubbles. Langmuir 2016;32(43):11086-100.
Cavalli R, Bisazza A, Rolfo A, Balbis S, Madonnaripa D, Caniggia I, et al. Ultrasound-mediated oxygen delivery from chitosan nanobubbles. International Journal of Pharmaceutics 2009;378(1-2):215-7.
Jin J, Li M, Li J, Li B, Duan L, Yang F, et al. Xenon Nanobubbles for the Image-Guided Preemptive Treatment of Acute Ischemic Stroke via Neuroprotection and Microcirculatory Restoration. ACS Applied Mater Interfaces 2021;13(37):43880-91.
Liu Y, Miyoshi H, Nakamura M. Encapsulated ultrasound microbubbles: Therapeutic application in drug/gene delivery. Journal of Controlled Release. 2006;114:89-99.
Wang T, Choe JW, Pu K, Devulapally R, Bachawal S, Machtaler S, et al. Ultrasound-guided delivery ofmicroRNA loaded nanoparticles into cancer. Journal of Controlled Release 2015;203:99-108.
Silindir M, Özer AY. Sterilization Methods and the Comparison of E-Beam Sterilization with Gamma Radiation Sterilization. FABAD Journal of Pharmaceutical Sciences 2009;34:43-53.
Senthilkumar G, Aravind Kumar J. Nanobubbles: a promising efficient tool for therapeutic delivery of antibacterial agents for the Staphylococcus aureus infections. Applied Nanoscience. 2023:1-14.
Baspinar Y, Erel-Akbaba G, Kotmakci M, Akbaba H. Development and characterization of nanobubbles containing paclitaxel and survivin inhibitor YM155 against lung cancer. International Journal of Pharmaceutics. 2019;566:149-56.
Hamarat Sanlier S, Ak G, Yilmaz H, Unal A, Bozkaya UF, Taniyan G, et al. Development of Ultrasound-Triggered and Magnetic-Targeted Nanobubble System for Dual-Drug Delivery. Journal of Pharmaceutical Science 2019;108(3):1272-83.
Argenziano M, Bessone F, Dianzani C, Cucci MA, Grattarola M, Pizzimenti S, et al. Ultrasound-Responsive Nrf2-Targeting siRNA-Loaded Nanobubbles for Enhancing the Treatment of Melanoma. Pharmaceutics 2022;14(2).
Hsiao YH, Kuo SJ, Tsai HD, Chou MC, Yeh GP. Clinical Application of High-intensity Focused Ultrasound in Cancer Therapy. Journal of Cancer. 2016;7(3):225-31.
Duan S, Guo L, Shi D, Shang M, Meng D, Li J. Development of a novel folate-modified nanobubbles with improved targeting ability to tumor cells. Ultrasonics Sonochemistry. 2017;37:235-43.
Chen H, Zhou X, Gao Y, Zheng B, Tang F, Huang J. Recent progress in development of new sonosensitizers for sonodynamic cancer therapy. Drug Discovery Today 2014;19:502-19.
Åslund AKO, Berg S, Gadel Hak SH, Mørch Y, Torp SH, Sandvig A, et al. Nanoparticle delivery to the brain--By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles. Journal of Controlled Release 2015;220:287-94.
Cavalli R, Bisazza A, Giustetto P, Civra A, Lembo D, Trotta G, et al. Preparation and characterization of dextran nanobubbles for oxygen delivery. International Journal of Pharmaceutics 2009;381(2):160-5.
Fournier L, de La Taille T, Chauvierre C. Microbubbles for human diagnosis and therapy. Biomaterials. 2023;294:122025.
Su C, Ren X, Nie F, Li T, Lv W, Li H, et al. Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives. RSC Advances 2021;11(21):12915-28.
Hernot S, Klibanov AL. Microbubbles in ultrasound-triggered drug and gene delivery. Advanced Drug Delivery Reviews. 2008;60:1153-66.
Agessandro Abrahao A, Meng Y, Llinas M, Huang, Y.,, Hamani C, Mainprize T, et al. First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound. Nature Communications. 2019.
Endo-Takahashi Y, Kurokawa R, Sato K, Takizawa N, Katagiri F, Hamano N, et al. Ternary Complexes of pDNA, Neuron-Binding Peptide, and PEGylated Polyethyleneimine for Brain Delivery with Nano-Bubbles and Ultrasound. Pharmaceutics. 2021;13(7).
Chan MH, Chen W, Li CH, Fang CY, Chang YC, Wei DH, et al. An Advanced In Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood-Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles. ACS Applied Material Interfaces. 2021;13(23):26759-69.
Fix SM, Koppolu BP, Novell A, Hopkins J, Kierski TM, Zaharoff DA, et al. Ultrasound-stimulated phase-change contrast agents for transepithelial delivery of macromolecules, toward gastrointestinal drug delivery. Ultrasound in Medicine & Biology. 2019;45:1762-76.
Moyer LC, Timbie KF, Sheeran PS, Price RJ, Miller GW, Dayton PA. High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles. Journal of Therapeutic Ultrasound. 2015;3:7.
Meloni MF, Livraghi T, Filice C, Lazzaroni S, Calliada F, Perretti L. Radiofrequency Ablation of Liver Tumors: The Role of Microbubble Ultrasound Contrast Agents. Ultrasound Quarterly. 2006;22(1).
Perera RH, Solorio L, Wu, H.,, Gangolli M, Silverman E, Hernandez, C.,, et al. Nanobubble Ultrasound Contrast Agents for Enhanced Delivery of Thermal Sensitizer to Tumors Undergoing Radiofrequency Ablation. Pharmaceutical Research 2014;31:1407–17.
Durham PG, Dayton PA. Applications of sub-micron low-boiling point phase change contrast agents for ultrasound imaging and therapy. Current Opinion in Colloid & Interface Science. 2021;56.
Unger E, Porter T, Lindner J, Grayburn P. Cardiovascular drug delivery with ultrasound and microbubbles. Advanced Drug Delivery Reviews 2014;72:110-26.
Xie F, Tsutsui JM, Lof J, Unger EC, Johanning J, Culp WC, et al. Effectiveness of lipid microbubbles and ultrasound in declotting thrombosis. Ultrasound Medical Biology 2005;31(7):979-85.
Unger E. Nanobubble-Enhanced Sonothrombolysis: From Benchtop to Bedside. Therapeutic Ultrasound 2006.
Paproski R.J, Forbich A, Hitt M., Zemp R. RNA Biomarker release with ultrasound and phase change nanodroplets. Ultrasound in Medicine & Biology 2014:1-10.
Referanslar
Thi Phan KK, Truong T, Wang Y, Bhandari B. Nanobubbles: Fundamental characteristics and applications in food processing. Trends in Food Science & Technology. 2020;95:118-30.
Wang Q, Zhao H, Qi N, Qin Y, Zhang X, Li Y. Generation and Stability of Size-Adjustable Bulk Nanobubbles Based on Periodic Pressure Change. Scientific Reports 2019;9(1):1118.
Lohse D., X Z. Surface nanobubbles and nanodroplets. Reviews Of Modern Physics 2018.
Park B, Yoon S, Choi Y, Jang J, Park S, Choi J. Stability of Engineered Micro or Nanobubbles for Biomedical Applications. Pharmaceutics.. 2020;12(11).
Lombard J, Biben T, Merabia S. Threshold for Vapor Nanobubble Generation Around Plasmonic Nanoparticles. The Journal of Physical Chemistry C. 2017;121(28):15402-15.
Johnson BD, Cooke RC. Generation of Stabilized Microbubbles in Seawater. Science 1981;213(4504):209-11.
Attard P. The stability of nanobubbles. The European Physical Journal Special Topics. 2013;223(5):1-22.
Yasui K, Tuziuti T, Kanematsu W. Mysteries of bulk nanobubbles (ultrafine bubbles); stability and radical formation. Ultrason Sonochemistry 2018;48:259-66.
Ljunggren S, Eriksson JC. The lifetime of a colloid-sized gas bubble in water and the cause of the hydrophobic attraction. Colloids and Surfaces A: Physicochemical and Engineering Aspects 1997;129-130:151-5.
Kanematsu W, Tuziuti T, Yasui K. The influence of storage conditions and container materials on the long term stability of bulk nanobubbles — Consideration from a perspective of interactions between bubbles and surroundings. Chemical Engineering Science 2020;219:115594.
Yasui K, Tuziuti T, Kanematsu W, Kato K. Dynamic Equilibrium Model for a Bulk Nanobubble and a Microbubble Partly Covered with Hydrophobic Material. Langmuir. 2016;32(43):11101-10.
Vehmas T, L M. Metastable Nanobubbles. ACS Omega. 2021;6:8021−7.
Degens ET, von Herzen RP, Wong H-K, Deuser WG, Jannasch HW. Lake Kivu: structure, chemistry and biology of an East African rift lake. Geologische Rundschau. 1973;62(1):245-77.
Kyzas GZ, Mitropoulos AC. From Bubbles to Nanobubbles. Nanomaterials (Basel). 2021;11(10).
Theodorakis P, Che Z. Surface nanobubbles: Theory, simulation, and experiment. A review. Advances in Colloid and Interface Science. 2019;272:101995.
Michailidi ED, Bomis G, Varoutoglou A, Efthimiadou EK, Mitropoulos AC, Favvas EP. Fundamentals and applications of nanobubbles. Advanced Low-Cost Separation Techniques in Interface Science. Interface Science and Technology 2019. p. 69-99.
Zargarzadeh L, Elliott JA. Thermodynamics of Surface Nanobubbles. Langmuir. 2016;32(43):11309-20.
Peng H, Birkett GR, Nguyen AV. Progress on the Surface Nanobubble Story: What is in the bubble? Why does it exist? Advance Colloid Interface Science 2015;222:573-80.
Falzarano MS, Argenziano M, Marsollier AC, Mariot V, Rossi D, Selvatici R, et al. Chitosan-Shelled Nanobubbles Irreversibly Encapsulate Morpholino Conjugate Antisense Oligonucleotides and Are Ineffective for Phosphorodiamidate Morpholino-Mediated Gene Silencing of DUX4. Nucleic Acid Therapy. 2021;31(3):201-7.
Fix SM, Borden MA, Dayton PA. Therapeutic gas delivery via microbubbles and liposomes. Journal of Control Release 2015;209:139-49.
Unger EC, Porter T, Culp W, Labell R, Matsunaga T, Zutshi R. Therapeutic applications of lipid-coated microbubbles. Advanced Drug Delivery Reviews 2004;56(9):1291-314.
Yano Y, Hamano N, Haruta K, Kobayashi T, Sato M, Kikkawa Y, et al. Development of an Antibody Delivery Method for Cancer Treatment by Combining Ultrasound with Therapeutic Antibody-Modified Nanobubbles Using Fc-Binding Polypeptide. Pharmaceutics 2022;15(1).
Jugniot N, Massoud TF, Dahl JJ, Paulmurugan R. Biomimetic nanobubbles for triple-negative breast cancer targeted ultrasound molecular imaging. Journal of Nanobiotechnology. 2022;20(1):267.
Azevedo A, Etchepare R, Calgaroto S, Rubio J. Aqueous dispersions of nanobubbles: Generation, properties and features. Minerals Engineering 2016;94:29-37.
Favvas EP, Kyzas GZ, Efthimiadou EK, Mitropoulos AC. Bulk nanobubbles, generation methods and potential applications. Current Opinion in Colloid & Interface Science 2021;54.
Pote AK, et al. State of Art Review on Nanobubbles. Advanced Materials Letters 2021;12:1-9.
Sekine S, Mayama S, Nishijima N, Kojima T, Endo-Takahashi Y, Ishii Y, et al. Development of a Gene and Nucleic Acid Delivery System for Skeletal Muscle Administration via Limb Perfusion Using Nanobubbles and Ultrasound. Pharmaceutics. 2023;15(6).
Banche G, Allizond V, Mandras N, Finesso N, Luganini A, Genova T, et al. Antimicrobial oxygen-loaded nanobubbles as promising tools to promote wound healing in hypoxic human keratinocytes. Toxicology Reports 2022;9:154-62.
Ma Y, Li J, Zhao Y, Hu B, Liu Y, Liu C. Nanobubble-mediated co-delivery of Ce6 and miR-195 for synergized sonodynamic and checkpoint blockade combination therapy with elicitation of robust immune response in hepatocellular carcinoma. European Journal of Pharmaceutics Biopharmaceutics 2022;181:36-48.
Xu J, Salari A, Wang Y, He X, Kerr L, Darbandi A, et al. Microfluidic Generation of Monodisperse Nanobubbles by Selective Gas Dissolution. Small. 2021;17(20):2100345.
Schmidt BJ, Sousa I, van Beek AA, Bohmer MR. Adhesion and ultrasound-induced delivery from monodisperse microbubbles in a parallel plate flow cell. Journal of Control Release. 2008;131(1):19-26.
Ma R, Nai J, Zhang J, Li Z, Xu F, Gao C. Co-delivery of CPP decorated doxorubicin and CPP decorated siRNA by NGR-modified nanobubbles for improving anticancer therapy. Pharmaceutical Development of Technology 2021;26(6):634-46.
Eklund F, Alheshibri M, Swenson J. Differentiating bulk nanobubbles from nanodroplets and nanoparticles. Current Opinion in Colloid & Interface Science 2021;53.
Ishida N, Inoue T, Miyahara M, Higashitani K. Nano Bubbles on a Hydrophobic Surface in Water Observed by Tapping-Mode Atomic Force Microscopy. Langmuir 2000;16:6377-80.
Lou S-T, Ouyang Z-Q, Zhang Y, Li X-J, Hu J, Li M-Q, et al. Nanobubbles on solid surface imaged by atomic force microscopy. Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures 2000;18(5).
Alheshibri M, Qian J, Jehannin M, Craig VS. A History of Nanobubbles. Langmuir 2016;32(43):11086-100.
Cavalli R, Bisazza A, Rolfo A, Balbis S, Madonnaripa D, Caniggia I, et al. Ultrasound-mediated oxygen delivery from chitosan nanobubbles. International Journal of Pharmaceutics 2009;378(1-2):215-7.
Jin J, Li M, Li J, Li B, Duan L, Yang F, et al. Xenon Nanobubbles for the Image-Guided Preemptive Treatment of Acute Ischemic Stroke via Neuroprotection and Microcirculatory Restoration. ACS Applied Mater Interfaces 2021;13(37):43880-91.
Liu Y, Miyoshi H, Nakamura M. Encapsulated ultrasound microbubbles: Therapeutic application in drug/gene delivery. Journal of Controlled Release. 2006;114:89-99.
Wang T, Choe JW, Pu K, Devulapally R, Bachawal S, Machtaler S, et al. Ultrasound-guided delivery ofmicroRNA loaded nanoparticles into cancer. Journal of Controlled Release 2015;203:99-108.
Silindir M, Özer AY. Sterilization Methods and the Comparison of E-Beam Sterilization with Gamma Radiation Sterilization. FABAD Journal of Pharmaceutical Sciences 2009;34:43-53.
Senthilkumar G, Aravind Kumar J. Nanobubbles: a promising efficient tool for therapeutic delivery of antibacterial agents for the Staphylococcus aureus infections. Applied Nanoscience. 2023:1-14.
Baspinar Y, Erel-Akbaba G, Kotmakci M, Akbaba H. Development and characterization of nanobubbles containing paclitaxel and survivin inhibitor YM155 against lung cancer. International Journal of Pharmaceutics. 2019;566:149-56.
Hamarat Sanlier S, Ak G, Yilmaz H, Unal A, Bozkaya UF, Taniyan G, et al. Development of Ultrasound-Triggered and Magnetic-Targeted Nanobubble System for Dual-Drug Delivery. Journal of Pharmaceutical Science 2019;108(3):1272-83.
Argenziano M, Bessone F, Dianzani C, Cucci MA, Grattarola M, Pizzimenti S, et al. Ultrasound-Responsive Nrf2-Targeting siRNA-Loaded Nanobubbles for Enhancing the Treatment of Melanoma. Pharmaceutics 2022;14(2).
Hsiao YH, Kuo SJ, Tsai HD, Chou MC, Yeh GP. Clinical Application of High-intensity Focused Ultrasound in Cancer Therapy. Journal of Cancer. 2016;7(3):225-31.
Duan S, Guo L, Shi D, Shang M, Meng D, Li J. Development of a novel folate-modified nanobubbles with improved targeting ability to tumor cells. Ultrasonics Sonochemistry. 2017;37:235-43.
Chen H, Zhou X, Gao Y, Zheng B, Tang F, Huang J. Recent progress in development of new sonosensitizers for sonodynamic cancer therapy. Drug Discovery Today 2014;19:502-19.
Åslund AKO, Berg S, Gadel Hak SH, Mørch Y, Torp SH, Sandvig A, et al. Nanoparticle delivery to the brain--By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles. Journal of Controlled Release 2015;220:287-94.
Cavalli R, Bisazza A, Giustetto P, Civra A, Lembo D, Trotta G, et al. Preparation and characterization of dextran nanobubbles for oxygen delivery. International Journal of Pharmaceutics 2009;381(2):160-5.
Fournier L, de La Taille T, Chauvierre C. Microbubbles for human diagnosis and therapy. Biomaterials. 2023;294:122025.
Su C, Ren X, Nie F, Li T, Lv W, Li H, et al. Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives. RSC Advances 2021;11(21):12915-28.
Hernot S, Klibanov AL. Microbubbles in ultrasound-triggered drug and gene delivery. Advanced Drug Delivery Reviews. 2008;60:1153-66.
Agessandro Abrahao A, Meng Y, Llinas M, Huang, Y.,, Hamani C, Mainprize T, et al. First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound. Nature Communications. 2019.
Endo-Takahashi Y, Kurokawa R, Sato K, Takizawa N, Katagiri F, Hamano N, et al. Ternary Complexes of pDNA, Neuron-Binding Peptide, and PEGylated Polyethyleneimine for Brain Delivery with Nano-Bubbles and Ultrasound. Pharmaceutics. 2021;13(7).
Chan MH, Chen W, Li CH, Fang CY, Chang YC, Wei DH, et al. An Advanced In Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood-Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles. ACS Applied Material Interfaces. 2021;13(23):26759-69.
Fix SM, Koppolu BP, Novell A, Hopkins J, Kierski TM, Zaharoff DA, et al. Ultrasound-stimulated phase-change contrast agents for transepithelial delivery of macromolecules, toward gastrointestinal drug delivery. Ultrasound in Medicine & Biology. 2019;45:1762-76.
Moyer LC, Timbie KF, Sheeran PS, Price RJ, Miller GW, Dayton PA. High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles. Journal of Therapeutic Ultrasound. 2015;3:7.
Meloni MF, Livraghi T, Filice C, Lazzaroni S, Calliada F, Perretti L. Radiofrequency Ablation of Liver Tumors: The Role of Microbubble Ultrasound Contrast Agents. Ultrasound Quarterly. 2006;22(1).
Perera RH, Solorio L, Wu, H.,, Gangolli M, Silverman E, Hernandez, C.,, et al. Nanobubble Ultrasound Contrast Agents for Enhanced Delivery of Thermal Sensitizer to Tumors Undergoing Radiofrequency Ablation. Pharmaceutical Research 2014;31:1407–17.
Durham PG, Dayton PA. Applications of sub-micron low-boiling point phase change contrast agents for ultrasound imaging and therapy. Current Opinion in Colloid & Interface Science. 2021;56.
Unger E, Porter T, Lindner J, Grayburn P. Cardiovascular drug delivery with ultrasound and microbubbles. Advanced Drug Delivery Reviews 2014;72:110-26.
Xie F, Tsutsui JM, Lof J, Unger EC, Johanning J, Culp WC, et al. Effectiveness of lipid microbubbles and ultrasound in declotting thrombosis. Ultrasound Medical Biology 2005;31(7):979-85.
Unger E. Nanobubble-Enhanced Sonothrombolysis: From Benchtop to Bedside. Therapeutic Ultrasound 2006.
Paproski R.J, Forbich A, Hitt M., Zemp R. RNA Biomarker release with ultrasound and phase change nanodroplets. Ultrasound in Medicine & Biology 2014:1-10.
