Sistemik Hastalıklar, Kanser Tedavileri ve Fertilitenin Korunması

Yazarlar

Emel Kabartan
https://orcid.org/0000-0002-6289-2310

Referanslar

Eisenberg ML. Risks beyond reproduction for infertile men. Fertility and Sterility. 2016;105(2):300-301.

Behboudi-Gandevani S, Bidhendi-Yarandi R, Panahi MH, et al. A systematic review and meta-analysis of male infertility and the subsequent risk of cancer. Frontiers in Oncology. 2021;11:696702.

Marozzi J, Hanly M, Venetis C, et al. Male infertility and risk of cardiometabolic conditions: a population-based cohort study. Human Reproduction. 2026;41(1):93-107.

Karagiannis A, Harsoulis F. Gonadal dysfunction in systemic diseases. European Journal of Endocrinology. 2005;152(4):501-513.

Condorelli RA, La Vignera S, Mongioì LM, et al. Diabetes Mellitus and Infertility: Different Pathophysiological Effects in Type 1 and Type 2 on Sperm Function. Frontiers in Endocrinology. 2018;9:268.

Dena SM, Adeleye AO, Mohlala K, et al. The Impact of Diabetes Mellitus-Related Oxidative Stress on Male Fertility: A Review. Journal of Diabetes. 2025;17(10):e70157.

Minas A, Camargo M, Alves MG, et al. Effects of diabetes-induced hyperglycemia on epigenetic modifications and DNA packaging and methylation during spermatogenesis: a narrative review. Iranian Journal of Basic Medical Sciences. 2024.

He Z, Yin G, Li QQ, et al. Diabetes Mellitus Causes Male Reproductive Dysfunction: A Review of the Evidence and Mechanisms. In Vivo. 2021;35(5):2503-2511.

Agbaje IM, Rogers DA, McVicar CM, et al. Insulin dependant diabetes mellitus: implications for male reproductive function. Human Reproduction. 2007;22(7):1871-1877.

Mallidis C, Agbaje IM, Rogers DA, et al. Distribution of the receptor for advanced glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus. Human Reproduction. 2007;22(8):2169-2177.

Gregorič N, Sikonja J, Janez A, Jensterle M. Semaglutide improved sperm morphology in obese men with type 2 diabetes mellitus and functional hypogonadism. Diabetes, Obesity and Metabolism. 2025;27(2):519-528.

Corona G, Rastrelli G, Sparano C, et al. Emerging Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors on Male Sexual Hormones and Behaviors: Systematic Review and Meta-Analysis. Andrology. 2026.

Lundy SD, Vij SC. Male infertility in renal failure and transplantation. Translational Andrology and Urology. 2019;8(2):173-181.

Carrero JJ, Qureshi AR, Nakashima A, et al. Prevalence and clinical implications of testosterone deficiency in men with end-stage renal disease. Nephrology Dialysis Transplantation. 2010.

Isidori AM, Caprio M, Strollo F, et al. Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. The Journal of Clinical Endocrinology and Metabolism. 1999;84(10):3673-3680.

Edey MM. Male sexual dysfunction and chronic kidney disease. Frontiers in Medicine. 2017;4:32.

Nitsche R, Coelho JCU, Freitas ACT, et al. Testosterone changes in patients with liver cirrhosis before and after orthotopic liver transplantation and its correlation with MELD. Arquivos de Gastroenterologia. 2014;51(1):59-63.

Hammoud AO, Gibson M, Peterson CM, et al. Impact of male obesity on infertility: a critical review of the current literature. Fertility and Sterility. 2008;90(4):897-904.

Liu Y, Ding Z. Obesity, a serious etiologic factor for male subfertility in modern society. Reproduction. 2017;154(4):R123-R131.

Jensterle M, Podbregar A, Goricar K, Gregoric N, Janez A. Effects of liraglutide on obesity-associated functional hypogonadism in men. Endocrine Connections. 2019;8(3):195-202.

Leathersich S, Hart RJ. Immune infertility in men. Fertility and Sterility. 2022;117(6):1121-1131.

Su HI, Lacchetti C, Letourneau J, et al. Fertility Preservation in People with Cancer: ASCO Guideline Update. Journal of Clinical Oncology. 2025;43(12):1488-1515.

Brannigan RE, Hermanson L, Kaczmarek J, et al. Updates to Male Infertility: AUA/ASRM Guideline. The Journal of Urology. 2024;212(5):789-799.

Anelli V, Gatta E, Pirola I, et al. Thyroid impairment and male fertility: a narrative review of literature. The Aging Male. 2024;27(1):2310303.

Cai Z, Li H. Congenital Bilateral Absence of the Vas Deferens. Frontiers in Genetics. 2022;13:775123.

Greenberg DR, Gago LC, et al. The association of hypertension and antihypertensive medications on semen parameters among men presenting for fertility evaluation. Andrology. 2025;13(2):226-233.

Chada AR, Andre KE, Al-Shibli N, et al. Fertility considerations in individuals affected by human immunodeficiency virus: a scoping review. F&S Reviews. 2025;6(2):100095.

Himpe J, Lammerant S, Van den Bergh L, et al. The Impact of Systemic Oncological Treatments on the Fertility of Adolescents and Young Adults—A Systematic Review. Life. 2023;13(5):1209.

Mulder RL, Font-Gonzalez A, Green DM, et al. Fertility preservation for male patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group. The Lancet Oncology. 2021;22(2):e57-e67.

Appiah LC, et al. Reproductive late effects after hematopoietic stem cell transplant in pediatric, adolescent, and young adult cancer survivors. Pediatric Blood & Cancer. 2023.

Sriram S, Macedo T, Mavinkurve-Groothuis A, et al. Alkylating agents-induced gonadotoxicity in prepubertal males: Insights on the clinical and preclinical front. Clinical and Translational Science. 2024;17(7):e13866.

Sriram S, Macedo T, Mavinkurve-Groothuis A, et al. Non-alkylating agents-induced gonadotoxicity in pre-pubertal males: Insights on the clinical and pre-clinical front. Clinical and Translational Science. 2024;17(11):e70075.

Meistrich ML. Effects of chemotherapy and radiotherapy on spermatogenesis in humans. Fertility and Sterility. 2013;100(5):1180-1186.

Green DM, Nolan VG, Goodman PJ, et al. The cyclophosphamide equivalent dose as an approach for quantifying alkylating agent exposure: a report from the Childhood Cancer Survivor Study. Pediatric Blood & Cancer. 2014;61(1):53-67.

Duffin K, Mitchell RT, Brougham MF, et al. Impacts of cancer therapy on male fertility: past and present. Molecular Aspects of Medicine. 2024;100:101308.

Baliga S, et al. Testicular Dysfunction in Male Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review. International Journal of Radiation Oncology, Biology, Physics. 2023.

Caserta S, Cancemi G, Murdaca G, et al. The Effects of Cancer Immunotherapy on Fertility: Focus on Hematological Malignancies. Biomedicines. 2024;12(9):2106.

Nalavenkata S, Li C, Patel MI. Nerve-sparing technique in RPLND for testicular cancer. Current Opinion in Urology. 2023;33(4):281-287.

Picton HM, Wyns C, Anderson RA, et al. A European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys. Human Reproduction. 2015;30(11):2463-2475.

Rives N, Courbiere B, Almont T, et al. What should be done in terms of fertility preservation for patients with cancer? The French 2021 guidelines. European Journal of Cancer. 2022.

Moussaoui D, Surbone A, Adam C, et al. Testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys: A 6-year experience from a Swiss multi-center network. Frontiers in Pediatrics. 2022;10:909000.

European Society of Human Reproduction and Embryology (ESHRE). ESHRE good practice recommendations on fertility preservation involving testicular tissue cryopreservation in children receiving gonadotoxic therapies. Human Reproduction. 2025;40(8):1391.

Handelsman DJ, Peng S, Sikka S, et al. Effects of gonadotropin-releasing hormone analogs on cis-platinum-induced spermatogenic damage. International Journal of Andrology. 1988;11(5):425-435.

Bentsen L, et al. Navigating an uncertain future: a qualitative study exploring thoughts about fertility and oncofertility counseling among young men with cancer. Supportive Care in Cancer. 2024.

Creta M, Arcaniolo D, Celentano G, et al. Toxicity of Antioxidant Supplements in Patients with Male Factor Infertility: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Antioxidants. 2022;11(1):89.

Bouhadana D, Godin Pagé MH, Montjean D, et al. The Role of Antioxidants in Male Fertility: A Comprehensive Review of Mechanisms and Clinical Applications. Antioxidants. 2025;14(8):1013.

Lahimer M, Capelle S, Lefranc E, et al. Micronutrient-Antioxidant Therapy and Male Fertility Improvement During ART Cycles. Nutrients. 2025;17(2):324.

Salas-Huetos A, Rosique-Esteban N, Becerra-Tomás N, et al. The Effect of Nutrients and Dietary Supplements on Sperm Quality Parameters: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Advances in Nutrition. 2018;9(6):833-848.

Bakri S, Saleh R, Cayan S, et al. Efficacy and Safety of Coenzyme Q10 in Idiopathic Male Infertility: A Systematic Review and Meta-Analysis of Randomized Trials. The World Journal of Men's Health. 2025.

Sadeghzadeh Oskouei B, Rahimi P, Azimzadeh N, et al. Therapeutic efficacy of antioxidant supplementation containing selenium and vitamin E on male infertility: a systematic review and meta-analysis. Clinical Nutrition Open Science. 2026.

Çayan A. Antioxidants and Male Infertility: Interpreting Meta-Analytical Evidence to the Skeptics and Discerning Clinicians. Andrologia. 2025;2025:4666847.

de Ligny W, Smits RM, Mackenzie-Proctor R, et al. Antioxidants for male subfertility. Cochrane Database of Systematic Reviews. 2022;5(5):CD007411.

Omotoso DR, Iwasokun O, Olatomide OD, et al. Harnessing therapeutic potential of vitamins and microelements to mitigate testicular damage caused by drugs or chemical toxins – a review. European Journal of Clinical and Experimental Medicine. 2025;23(4):1047-1059.

Kabartan E, Cirrik S, Hacioglu G, et al. Therapeutic potential of alpha-pinene in methotrexate-induced testicular toxicity: focus on apoptosis, oxidative stress, and inflammatory pathways. Naunyn-Schmiedeberg's Archives of Pharmacology. 2026;399:495-505.

Michaelsen MP, Poulsen M, Bjerregaard AA, et al. The Effect of Dietary Supplements on Male Infertility in Terms of Pregnancy, Live Birth, and Sperm Parameters: A Systematic Review and Meta-Analysis. Nutrients. 2025;17(10):1710.

Turgut H. The effect of varicocelectomy on the pregnancy rate in patients with severe oligospermia. Nigerian Journal of Clinical Practice. 2020;23(12):1744-1747.

Yayınlanan

9 Kasım 2026

Lisans

Lisans