Moleküler Baskılanmış İlaç Taşıyıcı Sistemler
Özet
Moleküler baskınlanmış polimerler (MIP), hedef moleküllerin yapay reseptörleri olarak işlev görerek, doğal antikor-antijen sistemlerinin biyomimetik bir yaklaşımını sunar. Bu polimerlerin işleyişi, kilit ve anahtar mekanizması perspektifinden anlaşılabilir; bu da MIP'lerin, sentez aşamasında kalıplanan molekülle seçici olarak etkileşime girdiğini vurgular. MIP'lerin birçok uygulaması arasında, ilaç taşıyıcı sistemler olarak kullanımı önemli bir yere sahiptir. Bu yöntem, istenen terapötik sonuçları elde etmek için ilacın sürekli ve kontrollü bir şekilde salınımını sağlamada mükemmel bir potansiyele sahiptir. Bu bölümde moleküler baskılanmış polimerlerden bahsedilip güncel olarak ilaç taşıyıcı sistemlerdeki kullanımı üzerinde durulmuştur.
Referanslar
Li S, Zhu M, Whitcombe MJ, et al. Molecularly imprinted polymers for enzyme-like catalysis: principle, design, and applications. Molecularly Imprinted Catalysts: Elsevier; 2016. p. 1-17.
Refaat D, Aggour MG, Farghali AA, et al. Strategies for molecular imprinting and the evolution of MIP nanoparticles as plastic antibodies—Synthesis and applications. International journal of molecular sciences. 2019; 20(24):6304.
Wackerlig J, Schirhagl R. Applications of molecularly imprinted polymer nanoparticles and their advances toward industrial use: a review. Analytical chemistry. 2016;88(1):250-261.
Xu S, Wang L, Liu Z. Molecularly imprinted polymer nanoparticles: an emerging versatile platform for cancer therapy. Angewandte Chemie International Edition. 2021;60(8):3858-3869.
Zhang H. Molecularly imprinted nanoparticles for biomedical applications. Advanced Materials. 2020;32(3):1806328.
Liu Z, Xu Z, Wang D, et al. A review on molecularly imprinted polymers preparation by computational simulation-aided methods. Polymers. 2021;13(16):2657.
Akgönüllü S, Kılıç S, Esen C, et al. Molecularly imprinted polymer-based sensors for protein detection. Polymers. 2023;15(3):629.
Hasanah AN, Safitri N, Zulfa A, et al. Factors affecting preparation of molecularly imprinted polymer and methods on finding template-monomer interaction as the key of selective properties of the materials. Molecules. 2021;26(18):5612.
Vasapollo G, Sole RD, Mergola L, et al. Molecularly imprinted polymers: present and future prospective. International journal of molecular sciences. 2011;12(9):5908-5945.
Chen L, Wang X, Lu W, Wu X, Li J. Molecular imprinting: perspectives and applications. Chemical society reviews. 2016;45(8):2137-2211.
Mueller A. A note about crosslinking density in imprinting polymerization. Molecules. 2021;26(17):5139.
Marć M, Wieczorek PP. Introduction to MIP synthesis, characteristics and analytical application. Comprehensive Analytical Chemistry. 86: Elsevier; 2019. p. 1-15.
Golker K, Karlsson BrC, Olsson GD, et al. Influence of composition and morphology on template recognition in molecularly imprinted polymers. Macromolecules. 2013;46(4):1408-1414.
Klejn D, Luliński P, Maciejewska D. Desorption of 3, 3′-diindolylmethane from imprinted particles: An impact of cross-linker structure on binding capacity and selectivity. Materials Science and Engineering: C. 2015;56:233-240.
Anene A, Kalfat R, Chevalier Y, et al. Design of molecularly imprinted polymeric materials: The crucial choice of functional monomers. Chemistry Africa. 2020;3(3):769-781.
Włoch M, Datta J. Synthesis and polymerisation techniques of molecularly imprinted polymers. Comprehensive analytical chemistry. 86: Elsevier; 2019. p. 17-40.
Kadhem AJ, Gentile GJ, Fidalgo de Cortalezzi MM. Molecularly imprinted polymers (MIPs) in sensors for environmental and biomedical applications: a review. Molecules. 2021;26(20):6233.
Farooq S, Nie J, Cheng Y, et al. Molecularly imprinted polymers’ application in pesticide residue detection. Analyst. 2018;143(17):3971-3989.
Sharma G, Kandasubramanian B. Molecularly imprinted polymers for selective recognition and extraction of heavy metal ions and toxic dyes. Journal of Chemical & Engineering Data. 2020;65(2):396-418.
Zhao G, Zhang Y, Sun D, et al. Recent advances in molecularly imprinted polymers for antibiotic analysis. Molecules. 2023;28(1):335.
Villa CC, Sánchez LT, Valencia GA, et al. Molecularly imprinted polymers for food applications: A review. Trends in Food Science & Technology. 2021;111:642-669.
Mustafa YL, Keirouz A, Leese HS. Molecularly imprinted polymers in diagnostics: Accessing analytes in biofluids. Journal of Materials Chemistry B. 2022;10(37):7418-7449.
Ayari MG, Kadhirvel P, Favetta P, et al. Synthesis of imprinted hydrogel microbeads by inverse Pickering emulsion to controlled release of adenosine 5′ monophosphate. Materials Science and Engineering: C. 2019;101:254-263.
He S, Zhang L, Bai S, et al. Advances of molecularly imprinted polymers (MIP) and the application in drug delivery. European Polymer Journal. 2021;143:110179.
Liu Z, Huang Y, Yang Y. Molecularly Imprinted Polymers as Advanced Drug Delivery Systems. Springer.
Alvarez-Lorenzo C. Handbook of molecularly imprinted polymers: Smithers Rapra; 2013.
BelBruno JJ. Molecularly imprinted polymers. Chemical reviews. 2018;119(1):94-119.
Piletsky S, Canfarotta F, Poma A, et al. Molecularly imprinted polymers for cell recognition. Trends in biotechnology. 2020;38(4):368-387.
Ahmad OS, Bedwell TS, Esen C, et al. Molecularly imprinted polymers in electrochemical and optical sensors. Trends in biotechnology. 2019;37(3):294-309.
Sung YK, Kim SW. Recent advances in polymeric drug delivery systems. Biomaterials Research. 2020;24(1):1-12.
Khalid M, El-Sawy HS. Polymeric nanoparticles: Promising platform for drug delivery. International Journal of Pharmaceutics. 2017;528(1-2):675-691.
Jhaveri AM, Torchilin VP. Multifunctional polymeric micelles for delivery of drugs and siRNA. Frontiers in pharmacology. 2014;5:77.
Zaidi SA. Molecular imprinted polymers as drug delivery vehicles. Drug delivery. 2016;23(7):2262-2271.
Luliński P. Molecularly imprinted polymers based drug delivery devices: A way to application in modern pharmacotherapy. A review. Materials Science and Engineering: C. 2017;76:1344-1353.
Hashemi-Moghaddam H, Kazemi-Bagsangani S, Jamili M, et al. Evaluation of magnetic nanoparticles coated by 5-fluorouracil imprinted polymer for controlled drug delivery in mouse breast cancer model. International Journal of Pharmaceutics. 2016;497(1-2):228-238.
Gagliardi M. Design and development of molecularly imprinted biodegradable polymers for nanomedicine. Advanced Industrial and Engineering Polymer Research. 2023.
Raina N, Rani R, Thakur VK, et al. New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective. ACS omega. 2023.
Jeong WY, Kwon M, Choi HE, et al. Recent advances in transdermal drug delivery systems: A review. Biomaterials Research. 2021;25:1-15.
Ruela ALM, Figueiredo EC, Pereira GR. Molecularly imprinted polymers as nicotine transdermal delivery systems. Chemical engineering journal. 2014;248:1-8.
Ruela ALM, de Figueiredo EC, Carvalho FC, et al. Adsorption and release of nicotine from imprinted particles synthesised by precipitation polymerisation: Optimising transdermal formulations. European Polymer Journal. 2018;100:67-76.
Men J, Dong C, Shi H, et al. Surface molecular imprinted membranes as a “gate” for selective transdermal release of chiral drug amlodipine. Journal of Membrane Science. 2022;664:121059.
Behnia N, Azar PA, Shekarchi M, et al. Synthesis of a new molecular imprinted polymer for oxycodone opioid and its formulation for transdermal controlled drug delivery application: A joint experimental and quantum chemical study. ChemistrySelect. 2022;7(38):e202202553.
Ahmed S, Amin MM, Sayed S. Ocular drug delivery: a comprehensive review. AAPS PharmSciTech. 2023;24(2):66.
Elsayed I, Sayed S. Tailored nanostructured platforms for boosting transcorneal permeation: box–Behnken statistical optimization, comprehensive in vitro, ex vivo and in vivo characterization. International journal of nanomedicine. 2017:7947-7962.
Hiratani H, Fujiwara A, Tamiya Y, et al. Ocular release of timolol from molecularly imprinted soft contact lenses. Biomaterials. 2005;26(11):1293-1298.
Tieppo A, White C, Paine A, et al. Sustained in vivo release from imprinted therapeutic contact lenses. Journal of Controlled Release. 2012;157(3):391-397.
Xu Y, Shrestha N, Préat V, et al. Overcoming the intestinal barrier: A look into targeting approaches for improved oral drug delivery systems. Journal of Controlled Release. 2020;322:486-508.
Tong T, Wang L, You X, et al. Nano and microscale delivery platforms for enhanced oral peptide/protein bioavailability. Biomaterials science. 2020;8(21):5804-5823.
Lulinski P. Molecularly imprinted polymers as the future drug delivery devices. Acta Pol Pharm. 2013;70:601-609.
Casale J, Patel P. Fluorouracil. StatPearls [Internet]: StatPearls Publishing; 2022.
Entezar-Almahdi E, Mohammadi-Samani S, Tayebi L, et al. Recent advances in designing 5-fluorouracil delivery systems: a stepping stone in the safe treatment of colorectal cancer. International journal of nanomedicine. 2020:5445-5458.
Zheng X-F, Lian Q, Yang H, et al. Surface molecularly imprinted polymer of chitosan grafted poly (methyl methacrylate) for 5-fluorouracil and controlled release. Scientific reports. 2016;6(1):21409.
Wang X, Yang FF, Zhang LP, et al. A polyhedral oligomeric silsesquioxane/molecular sieve codoped molecularly imprinted polymer for gastroretentive drug-controlled release in vivo. Biomaterials science. 2018;6(12):3170-3177.
Mo CE, Chai MH, Zhang LP, et al. Floating molecularly imprinted polymers based on liquid crystalline and polyhedral oligomeric silsesquioxanes for capecitabine sustained release. International Journal of Pharmaceutics. 2019;557:293-303.
Paul PK, Treetong A, Suedee R. Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system. Acta pharmaceutica. 2017;67(2):149-168.
Paul PK, Nopparat J, Nuanplub M, et al. Improvement in insulin absorption into gastrointestinal epithelial cells by using molecularly imprinted polymer nanoparticles: microscopic evaluation and ultrastructure. International Journal of Pharmaceutics. 2017;530(1-2):279-290.
Debela DT, Muzazu SG, Heraro KD, et al. New approaches and procedures for cancer treatment: Current perspectives. SAGE open medicine. 2021;9:20503121211034366.
Liu L, Ye Q, Lu M, et al. A new approach to reduce toxicities and to improve bioavailabilities of platinum-containing anti-cancer nanodrugs. Scientific reports. 2015;5(1):10881.
Jia C, Zhang M, Zhang Y, et al. Preparation of dual-template epitope imprinted polymers for targeted fluorescence imaging and targeted drug delivery to pancreatic cancer BxPC-3 cells. ACS applied materials & interfaces. 2019;11(35):32431-32440.
Canfarotta F, Lezina L, Guerreiro A, et al. Specific drug delivery to cancer cells with double-imprinted nanoparticles against epidermal growth factor receptor. Nano letters. 2018;18(8):4641-4646.
Asadi E, Abdouss M, Leblanc RM, et al. In vitro/in vivo study of novel anti-cancer, biodegradable cross-linked tannic acid for fabrication of 5-fluorouracil-targeting drug delivery nano-device based on a molecular imprinted polymer. RSC advances. 2016;6(43):37308-37318.
Dodda JM, Azar MG, Sadiku R. Crosslinking trends in multicomponent hydrogels for biomedical applications. Macromolecular Bioscience. 2021;21(12):2100232.
Bodoki AE, Iacob BC, Bodoki E. Perspectives of molecularly imprinted polymer-based drug delivery systems in cancer therapy. Polymers. 2019;11(12):2085.
Jamalzadeh L, Ghafoori H, Sariri R, et al. Cytotoxic effects of some common organic solvents on MCF-7, RAW-264.7 and human umbilical vein endothelial cells. Avicenna journal of medical biochemistry. 2016; 4(1)e33453
Reid GL. Residual solvents. Specification of Drug Substances and Products: Elsevier; 2020. p. 345-365.
Liu XL, Yao HF, Chai MH, et al. Green synthesis of carbon nanotubes-reinforced molecularly imprinted polymer composites for drug delivery of fenbufen. AAPS PharmSciTech. 2018;19:3895-3906.
Referanslar
Li S, Zhu M, Whitcombe MJ, et al. Molecularly imprinted polymers for enzyme-like catalysis: principle, design, and applications. Molecularly Imprinted Catalysts: Elsevier; 2016. p. 1-17.
Refaat D, Aggour MG, Farghali AA, et al. Strategies for molecular imprinting and the evolution of MIP nanoparticles as plastic antibodies—Synthesis and applications. International journal of molecular sciences. 2019; 20(24):6304.
Wackerlig J, Schirhagl R. Applications of molecularly imprinted polymer nanoparticles and their advances toward industrial use: a review. Analytical chemistry. 2016;88(1):250-261.
Xu S, Wang L, Liu Z. Molecularly imprinted polymer nanoparticles: an emerging versatile platform for cancer therapy. Angewandte Chemie International Edition. 2021;60(8):3858-3869.
Zhang H. Molecularly imprinted nanoparticles for biomedical applications. Advanced Materials. 2020;32(3):1806328.
Liu Z, Xu Z, Wang D, et al. A review on molecularly imprinted polymers preparation by computational simulation-aided methods. Polymers. 2021;13(16):2657.
Akgönüllü S, Kılıç S, Esen C, et al. Molecularly imprinted polymer-based sensors for protein detection. Polymers. 2023;15(3):629.
Hasanah AN, Safitri N, Zulfa A, et al. Factors affecting preparation of molecularly imprinted polymer and methods on finding template-monomer interaction as the key of selective properties of the materials. Molecules. 2021;26(18):5612.
Vasapollo G, Sole RD, Mergola L, et al. Molecularly imprinted polymers: present and future prospective. International journal of molecular sciences. 2011;12(9):5908-5945.
Chen L, Wang X, Lu W, Wu X, Li J. Molecular imprinting: perspectives and applications. Chemical society reviews. 2016;45(8):2137-2211.
Mueller A. A note about crosslinking density in imprinting polymerization. Molecules. 2021;26(17):5139.
Marć M, Wieczorek PP. Introduction to MIP synthesis, characteristics and analytical application. Comprehensive Analytical Chemistry. 86: Elsevier; 2019. p. 1-15.
Golker K, Karlsson BrC, Olsson GD, et al. Influence of composition and morphology on template recognition in molecularly imprinted polymers. Macromolecules. 2013;46(4):1408-1414.
Klejn D, Luliński P, Maciejewska D. Desorption of 3, 3′-diindolylmethane from imprinted particles: An impact of cross-linker structure on binding capacity and selectivity. Materials Science and Engineering: C. 2015;56:233-240.
Anene A, Kalfat R, Chevalier Y, et al. Design of molecularly imprinted polymeric materials: The crucial choice of functional monomers. Chemistry Africa. 2020;3(3):769-781.
Włoch M, Datta J. Synthesis and polymerisation techniques of molecularly imprinted polymers. Comprehensive analytical chemistry. 86: Elsevier; 2019. p. 17-40.
Kadhem AJ, Gentile GJ, Fidalgo de Cortalezzi MM. Molecularly imprinted polymers (MIPs) in sensors for environmental and biomedical applications: a review. Molecules. 2021;26(20):6233.
Farooq S, Nie J, Cheng Y, et al. Molecularly imprinted polymers’ application in pesticide residue detection. Analyst. 2018;143(17):3971-3989.
Sharma G, Kandasubramanian B. Molecularly imprinted polymers for selective recognition and extraction of heavy metal ions and toxic dyes. Journal of Chemical & Engineering Data. 2020;65(2):396-418.
Zhao G, Zhang Y, Sun D, et al. Recent advances in molecularly imprinted polymers for antibiotic analysis. Molecules. 2023;28(1):335.
Villa CC, Sánchez LT, Valencia GA, et al. Molecularly imprinted polymers for food applications: A review. Trends in Food Science & Technology. 2021;111:642-669.
Mustafa YL, Keirouz A, Leese HS. Molecularly imprinted polymers in diagnostics: Accessing analytes in biofluids. Journal of Materials Chemistry B. 2022;10(37):7418-7449.
Ayari MG, Kadhirvel P, Favetta P, et al. Synthesis of imprinted hydrogel microbeads by inverse Pickering emulsion to controlled release of adenosine 5′ monophosphate. Materials Science and Engineering: C. 2019;101:254-263.
He S, Zhang L, Bai S, et al. Advances of molecularly imprinted polymers (MIP) and the application in drug delivery. European Polymer Journal. 2021;143:110179.
Liu Z, Huang Y, Yang Y. Molecularly Imprinted Polymers as Advanced Drug Delivery Systems. Springer.
Alvarez-Lorenzo C. Handbook of molecularly imprinted polymers: Smithers Rapra; 2013.
BelBruno JJ. Molecularly imprinted polymers. Chemical reviews. 2018;119(1):94-119.
Piletsky S, Canfarotta F, Poma A, et al. Molecularly imprinted polymers for cell recognition. Trends in biotechnology. 2020;38(4):368-387.
Ahmad OS, Bedwell TS, Esen C, et al. Molecularly imprinted polymers in electrochemical and optical sensors. Trends in biotechnology. 2019;37(3):294-309.
Sung YK, Kim SW. Recent advances in polymeric drug delivery systems. Biomaterials Research. 2020;24(1):1-12.
Khalid M, El-Sawy HS. Polymeric nanoparticles: Promising platform for drug delivery. International Journal of Pharmaceutics. 2017;528(1-2):675-691.
Jhaveri AM, Torchilin VP. Multifunctional polymeric micelles for delivery of drugs and siRNA. Frontiers in pharmacology. 2014;5:77.
Zaidi SA. Molecular imprinted polymers as drug delivery vehicles. Drug delivery. 2016;23(7):2262-2271.
Luliński P. Molecularly imprinted polymers based drug delivery devices: A way to application in modern pharmacotherapy. A review. Materials Science and Engineering: C. 2017;76:1344-1353.
Hashemi-Moghaddam H, Kazemi-Bagsangani S, Jamili M, et al. Evaluation of magnetic nanoparticles coated by 5-fluorouracil imprinted polymer for controlled drug delivery in mouse breast cancer model. International Journal of Pharmaceutics. 2016;497(1-2):228-238.
Gagliardi M. Design and development of molecularly imprinted biodegradable polymers for nanomedicine. Advanced Industrial and Engineering Polymer Research. 2023.
Raina N, Rani R, Thakur VK, et al. New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective. ACS omega. 2023.
Jeong WY, Kwon M, Choi HE, et al. Recent advances in transdermal drug delivery systems: A review. Biomaterials Research. 2021;25:1-15.
Ruela ALM, Figueiredo EC, Pereira GR. Molecularly imprinted polymers as nicotine transdermal delivery systems. Chemical engineering journal. 2014;248:1-8.
Ruela ALM, de Figueiredo EC, Carvalho FC, et al. Adsorption and release of nicotine from imprinted particles synthesised by precipitation polymerisation: Optimising transdermal formulations. European Polymer Journal. 2018;100:67-76.
Men J, Dong C, Shi H, et al. Surface molecular imprinted membranes as a “gate” for selective transdermal release of chiral drug amlodipine. Journal of Membrane Science. 2022;664:121059.
Behnia N, Azar PA, Shekarchi M, et al. Synthesis of a new molecular imprinted polymer for oxycodone opioid and its formulation for transdermal controlled drug delivery application: A joint experimental and quantum chemical study. ChemistrySelect. 2022;7(38):e202202553.
Ahmed S, Amin MM, Sayed S. Ocular drug delivery: a comprehensive review. AAPS PharmSciTech. 2023;24(2):66.
Elsayed I, Sayed S. Tailored nanostructured platforms for boosting transcorneal permeation: box–Behnken statistical optimization, comprehensive in vitro, ex vivo and in vivo characterization. International journal of nanomedicine. 2017:7947-7962.
Hiratani H, Fujiwara A, Tamiya Y, et al. Ocular release of timolol from molecularly imprinted soft contact lenses. Biomaterials. 2005;26(11):1293-1298.
Tieppo A, White C, Paine A, et al. Sustained in vivo release from imprinted therapeutic contact lenses. Journal of Controlled Release. 2012;157(3):391-397.
Xu Y, Shrestha N, Préat V, et al. Overcoming the intestinal barrier: A look into targeting approaches for improved oral drug delivery systems. Journal of Controlled Release. 2020;322:486-508.
Tong T, Wang L, You X, et al. Nano and microscale delivery platforms for enhanced oral peptide/protein bioavailability. Biomaterials science. 2020;8(21):5804-5823.
Lulinski P. Molecularly imprinted polymers as the future drug delivery devices. Acta Pol Pharm. 2013;70:601-609.
Casale J, Patel P. Fluorouracil. StatPearls [Internet]: StatPearls Publishing; 2022.
Entezar-Almahdi E, Mohammadi-Samani S, Tayebi L, et al. Recent advances in designing 5-fluorouracil delivery systems: a stepping stone in the safe treatment of colorectal cancer. International journal of nanomedicine. 2020:5445-5458.
Zheng X-F, Lian Q, Yang H, et al. Surface molecularly imprinted polymer of chitosan grafted poly (methyl methacrylate) for 5-fluorouracil and controlled release. Scientific reports. 2016;6(1):21409.
Wang X, Yang FF, Zhang LP, et al. A polyhedral oligomeric silsesquioxane/molecular sieve codoped molecularly imprinted polymer for gastroretentive drug-controlled release in vivo. Biomaterials science. 2018;6(12):3170-3177.
Mo CE, Chai MH, Zhang LP, et al. Floating molecularly imprinted polymers based on liquid crystalline and polyhedral oligomeric silsesquioxanes for capecitabine sustained release. International Journal of Pharmaceutics. 2019;557:293-303.
Paul PK, Treetong A, Suedee R. Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system. Acta pharmaceutica. 2017;67(2):149-168.
Paul PK, Nopparat J, Nuanplub M, et al. Improvement in insulin absorption into gastrointestinal epithelial cells by using molecularly imprinted polymer nanoparticles: microscopic evaluation and ultrastructure. International Journal of Pharmaceutics. 2017;530(1-2):279-290.
Debela DT, Muzazu SG, Heraro KD, et al. New approaches and procedures for cancer treatment: Current perspectives. SAGE open medicine. 2021;9:20503121211034366.
Liu L, Ye Q, Lu M, et al. A new approach to reduce toxicities and to improve bioavailabilities of platinum-containing anti-cancer nanodrugs. Scientific reports. 2015;5(1):10881.
Jia C, Zhang M, Zhang Y, et al. Preparation of dual-template epitope imprinted polymers for targeted fluorescence imaging and targeted drug delivery to pancreatic cancer BxPC-3 cells. ACS applied materials & interfaces. 2019;11(35):32431-32440.
Canfarotta F, Lezina L, Guerreiro A, et al. Specific drug delivery to cancer cells with double-imprinted nanoparticles against epidermal growth factor receptor. Nano letters. 2018;18(8):4641-4646.
Asadi E, Abdouss M, Leblanc RM, et al. In vitro/in vivo study of novel anti-cancer, biodegradable cross-linked tannic acid for fabrication of 5-fluorouracil-targeting drug delivery nano-device based on a molecular imprinted polymer. RSC advances. 2016;6(43):37308-37318.
Dodda JM, Azar MG, Sadiku R. Crosslinking trends in multicomponent hydrogels for biomedical applications. Macromolecular Bioscience. 2021;21(12):2100232.
Bodoki AE, Iacob BC, Bodoki E. Perspectives of molecularly imprinted polymer-based drug delivery systems in cancer therapy. Polymers. 2019;11(12):2085.
Jamalzadeh L, Ghafoori H, Sariri R, et al. Cytotoxic effects of some common organic solvents on MCF-7, RAW-264.7 and human umbilical vein endothelial cells. Avicenna journal of medical biochemistry. 2016; 4(1)e33453
Reid GL. Residual solvents. Specification of Drug Substances and Products: Elsevier; 2020. p. 345-365.
Liu XL, Yao HF, Chai MH, et al. Green synthesis of carbon nanotubes-reinforced molecularly imprinted polymer composites for drug delivery of fenbufen. AAPS PharmSciTech. 2018;19:3895-3906.
