New Treatment Methods For Anal Fistules: Can a Forward - Looking Standard Algorithm Occur?

Yazarlar

Hakan Demir

Özet

Anal fistulas are challenging diseases that have been struggled with since ancient medical eras, and their ideal treatment is based on the principles of sepsis control, fistula closure, and maintaining continence. Perianal fistulas are categorized into two main groups as simple and complex according to the American Gastroenterological Association classification to facilitate operative decision-making. Simple fistulas, including subcutaneous, intersphincteric, or low transsphincteric fistulas, involve very little of the sphincter muscle complex and can be easily treated with high success rates and low incontinence risk using methods such as fistulotomy or marsupialization. Conversely, complex fistulas like high transsphincteric, suprasphincteric, and extrasphincteric fistulas involve a significant portion of the sphincter musculature, carry a higher risk of incontinence, and require staged treatments, seton placement, or modern sphincter-sparing techniques. Current management options include fistulectomy providing surgical excision, seton placement inducing fibrosis, sphincter-sparing LIFT, video-assisted anal fistula treatment (VAAFT), FiLAC utilizing a radial laser probe, endoanal advancement flap, anal fistula plug, and fibrin glue injection. In Crohn's patients, a combination of medical anti-TNF therapy and surgical loose seton is the primary approach. Consequently, while surgical preferences vary across centers, the new guideline algorithm proposed by Garg in 2021, which divides fistulas into five categories, stands out as the most up-to-date, standard, and appropriate treatment protocol.

Referanslar

Sandborn WJ, Fazio VW, Feagan BG, Hanauer SB; American Gastroenterological Association Clinical Practice Committee. AGA technical review on perianal Crohn's disease. Gastroenterology. 2003 Nov;125(5):1508-30. doi: 10.1016/j.gastro.2003.08.025. PMID: 14598268.

Garg P. Anal fistula associated with anal fissure. Tech Coloproctol. 2020 Jul;24(7):785. doi: 10.1007/s10151-020-02253-2. Epub 2020 May 31. PMID: 32476079.

Rizzo JA, Naig AL, Johnson EK. Anorectal abscess and fistula-in-ano: evidence-based management. Surg Clin North Am. 2010;90:45–68, Table of Contents.

Malik AI, Nelson RL. Surgical management of anal fistulae: a systematic review. Colorectal Dis. 2008 Jun;10(5):420-30. doi: 10.1111/j.1463-1318.2008.01483.x. PMID: 18479308.

Mizrahi N, Wexner SD, Zmora O, Da Silva G, Efron J, Weiss EG, Vernava AM 3rd, Nogueras JJ. Endorectal advancement flap: are there predictors of failure? Dis Colon Rectum. 2002 Dec;45(12):1616-21. doi: 10.1097/01.DCR.0000037654.01119.CD. PMID: 12473884.

Jimenez M, Mandava N. Anorectal Fistula. 2021 Sep 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 32809492.

Williams G, Williams A, Tozer P, Phillips R, Ahmad A, Jayne D, Maxwell-Armstrong C. The treatment of anal fistula: second ACPGBI Position Statement - 2018. Colorectal Dis. 2018 Jul;20 Suppl 3:5-31. doi: 10.1111/codi.14054. PMID: 30178915.

Wang Q, He Y, Shen J. The best surgical strategy for anal fistula based on a network meta-analysis. Oncotarget. 2017 Oct 12;8(58):99075-99084. doi: 10.18632/oncotarget.21836. PMID: 29228753; PMCID: PMC5716793

Bhatt Y, Fatima S, Shaikh GS, Shaikh S. Fistulotomy versus fistulectomy in the treatment of low fistula in ano. Rawal Medical Journal. 2011;36:284–286. [Google Scholar]

Practice parameters for treatment of fistula-in-ano--supporting documentation. The Standards Practice Task Force. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum. 1996;39:1361–1372. [PubMed

Malik AI, Nelson RL. Surgical management of anal fistulae: a systematic review. Colorectal Dis. 2008;10:420–430. [PubMed] [Google

Göttgens KW, Janssen PT, Heemskerk J, van Dielen FM, Konsten JL, Lettinga T, Hoofwijk AG, Belgers HJ, Stassen LP, Breukink SO. Long-term outcome of low perianal fistulas treated by fistulotomy: a multicenter study. Int J Colorectal Dis. 2015;30:213–219. [PubMed] [Google Scholar]

Schouten WR, van Vroonhoven TJ. Treatment of anorectal abscess with or without primary fistulectomy. Results of a prospective randomized trial. Dis Colon Rectum. 1991;34:60–63. [PubMed] [Google Scholar]

Garcia-Aguilar J, Belmonte C, Wong WD, Goldberg SM, Madoff RD. Anal fistula surgery. Factors associated with recurrence and incontinence. Dis Colon Rectum. 1996;39:723–729. [PubMed] [Google Scholar]

Steele SR, Kumar R, Feingold DL, Rafferty JL, Buie WD. Standards Practice Task Force of the American Society of Colon and Rectal Surgeons. Practice parameters for the management of perianal abscess and fistula-in-ano. Dis Colon Rectum. 2011;54:1465–74. [PubMed] [Google Scholar]

Corman ML, Bergamaschi RC, Nicholls RJ, Fazio VW. 6th ed. New York: Lippincott Williams and Wilkins; 2013. Corman's Colon and Rectal Surgery. [Google Scholar]

Izadpanah A, Rezazadehkermani M, Hosseiniasl SM, Farghadin A, Ghahramani L, Bananzadeh A, Roshanravan R, Izadpanah A. Pulling Seton: Combination of mechanisms. Adv Biomed Res. 2016 Apr 19;5:68. doi: 10.4103/2277-9175.180637. PMID: 27169099; PMCID: PMC4854033.

Michalopoulos A, Papadopoulos V, Tziris N, Apostolidis S. Perianal fistulas. Tech Coloproctol. 2010;14(Suppl 1):S15–7. [PubMed] [Google Scholar

Subhas G, Gupta A, Balaraman S, Mittal VK, Pearlman R. Non-cutting setons for progressive migration of complex fistula tracts: A new spin on an old technique. Int J Colorectal Dis. 2011;26:793–8. [PubMed] [Google Scholar

Cariati A. Fistulotomy or seton in anal fistula: A decisional algorithm. Updates Surg. 2013;65:201–5. [PubMed] [Google Scholar]

Rojanasakul A, Pattanaarun J, Sahakitrungruang C, Tantiphlachiva K. Total anal sphincter saving technique for fistula-in-ano; the ligation of intersphincteric fistula tract. J Med Assoc Thai. 2007 Mar;90(3):581-6. [PubMed]

Kang WH, Yang HK, Chang HJ, Ko YT, Yoo BE, Lim CH, Hwang JK, Lee YC, Shin HK, Son HJ. High ligation of the anal fistula tract by lateral approach: A prospective cohort study on a modification of the ligation of the intersphincteric fistula tract (LIFT) technique. Int J Surg. 2018 Dec;60:9-14.

Osterkamp J, Gocht-Jensen P, Hougaard K, Nordentoft T. Long-term outcomes in patients after ligation of the intersphincteric fistula tract. Dan Med J. 2019 Apr;66(4) [PubMed]

Vergara-Fernandez O, Espino-Urbina LA. Ligation of intersphincteric fistula tract: what is the evidence in a review? World J Gastroenterol. 2013 Oct 28;19(40):6805-13. [PMC free article] [PubMed]

Meinero P, Mori L. Video-assisted anal fistula treatment (VAAFT): a novel sphincter-saving procedure for treating complex anal fistulas. Tech Coloproctol. 2011;15(4):417–422. [PMC free article] [PubMed]

Kochhar G, Saha S, Andley M, Kumar A, Saurabh G, Pusuluri R, Bhise V, Kumar A. Video-assisted anal fistula treatment. JSLS. 2014 Jul-Sep;18(3):e2014.00127. doi: 10.4293/JSLS.2014.00127. PMID: 25419106; PMCID: PMC4236078.

Wilhelm A. A new technique for sphincter-preserving anal fistula repair using a novel radial emitting laser probe. Tech Coloproctol. 2011;15:445–449. [PubMed] [Google Scholar]

Giamundo P, Geraci M, Tibaldi L, Valente M. Closure of fistula-in-ano with laser--FiLaC™: an effective novel sphincter-saving procedure for complex disease. Colorectal Dis. 2014;16:110–115. [PubMed] [Google Scholar]

Oztürk E, Gülcü B. Laser ablation of fistula tract: a sphincter-preserving method for treating fistula-in-ano. Dis Colon Rectum. 2014;57:360–364. [PubMed

Limura E, Giordano P. Modern management of anal fistula. World J Gastroenterol. 2015 Jan 7;21(1):12-20. doi: 10.3748/wjg.v21.i1.12. PMID: 25574077; PMCID: PMC4284327.

Ortíz H, Marzo J. Endorectal flap advancement repair and fistulectomy for high trans-sphincteric and suprasphincteric fistulas. Br J Surg. 2000;87:1680–1683. [PubMed] [Google Scholar]

Van der Hagen SJ, Baeten CG, Soeters PB, van Gemert WG. Long-term outcome following mucosal advancement flap for high perianal fistulas and fistulotomy for low perianal fistulas: recurrent perianal fistulas: failure of treatment or recurrent patient disease? Int J Colorectal Dis. 2006;21:784–790. [PubMed] [Google Scholar]

Bleier JI, Moloo H. Current management of cryptoglandular fistula-in-ano. World J Gastroenterol. 2011 Jul 28;17(28):3286-91. doi: 10.3748/wjg.v17.i28.3286. PMID: 21876615; PMCID: PMC3160531.

Johnson EK, Gaw JU, Armstrong DN. Efficacy of anal fistula plug vs. fibrin glue in closure of anorectal fistulas. Dis Colon Rectum. 2006;49:371–376. [PubMed] [Google Scholar]

Champagne BJ, O’Connor LM, Ferguson M, Orangio GR, Schertzer ME, Armstrong DN. Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up. Dis Colon Rectum. 2006;49:1817–1821. [PubMed] [Google Scholar]

Jacob TJ, Perakath B, Keighley MR. Surgical intervention for anorectal fistula. Cochrane Database Syst Rev. 2010:CD006319. [PubMed] [Google Scholar]

Buchanan GN, Bartram CI, Phillips RK, Gould SW, Halligan S, Rockall TA, Sibbons P, Cohen RG. Efficacy of fibrin sealant in the management of complex anal fistula: a prospective trial. Dis Colon Rectum. 2003;46:1167–1174. [PubMed] [Google Scholar]

Gisbertz SS, Sosef MN, Festen S, Gerhards MF. Treatment of fistulas in ano with fibrin glue. Dig Surg. 2005;22:91–94. [PubMed] [Google Scholar]

Lee MJ, Freer C, Adegbola S, Elkady S, Parkes M, Hart A, Fearnhead NS, Lobo AJ, Brown SR. Patients with perianal Crohn's fistulas experience delays in accessing anti-TNF therapy due to slow recognition, diagnosis and integration of specialist services: lessons learned from three referral centres. Colorectal Dis. 2018 Sep;20(9):797-803. [PubMed]

Strik AS, Löwenberg M, Buskens CJ, B Gecse K, I Ponsioen C, Bemelman WA, D'Haens GR. Higher anti-TNF serum levels are associated with perianal fistula closure in Crohn's disease patients. Scand J Gastroenterol. 2019 Apr;54(4):453-458. [PubMed]

Hukkinen M, Pakarinen MP, Piekkala M, Koivusalo A, Rintala R, Kolho KL. Treatment of complex perianal fistulas with seton and infliximab in adolescents with Crohn's disease. J Crohns Colitis. 2014 Aug;8(8):756-62. [PubMed]

Yarur AJ, Kanagala V, Stein DJ, Czul F, Quintero MA, Agrawal D, Patel A, Best K, Fox C, Idstein K, Abreu MT. Higher infliximab trough levels are associated with perianal fistula healing in patients with Crohn's disease. Aliment Pharmacol Ther. 2017 Apr;45(7):933-940. [PubMed]

Ratto C, Grossi U, Litta F, Di Tanna GL, Parello A, De Simone V, Tozer P, DE Zimmerman D, Maeda Y. Contemporary surgical practice in the management of anal fistula: results from an international survey. Tech Coloproctol. 2019 Aug;23(8):729-741. doi: 10.1007/s10151-019-02051-5. Epub 2019 Jul 31. PMID: 31368010; PMCID: PMC6736896.

Włodarczyk M, Włodarczyk J, Sobolewska-Włodarczyk A, Trzciński R, Dziki Ł, Fichna J. Current concepts in the pathogenesis of cryptoglandular perianal fistula. J Int Med Res. 2021 Feb;49(2):300060520986669. doi: 10.1177/0300060520986669. PMID: 33595349; PMCID: PMC7894698.

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51-62

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28 Mart 2022

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