Mesane Ağrı Sendromu
Özet
Mesane ağrı sendromu (MAS), sıklık, aciliyet ve noktüri gibi üriner semptomlarının bir veya birkaçının eşlik ettiği, pelvik ağrı veya basınçla karakterize kronik bir durumur. MAS’ın kesin etyolojisi anlaşılamamıştır ve değişik patofizyolojik mekanizmalar öngörülmüştür. MAS’li hastaların uzun vadede semptomlarda iyileşme veya düzelme olabilir. Farmakolojik tedavi, yüksek bırakma oranları ve minimum uzun vadeli etkinlik ile değişken başarı oranlarına sahiptir. İntravezikal ajanlardan tedavide Dimetil sülfoksit (DMSO), hyaluronik asit (HA), kondroitin sülfat (KS), heparin, PPS ve lidokain dahil olmak üzere farmakolojik ajanlar kullanılmaktadır.
Referanslar
Fall M, Baranowski AP, Fowler CJ, et al. EAU guidelines on chronic pelvic pain. Eur Urol. 2010;57(1):35–48. doi:10.1016/j.eururo. 2009.08.020
Berry SH, Elliott MN, Suttorp M, et al. Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. J Urol. 2011;186(2):540–544. doi:10.1016/j. juro.2011.03.132
Suskind AM, Berry SH, Ewing BA, et al. The prevalence and overlap of interstitial cystitis/bladder pain syndrome and chronic prostatitis/ chronic pelvic pain syndrome in men: results of the RAND interstitial cystitis epidemiology male study. J Urol. 2013;189(1):141–145. doi:10.1016/j.juro.2012.08.088
Afari N, Buchwald D, Clauw D, et al. A MAPP network case-control study of urological chronic pelvic pain compared with nonurological pain conditions. Clin J Pain. 2020;36(1):8–15. doi:10.1097/ AJP.0000000000000769
Malde S, Palmisani S, Al-Kaisy A, Sahai A. Guideline of guidelines: bladder pain syndrome. BJU Int. 2018;122(5):729–743. doi:10.1111/ bju.14399
Doggweiler R, Whitmore KE, Meijlink JM, et al. A standard terminology in chronic pelvic pain syndromes: a report from the chronic pelvic pain working group of the international continence society. Neurourol Urodyn. 2017;36(4):984–1008. doi:10.1002/nau.23072
Crane A, Lloyd J, Shoskes DA. Improving the utility of clinical phenotyping in interstitial cystitis/painful bladder syndrome: from UPOINT to INPUT. Can J Urol. 2018;25(2):9250–9254.
Van de Merwe J, Nordling J, Bouchelouche P, et al. Diagnostic criteria, classification and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol. 2008;53(1):60–67. doi:10.1016/j.eururo.2007.09.019
Yeh HL, Jhang JF, Kuo YC, Kuo HC. Long-term outcome and symptom improvement in patients with interstitial cystitis/bladder pain syndrome with or without regular follow-up and treatment. Neurourol Urodyn. 2019;38(7):1985–1993. doi:10.1002/nau.24104
Propert KJ, Schaeffer AJ, Brensinger CM, Kusek JW, Nyberg LM, Landis JR. A prospective study of interstitial cystitis: results of longitudinal follow up of the interstitial cystitis data base cohort. The Interstitial Cystitis Data Base Study Group. J Urol. 2000;163 (5):1434–1439. doi:10.1016/S0022-5347(05)67637-9
11- Lukban J, Whitmore K, Kellogg-Spadt S, Bologna A, Lesher A, Fletcher E. The effect of manual physical therapy in patients diagnosed with interstitial cystitis, high tine pelvic floor dysfunction, and sacroiliac dysfunction. Urology. 2001;Jun;57(6 Suppl 1):121–122. doi:10.1016/S0090-4295(01)01074-3
Friedlander JI, Shorter B, Moldwin RM. Diet and its role in interstitial cystitis/bladder pain syndrome and comorbid conditions. BJU Int. 2012;109(11):1584–1591. doi:10.1111/j.1464-410X.2011.10860.x
Lee JW, Han DY, Jeong HJ. Bladder pain syndrome treated with triple therapy with gabapentin, amitriptyline and a nonsteroidal anti-inflammatory drug. Int Neurourol J. 2010;14:256–260. doi:10.5213/inj.2010.14.4.256
Pearce WA, Chen R, Jain N. Pigmentary maculopathy associated with chronic exposure to pentosan polysulfate sodium. Ophthalmology. 2018;125(11):1793–1802. doi:10.1016/j.ophtha.2018.04.026
Jain N, Li AL, Yu Y, Van der Beek BL. Association of macular disease with long-term use of pentosan polysulfate sodium: findings from a US cohort. Br J Ophthalmol. 2020;104 (8):1093–1097.
Rawls WF, Cox L, Rovner ES. Dimethyl Sulfoxide (DMSO) as intravesical therapy for interstitial cystitis/bladder pain syndrome: a review. Neurourol Urodyn. 2017;36(7):1677–1684. doi:10.1002/nau.23204
Parsons CL. Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis. Urology. 2005;65(1):45–48. doi:10.1016/j. urology.2004.08.056
Kuo HC. Urodynamic results of intravesical heparin therapy for women with frequency urgency syndrome and interstitial cystitis. J Formos Med Assoc. 2001;100(5):309–314.
Parsons CL, Zupkas P, Proctor J, et al. Alkalinized lidocaine and heparin provide immediate relief of pain and urgency in patients with interstitial cystitis. J Sex Med. 2012;9(1):207–212. doi:10.1111/ j.1743-6109.2011.02542.x
Riedl CR, Engelhardt PF, Daha KL, Morakis N, Pflüger H. Hyaluronan treatment of interstitial cystitis/painful bladder syndrome. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19 (5):717–721. doi:10.1007/s00192-007-0515-5
Daha LK, Riedl CR, Lazar D, Hohlbrugger G, Pflüger H. Do cystometric findings predict the results of intravesical hyaluronic acid in women with interstitial cystitis? Eur Urol. 2005;47(3):393–397. doi:10.1016/j.eururo.2004.10.022
Nickel JC, Egerdie B, Downey J, et al. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystitis. BJU Int. 2009;103(1):56–60. doi:10.1111/j.1464-410X.2008.08028.x
Nickel JC, Egerdie RB, Steinhoff G, Palmer B, Hanno P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with interstitial cystitis/painful bladder syndrome. Urology. 2010;76(4):804–809. doi:10.1016/j.urology.2010.03.016
Bade JJ, Laseur M, Nieuwenburg A, van der Weele LT, Mensink HJ. A placebo-controlled study of intravesical pentosanpolysulphate for the treatment of interstitial cystitis. Br J Urol. 1997;79(2):168–171. doi:10.1046/j.1464-410X.1997.03384.x
Davis EL, El Khoudary SR, Talbott EO, Davis J, Regan LJ. Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial. J Urol. 2008;179(1):177–185. doi:10.1016/j.juro.2007.08.170
International Painful Bladder Foundation. Interstitial cystitis/painful bladder syndrome: anesthetic intravesical cocktails. Available from: https://www.painful-bladder.org/pdf/IPBF.intravesicalcocktails.pdf. Accessed July, 2020.
Cox M, Klutke JJ, Klutke CG. Assessment of patient outcomes following submucosal injection of triamcinolone for treatment of hunner’s ulcer subtype interstitial cystitis. Can J Urol. 2009;16 (2):4536–4540.
Jiang T, Zhou X, Chen Z, et al. Clinical efficacy of submucosal injection of triamcinolone acetonide in the treatment of type II/III interstitial cystitis/bladder pain syndrome. BMC Urol. 2020;20(1):36. doi:10.1186/s12894-020-00597-3
Referanslar
Fall M, Baranowski AP, Fowler CJ, et al. EAU guidelines on chronic pelvic pain. Eur Urol. 2010;57(1):35–48. doi:10.1016/j.eururo. 2009.08.020
Berry SH, Elliott MN, Suttorp M, et al. Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. J Urol. 2011;186(2):540–544. doi:10.1016/j. juro.2011.03.132
Suskind AM, Berry SH, Ewing BA, et al. The prevalence and overlap of interstitial cystitis/bladder pain syndrome and chronic prostatitis/ chronic pelvic pain syndrome in men: results of the RAND interstitial cystitis epidemiology male study. J Urol. 2013;189(1):141–145. doi:10.1016/j.juro.2012.08.088
Afari N, Buchwald D, Clauw D, et al. A MAPP network case-control study of urological chronic pelvic pain compared with nonurological pain conditions. Clin J Pain. 2020;36(1):8–15. doi:10.1097/ AJP.0000000000000769
Malde S, Palmisani S, Al-Kaisy A, Sahai A. Guideline of guidelines: bladder pain syndrome. BJU Int. 2018;122(5):729–743. doi:10.1111/ bju.14399
Doggweiler R, Whitmore KE, Meijlink JM, et al. A standard terminology in chronic pelvic pain syndromes: a report from the chronic pelvic pain working group of the international continence society. Neurourol Urodyn. 2017;36(4):984–1008. doi:10.1002/nau.23072
Crane A, Lloyd J, Shoskes DA. Improving the utility of clinical phenotyping in interstitial cystitis/painful bladder syndrome: from UPOINT to INPUT. Can J Urol. 2018;25(2):9250–9254.
Van de Merwe J, Nordling J, Bouchelouche P, et al. Diagnostic criteria, classification and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol. 2008;53(1):60–67. doi:10.1016/j.eururo.2007.09.019
Yeh HL, Jhang JF, Kuo YC, Kuo HC. Long-term outcome and symptom improvement in patients with interstitial cystitis/bladder pain syndrome with or without regular follow-up and treatment. Neurourol Urodyn. 2019;38(7):1985–1993. doi:10.1002/nau.24104
Propert KJ, Schaeffer AJ, Brensinger CM, Kusek JW, Nyberg LM, Landis JR. A prospective study of interstitial cystitis: results of longitudinal follow up of the interstitial cystitis data base cohort. The Interstitial Cystitis Data Base Study Group. J Urol. 2000;163 (5):1434–1439. doi:10.1016/S0022-5347(05)67637-9
11- Lukban J, Whitmore K, Kellogg-Spadt S, Bologna A, Lesher A, Fletcher E. The effect of manual physical therapy in patients diagnosed with interstitial cystitis, high tine pelvic floor dysfunction, and sacroiliac dysfunction. Urology. 2001;Jun;57(6 Suppl 1):121–122. doi:10.1016/S0090-4295(01)01074-3
Friedlander JI, Shorter B, Moldwin RM. Diet and its role in interstitial cystitis/bladder pain syndrome and comorbid conditions. BJU Int. 2012;109(11):1584–1591. doi:10.1111/j.1464-410X.2011.10860.x
Lee JW, Han DY, Jeong HJ. Bladder pain syndrome treated with triple therapy with gabapentin, amitriptyline and a nonsteroidal anti-inflammatory drug. Int Neurourol J. 2010;14:256–260. doi:10.5213/inj.2010.14.4.256
Pearce WA, Chen R, Jain N. Pigmentary maculopathy associated with chronic exposure to pentosan polysulfate sodium. Ophthalmology. 2018;125(11):1793–1802. doi:10.1016/j.ophtha.2018.04.026
Jain N, Li AL, Yu Y, Van der Beek BL. Association of macular disease with long-term use of pentosan polysulfate sodium: findings from a US cohort. Br J Ophthalmol. 2020;104 (8):1093–1097.
Rawls WF, Cox L, Rovner ES. Dimethyl Sulfoxide (DMSO) as intravesical therapy for interstitial cystitis/bladder pain syndrome: a review. Neurourol Urodyn. 2017;36(7):1677–1684. doi:10.1002/nau.23204
Parsons CL. Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis. Urology. 2005;65(1):45–48. doi:10.1016/j. urology.2004.08.056
Kuo HC. Urodynamic results of intravesical heparin therapy for women with frequency urgency syndrome and interstitial cystitis. J Formos Med Assoc. 2001;100(5):309–314.
Parsons CL, Zupkas P, Proctor J, et al. Alkalinized lidocaine and heparin provide immediate relief of pain and urgency in patients with interstitial cystitis. J Sex Med. 2012;9(1):207–212. doi:10.1111/ j.1743-6109.2011.02542.x
Riedl CR, Engelhardt PF, Daha KL, Morakis N, Pflüger H. Hyaluronan treatment of interstitial cystitis/painful bladder syndrome. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19 (5):717–721. doi:10.1007/s00192-007-0515-5
Daha LK, Riedl CR, Lazar D, Hohlbrugger G, Pflüger H. Do cystometric findings predict the results of intravesical hyaluronic acid in women with interstitial cystitis? Eur Urol. 2005;47(3):393–397. doi:10.1016/j.eururo.2004.10.022
Nickel JC, Egerdie B, Downey J, et al. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystitis. BJU Int. 2009;103(1):56–60. doi:10.1111/j.1464-410X.2008.08028.x
Nickel JC, Egerdie RB, Steinhoff G, Palmer B, Hanno P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with interstitial cystitis/painful bladder syndrome. Urology. 2010;76(4):804–809. doi:10.1016/j.urology.2010.03.016
Bade JJ, Laseur M, Nieuwenburg A, van der Weele LT, Mensink HJ. A placebo-controlled study of intravesical pentosanpolysulphate for the treatment of interstitial cystitis. Br J Urol. 1997;79(2):168–171. doi:10.1046/j.1464-410X.1997.03384.x
Davis EL, El Khoudary SR, Talbott EO, Davis J, Regan LJ. Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial. J Urol. 2008;179(1):177–185. doi:10.1016/j.juro.2007.08.170
International Painful Bladder Foundation. Interstitial cystitis/painful bladder syndrome: anesthetic intravesical cocktails. Available from: https://www.painful-bladder.org/pdf/IPBF.intravesicalcocktails.pdf. Accessed July, 2020.
Cox M, Klutke JJ, Klutke CG. Assessment of patient outcomes following submucosal injection of triamcinolone for treatment of hunner’s ulcer subtype interstitial cystitis. Can J Urol. 2009;16 (2):4536–4540.
Jiang T, Zhou X, Chen Z, et al. Clinical efficacy of submucosal injection of triamcinolone acetonide in the treatment of type II/III interstitial cystitis/bladder pain syndrome. BMC Urol. 2020;20(1):36. doi:10.1186/s12894-020-00597-3
