Effects of Electromagnetic Fields on Human Health
Özet
This chapter comprehensive reviews the biological and environmental impacts of non-ionizing electromagnetic fields (EMF), emphasizing the ongoing debate regarding their long-term health risks. As modern technologies like 5G and 6G rapidly expand, global population exposure begins as early as infancy, eliminating traditional control groups for epidemiological studies. The International Agency for Research on Cancer classified radiofrequency radiation as a Group 2B possible carcinogen, noting its potential link to malignancies. On a cellular level, EMF exposure is shown to induce oxidative stress by increasing reactive oxygen species (ROS), which can lead to single- and double-stranded DNA breaks, cellular damage, and decreased fertility. Specifically, prolonged exposure is associated with health anomalies such as electromagnetic hypersensitivity (EHS)—characterized by headaches, fatigue, and cognitive changes—along side potential risks for salivary gland tumors, lymphoma, and impaired ovarian reserves. However, the author notes a dual nature to EMF, akin to Yin and Yang philosophy; it also demonstrates therapeutic potential, including accelerating wound healing, promoting osteoblast formation, and mitigating neurological pathologies like Parkinson’s and Alzheimer’s diseases. Ultimately, because total avoidance is impossible in a highly connected world, the literature emphasizes public awareness and minimizing exposure times as primary precautionary measures.
Referanslar
FCC. Evaluating compliance with FCC guidelines for human exposure to radiofrequency electromagnetic fields. OET bulletin. 1997; 65(10).
ICNIRP. Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz). Health physics. 1998;74(4):494-521.
IEEE. Synopsis of IEEE Std C95. 1™-2019 “IEEE Standard for Safety Levels With Respect to Human Exposure to Electric, Magnetic, and Electromagnetic Fields, 0 Hz to 300 GHz”. IEEE Access. 2019; 7:171346-171356.
Canada H. Limits of Human Exposure to Radiofrequency Electromagnetic Energy in the Frequency Range from 3 khz to 300 ghz. Health Canada, 2015.
ICNIRP. Guidelines for Limiting Exposure to Electromagnetic Fields (100 kHz to 300 GHz). Health Physics. 2020;118(5):483-524.
Belyaev IY. Dependence of non-thermal biological effects of microwaves on physical and biological variables: implications for reproducibility and safety standards. 2010.
IARC. I.A.f.R.o.C., IARC Classiifies Radiofrequency Electromagnetic Fields As Possibly Carcinogenic To Humans. Lyon, France. 2011;1-6.
ITU. International Telecommunication Union. ICT Statistics. . 2022 (cited 2022 14 July); Available from: https://www.itu.int/en/ITU-D/Statistics/Pages/stat/default.aspx.
Sagar S, Adem SM, Struchen B, et al. Comparison of radiofrequency electromagnetic field exposure levels in different everyday microenvironments in an international context. Environment International. 2018;114:297-306.
Wikipedia. Electromagnetic spectrum. 2022 (cited 2022 31 Aug 2022); Available from: https://commons.wikimedia.org/wiki/File:Electromagnetic-Spectrum.png.
Saliev T, Begimbetova D, Masoud A-R, et al. Biological effects of non-ionizing electromagnetic fields: Two sides of a coin. Progress in Biophysics and Molecular Biology. 2019;141:25-36.
Verbeek J, Oftedal G, Feychting M, et al. Prioritizing health outcomes when assessing the effects of exposure to radiofrequency electromagnetic fields: A survey among experts. Environment International. 2021;146:106300.
Moon JH. Health effects of electromagnetic fields on children. Clinical and Experimental Pediatrics. 2020;63(11):422-428.
Poljsak B, Šuput D, Milisav I. Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxidative Medicine and Cellular Longevity. 2013;956792.
Schuermann D, Mevissen M. Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health. International Journal of Molecular Sciences. 2021;22(7):3772.
Henschenmacher B, Bitsch A, de Las Heras Gala T, et al. The effect of radiofrequency electromagnetic fields (RF-EMF) on biomarkers of oxidative stress in vivo and in vitro: A protocol for a systematic review. Environment International. 2022;158:106932.
Forman HJ, Zhang H. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nature Reviews Drug Discovery, 2021. 20(9): p. 689-709.
Sharifi-Rad M, Anil Kumar NV, Zucca P, et al. Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. Frontiers in Physiology. 2020;11.
Alkis ME, Bilgin HM, Akpolat V, et al. Effect of 900-, 1800-, and 2100-MHz radiofrequency radiation on DNA and oxidative stress in brain. Electromagnetic Biology and Medicine. 2019;38(1):32-47.
Kesari KK, Behari J. Evidence for mobile phone radiation exposure effects on reproductive pattern of male rats: role of ROS. Electromagnetic Biology and Medicine, 2012. 31(3): p. 213-22.
Smith-Roe SL, Wyde ME, Stout MD, et al. Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure. Environmental and Molecular Mutagenesis. 2020;61(2):276-90.
Repacholi MH, Basten A, Gebski V, et al. Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ electromagnetic fields. Radiation Research. 1997;147(5):631-40.
de Siqueira EC, de Souza FTA, Gomez RS, et al. Does cell phone use increase the chances of parotid gland tumor development? A systematic review and meta-analysis. Journal of Oral Pathology & Medicine. 2017;46(7):480-483.
Al-Qahtani, K. Mobile Phone Use and the Risk of Parotid Gland Tumors: A Retrospective Case-Control Study. Gulf Journal of Oncology. 2016;1(20):71-8.
Momoli F, Siemiatycki J, McBride ML,et al. Probabilistic Multiple-Bias Modeling Applied to the Canadian Data From the Interphone Study of Mobile Phone Use and Risk of Glioma, Meningioma, Acoustic Neuroma, and Parotid Gland Tumors. American Journal of Epidemiology. 2017;186(7):885-893.
Ahmadi SS, Khaki AA, Ainehchi N, et al. Effect of non-ionizing electromagnetic field on the alteration of ovarian follicles in rats. Electron Physician. 2016;8(3):2168-74.
Elsawy N, Elkholy S, Azmy R, et al. Electrophysiological Assessment of the Impact of Mobile Phone Radiation on Cognition in Persons With Epilepsy. Journal of Clinical Neurophysiology. 2019;36(2):112-118.
Hardell, L, Koppel T. Electromagnetic hypersensitivity close to mobile phone base stations - a case study in Stockholm, Sweden. Rev Environmental Health, 2022.
Gruber MJ, Palmquist E, Nordin S. Characteristics of perceived electromagnetic hypersensitivity in the general population. Scandinavian Journal of Psychology. 2018;59(4):422-427.
Kesari KK, Kumar S, Nirala J, et al. Biophysical Evaluation of Radiofrequency Electromagnetic Field Effects on Male Reproductive Pattern. Cell Biochemistry and Biophysics. 2013;65(2):85-96.
Capelli E, Torrisi F, Venturini L, et al. Low-Frequency Pulsed Electromagnetic Field Is Able to Modulate miRNAs in an Experimental Cell Model of Alzheimer’s Disease. Journal of Healthcare Engineering. 2017;2530270.
Morberg BM, Malling AS, Jensen BR, et al. Parkinson's disease and transcranial pulsed electromagnetic fields: A randomized clinical trial. Movement Disorders. 2017;32(4):625-626.
Tatarov I, Panda A, Petkov D, et al. Effect of magnetic fields on tumor growth and viability. Comparative Medicine. 2011;61(4):339-345.
De Carlo, F, Ledda, M, Pozzi, D, et al. Nonionizing Radiation as a Noninvasive Strategy in Regenerative Medicine: The Effect of Ca2+-ICR on Mouse Skeletal Muscle Cell Growth and Differentiation. Tissue Engineering Part A. 2012;18(21-22):2248-2258.
Callaghan MJ, Chang EI, Seiser N, et al. Pulsed Electromagnetic Fields Accelerate Normal and Diabetic Wound Healing by Increasing Endogenous FGF-2 Release. Plastic and Reconstructive Surgery. 2008;121(1):130-141.
Wang J, An Y, Li F, et al. The effects of pulsed electromagnetic field on the functions of osteoblasts on implant surfaces with different topographies. Acta Biomaterialia. 2014;10(2):975-985.
Kucukbagriacik Y, Dastouri M. Mechanisms of Formation of Adaptation, in Reviews in Medical and Health Science Methodology, Research and Practice. Livre de Lyon: Lyon. 2022;220.
Sannino A, Sarti M, Reddy SB, et al. Induction of adaptive response in human blood lymphocytes exposed to radiofrequency radiation. Journal of Radiation Research. 2009;171(6):735-42.
