Diyabetik Ketoasidoz

Yazarlar

Ömer Salt

Özet

Referanslar

Kitabchi AE, Fisher JN. Insulin therapy of diabetic ketoacidosis: Physiologic versus pharma- cologic doses of insulin and their routes of administration. In: Brownlee M, ed. Handbook of Diabetes Mellitus. New York: Garland Press; 1981. p. 95–149.

Casteels K, Mathieu C. Diabetic ketoacidosis. Reviews in Endocrine and Metabolic Disorders. 2003;4(2): 159–66. DOI: 10.1023/A:1022942120000

Muneer M, Akbar I. Acute Metabolic Emergencies in Diabetes: DKA, HHS and EDKA. In: Islam S, ed. Advances in Experimental Medicine and Biology. Springer, Cham; 2020. p. 85–114. DOI: 10.1007/5584_2020_545

Turan T, Karahan İ, Güngüneş A. Diagnostic and therapeutic approach to diabetic ketoacido- sis. Journal of Health Sciences and Medicine. 2018; 92–8. DOI: 10.32322/jhsm.452023

Umpierrez G, Korytkowski M. Diabetic emergencies—ketoacidosis, hyperglycaemic hype- rosmolar state and hypoglycaemia. Nature Reviews Endocrinology. 2016;12(4): 222–32. DOI: 10.1038/nrendo.2016.15

Murunga AN, Owira PMO. Diabetic ketoacidosis: an overlooked child killer in sub-Saha- ran Africa? Tropical medicine & international health. 2013;18(11): 1357–64. DOI: 10.1111/ tmi.12195

Nyenwe EA, Kitabchi AE. The evolution of diabetic ketoacidosis: An update of its etiology, pat- hogenesis and management. Metabolism: clinical and experimental. 2016;65(4): 507–21. DOI: 10.1016/j.metabol.2015.12.007

Desai D, Mehta D, Mathias P, et al. Health Care Utilization and Burden of Diabetic Ketoacidosis in the U.S. Over the Past Decade: A Nationwide Analysis. Diabetes care. 2018;41(8): 1631–8. DOI: 10.2337/dc17-1379

Benoit SR, Zhang Y, Geiss LS, et al. Trends in Diabetic Ketoacidosis Hospitalizations and In-Hospital Mortality - United States, 2000-2014. MMWR Morbidity and mortality weekly re- port. 2018;67(12): 362–5. DOI: 10.15585/mmwr.mm6712a3

Li L, Andrews EB, Li X, et al. Incidence of diabetic ketoacidosis and its trends in patients with type 1 diabetes mellitus identified using a U.S. claims database, 2007-2019. Journal of diabetes and its complications. 2021;35(7): 107932. DOI: 10.1016/j.jdiacomp.2021.107932

Wolfsdorf J, Glaser N, Sperling MA, et al. Diabetic ketoacidosis in infants, children, and adolescents: A consensus statement from the American Diabetes Association. Diabetes care. 2006;29(5): 1150–9. DOI: 10.2337/diacare.2951150

Dabelea D, Rewers A, Stafford JM, et al. Trends in the prevalence of ketoacidosis at diabetes diagnosis: the SEARCH for diabetes in youth study. Pediatrics. 2014;133(4): e938–45. DOI: 10.1542/peds.2013-2795

Jensen ET, Stafford JM, Saydah S, et al. Increase in Prevalence of Diabetic Ketoacidosis at Diag- nosis Among Youth With Type 1 Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2021;44(7): 1573–8. DOI: 10.2337/dc20-0389

Ramphul K, Joynauth J. An Update on the Incidence and Burden of Diabetic Ketoacidosis in the U.S. Diabetes care. 2020;43(12): e196–7. DOI: 10.2337/dc20-1258

Hirsch IB, Emmett M. Diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults: Epidemiology and pathogenesis [Internet]. UpToDate. 2020 [cited 03/15/2020].

Unger RH, Orci L. Glucagon and the A cell: physiology and pathophysiology. The New England journal of medicine. 1981;304(26): 1575–80. DOI: 10.1056/NEJM198106253042604

Diamond MP, Hallarman L, Starick-Zych K, et al. Suppression of counterregulatory hormone response to hypoglycemia by insulin per se. The Journal of clinical endocrinology and metabo- lism. 1991;72(6): 1388–90. DOI: 10.1210/jcem-72-6-1388

Philippe J. Insulin regulation of the glucagon gene is mediated by an insulin-responsive DNA element. Proceedings of the National Academy of Sciences. 1991;88(16): 7224–7. DOI: 10.1073/ pnas.88.16.7224

Rose BD, Post TW. Clinical physiology of acid-base and electrolyte disorders. Fifth. New York: McGraw-Hill; 2001.

Fayfman M, Pasquel FJ, Umpierrez GE. Management of Hyperglycemic Crises: Diabetic Ke- toacidosis and Hyperglycemic Hyperosmolar State. The Medical clinics of North America. 2017;101(3): 587–606. DOI: 10.1016/j.mcna.2016.12.011

Miles JM, Haymond MW, Nissen SL, et al. Effects of free fatty acid availability, glucagon excess, and insulin deficiency on ketone body production in postabsorptive man. The Journal of clinical investigation. 1983;71(6): 1554–61. DOI: 10.1172/jci110911

Cook GA, Nielsen RC, Hawkins RA, et al. Effect of glucagon on hepatic malonyl coenzyme A concentration and on lipid synthesis. The Journal of biological chemistry. 1977;252(12): 4421–4.

McGarry JD, Woeltje KF, Kuwajima M, et al. Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase. Diabetes/metabolism reviews. 1989;5(3): 271–84. DOI: 10.1002/ dmr.5610050305

Owen OE, Trapp VE, Skutches CL, et al. Acetone metabolism during diabetic ketoacidosis.

Diabetes. 1982;31(3): 242–8. DOI: 10.2337/diab.31.3.242

Lu J, Zello GA, Randell E, et al. Closing the anion gap: contribution of D-lactate to diabetic ketoacidosis. Clinica chimica acta; international journal of clinical chemistry. 2011;412(3–4): 286–91. DOI: 10.1016/j.cca.2010.10.020

Arieff AI, Carroll HJ. Nonketotic hyperosmolar coma with hyperglycemia: clinical features, pathophysiology, renal function, acid-base balance, plasma-cerebrospinal fluid equilibria and the effects of therapy in 37 cases. Medicine. 1972;51(2): 73–94. DOI: 10.1097/00005792- 197203000-00001

Katz MA. Hyperglycemia-induced hyponatremia--calculation of expected serum sodi- um depression. The New England journal of medicine. 1973;289(16): 843–4. DOI: 10.1056/ NEJM197310182891607

Kreisberg RA. Diabetic ketoacidosis: new concepts and trends in pathogenesis and treatment.

Annals of internal medicine. 1978;88(5): 681–95. DOI: 10.7326/0003-4819-88-5-681

Abramson E, Arky R. Diabetic acidosis with initial hypokalemia. Therapeutic implications.

JAMA. 1966;196(5): 401–3.

Adrogué HJ, Lederer ED, Suki WN, et al. Determinants of plasma potassium levels in diabetic ketoacidosis. Medicine. 1986;65(3): 163–72. DOI: 10.1097/00005792-198605000-00004

DeFronzo RA, Matsuda M. Diabetic ketoacidosis. A combined metabolic-nephrologic approa- ch to therapy. Diabetes Reviews. 1994;2(2): 209–38.

Kitabchi AE, Wall BM. Management of diabetic ketoacidosis. American family physician. 1999;60(2): 455–64.

Kitabchi AE, Stentz FB, Umpierrez GE. Diabetic ketoacidosis induces in vivo activation of hu- man T-lymphocytes. Biochemical and biophysical research communications. 2004;315(2): 404–7. DOI: 10.1016/j.bbrc.2004.01.065

Randall L, Begovic J, Hudson M, et al. Recurrent diabetic ketoacidosis in inner-city mino- rity patients: behavioral, socioeconomic, and psychosocial factors. Diabetes care. 2011;34(9): 1891–6. DOI: 10.2337/dc11-0701

Wachtel TJ, Silliman RA, Lamberton P. Prognostic factors in the diabetic hyperosmolar state. Journal of the American Geriatrics Society. 1987;35(8): 737–41. DOI: 10.1111/j.1532-5415.1987. tb06351.x

Lapolla A, Amaro F, Bruttomesso D, et al. Diabetic ketoacidosis: A consensus statement of the Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology and Pediatric Diabetoloy (SIEDP). Nutrition, metabolism, and cardiovascular diseases : NMCD. 2020;30(10): 1633–44. DOI: 10.1016/j.numecd.2020.06.006

Hirsch IB, Emmet M. Diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults: Clinical features, evaluation, and diagnosis [Internet]. UpToDate. 2022 [cited 03/10/2020].

Taylor SI, Blau JE, Rother KI. SGLT2 Inhibitors May Predispose to Ketoacidosis. The Journal of clinical endocrinology and metabolism. 2015;100(8): 2849–52. DOI: 10.1210/jc.2015-1884

Newcomer JW. Second-generation (atypical) antipsychotics and metabolic effects: a com- prehensive literature review. CNS drugs. 2005;19 Suppl 1: 1–93. DOI: 10.2165/00023210- 200519001-00001

Warner EA, Greene GS, Buchsbaum MS, et al. Diabetic ketoacidosis associated with cocaine use. Archives of internal medicine. 1998;158(16): 1799–802. DOI: 10.1001/archinte.158.16.1799

Polonsky WH, Anderson BJ, Lohrer PA, et al. Insulin omission in women with IDDM. Diabetes care. 1994;17(10): 1178–85. DOI: 10.2337/diacare.17.10.1178

Azkoul A, Sim S, Lawrence V. Diabetic Ketoacidosis in adults: Part 1. Pathogenesis and diagno- sis. South Sudan Medical Journal. 2022;15(2): 62–6. DOI: 10.4314/ssmj.v15i2.6

Daugirdas JT, Kronfol NO, Tzamaloukas AH, et al. Hyperosmolar coma: cellular dehydration and the serum sodium concentration. Annals of internal medicine. 1989;110(11): 855–7. DOI: 10.7326/0003-4819-110-11-855

Nyenwe EA, Razavi LN, Kitabchi AE, et al. Acidosis: the prime determinant of depressed sen- sorium in diabetic ketoacidosis. Diabetes care. 2010;33(8): 1837–9. DOI: 10.2337/dc10-0102

Satman İ, Salman S, İmamoğlu Ş, et al. TEMD Diabetes Mellitus ve Komplikasyonlarının Tanı, Tedavi ve İzlem Kılavuzu.. On ikinci baskı. Ankara: Türkiye Endokrinoloji ve Metabolizma Derneği (TEMD) Yayınları; 2019.

Malone ML, Gennis V, Goodwin JS. Characteristics of diabetic ketoacidosis in older versus younger adults. Journal of the American Geriatrics Society. 1992;40(11): 1100–4. DOI: 10.1111/ j.1532-5415.1992.tb01797.x

Umpierrez G, Freire AX. Abdominal pain in patients with hyperglycemic crises. Journal of cri- tical care. 2002;17(1): 63–7. DOI: 10.1053/jcrc.2002.33030

Gosmanov AR, Gosmanova EO, Kitabchi AE. Hyperglycemic Crises: Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State. Feringold KR, Anawalt B, Boyce A, et al., eds. South Dartmouth: MDText.com, Inc.; 2000; 2021.

Kitabchi AE, Umpierrez GE, Miles JM, et al. Hyperglycemic crises in adult patients with diabe- tes. Diabetes care. 2009;32(7): 1335–43. DOI: 10.2337/dc09-9032

Calimag APP, Chlebek S, Lerma EV, et al. Diabetic ketoacidosis. Disease-a-month : DM. 2022; 101418. DOI: 10.1016/j.disamonth.2022.101418

Kitabchi AE, Umpierrez GE, Murphy MB, et al. Management of hyperglycemic crises in pa- tients with diabetes. Diabetes care. 2001;24(1): 131–53. DOI: 10.2337/diacare.24.1.131

Long B, Lentz S, Koyfman A, et al. Euglycemic diabetic ketoacidosis: Etiologies, evaluation, and management. The American journal of emergency medicine. 2021;44: 157–60. DOI: 10.1016/j. ajem.2021.02.015

Qiu H, Novikov A, Vallon V. Ketosis and diabetic ketoacidosis in response to SGLT2 inhibitors: Basic mechanisms and therapeutic perspectives. Diabetes/metabolism research and reviews. 2017;33(5). DOI: 10.1002/dmrr.2886

Lee K, Park IB, Yu SH, et al. Characterization of variable presentations of diabetic ketoacidosis based on blood ketone levels and major society diagnostic criteria: a new view point on the assessment of diabetic ketoacidosis. Diabetes, metabolic syndrome and obesity : targets and the- rapy. 2019;12: 1161–71. DOI: 10.2147/DMSO.S209938

Savage MW, Dhatariya KK, Kilvert A, et al. Joint British Diabetes Societies guideline for the management of diabetic ketoacidosis. Diabetic medicine : a journal of the British Diabetic Asso- ciation. 2011;28(5): 508–15. DOI: 10.1111/j.1464-5491.2011.03246.x

Porter WH, Yao HH, Karounos DG. Laboratory and clinical evaluation of assays for be- ta-hydroxybutyrate. American journal of clinical pathology. 1997;107(3): 353–8. DOI: 10.1093/ ajcp/107.3.353

Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes/metabolism research and reviews. 1999;15(6): 412–26. DOI: 10.1002/(si- ci)1520-7560(199911/12)15:6<412::aid-dmrr72>3.0.co;2-8

Sheikh-Ali M, Karon BS, Basu A, et al. Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis? Diabetes care. 2008;31(4): 643–7. DOI: 10.2337/dc07-1683

Smith SW, Manini AF, Szekely T, et al. Bedside detection of urine beta-hydroxybutyrate in diagnosing metabolic acidosis. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2008;15(8): 751–6. DOI: 10.1111/j.1553-2712.2008.00175.x

Bektas F, Eray O, Sari R, et al. Point of Care Blood Ketone Testing of Diabetic Patients in the Emergency Department. Endocrine Research. 2004;30(3): 395–402. DOI: 10.1081/ERC- 200035231

Beck LH. Should the actual or the corrected serum sodium be used to calculate the anion gap in diabetic ketoacidosis? Cleveland Clinic journal of medicine. 2001;68(8): 673–4. DOI: 10.3949/ ccjm.68.8.673

Chambliss AB, Merrill AE. Contemporary Practice in Clinical Chemistry. Fourth Edition. Clarke W, Marzinke M, eds. Elsevier; 2020. 651–663 p. DOI: 10.1016/C2017-0-03060-4

Murthy K, Harrington JT, Siegel RD. Profound hypokalemia in diabetic ketoacidosis: a thera- peutic challenge. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2005;11(5): 331–4. DOI: 10.4158/ EP.11.5.331

Arora S, Cheng D, Wyler B, et al. Prevalence of hypokalemia in ED patients with diabetic ke- toacidosis. The American journal of emergency medicine. 2012;30(3): 481–4. DOI: 10.1016/j. ajem.2011.01.002

Shen T, Braude S. Changes in serum phosphate during treatment of diabetic ketoacidosis: predi- ctive significance of severity of acidosis on presentation. Internal medicine journal. 2012;42(12): 1347–50. DOI: 10.1111/imj.12001

Kemperman FA, Weber JA, Gorgels J, et al. The influence of ketoacids on plasma creatini- ne assays in diabetic ketoacidosis. Journal of internal medicine. 2000;248(6): 511–7. DOI: 10.1046/j.1365-2796.2000.00768.x

Vantyghem MC, Haye S, Balduyck M, et al. Changes in serum amylase, lipase and leukocy- te elastase during diabetic ketoacidosis and poorly controlled diabetes. Acta diabetologica. 1999;36(1–2): 39–44. DOI: 10.1007/s005920050143

Yadav D, Nair S, Norkus EP, et al. Nonspecific hyperamylasemia and hyperlipasemia in diabetic ketoacidosis: incidence and correlation with biochemical abnormalities. The American journal of gastroenterology. 2000;95(11): 3123–8. DOI: 10.1111/j.1572-0241.2000.03279.x

Stentz FB, Umpierrez GE, Cuervo R, et al. Proinflammatory cytokines, markers of cardiovascu- lar risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises. Diabetes. 2004;53(8): 2079–86. DOI: 10.2337/diabetes.53.8.2079

Nematollahi LR, Taheri E, Larijani B, et al. Catecholamine-Induced Leukocytosis in Acute Hy- poglycemic Stress. Journal of Investigative Medicine [Internet]. 2007;55(1): S262.

Slovis CM, Mork VG, Slovis RJ, et al. Diabetic ketoacidosis and infection: leukocyte count and differential as early predictors of serious infection. The American journal of emergency medici- ne. 1987;5(1): 1–5. DOI: 10.1016/0735-6757(87)90280-4

Morris LR, Kitabchi AE. Efficacy of low-dose insulin therapy for severely obtunded patients in diabetic ketoacidosis. Diabetes care. 1980;3(1): 53–6. DOI: 10.2337/diacare.3.1.53

Handelsman Y, Henry RR, Bloomgarden ZT, et al. American Association of Clinical Endoc- rinologists and American College of Endocrinology position statement on the association of SGLT-2 inhibitors and diabetic ketoacidosis. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2016;22(6): 753–62. DOI: 10.4158/EP161292.PS

Dhatariya K. Blood Ketones: Measurement, Interpretation, Limitations, and Utility in the Ma- nagement of Diabetic Ketoacidosis. The review of diabetic studies : RDS. 2016;13(4): 217–25. DOI: 10.1900/RDS.2016.13.217

Dhatariya KK. Defining and characterising diabetic ketoacidosis in adults. Diabetes research and clinical practice. 2019;155: 107797. DOI: 10.1016/j.diabres.2019.107797

Wolfsdorf JI, Glaser N, Agus M, et al. ISPAD Clinical Practice Consensus Guidelines 2018: Diabetic ketoacidosis and the hyperglycemic hyperosmolar state. Pediatric diabetes. 2018;19 Suppl 27: 155–77. DOI: 10.1111/pedi.12701

Heddy N. Guideline for the management of children and young people under the age of 18 ye- ars with diabetic ketoacidosis (British Society for Paediatric Endocrinology and Diabetes). Ar- chives of disease in childhood Education and practice edition. 2021;106(4): 220–2. DOI: 10.1136/ archdischild-2020-320076

Kitabchi AE, Nyenwe EA. Hyperglycemic crises in diabetes mellitus: diabetic ketoacidosis and hyperglycemic hyperosmolar state. Endocrinology and metabolism clinics of North America. 2006;35(4): 725–51, viii. DOI: 10.1016/j.ecl.2006.09.006

McGuire LC, Cruickshank AM, Munro PT. Alcoholic ketoacidosis. Emergency medicine jour- nal. 2006;23(6): 417–20. DOI: 10.1136/emj.2004.017590

Cahill GF. Fuel metabolism in starvation. Annual review of nutrition. 2006;26: 1–22. DOI: 10.1146/annurev.nutr.26.061505.111258

Evans K. Diabetic ketoacidosis: update on management. Clinical medicine (London, England). 2019;19(5): 396–8. DOI: 10.7861/clinmed.2019-0284

Roumelioti ME, Sun Y, Ganta K, et al. Management of extracellular volume in patients with end-stage kidney disease and severe hyperglycemia. Journal of diabetes and its complications. 2020;34(8): 107615. DOI: 10.1016/j.jdiacomp.2020.107615

Galindo RJ, Pasquel FJ, Fayfman M, et al. Clinical characteristics and outcomes of patients with end-stage renal disease hospitalized with diabetes ketoacidosis. BMJ open diabetes research & care. 2020;8(1). DOI: 10.1136/bmjdrc-2019-000763

Blicker J, Herd AM, Talbot J. Diabetic ketoacidosis in the dialysis-dependent patient: two case reports and recommendations for treatment. CJEM. 2004;6(4): 281–4. DOI: 10.1017/ s1481803500009271

Sun Y, Roumelioti ME, Ganta K, et al. Dialysis-associated hyperglycemia: manifestations and treatment. International urology and nephrology. 2020;52(3): 505–17. DOI: 10.1007/s11255- 019-02373-1

Nyenwe EA, Kitabchi AE. Evidence-based management of hyperglycemic emergencies in dia- betes mellitus. Diabetes research and clinical practice. 2011;94(3): 340–51. DOI: 10.1016/j.diab- res.2011.09.012

Praveen PA, Hockett CW, Ong TC, et al. Diabetic ketoacidosis at diagnosis among youth with type 1 and type 2 diabetes: Results from SEARCH (United States) and YDR (India) registries. Pediatric diabetes. 2021;22(1): 40–6. DOI: 10.1111/pedi.12979

Kraut JA, Madias NE. Treatment of acute metabolic acidosis: a pathophysiologic approach.

Nature reviews Nephrology. 2012;8(10): 589–601. DOI: 10.1038/nrneph.2012.186

Middleton P, Kelly AM, Brown J, et al. Agreement between arterial and central venous values for pH, bicarbonate, base excess, and lactate. Emergency medicine journal : EMJ. 2006;23(8): 622–4. DOI: 10.1136/emj.2006.035915

Loh TP, Saw S, Sethi SK. Bedside monitoring of blood ketone for management of diabetic ke- toacidosis: proceed with care. Diabetic medicine : a journal of the British Diabetic Association. 2012;29(6): 827–8. DOI: 10.1111/j.1464-5491.2011.03490.x

Hirsch IB, Emmet M. Diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults: Treatment [Internet]. UpToDate. 2022 [cited 03/10/2020].

Reddy PK, Kuchay MS, Mehta Y, et al. Diabetic ketoacidosis precipitated by COVID-19: A re- port of two cases and review of literature. Diabetes & metabolic syndrome. 2020;14(5): 1459–62. DOI: 10.1016/j.dsx.2020.07.050

Yang JK, Lin SS, Ji XJ, et al. Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta diabetologica. 2010;47(3): 193–9. DOI: 10.1007/s00592-009-0109-4

Pal R, Banerjee M, Yadav U, et al. Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: A systematic review of literature. Diabetes & metabolic syndrome. 2020;14(6): 1563–9. DOI: 10.1016/j.dsx.2020.08.015

Wang Y, Zhang D, Du G, et al. Remdesivir in adults with severe COVID-19: a randomised, doub- le-blind, placebo-controlled, multicentre trial. Lancet (London, England). 2020;395(10236): 1569–78. DOI: 10.1016/S0140-6736(20)31022-9

Rayman G, Lumb A, Kennon B, et al. Guidance on the management of Diabetic Ketoacidosis in the exceptional circumstances of the COVID-19 pandemic. Diabetic medicine : a journal of the British Diabetic Association. 2020;37(7): 1214–6. DOI: 10.1111/dme.14328

Palermo NE, Sadhu AR, McDonnell ME. Diabetic Ketoacidosis in COVID-19: Unique Concer- ns and Considerations. The Journal of clinical endocrinology and metabolism. 2020;105(8). DOI: 10.1210/clinem/dgaa360

Priyambada L, Wolfsdorf JI, Brink SJ, et al. ISPAD Clinical Practice Consensus Guideline: Dia- betic ketoacidosis in the time of COVID-19 and resource-limited settings-role of subcutaneous insulin. Pediatric diabetes. 2020;21(8): 1394–402. DOI: 10.1111/pedi.13118

Referanslar

Kitabchi AE, Fisher JN. Insulin therapy of diabetic ketoacidosis: Physiologic versus pharma- cologic doses of insulin and their routes of administration. In: Brownlee M, ed. Handbook of Diabetes Mellitus. New York: Garland Press; 1981. p. 95–149.

Casteels K, Mathieu C. Diabetic ketoacidosis. Reviews in Endocrine and Metabolic Disorders. 2003;4(2): 159–66. DOI: 10.1023/A:1022942120000

Muneer M, Akbar I. Acute Metabolic Emergencies in Diabetes: DKA, HHS and EDKA. In: Islam S, ed. Advances in Experimental Medicine and Biology. Springer, Cham; 2020. p. 85–114. DOI: 10.1007/5584_2020_545

Turan T, Karahan İ, Güngüneş A. Diagnostic and therapeutic approach to diabetic ketoacido- sis. Journal of Health Sciences and Medicine. 2018; 92–8. DOI: 10.32322/jhsm.452023

Umpierrez G, Korytkowski M. Diabetic emergencies—ketoacidosis, hyperglycaemic hype- rosmolar state and hypoglycaemia. Nature Reviews Endocrinology. 2016;12(4): 222–32. DOI: 10.1038/nrendo.2016.15

Murunga AN, Owira PMO. Diabetic ketoacidosis: an overlooked child killer in sub-Saha- ran Africa? Tropical medicine & international health. 2013;18(11): 1357–64. DOI: 10.1111/ tmi.12195

Nyenwe EA, Kitabchi AE. The evolution of diabetic ketoacidosis: An update of its etiology, pat- hogenesis and management. Metabolism: clinical and experimental. 2016;65(4): 507–21. DOI: 10.1016/j.metabol.2015.12.007

Desai D, Mehta D, Mathias P, et al. Health Care Utilization and Burden of Diabetic Ketoacidosis in the U.S. Over the Past Decade: A Nationwide Analysis. Diabetes care. 2018;41(8): 1631–8. DOI: 10.2337/dc17-1379

Benoit SR, Zhang Y, Geiss LS, et al. Trends in Diabetic Ketoacidosis Hospitalizations and In-Hospital Mortality - United States, 2000-2014. MMWR Morbidity and mortality weekly re- port. 2018;67(12): 362–5. DOI: 10.15585/mmwr.mm6712a3

Li L, Andrews EB, Li X, et al. Incidence of diabetic ketoacidosis and its trends in patients with type 1 diabetes mellitus identified using a U.S. claims database, 2007-2019. Journal of diabetes and its complications. 2021;35(7): 107932. DOI: 10.1016/j.jdiacomp.2021.107932

Wolfsdorf J, Glaser N, Sperling MA, et al. Diabetic ketoacidosis in infants, children, and adolescents: A consensus statement from the American Diabetes Association. Diabetes care. 2006;29(5): 1150–9. DOI: 10.2337/diacare.2951150

Dabelea D, Rewers A, Stafford JM, et al. Trends in the prevalence of ketoacidosis at diabetes diagnosis: the SEARCH for diabetes in youth study. Pediatrics. 2014;133(4): e938–45. DOI: 10.1542/peds.2013-2795

Jensen ET, Stafford JM, Saydah S, et al. Increase in Prevalence of Diabetic Ketoacidosis at Diag- nosis Among Youth With Type 1 Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2021;44(7): 1573–8. DOI: 10.2337/dc20-0389

Ramphul K, Joynauth J. An Update on the Incidence and Burden of Diabetic Ketoacidosis in the U.S. Diabetes care. 2020;43(12): e196–7. DOI: 10.2337/dc20-1258

Hirsch IB, Emmett M. Diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults: Epidemiology and pathogenesis [Internet]. UpToDate. 2020 [cited 03/15/2020].

Unger RH, Orci L. Glucagon and the A cell: physiology and pathophysiology. The New England journal of medicine. 1981;304(26): 1575–80. DOI: 10.1056/NEJM198106253042604

Diamond MP, Hallarman L, Starick-Zych K, et al. Suppression of counterregulatory hormone response to hypoglycemia by insulin per se. The Journal of clinical endocrinology and metabo- lism. 1991;72(6): 1388–90. DOI: 10.1210/jcem-72-6-1388

Philippe J. Insulin regulation of the glucagon gene is mediated by an insulin-responsive DNA element. Proceedings of the National Academy of Sciences. 1991;88(16): 7224–7. DOI: 10.1073/ pnas.88.16.7224

Rose BD, Post TW. Clinical physiology of acid-base and electrolyte disorders. Fifth. New York: McGraw-Hill; 2001.

Fayfman M, Pasquel FJ, Umpierrez GE. Management of Hyperglycemic Crises: Diabetic Ke- toacidosis and Hyperglycemic Hyperosmolar State. The Medical clinics of North America. 2017;101(3): 587–606. DOI: 10.1016/j.mcna.2016.12.011

Miles JM, Haymond MW, Nissen SL, et al. Effects of free fatty acid availability, glucagon excess, and insulin deficiency on ketone body production in postabsorptive man. The Journal of clinical investigation. 1983;71(6): 1554–61. DOI: 10.1172/jci110911

Cook GA, Nielsen RC, Hawkins RA, et al. Effect of glucagon on hepatic malonyl coenzyme A concentration and on lipid synthesis. The Journal of biological chemistry. 1977;252(12): 4421–4.

McGarry JD, Woeltje KF, Kuwajima M, et al. Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase. Diabetes/metabolism reviews. 1989;5(3): 271–84. DOI: 10.1002/ dmr.5610050305

Owen OE, Trapp VE, Skutches CL, et al. Acetone metabolism during diabetic ketoacidosis.

Diabetes. 1982;31(3): 242–8. DOI: 10.2337/diab.31.3.242

Lu J, Zello GA, Randell E, et al. Closing the anion gap: contribution of D-lactate to diabetic ketoacidosis. Clinica chimica acta; international journal of clinical chemistry. 2011;412(3–4): 286–91. DOI: 10.1016/j.cca.2010.10.020

Arieff AI, Carroll HJ. Nonketotic hyperosmolar coma with hyperglycemia: clinical features, pathophysiology, renal function, acid-base balance, plasma-cerebrospinal fluid equilibria and the effects of therapy in 37 cases. Medicine. 1972;51(2): 73–94. DOI: 10.1097/00005792- 197203000-00001

Katz MA. Hyperglycemia-induced hyponatremia--calculation of expected serum sodi- um depression. The New England journal of medicine. 1973;289(16): 843–4. DOI: 10.1056/ NEJM197310182891607

Kreisberg RA. Diabetic ketoacidosis: new concepts and trends in pathogenesis and treatment.

Annals of internal medicine. 1978;88(5): 681–95. DOI: 10.7326/0003-4819-88-5-681

Abramson E, Arky R. Diabetic acidosis with initial hypokalemia. Therapeutic implications.

JAMA. 1966;196(5): 401–3.

Adrogué HJ, Lederer ED, Suki WN, et al. Determinants of plasma potassium levels in diabetic ketoacidosis. Medicine. 1986;65(3): 163–72. DOI: 10.1097/00005792-198605000-00004

DeFronzo RA, Matsuda M. Diabetic ketoacidosis. A combined metabolic-nephrologic approa- ch to therapy. Diabetes Reviews. 1994;2(2): 209–38.

Kitabchi AE, Wall BM. Management of diabetic ketoacidosis. American family physician. 1999;60(2): 455–64.

Kitabchi AE, Stentz FB, Umpierrez GE. Diabetic ketoacidosis induces in vivo activation of hu- man T-lymphocytes. Biochemical and biophysical research communications. 2004;315(2): 404–7. DOI: 10.1016/j.bbrc.2004.01.065

Randall L, Begovic J, Hudson M, et al. Recurrent diabetic ketoacidosis in inner-city mino- rity patients: behavioral, socioeconomic, and psychosocial factors. Diabetes care. 2011;34(9): 1891–6. DOI: 10.2337/dc11-0701

Wachtel TJ, Silliman RA, Lamberton P. Prognostic factors in the diabetic hyperosmolar state. Journal of the American Geriatrics Society. 1987;35(8): 737–41. DOI: 10.1111/j.1532-5415.1987. tb06351.x

Lapolla A, Amaro F, Bruttomesso D, et al. Diabetic ketoacidosis: A consensus statement of the Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology and Pediatric Diabetoloy (SIEDP). Nutrition, metabolism, and cardiovascular diseases : NMCD. 2020;30(10): 1633–44. DOI: 10.1016/j.numecd.2020.06.006

Hirsch IB, Emmet M. Diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults: Clinical features, evaluation, and diagnosis [Internet]. UpToDate. 2022 [cited 03/10/2020].

Taylor SI, Blau JE, Rother KI. SGLT2 Inhibitors May Predispose to Ketoacidosis. The Journal of clinical endocrinology and metabolism. 2015;100(8): 2849–52. DOI: 10.1210/jc.2015-1884

Newcomer JW. Second-generation (atypical) antipsychotics and metabolic effects: a com- prehensive literature review. CNS drugs. 2005;19 Suppl 1: 1–93. DOI: 10.2165/00023210- 200519001-00001

Warner EA, Greene GS, Buchsbaum MS, et al. Diabetic ketoacidosis associated with cocaine use. Archives of internal medicine. 1998;158(16): 1799–802. DOI: 10.1001/archinte.158.16.1799

Polonsky WH, Anderson BJ, Lohrer PA, et al. Insulin omission in women with IDDM. Diabetes care. 1994;17(10): 1178–85. DOI: 10.2337/diacare.17.10.1178

Azkoul A, Sim S, Lawrence V. Diabetic Ketoacidosis in adults: Part 1. Pathogenesis and diagno- sis. South Sudan Medical Journal. 2022;15(2): 62–6. DOI: 10.4314/ssmj.v15i2.6

Daugirdas JT, Kronfol NO, Tzamaloukas AH, et al. Hyperosmolar coma: cellular dehydration and the serum sodium concentration. Annals of internal medicine. 1989;110(11): 855–7. DOI: 10.7326/0003-4819-110-11-855

Nyenwe EA, Razavi LN, Kitabchi AE, et al. Acidosis: the prime determinant of depressed sen- sorium in diabetic ketoacidosis. Diabetes care. 2010;33(8): 1837–9. DOI: 10.2337/dc10-0102

Satman İ, Salman S, İmamoğlu Ş, et al. TEMD Diabetes Mellitus ve Komplikasyonlarının Tanı, Tedavi ve İzlem Kılavuzu.. On ikinci baskı. Ankara: Türkiye Endokrinoloji ve Metabolizma Derneği (TEMD) Yayınları; 2019.

Malone ML, Gennis V, Goodwin JS. Characteristics of diabetic ketoacidosis in older versus younger adults. Journal of the American Geriatrics Society. 1992;40(11): 1100–4. DOI: 10.1111/ j.1532-5415.1992.tb01797.x

Umpierrez G, Freire AX. Abdominal pain in patients with hyperglycemic crises. Journal of cri- tical care. 2002;17(1): 63–7. DOI: 10.1053/jcrc.2002.33030

Gosmanov AR, Gosmanova EO, Kitabchi AE. Hyperglycemic Crises: Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State. Feringold KR, Anawalt B, Boyce A, et al., eds. South Dartmouth: MDText.com, Inc.; 2000; 2021.

Kitabchi AE, Umpierrez GE, Miles JM, et al. Hyperglycemic crises in adult patients with diabe- tes. Diabetes care. 2009;32(7): 1335–43. DOI: 10.2337/dc09-9032

Calimag APP, Chlebek S, Lerma EV, et al. Diabetic ketoacidosis. Disease-a-month : DM. 2022; 101418. DOI: 10.1016/j.disamonth.2022.101418

Kitabchi AE, Umpierrez GE, Murphy MB, et al. Management of hyperglycemic crises in pa- tients with diabetes. Diabetes care. 2001;24(1): 131–53. DOI: 10.2337/diacare.24.1.131

Long B, Lentz S, Koyfman A, et al. Euglycemic diabetic ketoacidosis: Etiologies, evaluation, and management. The American journal of emergency medicine. 2021;44: 157–60. DOI: 10.1016/j. ajem.2021.02.015

Qiu H, Novikov A, Vallon V. Ketosis and diabetic ketoacidosis in response to SGLT2 inhibitors: Basic mechanisms and therapeutic perspectives. Diabetes/metabolism research and reviews. 2017;33(5). DOI: 10.1002/dmrr.2886

Lee K, Park IB, Yu SH, et al. Characterization of variable presentations of diabetic ketoacidosis based on blood ketone levels and major society diagnostic criteria: a new view point on the assessment of diabetic ketoacidosis. Diabetes, metabolic syndrome and obesity : targets and the- rapy. 2019;12: 1161–71. DOI: 10.2147/DMSO.S209938

Savage MW, Dhatariya KK, Kilvert A, et al. Joint British Diabetes Societies guideline for the management of diabetic ketoacidosis. Diabetic medicine : a journal of the British Diabetic Asso- ciation. 2011;28(5): 508–15. DOI: 10.1111/j.1464-5491.2011.03246.x

Porter WH, Yao HH, Karounos DG. Laboratory and clinical evaluation of assays for be- ta-hydroxybutyrate. American journal of clinical pathology. 1997;107(3): 353–8. DOI: 10.1093/ ajcp/107.3.353

Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes/metabolism research and reviews. 1999;15(6): 412–26. DOI: 10.1002/(si- ci)1520-7560(199911/12)15:6<412::aid-dmrr72>3.0.co;2-8

Sheikh-Ali M, Karon BS, Basu A, et al. Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis? Diabetes care. 2008;31(4): 643–7. DOI: 10.2337/dc07-1683

Smith SW, Manini AF, Szekely T, et al. Bedside detection of urine beta-hydroxybutyrate in diagnosing metabolic acidosis. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2008;15(8): 751–6. DOI: 10.1111/j.1553-2712.2008.00175.x

Bektas F, Eray O, Sari R, et al. Point of Care Blood Ketone Testing of Diabetic Patients in the Emergency Department. Endocrine Research. 2004;30(3): 395–402. DOI: 10.1081/ERC- 200035231

Beck LH. Should the actual or the corrected serum sodium be used to calculate the anion gap in diabetic ketoacidosis? Cleveland Clinic journal of medicine. 2001;68(8): 673–4. DOI: 10.3949/ ccjm.68.8.673

Chambliss AB, Merrill AE. Contemporary Practice in Clinical Chemistry. Fourth Edition. Clarke W, Marzinke M, eds. Elsevier; 2020. 651–663 p. DOI: 10.1016/C2017-0-03060-4

Murthy K, Harrington JT, Siegel RD. Profound hypokalemia in diabetic ketoacidosis: a thera- peutic challenge. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2005;11(5): 331–4. DOI: 10.4158/ EP.11.5.331

Arora S, Cheng D, Wyler B, et al. Prevalence of hypokalemia in ED patients with diabetic ke- toacidosis. The American journal of emergency medicine. 2012;30(3): 481–4. DOI: 10.1016/j. ajem.2011.01.002

Shen T, Braude S. Changes in serum phosphate during treatment of diabetic ketoacidosis: predi- ctive significance of severity of acidosis on presentation. Internal medicine journal. 2012;42(12): 1347–50. DOI: 10.1111/imj.12001

Kemperman FA, Weber JA, Gorgels J, et al. The influence of ketoacids on plasma creatini- ne assays in diabetic ketoacidosis. Journal of internal medicine. 2000;248(6): 511–7. DOI: 10.1046/j.1365-2796.2000.00768.x

Vantyghem MC, Haye S, Balduyck M, et al. Changes in serum amylase, lipase and leukocy- te elastase during diabetic ketoacidosis and poorly controlled diabetes. Acta diabetologica. 1999;36(1–2): 39–44. DOI: 10.1007/s005920050143

Yadav D, Nair S, Norkus EP, et al. Nonspecific hyperamylasemia and hyperlipasemia in diabetic ketoacidosis: incidence and correlation with biochemical abnormalities. The American journal of gastroenterology. 2000;95(11): 3123–8. DOI: 10.1111/j.1572-0241.2000.03279.x

Stentz FB, Umpierrez GE, Cuervo R, et al. Proinflammatory cytokines, markers of cardiovascu- lar risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises. Diabetes. 2004;53(8): 2079–86. DOI: 10.2337/diabetes.53.8.2079

Nematollahi LR, Taheri E, Larijani B, et al. Catecholamine-Induced Leukocytosis in Acute Hy- poglycemic Stress. Journal of Investigative Medicine [Internet]. 2007;55(1): S262.

Slovis CM, Mork VG, Slovis RJ, et al. Diabetic ketoacidosis and infection: leukocyte count and differential as early predictors of serious infection. The American journal of emergency medici- ne. 1987;5(1): 1–5. DOI: 10.1016/0735-6757(87)90280-4

Morris LR, Kitabchi AE. Efficacy of low-dose insulin therapy for severely obtunded patients in diabetic ketoacidosis. Diabetes care. 1980;3(1): 53–6. DOI: 10.2337/diacare.3.1.53

Handelsman Y, Henry RR, Bloomgarden ZT, et al. American Association of Clinical Endoc- rinologists and American College of Endocrinology position statement on the association of SGLT-2 inhibitors and diabetic ketoacidosis. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2016;22(6): 753–62. DOI: 10.4158/EP161292.PS

Dhatariya K. Blood Ketones: Measurement, Interpretation, Limitations, and Utility in the Ma- nagement of Diabetic Ketoacidosis. The review of diabetic studies : RDS. 2016;13(4): 217–25. DOI: 10.1900/RDS.2016.13.217

Dhatariya KK. Defining and characterising diabetic ketoacidosis in adults. Diabetes research and clinical practice. 2019;155: 107797. DOI: 10.1016/j.diabres.2019.107797

Wolfsdorf JI, Glaser N, Agus M, et al. ISPAD Clinical Practice Consensus Guidelines 2018: Diabetic ketoacidosis and the hyperglycemic hyperosmolar state. Pediatric diabetes. 2018;19 Suppl 27: 155–77. DOI: 10.1111/pedi.12701

Heddy N. Guideline for the management of children and young people under the age of 18 ye- ars with diabetic ketoacidosis (British Society for Paediatric Endocrinology and Diabetes). Ar- chives of disease in childhood Education and practice edition. 2021;106(4): 220–2. DOI: 10.1136/ archdischild-2020-320076

Kitabchi AE, Nyenwe EA. Hyperglycemic crises in diabetes mellitus: diabetic ketoacidosis and hyperglycemic hyperosmolar state. Endocrinology and metabolism clinics of North America. 2006;35(4): 725–51, viii. DOI: 10.1016/j.ecl.2006.09.006

McGuire LC, Cruickshank AM, Munro PT. Alcoholic ketoacidosis. Emergency medicine jour- nal. 2006;23(6): 417–20. DOI: 10.1136/emj.2004.017590

Cahill GF. Fuel metabolism in starvation. Annual review of nutrition. 2006;26: 1–22. DOI: 10.1146/annurev.nutr.26.061505.111258

Evans K. Diabetic ketoacidosis: update on management. Clinical medicine (London, England). 2019;19(5): 396–8. DOI: 10.7861/clinmed.2019-0284

Roumelioti ME, Sun Y, Ganta K, et al. Management of extracellular volume in patients with end-stage kidney disease and severe hyperglycemia. Journal of diabetes and its complications. 2020;34(8): 107615. DOI: 10.1016/j.jdiacomp.2020.107615

Galindo RJ, Pasquel FJ, Fayfman M, et al. Clinical characteristics and outcomes of patients with end-stage renal disease hospitalized with diabetes ketoacidosis. BMJ open diabetes research & care. 2020;8(1). DOI: 10.1136/bmjdrc-2019-000763

Blicker J, Herd AM, Talbot J. Diabetic ketoacidosis in the dialysis-dependent patient: two case reports and recommendations for treatment. CJEM. 2004;6(4): 281–4. DOI: 10.1017/ s1481803500009271

Sun Y, Roumelioti ME, Ganta K, et al. Dialysis-associated hyperglycemia: manifestations and treatment. International urology and nephrology. 2020;52(3): 505–17. DOI: 10.1007/s11255- 019-02373-1

Nyenwe EA, Kitabchi AE. Evidence-based management of hyperglycemic emergencies in dia- betes mellitus. Diabetes research and clinical practice. 2011;94(3): 340–51. DOI: 10.1016/j.diab- res.2011.09.012

Praveen PA, Hockett CW, Ong TC, et al. Diabetic ketoacidosis at diagnosis among youth with type 1 and type 2 diabetes: Results from SEARCH (United States) and YDR (India) registries. Pediatric diabetes. 2021;22(1): 40–6. DOI: 10.1111/pedi.12979

Kraut JA, Madias NE. Treatment of acute metabolic acidosis: a pathophysiologic approach.

Nature reviews Nephrology. 2012;8(10): 589–601. DOI: 10.1038/nrneph.2012.186

Middleton P, Kelly AM, Brown J, et al. Agreement between arterial and central venous values for pH, bicarbonate, base excess, and lactate. Emergency medicine journal : EMJ. 2006;23(8): 622–4. DOI: 10.1136/emj.2006.035915

Loh TP, Saw S, Sethi SK. Bedside monitoring of blood ketone for management of diabetic ke- toacidosis: proceed with care. Diabetic medicine : a journal of the British Diabetic Association. 2012;29(6): 827–8. DOI: 10.1111/j.1464-5491.2011.03490.x

Hirsch IB, Emmet M. Diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults: Treatment [Internet]. UpToDate. 2022 [cited 03/10/2020].

Reddy PK, Kuchay MS, Mehta Y, et al. Diabetic ketoacidosis precipitated by COVID-19: A re- port of two cases and review of literature. Diabetes & metabolic syndrome. 2020;14(5): 1459–62. DOI: 10.1016/j.dsx.2020.07.050

Yang JK, Lin SS, Ji XJ, et al. Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta diabetologica. 2010;47(3): 193–9. DOI: 10.1007/s00592-009-0109-4

Pal R, Banerjee M, Yadav U, et al. Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: A systematic review of literature. Diabetes & metabolic syndrome. 2020;14(6): 1563–9. DOI: 10.1016/j.dsx.2020.08.015

Wang Y, Zhang D, Du G, et al. Remdesivir in adults with severe COVID-19: a randomised, doub- le-blind, placebo-controlled, multicentre trial. Lancet (London, England). 2020;395(10236): 1569–78. DOI: 10.1016/S0140-6736(20)31022-9

Rayman G, Lumb A, Kennon B, et al. Guidance on the management of Diabetic Ketoacidosis in the exceptional circumstances of the COVID-19 pandemic. Diabetic medicine : a journal of the British Diabetic Association. 2020;37(7): 1214–6. DOI: 10.1111/dme.14328

Palermo NE, Sadhu AR, McDonnell ME. Diabetic Ketoacidosis in COVID-19: Unique Concer- ns and Considerations. The Journal of clinical endocrinology and metabolism. 2020;105(8). DOI: 10.1210/clinem/dgaa360

Priyambada L, Wolfsdorf JI, Brink SJ, et al. ISPAD Clinical Practice Consensus Guideline: Dia- betic ketoacidosis in the time of COVID-19 and resource-limited settings-role of subcutaneous insulin. Pediatric diabetes. 2020;21(8): 1394–402. DOI: 10.1111/pedi.13118

Sayfalar

35-62

Yayınlanan

14 Mart 2023

Lisans

Lisans