Üç Boyutlu Baskılı (3D-Printing) Prototiplerinin Farmasötik Teknoloji Alanında Geliştirilmesi
Özet
3 boyutlu (3B) baskılama, katman katman malzeme ekleyerek üç boyutlu nesnelerin üretildiği bir üretim teknolojisidir. İlaçlar için 3B baskı, özel bir tür ilaç üretimine olanak tanır. Bu teknoloji, hassas ve özelleştirilebilir ilaçların üretilmesini sağlar. Özellikle kişiselleştirilmiş tedaviye ihtiyaç duyulan durumlarda, hastaların spesifik ihtiyaçlarına göre ilaçların üretilmesine olanak verir. Bu, ilaçların dozajını, salımını ve bileşimini kişiselleştirmek için kullanılabilir. Ayrıca 3B baskı, ilaçların karmaşık yapısını ve şeklini üretmek için kullanılabilir, bu da geleneksel üretim yöntemleriyle mümkün olmayan ilaç formlarının geliştirilmesini sağlar. İlaçlar için 3B baskı, farmasötik endüstrisinde daha etkili ve kişiselleştirilmiş tedavi seçenekleri sunma potansiyeline sahiptir. Ancak bu teknolojinin düzenleyici ve kalite kontrol gereksinimleri dikkatle ele alınmalıdır.Bu bölüm genel olarak, 3B baskıların tetiklediği ve yaratmaya devam edeceği etkiyi farmasötik teknoloji alanında analiz ederek, mevcut 3B baskı formülasyonlarının özellikleri ve uygulamasına ilişkin genel bir tablo sunmayı amaçlamaktadır.
Referanslar
Jamróz W, Kurek M, Łyszczarz E, Brniak W, Jachowicz R. Printing techniques: Recent developments in pharmaceutical technology. Acta Poloniae Pharmaceutica - Drug Research. 2017;74(3):753–63.
Wu Y, Woodbine L, Carr AM, Pillai AR, Nokhodchi A, Maniruzzaman M. 3D printed calcium phosphate cement (CPC) scaffolds for anti-cancer drug delivery. Pharmaceutics. 2020;12(11):1–15.
Jacob S, Nair AB, Patel V, Shah J. 3D Printing Technologies: Recent Development and Emerging Applications in Various Drug Delivery Systems. AAPS PharmSciTech. 2020;21(6).
Jamróz W, Szafraniec J, Kurek M, Jachowicz R. 3D printing in pharmaceutical and medical applications. Pharmaceutical Research. 2018;35(9):Article 176.
Marchment T, Xia M, Dodd E, Sanjayan J, Nematollahi B. Effect of delay time on the mechanical properties of extrusion-based 3D printed concrete. 34th International Symposium on Automation and Robotics in Construction and Mining (ISARC 2017). 2017;(Isarc):240–5.
Hwang HH, Zhu W, Victorine G, Lawrence N, Chen S. 3D-Printing of Functional Biomedical Microdevices via Light- and Extrusion-Based Approaches. Small Methods. 2018;2(2):1–18.
Chen Y, He S, Gan Y, Çopuroğlu O, Veer F, Schlangen E. A review of printing strategies, sustainable cementitious materials and characterization methods in the context of extrusion-based 3D concrete printing. Journal of Building Engineering. 2022;45(February 2021).
Xiao J, Ji G, Zhang Y, Ma G, Mechtcherine V, Pan J, et al. Large-scale 3D printing concrete technology: Current status and future opportunities. Cement and Concrete Composites. 2021;122(June):104115. Available from: https://doi.org/10.1016/j.cemconcomp.2021.104115
Bagheri A, Jin J. Photopolymerization in 3D Printing. ACS Applied Polymeric Materials. 2019;1(4):593–611.
Fiedor P, Ortyl J. A new approach to micromachining: High-precision and innovative additive manufacturing solutions based on photopolymerization technology. Materials (Basel). 2020;13(13):1–25.
Pagac M, Hajnys J, Ma Q, Jancar L, Jansa J, Stefek P, et al. A Review of Vat Photopolymerization Technology : Materials. Polymers (Basel). 2021;13(13):598.
Kasperovich G, Haubrich J, Gussone J, Requena G. Correlation between porosity and processing parameters in TiAl6V4 produced by selective laser melting. Material Design. 2016;105:160–70. Available from: http://dx.doi.org/10.1016/j.matdes.2016.05.070
Mazzoli A. Selective laser sintering in biomedical engineering. Medical & Biological Engineering & Computing. 2013;51(3):245–56.
Awad A, Fina F, Goyanes A, Gaisford S, Basit AW. 3D printing: Principles and pharmaceutical applications of selective laser sintering. International Journal of Pharmaceutics. 2020;586(June):119594. Available from: https://doi.org/10.1016/j.ijpharm.2020.119594
Gueche YA, Sanchez-Ballester NM, Cailleaux S, Bataille B, Soulairol I. Selective laser sintering (Sls), a new chapter in the production of solid oral forms (sofs) by 3D printing. Pharmaceutics. 2021;13(8).
Davis DA, Thakkar R, Su Y, Williams RO, Maniruzzaman M. Selective Laser Sintering 3-Dimensional Printing as a Single Step Process to Prepare Amorphous Solid Dispersion Dosage Forms for Improved Solubility and Dissolution rate. Journal of Pharmaceutical Sciences. 2020;1–12. Available from: https://doi.org/10.1016/j.xphs.2020.11.012
Xia H, Zhao D, Zhu H, Hua Y, Xiao K, Xu Y, et al. Lyophilized Scaffolds Fabricated from 3D-Printed Photocurable Natural Hydrogel for Cartilage Regeneration. ACS Applied Materials & Interfaces. 2018;10(37):31704–15.
Bharadwaz A, Jayasuriya AC. Fabrication of porous chitosan particles using a novel two-step porogen leaching and lyophilization method with the label-free multivariate spectral assessment of live adhered cells. Colloids Surfaces B Biointerfaces . 2021;208(July):112094. Available from: https://doi.org/10.1016/j.colsurfb.2021.112094
Kuo CC, Qin H, Cheng Y, Jiang X, Shi X. An integrated manufacturing strategy to fabricate delivery system using gelatin/alginate hybrid hydrogels: 3D printing and freeze-drying. Food Hydrocolloid. 2021;111(June 2020):106262. Available from: https://doi.org/10.1016/j.foodhyd.2020.106262
Koranne V, Li Cong Jonas O, Mitra H, Bapat S, Ardekani AM, Sealy MP, et al. Exploring Properties of Edible Hydrolyzed Collagen for 3D Food Printing of Scaffold for Biomanufacturing Cultivated Meat. Procedia CIRP. 2022;110(C):187–92. Available from: https://doi.org/10.1016/j.procir.2022.06.034
Tagami T, Goto E, Kida R, Hirose K, Noda T, Ozeki T. Lyophilized ophthalmologic patches as novel corneal drug formulations using a semi-solid extrusion 3D printer. International Journal of Pharmaceutics. 2022;617(May 2021):121448. Available from: https://doi.org/10.1016/j.ijpharm.2022.121448
Alqahtani AA, Ahmed MM, Mohammed AA, Ahmad J. 3D Printed Pharmaceutical Systems for Personalized Treatment in Metabolic Syndrome. Pharmaceutics. 2023;15(4):1–23.
Tsintavi E, Rekkas DM, Bettini R. Partial tablet coating by 3D printing. International Journal of Pharmaceutics. 2020;581(March):119298. Available from: https://doi.org/10.1016/j.ijpharm.2020.119298
Referanslar
Jamróz W, Kurek M, Łyszczarz E, Brniak W, Jachowicz R. Printing techniques: Recent developments in pharmaceutical technology. Acta Poloniae Pharmaceutica - Drug Research. 2017;74(3):753–63.
Wu Y, Woodbine L, Carr AM, Pillai AR, Nokhodchi A, Maniruzzaman M. 3D printed calcium phosphate cement (CPC) scaffolds for anti-cancer drug delivery. Pharmaceutics. 2020;12(11):1–15.
Jacob S, Nair AB, Patel V, Shah J. 3D Printing Technologies: Recent Development and Emerging Applications in Various Drug Delivery Systems. AAPS PharmSciTech. 2020;21(6).
Jamróz W, Szafraniec J, Kurek M, Jachowicz R. 3D printing in pharmaceutical and medical applications. Pharmaceutical Research. 2018;35(9):Article 176.
Marchment T, Xia M, Dodd E, Sanjayan J, Nematollahi B. Effect of delay time on the mechanical properties of extrusion-based 3D printed concrete. 34th International Symposium on Automation and Robotics in Construction and Mining (ISARC 2017). 2017;(Isarc):240–5.
Hwang HH, Zhu W, Victorine G, Lawrence N, Chen S. 3D-Printing of Functional Biomedical Microdevices via Light- and Extrusion-Based Approaches. Small Methods. 2018;2(2):1–18.
Chen Y, He S, Gan Y, Çopuroğlu O, Veer F, Schlangen E. A review of printing strategies, sustainable cementitious materials and characterization methods in the context of extrusion-based 3D concrete printing. Journal of Building Engineering. 2022;45(February 2021).
Xiao J, Ji G, Zhang Y, Ma G, Mechtcherine V, Pan J, et al. Large-scale 3D printing concrete technology: Current status and future opportunities. Cement and Concrete Composites. 2021;122(June):104115. Available from: https://doi.org/10.1016/j.cemconcomp.2021.104115
Bagheri A, Jin J. Photopolymerization in 3D Printing. ACS Applied Polymeric Materials. 2019;1(4):593–611.
Fiedor P, Ortyl J. A new approach to micromachining: High-precision and innovative additive manufacturing solutions based on photopolymerization technology. Materials (Basel). 2020;13(13):1–25.
Pagac M, Hajnys J, Ma Q, Jancar L, Jansa J, Stefek P, et al. A Review of Vat Photopolymerization Technology : Materials. Polymers (Basel). 2021;13(13):598.
Kasperovich G, Haubrich J, Gussone J, Requena G. Correlation between porosity and processing parameters in TiAl6V4 produced by selective laser melting. Material Design. 2016;105:160–70. Available from: http://dx.doi.org/10.1016/j.matdes.2016.05.070
Mazzoli A. Selective laser sintering in biomedical engineering. Medical & Biological Engineering & Computing. 2013;51(3):245–56.
Awad A, Fina F, Goyanes A, Gaisford S, Basit AW. 3D printing: Principles and pharmaceutical applications of selective laser sintering. International Journal of Pharmaceutics. 2020;586(June):119594. Available from: https://doi.org/10.1016/j.ijpharm.2020.119594
Gueche YA, Sanchez-Ballester NM, Cailleaux S, Bataille B, Soulairol I. Selective laser sintering (Sls), a new chapter in the production of solid oral forms (sofs) by 3D printing. Pharmaceutics. 2021;13(8).
Davis DA, Thakkar R, Su Y, Williams RO, Maniruzzaman M. Selective Laser Sintering 3-Dimensional Printing as a Single Step Process to Prepare Amorphous Solid Dispersion Dosage Forms for Improved Solubility and Dissolution rate. Journal of Pharmaceutical Sciences. 2020;1–12. Available from: https://doi.org/10.1016/j.xphs.2020.11.012
Xia H, Zhao D, Zhu H, Hua Y, Xiao K, Xu Y, et al. Lyophilized Scaffolds Fabricated from 3D-Printed Photocurable Natural Hydrogel for Cartilage Regeneration. ACS Applied Materials & Interfaces. 2018;10(37):31704–15.
Bharadwaz A, Jayasuriya AC. Fabrication of porous chitosan particles using a novel two-step porogen leaching and lyophilization method with the label-free multivariate spectral assessment of live adhered cells. Colloids Surfaces B Biointerfaces . 2021;208(July):112094. Available from: https://doi.org/10.1016/j.colsurfb.2021.112094
Kuo CC, Qin H, Cheng Y, Jiang X, Shi X. An integrated manufacturing strategy to fabricate delivery system using gelatin/alginate hybrid hydrogels: 3D printing and freeze-drying. Food Hydrocolloid. 2021;111(June 2020):106262. Available from: https://doi.org/10.1016/j.foodhyd.2020.106262
Koranne V, Li Cong Jonas O, Mitra H, Bapat S, Ardekani AM, Sealy MP, et al. Exploring Properties of Edible Hydrolyzed Collagen for 3D Food Printing of Scaffold for Biomanufacturing Cultivated Meat. Procedia CIRP. 2022;110(C):187–92. Available from: https://doi.org/10.1016/j.procir.2022.06.034
Tagami T, Goto E, Kida R, Hirose K, Noda T, Ozeki T. Lyophilized ophthalmologic patches as novel corneal drug formulations using a semi-solid extrusion 3D printer. International Journal of Pharmaceutics. 2022;617(May 2021):121448. Available from: https://doi.org/10.1016/j.ijpharm.2022.121448
Alqahtani AA, Ahmed MM, Mohammed AA, Ahmad J. 3D Printed Pharmaceutical Systems for Personalized Treatment in Metabolic Syndrome. Pharmaceutics. 2023;15(4):1–23.
Tsintavi E, Rekkas DM, Bettini R. Partial tablet coating by 3D printing. International Journal of Pharmaceutics. 2020;581(March):119298. Available from: https://doi.org/10.1016/j.ijpharm.2020.119298
