Current Nursing Approaches For Symptom Management And Assessment Of Quality Of Life In Childhood Cancers
Özet
Childhood cancers, primarily of embryological origin, present a heterogeneous group of life-threatening diseases that introduce severe physical and psychosocial challenges for both children and their parent caregivers. While therapeutic advancements in chemotherapy, radiotherapy, and biological targeted therapies have significantly increased pediatric survival rates to approximately 80% in developed countries, survival figures remain critically low at 30% within underdeveloped or developing regions. The administration of intensive cytotoxic chemotherapy effectively destroys malignant cells, yet it concurrently triggers debilitating side effects including oral mucositis, risky neutropenia, persistent nausea, vomiting, intense pain, gastrointestinal disruptions, alopecia, and treatment-induced cachexia. These common symptoms frequently emerge in clusters, intensifying distress and diminishing the overall health-related quality of life. Pediatric oncology nursing holds a multifaceted responsibility in optimizing standard care by executing continuous symptom assessments, delivering family education, and applying diverse pharmacological and non-pharmacological supportive approaches. Additionally, modern nursing care synergizes with mobile health (m-Health) innovations and therapeutic computer-designed applications—such as KeTO, Sisom, and Re-Mission—to offer interactive psychoeducation. These digital games systematically increase the child's knowledge, promote active involvement in self-care, reduce depressive manifestations, and strategically distract from procedure-related pain, thereby improving clinical functionality and fostering adaptive coping mechanisms during long-term hospitalization periods.
Referanslar
Abrams, A.N., Hazen, E.P., Penson, R.T. (2007). Psychosocial issues in adolescents with cancer. Cancer Treatment Reviews. 33(7), 622– 630. doi: 10.1016/j.ctrv.2006.12.006
Andreyev, J., Ross, P., Donnellan, C., Lennan, E., Leonard, P., Waters, C., Wedlake, L., Bridgewater, J., Glynne-Jones, R., Allum, W., Chau, I. (2014). Guidance on the management of diarrhoea during cancer chemotherapy. The Lancet Oncology, 15(10), e447-e460.doi:10.1016/S1470-2045(14)70006-3
Ardahan Sevgili, S., Şenol, S. (2019). Akut Lenfoblastik Lösemide Bakım. In: Şenol, S. (Ed). Olgularla Pediatrik Bakım. Ankara Nobel Tıp Kitabevleri: Ankara. Pp. 365-80.
Ardahan Sevgili, S., Şenol, S. (2022). Prediction of chemotherapy-related complications in pediatric oncology patients: artificial intelligence and machine learning implementations. Pediatric Research, 1-6.
Bal Yılmaz, H., Gerçeker, G.Ö., Muslu, G.K. (2016). Evaluating the cancer related fatigue by children, mothers, and nurses in Turkish pediatric oncology patients. European Journal of Oncology Nursing, 23, 66-71.doi: 10.1016/j.ejon.2016.05.002
Beale, I.L., Bradlyn, A.S., Kato, P. M. (2003). Psychoeducational interventions with pediatric cancer patients: Part II. Effects of information and skills training on health-related outcomes. Journal of Child and Family Studies, 12(4), 385-397.doi:10.1023/A:1026007922274
Bleyer, W.A., Albritton, K.H., Ries, L.A.G., Barr, R. (2017). Introduction. In: Bleyer, A., Barr, R., Ries, L., Whelan, J., Ferrari, A. Cancer in Adolescents and Young Adults. Second Edition. Springer International Publishing: USA. pp. 1-23.
Blumenthal, D., Glaser, J.P. (2007). Information technology comes to medicine. N Engl. J Med. 356(24), 2527–2534.
Bomken, S.N., Vormoor, H.J. (2009). Childhood leukaemia. Paediatrics and Child Health, 19(8), 345-350.doi:10.1016/j.paed.2009.04.003
Bradford, N. (2017). Very early discharge compared with early or non-early discharge in children with cancer and febrile neutropenia: A Cochrane review summary. International journal of nursing studies, 67, 85-86.doi:10.1016/j.ijnurstu.2016.07.005
Bradlyn, A., Beale, I., Kato, P. (2003). Psychoeducational interventions with pediatric cancer patients: Part I. Patient information and knowledge. Journal of Child and Family Studies, 12, 257–277..doi:10.1023/A:1023983609702
Caggiano, V., Weiss, R.V., Rickert, T.S., Linde-Zwirble, W.T. (2005). Incidence, cost, and mortality of neutropenia hospitalization associated with chemotherapy. Cancer, 103(9), 1916-1924.doi:10.1002/cncr.20983
Cheng, K.K., Goggins, W.B., Lee, V.W., Thompson, D.R. (2008). Risk factors for oral mucositis in children undergoing chemotherapy: a matched case-control study. Oral oncology, 44(11), 1019-1025. doi:0.1016/j.oraloncology.2008.01.003
Choi, M., Kim, M.S., Park, S.Y., Park, G.H., Jo, S.J., Cho, K.H., Lee, J.W., Park, K.D., Shin, H.Y., Kang, H.J. and Kwon, O. (2014). Clinical characteristics of chemotherapy-induced alopecia in childhood. Journal of the American Academy of Dermatology, 70(3), 499-505.doi:10.1016/j.jaad.2013.10.034
Çavuşoğlu, H. (2013). Child health nursing. Volume 1. Ankara: Sistem Ofset.
da Cunha Batalha, L.M., Mota, A.A. (2013). Massage in children with cancer: effectiveness of a protocol. Jornal de pediatria, 89(6), 595-600.doi.org/10.1016/j.jped.2013.03.022
Dibble, S.L., Chapman, J., Mack, K.A., Shih, A.S. (2000). Acupressure for nausea: results of a pilot study. Oncology nursing forum 27(1), 41-47.
Dragone, M.A., Bush, P.J., Jones, J.K., Bearison, D.J., Kamani, S. (2002). Development and evaluation of an interactive CD-ROM for children with leukemia and their families. Patient education and counseling, 46(4), 297-307.doi:10.1016/S0738-3991(01)00166-5
Eilertsen, M.E.B., Jozefiak, T., Rannestad, T., Indredavik, M.S., Vik, T. (2012). Quality of life in children and adolescents surviving cancer. European Journal of Oncology Nursing, 16(2), 185-193.doi:10.1016/j.ejon.2011.08.001
Escalante, J., McQuade, R.M., Stojanovska, V., Nurgali, K. (2017). Impact of chemotherapy on gastrointestinal functions and the enteric nervous system. Maturitas, 105, 23-29.doi:10.1016/j.maturitas.2017.04.021
Franklin, V.L., Greene, A., Waller, A., Greene, S.A., Pagliari, C. (2008). Patients’ engagement with “Sweet Talk”–a text messaging support system for young people with diabetes. Journal of medical Internet research, 10(2), e20.doi:10.2196/jmir.962
Garcia, M.K., McQuade, J., Haddad, R., Patel, S., Lee, R., Yang, P., Palmer, J.L., Cohen, L. (2013). Systematic review of acupuncture in cancer care: a synthesis of the evidence. Journal of Clinical Oncology, 31(7), 952.
Gibson, R.J., Stringer, A.M. (2009). Chemotherapy-induced diarrhoea. Current Opinion in Supportive and Palliative Care, 3, 31–35. doi: 10.1200/JCO.2012.43.5818
Gordijn, M.S., van Litsenburg, R.R., Gemke, R.J., Huisman, J., Bierings, M.B., Hoogerbrugge, P.M., Kaspers, G.J. (2013). Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia. Pediatr. Blood Cancer, 60(3), 479-485.doi.org/10.1002/pbc.24261
Gordon, P., LeGrand, S. B., Walsh, D. (2014). Nausea and vomiting in advanced cancer. European journal of pharmacology, 722, 187-191. doi:10.1016/j.ejphar.2013.10.010
Govender, M., Bowen, R.C., German, M.L., Bulaj, G., Bruggers, C.S. (2015). Clinical and neurobiological perspectives of empowering pediatric cancer patients using videogames. Games for health journal, 4(5), 362-374. doi.org/10.1089/g4h.2015.0014
Griffiths, M. (2003). The therapeutic use of videogames in childhood and adolescence. Clinical child psychology and psychiatry, 8(4), 547-554.doi:10.1177/13591045030084012
Handel, M.J. (2011). mHealth (mobile health)—using apps for health and wellness. The Journal of Science and Healing, 7(4), 256-261. doi: 10.1016/j.explore.2011.04.011.
Harrison, S., Sinclair, R. (2003). Optimal management of hair loss (alopecia) in children. American journal of clinical dermatology, 4(11), 757-770. doi:10.2165/00128071-200304110-00004
Hendershot, E. (2009). Solid Tumors. In: Tomlinson, D., Kline, N. E. Pediatric oncology nursing. Springer: Germany. pp.60-99.
Hochstenbach, L.M., Zwakhalen, S.M., Courtens, A.M., van Kleef, M., de Witte, L.P. (2016). Feasibility of a mobile and web-based intervention to support self-management in outpatients with cancer pain. European Journal of Oncology Nursing, 23, 97-105. doi:10.1016/j.ejon.2016.03.009
International Incidence of Childhood Cancer, Volume III 2022. International Agency for Research on Cancer. World Health Organization. (30/11/2022 tarihinde https://iicc.iarc.fr/results/ adresinden ulaşılmıştır.
Ismail, A. (2016). The challenges of providing effective pain management for children in the pediatric intensive care unit. Pain Management Nursing, 17(6), 372-383. doi:10.1016/j.pmn.2016.08.005
Istepanian, R.S. (2014). M-health: A decade of evolution and impact on services and global health. British Journal of Healthcare Management, 20(7), 334-337. doi.org/10.12968/bjhc.2014.20.7.334
Javed, F., Utreja, A., Correa, F.O.B., Al-Askar, M., Hudieb, M., Qayyum, F., Al-Rasheed, A., Almas, K., Al-Hezaimi, K. (2012). Oral health status in children with acute lymphoblastic leukemia.Critical reviews in oncology/hematology,83(3),303-9.doi:10.1016/j.critrevonc.2011.11.003
Jones, J.K., Kamani, S.A., Bush, P.J., Hennessy, K.A., Marfatia, A., Shad, A.T. (2010). Development and evaluation of an educational interactive CD-ROM for teens with cancer. Pediatric blood & cancer, 55(3), 512-519. doi.org/10.1002/pbc.22608
Kaplow, R., Spinks, R. (2015). Neutropenia: A nursing perspective. Current problems in cancer, 39(5), 297-308. doi: 10.1016/j.currproblcancer.2015.07.009.
Kerimoğlu Yıldız, G., Yıldız, S. Sevgen, S. (2018). Kemoterapi Alan Çocuklar İçin Mobil Bir Oyun: Keto. 1.Uluslararası İnovatif Hemşirelik Kongresi Bildiri Kitabı. İstanbul.
Kennedy, R.M., Luhmann, J., Zempsky, W.T. (2008). Clinical implications of unmanaged needle-insertion pain and distress in children. Pediatrics, 122(Supplement 3), S130-S133.doi:10.1542/peds.2008-1055e
Klanjsek, P., Pajnkihar, M. (2016). Causes of inadequate intake of nutrients during the treatment of children with chemotherapy. European Journal of Oncology Nursing, 23, 24-33.doi:10.1016/j.ejon.2016.03.003
Klassen, A.F., Anthony, S.J., Khan, A., Sung, L., Klaassen, R. (2011). Identifying determinants of quality of life of children with cancer and childhood cancer survivors: a systematic review. Supportive Care in Cancer, 19(9), 1275-1287.doi:10.1007/s00520-011-1193-x
Klassen, A., Wickert, N., Tsangaris, E., Klaassen, R., Anthony, S. (2017). Health-Related Quality of Life. In: Bleyer, A., Barr, R., Ries, L., Whelan, J., Ferrari, A. Cancer in Adolescents and Young Adults. Second Edition. Springer International Publishing: USA. pp.735-747.
Kobya Bulut, H., Tüfekci, F.G. (2016). Honey prevents oral mocositis in children undergoing chemotherapy: A quasi-experimental study with a control group. Complementary therapies in medicine, 29, 132-140. doi:10.1016/j.ctim.2016.09.018
Koller, D., Goldman, R.D. (2012). Distraction techniques for children undergoing procedures: a critical review of pediatric research. Journal of pediatric nursing, 27(6), 652-681.doi:10.1016/j.pedn.2011.08.001
Koller, A., Miaskowski, C., De Geest, S., Opitz, O., Spichiger, E. (2012). A systematic evaluation of content, structure, and efficacy of interventions to improve patients' self-management of cancer pain. Journal of Pain and Symptom Management, 44, 264-284.doi:10.1016/j.jpainsymman.2011.08.015
Kornblith, A.B., Herndon, J.E., Weiss, R.B., Zhang, C., Zuckerman, E.L., Rosenberg, S., Mertz, M., Payne, D., Jane Massie, M., Holland, J.F., Wingate, P. (2003). Long‐term adjustment of survivors of early‐stage breast carcinoma, 20 years after adjuvant chemotherapy. Cancer: Interdisciplinary International Journal of the American Cancer Society, 98(4), 679-689.doi:10.1002/cncr.11531
Kottschade, L., Novotny, P., Lyss, A., Mazurczak, M., Loprinzi, C., Barton, D. (2016). Chemotherapy-induced nausea and vomiting: incidence and characteristics of persistent symptoms and future directions NCCTG N08C3 (Alliance). Supportive Care in Cancer, 24(6), 2661-2667.doi:10.1007/s00520-016-3080-y
Koukourikos, K., Tzeha, L., Pantelidou, P., Tsaloglidou, A. (2015). The importance of play during hospitalization of children. Materia socio-medica, 27(6), 438. doi: 10.5455/msm.2015.27.438-441
Lalla, R.V., Bowen, J., Barasch, A., Elting, L., Epstein, J., Keefe, D.M., McGuire, D.B., Migliorati, C., Nicolatou‐Galitis, O., Peterson, D.E., Raber‐Durlacher, J.E., Sonis, S.T., Elad, S. (2014). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer, 120(10), 1453-1461. doi:10.1002/cncr.28592
Lam, C.G., Howard SC, Bouffet E, Pritchard-Jones K. Science and health for all children with cancer. Science. 2019 Mar 15;363(6432):1182-1186. doi: 10.1126/science.aaw4892.
Lee, E.J., Frazier, S.K. (2011). The efficacy of acupressure for symptom management: a systematic review. Journal of pain and symptom management, 42(4), 589-603. doi:10.1016/j.jpainsymman.2011.01.007
Li, W.H., Chung, J.O., Ho, E.K. (2011). The effectiveness of therapeutic play, using virtual reality computer games, in promoting the psychological well-being of children hospitalised with cancer. Journal of Clinical Nursing, 20 (15-16), 2135-2143.doi:10.1111/j.1365-2702.2011.03733.x
Li, W.H., Lopez, V., Chung, O.J., Ho, K.Y., Chiu, S.Y. (2013). The impact of cancer on the physical, psychological and social well-being of childhood cancer survivors. European Journal of Oncology Nursing, 17(2), 214-219.doi:10.1016/j.ejon.2012.07.010
Lynn Woodgate, R., Faith Degner, L., Yanofsky, R. (2003). A Different Perspective to Approaching Cancer Symptoms in Children. Journal of Pain and Symptom Management, 26(3), 800-17.doi:10.1016/S0885-3924(03)00285-9
Matziou, V., Perdikaris, P., Feloni, D., Moshovi, M., Tsoumakas, K., Merkouris, A. (2008). Cancer in childhood: Children's and parents’ aspects for quality of life. European Journal of Oncology Nursing, 12(3), 209-216. doi:10.1016/j.ejon.2007.10.005
McCaffrey, C.N. (2006). Major stressors and their effects on the well-being of children with cancer. Journal of Pediatric Nursing, 21(1), 59-66.doi:10.1016/j.pedn.2005.07.003
McCulloch, R., Hemsley, J., Kelly, P. (2018). Symptom management during chemotherapy. Paediatrics and Child Health, 28(4), 189-195. doi:10.1016/j.paed.2013.10.007
McNaughton, D., Light, J. (2013). The iPad and mobile technology revolution: Benefits and challenges for individuals who require augmentative and alternative communication, Augmentative and alternative communication, 29(2), 107-116.doi:10.3109/07434618.2013.784930
Mihelic, R.A. (2005). Pharmacology of palliative medicine. Seminars in Oncology Nursing 21(1), 29-35.doi:10.1053/j.soncn.2004.10.005
Montazeri, A.S., Raei, M., Ghanbari, A., Dadgari, A., Montazeri, A.S., Hamidzadeh, A. (2013). Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients. Iranian Red Crescent medical journal, 15(2), 101-106. doi:10.5812/ircmj.4392
Murphy, A.J., White, M., Viani, K., Mosby, T.T. (2016). Evaluation of the nutrition screening tool for childhood cancer (SCAN). Clinical nutrition, 35(1), 219-224.doi:10.1016/j.clnu.2015.02.009
Peterson, D.E., Boers-Doets, C.B., Bensadoun, R.J., Herrstedt, J. (2015). Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up. Annals of oncology, 26(suppl_5), 139-151.doi:10.1093/annonc/mdv202
Peterson, A.M., Harper, F.W., Albrecht, T.L., Taub, J.W., Orom, H., Phipps, S., Penner, L.A. (2014). Parent caregiver self-efficacy and child reactions to pediatric cancer treatment procedures. Journal of Pediatric Oncology Nursing, 31(1), 18-27.doi:10.1177/1043454213514
Potasz, C., Varela, M. J.V.D., Carvalho, L.C.D., Prado, L.F.D., Prado, G.F.D. (2013). Effect of play activities on hospitalized children's stress: a randomized clinical trial. Scandinavian journal of occupational therapy, 20(1), 71-79.doi:10.3109/11038128.2012.729087
Raber-Durlacher, J.E., Elad, S., Barasch, A. (2010). Oral mucositis. Oral oncology, 46(6), 452-456.doi:10.1016/j.oraloncology.2010.03.012
Ravens-Sieberer, U., Bullinger, M. (2000). KINDL-R. Questionnaire for measuring health-related quality of life in children and adolescents, revised version. Manual. Erişim adresi: https://www. kindl. org/english/manual/[Links].
Robinson, D.L., Loman, D.G., Balakas, K., Flowers, M. (2012). Nutrition screening and early intervention in children, adolescents, and young adults with cancer. Journal of Pediatric Oncology Nursing 29 (6), 346-355.doi:10.1177/104345421246
Ruland, C.M., Hamilton, G.A., Schjødt-Osmo, B. (2009). The Complexity of Symptoms and Problems Experienced in Children with Cancer: A Review of the Literature. Journal of Pain and Symptom Management, 37(3), 403-18.doi:10.1016/j.jpainsymman.2008.03.009
Ruland, C.M., Starren, J., Vatne, T.M. (2008). Participatory design with children in the development of a support system for patient-centered care in pediatric oncology. J Biomed Inform, 41(4), 624-635.doi:10.1016/j.jbi.2007.10.004
Russell, K.M., Hudson, M., Long, A., Phipps, S. (2006). Assessment of health‐related quality of life in children with cancer: consistency and agreement between parent and child reports. Cancer, 106(10), 2267-2274.doi:10.1002/cncr.21871
Schlesinger, A., Paul, M., Gafter-Gvili, A., Rubinovitch, B., Leibovici, L. (2009). Infection-control interventions for cancer patients after chemotherapy: a systematic review and meta-analysis. The Lancet Infectious Diseases, 9(2), 97-107.doi:10.1016/S1473-3099(08)70284-6
Selwood, K., Ward, E., Gibson, F. (2010). Assessment and management of nutritional challenges in children’s cancer care: a survey of current practice in the United Kingdom. European Journal of Oncology Nursing, 14(5), 439-446. doi:10.1016/j.ejon.2010.04.004
Simons, J. (2015). A proposed model of the effective management of children's pain. Pain Management Nursing, 16(4), 570-578.doi:10.1016/j.pmn.2014.10.008
Spapen, H., Diltoer, M., Van Malderen, C., Opdenacker, G., Suys, E., Huyghens, L. (2001). Soluble fiber reduces the incidence of diarrhea in septic patients receiving total enteral nutrition: a prospective, double-blind, randomized, and controlled trial. Clinical Nutrition, 20(4), 301-305.doi:10.1054/clnu.2001.0399
So, W.K., Chan, D.N., Chan, H.Y., Krishnasamy, M., Chan, T., Ling, W.M., Lo, J.C., Aranda, S. (2013). Knowledge and practice among Hong Kong oncology nurses in the management of chemotherapy-induced nausea and vomiting. European Journal of Oncology Nursing, 17(3), 370-374.doi:10.1016/j.ejon.2012.10.001
Sonis, S.T. (2010). New thoughts on the initiation of mucositis. Oral diseases, 16(7), 597-600. doi:10.1111/j.1601-0825.2010.01681.x
Stern, J., Ippoliti, C. (2003). Management of acute cancer treatment-induced diarrhea. Seminars in oncology nursing, 19, 11-16.doi:10.1053/j.soncn.2003.09.009
Steliarova-Foucher E, Colombet M, Ries LAG, et al. International incidence of childhood cancer, 2001-10: a population-based registry study. Lancet Oncol. 2017;18(6):719-731. doi:10.1016/S1470-2045(17)30186-9
Taddio, A., Appleton, M., Bortolussi, R., Chambers, C., Dubey, V., Halperin, S., Hanrahan, A., Ipp, M., Lockett, D., MacDonald, N. and Midmer, D. (2010). Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline. Canadian Medical Association Journal, 182(18), E843-E855.doi:10.1503/cmaj.101720
Taspinar, A., Sirin, A. (2010). Effect of acupressure on chemotherapy-induced nausea and vomiting in gynecologic cancer patients in Turkey. European Journal of Oncology Nursing 14 (1), 49-54.doi:10.1016/j.ejon.2009.07.006
Vogels, T. G. C., Koopman, H. M., Verrips, G. H. W., Zwinderman, K. A. H., Verloove-Vanhorick, S. P., & Wit, J. M. (1998). The proxy problem: child report versus parent report in health-related quality of life research. Quality of Life Research, 7(5), 387-397.doi:10.1023/A:1008801802877
Twycross, R., Sykes, N., Mihalyo, M., Wilcock, A. (2012). Stimulant laxatives and opioid-induced constipation. Journal of pain and symptom management, 43(2), 306-313. doi:10.1016/j.jpainsymman.2011.12.002
UICC. Union for International Cancer Control 2015. Childhood cancer. (19.06.2016 tarihinde http://www.uicc.org/programmes/childhood-cancer adresinden ulaşılmıştır.)
United States Department of Health and Human Services. (2009). Common terminology criteria for adverse events (CTCAE) version 4.0. National Institutes of Health, National Cancer Institute, 4(03).
Van den Hurk, C.J.G., Van den Akker-van Marle, M.E., Breed, W.P.M., Van de Poll-Franse, L.V., Nortier, J.W.R., Coebergh, J.W.W. (2013). Impact of scalp cooling on chemotherapy-induced alopecia, wig use and hair growth of patients with cancer. European Journal of Oncology Nursing, 17(5), 536-540. doi:10.1016/j.ejon.2013.02.004
Varni, J.W., Burwinkle, T.M., Katz, E.R., Meeske, K., Dickinson, P. (2002). The PedsQL™ in pediatric cancer: reliability and validity of the pediatric quality of life inventory™ generic core scales, multidimensional fatigue scale, and cancer module. Cancer, 94(7), 2090-2106. doi:10.1002/cncr.10428
Varni, J.W., Katz, E.R., Seid, M., Quiggins, D.J., Friedman-Bender, A., Castro, C.M. (1998). The Pediatric Cancer Quality of Life Inventory (PCQL). I. Instrument development, descriptive statistics, and cross-informant variance. Journal of behavioral medicine, 21(2), 179-204. doi:10.1023/A:1018779908502
Varni, J.W., Seid, M., Rode, C.A. (1999). The PedsQL™: measurement model for the pediatric quality of life inventory. Medical care, 37, 126-139.
Viele, C.S. (2003). Overview of chemotherapy-induced diarrhea. Seminars in Oncology Nursing, 19, 2-5.doi:10.1053/j.soncn.2003.09.007
Ward-Smith, P., Hamlin, J., Bartholomew, J., Stegenga, K. (2007). Quality of life among adolescents with cancer. Journal of Pediatric Oncology Nursing, 24(3), 166-171. doi:10.1177/1043454207299
Wheeler, D.S., Giaccone, M.J., Hutchinson, N., Haygood, M., Bondurant, P., Demmel, K., Kotagal, U.R., Connelly, B., Corcoran, M.S., Line, K., Rich, K. (2011). A hospital-wide quality-improvement collaborative to reduce catheter-associated bloodstream infections. Pediatrics, 128(4), 995-1007.doi:10.1542/peds.2010-2601
WHO. World Health Organization global initiative for childhood cancer: increasing access, advancing quality, saving lives 2021. (26/11/2022 tarihinde https://apps.who.int/iris/handle/10665/347370 adresinden ulaşılmıştır).
Williams, A.M., Estrada, C., Gary-Bryan, H., MacKeil-White, K. (2012). The Hematology and Oncology Pediatric Patient: A Review of Fever and Neutropenia, Blood Transfusions, and Other Complex Problems. Clinical Pediatric Emergency Medicine, 13(2), 91-98.doi:10.1016/j.cpem.2012.04.006
Wolfe, J., Orellana, L., Ullrich, C., Cook, E.F., Kang, T.I., Rosenberg, A., Geyer, R., Feudtner, C. and Dussel, V. (2015). Symptoms and distress in children with advanced Cancer: prospective patientreported outcomes from the pedi QUEST study. Journal of Clinical Oncology, 33(17), 1928-1935. doi: 10.1200/JCO.2014.59.1222
Wool, M.S., Mor, V. (2005). A multidimensional model for understanding cancer pain. Cancer investigation, 23(8), 727-734. doi:10.1080/07357900500360032
Yeh, C.H., Chao, K.Y., Hung, L.C. (2004). The quality of life for cancer children (QOLCC) in Taiwan (part I): reliability and construct validity by confirmatory factor analysis. Psycho-Oncology: Journal of the Psychological, Social and Behavioral Dimensions of Cancer, 13(3), 161-170. doi:10.1002/pon.728
Zupanec, S., Tomlinson, D. (2009). Leukemia. In: Tomlinson, D., Kline, N. E. Pediatric oncology nursing. Springer: Germany. pp.2-29