Hipofiz Adenomlarında Moleküler Patogenez ve Rna Temelli Düzenleme

Bonczar, M., Wysiadecki, G., Ostrowski, P., Michalczak, M., Plutecki, D., Wilk, J., ... & Żytkowski, A. (2023). The morphology of the pituitary gland: A meta-analysis with implications for diagnostic imaging. Brain Sciences, 13(1), 89.

Scott, I. S., Chattopadhyay, A., & Ansorge, O. (2024). Development and microscopic anatomy of the pituitary gland. Endotext [Internet].

De Bonis, P., Ghidoni, F., Tisato, V., Rimondi, E., Gafà, R., Picciocchi, M., ... & Madoglio, A. (2025). NOVA2 expression in pituitary gland and in functioning and non-functioning pituitary adenomas: a preliminary study. Acta Neurochirurgica, 167(1), 175.

Brady, K., Long, J. A., Liu, H. C., & Porter, T. E. (2021). Characterization of hypothalamo–pituitary–thyroid axis gene expression in the hypothalamus, pituitary gland, and ovarian follicles of turkey hens during the preovulatory surge and in hens with low and high egg production. Poultry science, 100(4), 100928.

Melmed, S., Kaiser, U. B., Lopes, M. B., Bertherat, J., Syro, L. V., Raverot, G., ... & Ho, K. K. (2022). Clinical biology of the pituitary adenoma. Endocrine reviews, 43(6), 1003-1037.

Petersenn, S., Fleseriu, M., Casanueva, F. F., Giustina, A., Biermasz, N., Biller, B. M., ... & Melmed, S. (2023). Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement. Nature Reviews Endocrinology, 19(12), 722-740.

Ilie, M. D., Vasiljevic, A., Bertolino, P., & Raverot, G. (2023). Biological and therapeutic implications of the tumor microenvironment in pituitary adenomas. Endocrine reviews, 44(2), 297-311.

Wan, X. Y., Chen, J., Wang, J. W., Liu, Y. C., Shu, K., & Lei, T. (2022). Overview of the 2022 WHO classification of pituitary adenomas/pituitary neuroendocrine tumors: clinical practices, controversies, and perspectives. Current Medical Science, 42(6), 1111-1118.

Castellanos, L. E., Gutierrez, C., Smith, T., Laws, E. R., & Iorgulescu, J. B. (2022). Epidemiology of common and uncommon adult pituitary tumors in the US according to the 2017 World Health Organization classification. Pituitary, 25(1), 201-209.

Graffeo, C. S., Yagnik, K. J., Carlstrom, L. P., Lakomkin, N., Bancos, I., Davidge-Pitts, C., ... & Van Gompel, J. J. (2022, October). Pituitary adenoma incidence, management trends, and long-term outcomes: a 30-year population-based analysis. In Mayo Clinic Proceedings (Vol. 97, No. 10, pp. 1861-1871). Elsevier.

Di Somma, C., Scarano, E., De Alteriis, G., Barrea, L., Riccio, E., Arianna, R., ... & Colao, A. (2021). Is there any gender difference in epidemiology, clinical presentation and co-morbidities of non-functioning pituitary adenomas? A prospective survey of a National Referral Center and review of the literature. Journal of Endocrinological Investigation, 44(5), 957-968.

Castellanos, L. E., Misra, M., Smith, T. R., Laws, E. R., & Iorgulescu, J. B. (2021). The epidemiology and management patterns of pediatric pituitary tumors in the United States. Pituitary, 24(3), 412-419.

Alabri, M. A. (2021). AACE2021-A-1063: Pituitary Adenoma: Epidemiology, Clinical, Biochemical, and Radiological Features. Endocrine Practice, 27(12), S19-S20.

Watanabe, G., Choi, S. Y., & Adamson, D. C. (2022). Pituitary incidentalomas in the United States: a national database estimate. World Neurosurgery, 158, e843-e855.

Ghaffari–Rafi, A., Mehdizadeh, R., Ghaffari-Rafi, S., Castillo Jr, J. A., Rodriguez-Beato, F. Y., & Leon-Rojas, J. (2022). Demographic and socioeconomic disparities of pituitary adenomas and carcinomas in the United States. Journal of Clinical Neuroscience, 98, 96-103.

Oh, J. S., Kim, H. J., Hann, H. J., Kang, T. U., Kim, D. S., Kang, M. J., ... & Ahn, H. S. (2021). Incidence, mortality, and cardiovascular diseases in pituitary adenoma in Korea: a nationwide population-based study. Pituitary, 24(1), 38-47.

Brosius, J., & Raabe, C. A. (2016). What is an RNA? A top layer for RNA classification. RNA biology, 13(2), 140-144.

Elliott, D., & Ladomery, M. (2011). Molecular biology of RNA. Oxford University Press, USA.

Wright, L. K., Fisk, J. N., & Newman, D. L. (2014). DNA→ RNA: What do students think the arrow means?. CBE—Life Sciences Education, 13(2), 338-348.

Robertson, M. P., & Joyce, G. F. (2012). The origins of the RNA world. Cold Spring Harbor perspectives in biology, 4(5), a003608.

Chen, X., & Lu, Y. (2021). Circular RNA: Biosynthesis in vitro. Frontiers in Bioengineering and Biotechnology, 9, 787881.

Hajjawi, O. S. (2015). Ribonucleic acid (RNA) biosynthesis in human cancer. Cancer cell international, 15(1), 22.

Yi, C., & Pan, T. (2011). Cellular dynamics of RNA modification. Accounts of chemical research, 44(12), 1380-1388.

Cieśla, J. (2006). Metabolic enzymes that bind RNA: yet another level of cellular regulatory network?. Acta Biochimica Polonica, 53(1), 11-32.

Lehman, N. (2010). RNA in evolution. Wiley Interdisciplinary Reviews: RNA, 1(2), 202-213.

Pyle, A. (2002). Metal ions in the structure and function of RNA. JBIC Journal of Biological Inorganic Chemistry, 7(7), 679-690.

Phua, K. K., Nair, S. K., & Leong, K. W. (2014). Messenger RNA (mRNA) nanoparticle tumour vaccination. Nanoscale, 6(14), 7715-7729.

Wu, Q., Huang, L., & Zhang, Y. (2009). The structure and function of catalytic RNAs. Science in China Series C: Life Sciences, 52(3), 232-244.

Hori, Y., Engel, C., & Kobayashi, T. (2023). Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes. Nature reviews Molecular cell biology, 24(6), 414-429.

Jansson, M. D., Häfner, S. J., Altinel, K., Tehler, D., Krogh, N., Jakobsen, E., ... & Lund, A. H. (2021). Regulation of translation by site-specific ribosomal RNA methylation. Nature structural & molecular biology, 28(11), 889-899.

Akiyama, Y., & Ivanov, P. (2023). tRNA‐derived RNAs: Biogenesis and roles in translational control. Wiley Interdisciplinary Reviews: RNA, 14(6), e1805.

Wang, F., Li, Y., Yuan, J., Li, C., Lin, Y., Gu, J., & Wang, Z. Y. (2024). The U1 small nuclear RNA enhances drought tolerance in Arabidopsis. Plant Physiology, 196(2), 1126-1146.

Shen, L. P., Zhang, W. C., Deng, J. R., Qi, Z. H., Lin, Z. W., & Wang, Z. D. (2024). Advances in the mechanism of small nucleolar RNA and its role in DNA damage response. Military Medical Research, 11(1), 53.

Boulias, K., & Greer, E. L. (2023). Biological roles of adenine methylation in RNA. Nature Reviews Genetics, 24(3), 143-160.

May, J. M., Bylicky, M., Chopra, S., Coleman, C. N., & Aryankalayil, M. J. (2021). Long and short non-coding RNA and radiation response: a review. Translational Research, 233, 162-179.

Smith, E. S., Whitty, E., Yoo, B., Moore, A., Sempere, L. F., & Medarova, Z. (2022). Clinical applications of short non-coding RNA-based therapies in the era of precision medicine. Cancers, 14(6), 1588.

Chen, L. L., & Kim, V. N. (2024). Small and long non-coding RNAs: Past, present, and future. Cell, 187(23), 6451-6485.

Koffler-Brill, T., Noy, Y., & Avraham, K. B. (2023). The long and short: Non-coding RNAs in the mammalian inner ear. Hearing research, 428, 108666.

Mattick, J. S., Amaral, P. P., Carninci, P., Carpenter, S., Chang, H. Y., Chen, L. L., ... & Wu, M. (2023). Long non-coding RNAs: definitions, functions, challenges and recommendations. Nature reviews Molecular cell biology, 24(6), 430-447.

Wang, W., Min, L., Qiu, X., Wu, X., Liu, C., Ma, J., ... & Zhu, L. (2021). Biological function of long non-coding RNA (LncRNA) Xist. Frontiers in cell and developmental biology, 9, 645647.

Ahmad, F., Sudesh, R., Ahmed, A. T., & Haque, S. (2024). Roles of HOTAIR long non-coding RNA in gliomas and other CNS disorders. Cellular and Molecular Neurobiology, 44(1), 23.

Ran, L., Pan, W., Feng, J., & Tang, L. (2025). Long non-coding RNA MALAT1: A crucial factor in fibrotic diseases. Molecular Therapy Nucleic Acids.

Chen, S., Liu, D., Zhou, Z., & Qin, S. (2021). Role of long non-coding RNA H19 in the development of osteoporosis. Molecular Medicine, 27(1), 122.

Grossi, I., Marchina, E., De Petro, G., & Salvi, A. (2023). The biological role and translational implications of the long non-coding RNA GAS5 in breast cancer. Cancers, 15(13), 3318.

Zhao, Y., Liu, Y., Zhang, Q., Liu, H., & Xu, J. (2023). The mechanism underlying the regulation of long non-coding RNA MEG3 in cerebral ischemic stroke. Cellular and molecular neurobiology, 43(1), 69-78.

Knutsen, E., Harris, A. L., & Perander, M. (2022). Expression and functions of long non-coding RNA NEAT1 and isoforms in breast cancer. British journal of cancer, 126(4), 551-561.

Yang, J., Qi, M., Fei, X., Wang, X., & Wang, K. (2021). Long non-coding RNA XIST: a novel oncogene in multiple cancers. Molecular Medicine, 27(1), 159.

Wang, L., & Xu, D. (2023). Regulation of long noncoding RNAs in the pathogenesis and clinical implications of pituitary adenomas. Immunity, Inflammation and Disease, 11(10), e1047.

Wu, W., Cao, L., Jia, Y., Xiao, Y., Zhang, X., & Gui, S. (2022). Emerging roles of miRNA, lncRNA, circRNA, and their cross-talk in pituitary adenoma. Cells, 11(18), 2920.

Bahreini, F., Jabbari, P., Gossing, W., Aziziyan, F., Frohme, M., & Rezaei, N. (2021). The role of noncoding RNAs in pituitary adenoma. Epigenomics, 13(17), 1421-1437.

Wang, L., & Xu, D. (2023). Regulation of long noncoding RNAs in the pathogenesis and clinical implications of pituitary adenomas. Immunity, Inflammation and Disease, 11(10), e1047.

Donati, S., Aurilia, C., Palmini, G., Miglietta, F., Falsetti, I., Iantomasi, T., & Brandi, M. L. (2021). Micrornas as potential biomarkers in pituitary adenomas. Non-coding RNA, 7(3), 55.

Zhang, Q., Wang, Y., Zhou, Y., Zhang, Q., & Xu, C. (2021). Potential biomarkers of miRNA in non-functional pituitary adenomas. World Journal of Surgical Oncology, 19(1), 270.

Bosna, I. C., Edgunlu, T., Akbaba, G., Yaylali, G. F., Celik, S. K., Etem, E. O., ... & Cinar, N. (2025). The clinical effects of miR-26a, miR-16, let-7, miR-128a and miR-223 in acromegaly. Irish Journal of Medical Science (1971-), 1-7.

Aboregela, A. M. (2025). Approaches based on natural products and miRNAs in pituitary adenomas: unveiling therapeutic intervention. Naunyn-Schmiedeberg's Archives of Pharmacology, 398(1), 69-88.

Xu, D., & Wang, L. (2022). The involvement of miRNAs in pituitary adenomas pathogenesis and the clinical implications. European Neurology, 85(3), 171-176.

Derwich-Rudowicz, A., Żbikowska, A., Ruchała, M., Andrusiewicz, M., Moskal, J., & Sawicka-Gutaj, N. (2025). MicroRNA Is Downregulated in Invasive Non-Functioning Pituitary Adenomas. International Journal of Molecular Sciences, 26(9), 4408.

Zhang, Q., Wang, Y., Zhou, Y., Zhang, Q., & Xu, C. (2021). Potential biomarkers of miRNA in non-functional pituitary adenomas. World Journal of Surgical Oncology, 19(1), 270.

Chang, M., Yang, C., Bao, X., & Wang, R. (2021). Genetic and epigenetic causes of pituitary adenomas. Frontiers in endocrinology, 11, 596554.

Shi, X., Tao, B., He, H., Sun, Q., Fan, C., Bian, L., ... & Lu, Y. C. (2012). MicroRNAs-based network: a novel therapeutic agent in pituitary adenoma. Medical hypotheses, 78(3), 380-384.

Cui, M., Zhang, M., Liu, H. F., & Wang, J. P. (2017). Effects of microRNA-21 targeting PITX2 on proliferation and apoptosis of pituitary tumor cells. European Review for Medical & Pharmacological Sciences, 21(13).

Yu, G., Wang, H., Yu, S., Li, C., Bai, J., Gui, S., ... & Zhao, P. (2017). Study on miRNAs’ expression for the invasion of pituitary adenomas. Turk Neurosurg, 28, 530-7.

Xu, D., & Wang, L. (2022). The involvement of miRNAs in pituitary adenomas pathogenesis and the clinical implications. European Neurology, 85(3), 171-176.

Garbicz, F., Mehlich, D., Rak, B., Sajjad, E., Maksymowicz, M., Paskal, W., ... & Włodarski, P. K. (2017). Increased expression of the microRNA 106b~ 25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crooke’s cell morphology. Pituitary, 20(4), 450-463.

Feng, Y., Mao, Z. G., Wang, X., Du, Q., Jian, M., Zhu, D., ... & Zhu, Y. H. (2018). MicroRNAs and target genes in pituitary adenomas. Hormone and Metabolic Research, 50(03), 179-192.

Li, X. H., Wang, E. L., Zhou, H. M., Yoshimoto, K., & Qian, Z. R. (2014). MicroRNAs in human pituitary adenomas. International Journal of Endocrinology, 2014(1), 435171.

Zhan, X., & Desiderio, D. M. (2010). Signaling pathway networks mined from human pituitary adenoma proteomics data. BMC Medical Genomics, 3(1), 13.

Zatelli, M. C. (2018). Pathogenesis of non-functioning pituitary adenomas. Pituitary, 21(2), 130-137.

Dworakowska, D., Wlodek, E., Leontiou, C. A., Igreja, S., Cakir, M., Teng, M., ... & Grossman, A. B. (2009). Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors. Endocrine-related cancer, 16(4), 1329-1338.

Butz, H., Likó, I., Czirják, S., Igaz, P., Korbonits, M., Rácz, K., & Patócs, A. (2011). MicroRNA profile indicates downregulation of the TGFβ pathway in sporadic non-functioning pituitary adenomas. Pituitary, 14(2), 112-124.

Saan, M. C. V. (2022). The role of the TGFβ signaling pathway in clinically non-functioning pituitary adenoma and the potential role of inhibitors of this pathway as a new target in pituitary tumor therapy (Doctoral dissertation, lmu).

Tang, J., Chen, L., Wang, Z., Huang, G., & Hu, X. (2019). SOX2 mediates crosstalk between Sonic Hedgehog and the Wnt/β-catenin signaling pathway to promote proliferation of pituitary adenoma cells. Oncology Letters, 18(1), 81-86.

Gueorguiev, M., & Grossman, A. B. (2009). Pituitary gland and β-catenin signaling: from ontogeny to oncogenesis. Pituitary, 12(3), 245-255.

Du, Q., Yao, D. S., Wang, Y. W., & Cheng, C. (2020). Research progress on lncRNA functions and mechanisms in pituitary adenomas. Hormone and Metabolic Research, 52(05), 280-288.

Beylerli, O., Gareev, I., Pavlov, V., Chen, X., & Zhao, S. (2020). The role of long noncoding RNAs in the biology of pituitary adenomas. World Neurosurgery, 137, 252-256.

Wang, L., & Xu, D. (2023). Regulation of long noncoding RNAs in the pathogenesis and clinical implications of pituitary adenomas. Immunity, Inflammation and Disease, 11(10), e1047.