İmmünokontraseptif Yöntemler
Özet
İmmünokontrasepsiyon viral, bakteriyel ve toksik ajanlar içeren aşılar kullanılarak, bireyin immün sisteminin fertilizasyonu önlemek amacıyla aktive edildiği bir kontrasepsiyon yöntemidir. Bu yöntemin kolay uygulanabilmesi, yan etkilerinin az olması, geri dönüşümlü olması, maliyetinin düşük ve seri üretime uygun olması gibi özelliklerinden dolayı gelecekte ön plana çıkması beklenmektedir. Kontraseptif aşılar, hedef aldıkları antijene göre, gamet üretimini, gamet fonksiyonlarını ve fertilizasyon sonrasını hedef alan aşılar olarak üç gruba ayrılmaktadır. Son zamanlarda başarılı bir aşı üretilmesi için birden fazla antijenin kullanılması gerektiği kabul edilmektedir. Proteomik, immünomik ve immünogenomik gelişmelerle birlikte bütüncül yaklaşımların, gelecekte kontraseptif aşı geliştirilmesine yardım edeceği düşünülmektedir.
Referanslar
AbdelKhalek, A., Ostafe, R., Olave, C., HogenEsch, H., & Turner Jr, J. W. (2022). Effect of different adjuvant formulations on the antibody response of horses to porcine zona pellucida proteins. Veterinary Immunology and Immunopathology, 253, 1-6. https://doi.org/10.1016/j.vetimm.2022.110507
Vickram, A. S., Dhama, K., Chakraborty, S., Abdul Samad, H., K Latheef, S., Sharun, K., ... & Chaicumpa, W. (2019). Role of antisperm antibodies in infertility, pregnancy, and potential for contraceptive and antifertility vaccine designs: Research progress and pioneering vision. Vaccines, 7(3), 116-146. https://doi.org/10.3390/vaccines7030116
Bakkensen, J. B., & Feinberg, E. C. (2021). Promises and pitfalls of male contraceptive vaccines. Fertility and Sterility, 115(2), 347.
Chang, A. M., Chen, C. C., Hou, D. L., Ke, G. M., & Lee, J. W. (2021). Effects of a Recombinant Gonadotropin-Releasing Hormone Vaccine on Reproductive Function in Adult Male ICR Mice. Vaccines, 9(8), 808. https://doi.org/10.3390/vaccines9080808
Çevik, M., Genç, M. D., Yalçın, B. (2019). Erkek hayvanlarda üremenin kontrolü (Kontrasepsiyon). Çevik M, editör. Erkek Hayvanlarda İnfertilite Sorunu ve Çözüme Yönelik Güncel Yaklaşımlar. 1. Baskı. Ankara: Türkiye Klinikleri, p.49-58.
Dahril, D., Aulanni'am, A., Hilmanto, D., & Purwatiningsih, W. (2014). The characterization of proprotein convertase subtilisin/kexin type4 (PCSK4) on human sperm membran for developping male immunocontraception candidates. International Journal of ChemTech Research, 5, 2229-2234.
Duman, N. B. (2019). Cinsel Sağlık. Nobel Tıp Kitabevleri. S:359
Faruck, M. O., Koirala, P., Yang, J., D’Occhio, M. J., Skwarczynski, M., & Toth, I. (2021). Polyacrylate-GnRH Peptide Conjugate as an Oral Contraceptive Vaccine Candidate. Pharmaceutics, 13(7), 1081. https://doi.org/10.3390/pharmaceutics13071081
French, H., Peterson, E., Schulman, M., Roth, R., Crampton, M., Conan, A., ... & Bertschinger, H. (2020). Efficacy and safety of native and recombinant zona pellucida immunocontraceptive vaccines in donkeys. Theriogenology, 153, 27-33. https://doi.org/10.1016/j.theriogenology.2020.04.041
Gionfriddo, J. P., Denicola, A. J., Miller, L. A., & Fagerstone, K. A. (2011). Efficacy of GnRH immunocontraception of wild white‐tailed deer in New Jersey. Wildlife Society Bulletin, 35(3), 142-148.
Gupta, S. K., & Bansal, P. (2010). Vaccines for immunological control of fertility. Reproductive Medicine and Biology, 9(2), 61-71.
Gupta, S. K., Shrestha, A., & Minhas, V. (2014). Milestones in contraceptive vaccines development and hurdles in their application. Human Vaccines & Immunotherapeutics, 10(4), 911-925.
Gupta, S. K., & Minhas, V. (2017). Wildlife population management: are contraceptive vaccines a feasible proposition. Front Biosci (Schol Ed), 9(9), 357-74.
Joonè, C. J., Schulman, M. L., & Bertschinger, H. J. (2017). Ovarian dysfunction associated with zona pellucida–based immunocontraceptive vaccines. Theriogenology, 89, 329-337.
Kalem, M. N., Köşüş, A., Köşüş, N., Kalem, Z., & Eser, A. A. (2016). Kontraseptif Aşılar. Türkiye Klinikleri Jinekoloji Obstetrik Dergisi, 26(1), 42-51.
Kaur, K., & Prabha, V. (2014). Immunocontraceptives: new approaches to fertility control. Hindawi Publishing BioMed Research International, 1-15. https://doi.org/10.1155/2014/868196
Lestari, S. W., Khairunissa, S. T., Midoen, Y. H., Hestiantoro, A., Tanojo, T. D., & I'tishom, R. (2019). An update of Male contraception: A review of cellular perspective. Journal of Global Pharma Technology, 11(1), 219-229.
Levy, J. K., Friary, J. A., Miller, L. A., Tucker, S. J., & Fagerstone, K. A. (2011). Long-term fertility control in female cats with GonaCon™, a GnRH immunocontraceptive. Theriogenology, 76(8), 1517-1525.
Mask, T. A., Schoenecker, K. A., Kane, A. J., Ransom, J. I., & Bruemmer, J. E. (2015). Serum antibody immunoreactivity to equine zona protein after SpayVac vaccination. Theriogenology, 84(2), 261-267.
Massei, G., Koon, K. K., Law, S. I., Gomm, M., Mora, D. S., Callaby, R., ... & Eckery, D. C. (2018). Fertility control for managing free-roaming feral cattle in Hong Kong. Vaccine, 36(48), 7393-7398.
McLaughlin, E. A., & Aitken, R. J. (2011). Is there a role for immunocontraception?. Molecular and Cellular Endocrinology, 335(1), 78-88.
Minhas, V., Shrestha, A., Wadhwa, N., Singh, R., & Gupta, S. K. (2016). Novel sperm and gonadotropin‐releasing hormone‐based recombinant fusion protein: achievement of 100% contraceptive efficacy by co‐immunization of male and female mice. Molecular Reproduction and Development, 83(12), 1048-1059.
Mohammad, I., Khilwani, B., Ansari, A. S., & Lohiya, N. K. (2018). Contraceptive vaccines: Implications in male and female fertility regulation. Molecular Medicine: Bench to bedside and beyond. First Edition. Indian Society for Study of Reproduction and Fertility, 57-83.
Moudgal, N. R., Murthy, G. S., Prasanna Kumar, K. M., Martin, F., Suresh, R., Medhamurthy, R., ... & Saxena, B. N. (1997). Responsiveness of human male volunteers to immunization with ovine follicle stimulating hormone vaccine: results of a pilot study. Human Reproduction (Oxford, England), 12(3), 457-463.
Naz, R. K. (2017). Antisperm contraceptive vaccine. In Immune Infertility (pp. 249-261). Springer, Cham.
Nolan, M. B., Schulman, M. L., Botha, A. E., Human, A. M., Roth, R., Crampton, M. C., & Bertschinger, H. J. (2019). Serum antibody immunoreactivity and safety of native porcine and recombinant zona pellucida vaccines formulated with a non-Freund’s adjuvant in horses. Vaccine, 37(10), 1299-1306. https://doi.org/10.1016/j.vaccine.2019.01.053
Samoylova, T. I., Braden, T. D., Spencer, J. A., & Bartol, F. F. (2017). Immunocontraception: filamentous bacteriophage as a platform for vaccine development. Current Medicinal Chemistry, 24(35), 3907-3920.
Sandam, N. P., Prakash, D., & Thimmareddy, P. (2021). Immunocontraceptive potential of a GnRH receptor-based fusion recombinant protein. Journal of Genetic Engineering and Biotechnology, 19(1), 1-8.
Suresh, R., & Moudgal, N. R. (1995). A role for nocturnal serum testosterone surge in regulating spermatogenesis in the adult non-human primate. Endocrine, 3(7), 487-492.
Talwar, G. P., Singh, O. M., Pal, R., Chatterjee, N., Sahai, P., Dhall, K., ... & Buckshee, K. (1994). A vaccine that prevents pregnancy in women. Proceedings of the National Academy of Sciences, 91(18), 8532-8536.
Talwar, G. P., Singh, O. M., Gupta, S. K., Hasnain, S. E., Pal, R., Majumdar, S. S., ... & Gupta, A. (1997). The HSD‐hCG vaccine prevents pregnancy in women: feasibility study of a reversible safe contraceptive vaccine. American Journal of Reproductive Immunology, 37(2), 153-160.
Talwar, G. P., Nand, K. N., Gupta, J. C., Bandivdekar, A. H., Sharma, R. S., & Lohiya, N. K. (2017). Current status of a unique vaccine preventing pregnancy. Front Biosci (Elite Ed), 9, 321-32.
Tollner, T. L., Overstreet, J. W., Branciforte, D., & Primakoff, P. D. (2002). Immunization of female cynomolgus macaques with a synthetic epitope of sperm‐specific lactate dehydrogenase results in high antibody titers but does not reduce fertility. Molecular Reproduction and Development: Incorporating Gamete Research, 62(2), 257-264.
Türk, G., & Ataman, O. (2016). Erkeklerde Kullanılan Cerrahi ve Cerrahi Olmayan Kontrasepsiyon Yöntemleri. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi, 30(1), 67-74.
Vickram, A. S., Dhama, K., Thanigaivel, S., Chakraborty, S., Anbarasu, K., Dey, N., & Karunakaran, R. (2022). Strategies for successful designing of immunocontraceptive vaccines and recent updates in vaccine development against sexually transmitted infections-A Review. Saudi Journal of Biological Sciences. https://doi.org/10.1016/j.sjbs.2022.01.006
Xue, F., Liu, Y., Wang, L., Tang, H., Xu, W., & Xu, C. (2013). Developing a polyvalent chimeric peptide contraceptive vaccine. American Journal of Reproductive Immunology, 70, 17-18.
O'rand, M. G., Widgren, E. E., Sivashanmugam, P., Richardson, R. T., Hall, S. H., French, F. S., ... & Rao, A. J. (2004). Reversible immunocontraception in male monkeys immunized with eppin. Science, 306(5699), 1189-1190.
Quy, R. J., Massei, G., Lambert, M. S., Coats, J., Miller, L. A., & Cowan, D. P. (2014). Effects of a GnRH vaccine on the movement and activity of free-living wild boar (Sus scrofa). Wildlife Research, 41(3), 185-193.
Referanslar
AbdelKhalek, A., Ostafe, R., Olave, C., HogenEsch, H., & Turner Jr, J. W. (2022). Effect of different adjuvant formulations on the antibody response of horses to porcine zona pellucida proteins. Veterinary Immunology and Immunopathology, 253, 1-6. https://doi.org/10.1016/j.vetimm.2022.110507
Vickram, A. S., Dhama, K., Chakraborty, S., Abdul Samad, H., K Latheef, S., Sharun, K., ... & Chaicumpa, W. (2019). Role of antisperm antibodies in infertility, pregnancy, and potential for contraceptive and antifertility vaccine designs: Research progress and pioneering vision. Vaccines, 7(3), 116-146. https://doi.org/10.3390/vaccines7030116
Bakkensen, J. B., & Feinberg, E. C. (2021). Promises and pitfalls of male contraceptive vaccines. Fertility and Sterility, 115(2), 347.
Chang, A. M., Chen, C. C., Hou, D. L., Ke, G. M., & Lee, J. W. (2021). Effects of a Recombinant Gonadotropin-Releasing Hormone Vaccine on Reproductive Function in Adult Male ICR Mice. Vaccines, 9(8), 808. https://doi.org/10.3390/vaccines9080808
Çevik, M., Genç, M. D., Yalçın, B. (2019). Erkek hayvanlarda üremenin kontrolü (Kontrasepsiyon). Çevik M, editör. Erkek Hayvanlarda İnfertilite Sorunu ve Çözüme Yönelik Güncel Yaklaşımlar. 1. Baskı. Ankara: Türkiye Klinikleri, p.49-58.
Dahril, D., Aulanni'am, A., Hilmanto, D., & Purwatiningsih, W. (2014). The characterization of proprotein convertase subtilisin/kexin type4 (PCSK4) on human sperm membran for developping male immunocontraception candidates. International Journal of ChemTech Research, 5, 2229-2234.
Duman, N. B. (2019). Cinsel Sağlık. Nobel Tıp Kitabevleri. S:359
Faruck, M. O., Koirala, P., Yang, J., D’Occhio, M. J., Skwarczynski, M., & Toth, I. (2021). Polyacrylate-GnRH Peptide Conjugate as an Oral Contraceptive Vaccine Candidate. Pharmaceutics, 13(7), 1081. https://doi.org/10.3390/pharmaceutics13071081
French, H., Peterson, E., Schulman, M., Roth, R., Crampton, M., Conan, A., ... & Bertschinger, H. (2020). Efficacy and safety of native and recombinant zona pellucida immunocontraceptive vaccines in donkeys. Theriogenology, 153, 27-33. https://doi.org/10.1016/j.theriogenology.2020.04.041
Gionfriddo, J. P., Denicola, A. J., Miller, L. A., & Fagerstone, K. A. (2011). Efficacy of GnRH immunocontraception of wild white‐tailed deer in New Jersey. Wildlife Society Bulletin, 35(3), 142-148.
Gupta, S. K., & Bansal, P. (2010). Vaccines for immunological control of fertility. Reproductive Medicine and Biology, 9(2), 61-71.
Gupta, S. K., Shrestha, A., & Minhas, V. (2014). Milestones in contraceptive vaccines development and hurdles in their application. Human Vaccines & Immunotherapeutics, 10(4), 911-925.
Gupta, S. K., & Minhas, V. (2017). Wildlife population management: are contraceptive vaccines a feasible proposition. Front Biosci (Schol Ed), 9(9), 357-74.
Joonè, C. J., Schulman, M. L., & Bertschinger, H. J. (2017). Ovarian dysfunction associated with zona pellucida–based immunocontraceptive vaccines. Theriogenology, 89, 329-337.
Kalem, M. N., Köşüş, A., Köşüş, N., Kalem, Z., & Eser, A. A. (2016). Kontraseptif Aşılar. Türkiye Klinikleri Jinekoloji Obstetrik Dergisi, 26(1), 42-51.
Kaur, K., & Prabha, V. (2014). Immunocontraceptives: new approaches to fertility control. Hindawi Publishing BioMed Research International, 1-15. https://doi.org/10.1155/2014/868196
Lestari, S. W., Khairunissa, S. T., Midoen, Y. H., Hestiantoro, A., Tanojo, T. D., & I'tishom, R. (2019). An update of Male contraception: A review of cellular perspective. Journal of Global Pharma Technology, 11(1), 219-229.
Levy, J. K., Friary, J. A., Miller, L. A., Tucker, S. J., & Fagerstone, K. A. (2011). Long-term fertility control in female cats with GonaCon™, a GnRH immunocontraceptive. Theriogenology, 76(8), 1517-1525.
Mask, T. A., Schoenecker, K. A., Kane, A. J., Ransom, J. I., & Bruemmer, J. E. (2015). Serum antibody immunoreactivity to equine zona protein after SpayVac vaccination. Theriogenology, 84(2), 261-267.
Massei, G., Koon, K. K., Law, S. I., Gomm, M., Mora, D. S., Callaby, R., ... & Eckery, D. C. (2018). Fertility control for managing free-roaming feral cattle in Hong Kong. Vaccine, 36(48), 7393-7398.
McLaughlin, E. A., & Aitken, R. J. (2011). Is there a role for immunocontraception?. Molecular and Cellular Endocrinology, 335(1), 78-88.
Minhas, V., Shrestha, A., Wadhwa, N., Singh, R., & Gupta, S. K. (2016). Novel sperm and gonadotropin‐releasing hormone‐based recombinant fusion protein: achievement of 100% contraceptive efficacy by co‐immunization of male and female mice. Molecular Reproduction and Development, 83(12), 1048-1059.
Mohammad, I., Khilwani, B., Ansari, A. S., & Lohiya, N. K. (2018). Contraceptive vaccines: Implications in male and female fertility regulation. Molecular Medicine: Bench to bedside and beyond. First Edition. Indian Society for Study of Reproduction and Fertility, 57-83.
Moudgal, N. R., Murthy, G. S., Prasanna Kumar, K. M., Martin, F., Suresh, R., Medhamurthy, R., ... & Saxena, B. N. (1997). Responsiveness of human male volunteers to immunization with ovine follicle stimulating hormone vaccine: results of a pilot study. Human Reproduction (Oxford, England), 12(3), 457-463.
Naz, R. K. (2017). Antisperm contraceptive vaccine. In Immune Infertility (pp. 249-261). Springer, Cham.
Nolan, M. B., Schulman, M. L., Botha, A. E., Human, A. M., Roth, R., Crampton, M. C., & Bertschinger, H. J. (2019). Serum antibody immunoreactivity and safety of native porcine and recombinant zona pellucida vaccines formulated with a non-Freund’s adjuvant in horses. Vaccine, 37(10), 1299-1306. https://doi.org/10.1016/j.vaccine.2019.01.053
Samoylova, T. I., Braden, T. D., Spencer, J. A., & Bartol, F. F. (2017). Immunocontraception: filamentous bacteriophage as a platform for vaccine development. Current Medicinal Chemistry, 24(35), 3907-3920.
Sandam, N. P., Prakash, D., & Thimmareddy, P. (2021). Immunocontraceptive potential of a GnRH receptor-based fusion recombinant protein. Journal of Genetic Engineering and Biotechnology, 19(1), 1-8.
Suresh, R., & Moudgal, N. R. (1995). A role for nocturnal serum testosterone surge in regulating spermatogenesis in the adult non-human primate. Endocrine, 3(7), 487-492.
Talwar, G. P., Singh, O. M., Pal, R., Chatterjee, N., Sahai, P., Dhall, K., ... & Buckshee, K. (1994). A vaccine that prevents pregnancy in women. Proceedings of the National Academy of Sciences, 91(18), 8532-8536.
Talwar, G. P., Singh, O. M., Gupta, S. K., Hasnain, S. E., Pal, R., Majumdar, S. S., ... & Gupta, A. (1997). The HSD‐hCG vaccine prevents pregnancy in women: feasibility study of a reversible safe contraceptive vaccine. American Journal of Reproductive Immunology, 37(2), 153-160.
Talwar, G. P., Nand, K. N., Gupta, J. C., Bandivdekar, A. H., Sharma, R. S., & Lohiya, N. K. (2017). Current status of a unique vaccine preventing pregnancy. Front Biosci (Elite Ed), 9, 321-32.
Tollner, T. L., Overstreet, J. W., Branciforte, D., & Primakoff, P. D. (2002). Immunization of female cynomolgus macaques with a synthetic epitope of sperm‐specific lactate dehydrogenase results in high antibody titers but does not reduce fertility. Molecular Reproduction and Development: Incorporating Gamete Research, 62(2), 257-264.
Türk, G., & Ataman, O. (2016). Erkeklerde Kullanılan Cerrahi ve Cerrahi Olmayan Kontrasepsiyon Yöntemleri. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi, 30(1), 67-74.
Vickram, A. S., Dhama, K., Thanigaivel, S., Chakraborty, S., Anbarasu, K., Dey, N., & Karunakaran, R. (2022). Strategies for successful designing of immunocontraceptive vaccines and recent updates in vaccine development against sexually transmitted infections-A Review. Saudi Journal of Biological Sciences. https://doi.org/10.1016/j.sjbs.2022.01.006
Xue, F., Liu, Y., Wang, L., Tang, H., Xu, W., & Xu, C. (2013). Developing a polyvalent chimeric peptide contraceptive vaccine. American Journal of Reproductive Immunology, 70, 17-18.
O'rand, M. G., Widgren, E. E., Sivashanmugam, P., Richardson, R. T., Hall, S. H., French, F. S., ... & Rao, A. J. (2004). Reversible immunocontraception in male monkeys immunized with eppin. Science, 306(5699), 1189-1190.
Quy, R. J., Massei, G., Lambert, M. S., Coats, J., Miller, L. A., & Cowan, D. P. (2014). Effects of a GnRH vaccine on the movement and activity of free-living wild boar (Sus scrofa). Wildlife Research, 41(3), 185-193.
