Femoropopliteal Arter Darlık ve Kronik Oklüzyonlarının Endovasküler Tedavisi
Synopsis
Femoropopliteal arter hastalığı, alt ekstremite periferik arter hastalığının en sık karşılaşılan anatomik tutulum alanlarından biridir. Bu segmentin belirgin biyomekanik strese maruz kalması, uzun ve kalsifiye lezyonların sık görülmesi ve kronik total oklüzyonların varlığı endovasküler tedaviyi teknik açıdan güçleştirmektedir. Güncel tedavi yaklaşımı; lezyon anatomisi, kalsifikasyon yükü, klinik tablo ve hastanın cerrahi uygunluğu dikkate alınarak bireyselleştirilmektedir. Kronik total oklüzyonlarda intralüminal ve subintimal geçiş teknikleri, re-entry cihazları ve retrograd yaklaşımlar teknik başarıyı artırabilmektedir. Damar hazırlığında balon anjiyoplasti, aterektomi ve intravasküler litotripsi kullanılabilirken, definitif tedavide ilaç kaplı balonlar, ilaç salınımlı stentler, interwoven nitinol stentler ve stent-graftlar önemli seçeneklerdir. İntravasküler ultrason, özellikle kompleks lezyonlarda işlem optimizasyonuna katkı sağlayabilir. Kronik ekstremiteyi tehdit eden iskemide endovasküler ve cerrahi revaskülarizasyon seçimi hasta ve anatomiye göre yapılmalıdır. İşlem sonrası uygun antitrombotik tedavi ve uzun dönem takip, revaskülarizasyon başarısının sürdürülebilmesi açısından önem taşımaktadır.
References
Korosoglou G, Schmidt A, Lichtenberg M, Malyar N, Stavroulakis K, Reinecke H, et al. Global Algorithm for the Endovascular Treatment of Chronic Femoropopliteal Lesions: An Interdisciplinary Expert Opinion Statement. JACC: Cardiovascular Interventions. Elsevier Inc.; 2025. p. 545–57. doi:10.1016/j.jcin.2024.11.038 PubMed PMID: 40074516.
Nordanstig J, Behrendt CA, Baumgartner I, Belch J, Bäck M, Fitridge R, et al. Editor’s Choice – European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Asymptomatic Lower Limb Peripheral Arterial Disease and Intermittent Claudication. European Journal of Vascular and Endovascular Surgery. 2024 Jan 1;67(1):9–96. doi:10.1016/j.ejvs.2023.08.067 PubMed PMID: 37949800.
MacTaggart JN, Phillips NY, Lomneth CS, Pipinos II, Bowen R, Timothy Baxter B, et al. Three-dimensional bending, torsion and axial compression of the femoropopliteal artery during limb flexion. J Biomech. 2014 Jul 18;47(10):2249–56. doi:10.1016/j.jbiomech.2014.04.053 PubMed PMID: 24856888.
Tosaka A, Soga Y, Iida O, Ishihara T, Hirano K, Suzuki K, et al. Classification and clinical impact of restenosis after femoropopliteal stenting. J Am Coll Cardiol. 2012 Jan 3;59(1):16–23. doi:10.1016/j.jacc.2011.09.036 PubMed PMID: 22192663.
Garcia L, Jaff MR, Metzger C, Sedillo G, Pershad A, Zidar F, et al. Wire-Interwoven Nitinol Stent Outcome in the Superficial Femoral and Proximal Popliteal Arteries: Twelve-Month Results of the SUPERB Trial. Circ Cardiovasc Interv. 2015 May 20;8(5). doi:10.1161/CIRCINTERVENTIONS.113.000937 PubMed PMID: 25969545.
L Norgren, W R Hiatt, J A Dormandy, M R Nehler, K A Harris, F G R Fowkes. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J Vasc Surg. 2007 Jan;(45 Suppl):S:S5-S67. doi:10.1016/j.jvs.2006.12.037
Mills JL, Conte MS, Armstrong DG, Pomposelli FB, Schanzer A, Sidawy AN, et al. The society for vascular surgery lower extremity threatened limb classification system: Risk stratification based on Wound, Ischemia, and foot Infection (WIfI). J Vasc Surg. 2014;59(1). doi:10.1016/j.jvs.2013.08.003 PubMed PMID: 24126108.
Michael S Conte, Andrew W Bradbury, Philippe Kolh, John V White, Florian Dick, Robert Fitridge, et al. Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia. Eur J Vasc Endovasc Surg. 2019 Jul;58(1S):S1-S109.e33. doi:10.1016/j.ejvs.2019.05.006
Gornik HL, Aronow HD, Goodney PP, Arya S, Brewster LP, Byrd L, et al. 2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. Lippincott Williams and Wilkins; 2024. p. e1313–410. doi:10.1161/CIR.0000000000001251 PubMed PMID: 38743805.
Mazzolai L, Teixido-Tura G, Lanzi S, Boc V, Bossone E, Brodmann M, et al. 2024 ESC Guidelines for the management of peripheral arterial and aortic diseases : Developed by the task force on the management of peripheral arterial and aortic diseases of the European Society of Cardiology (ESC Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS, the European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN, and the European Society of Vascular Medicine (ESVM). Eur Heart J. 2024 Sep 21;45(36):3538–700. doi:10.1093/eurheartj/ehae179 PubMed PMID: 39210722.
Gandini R, Fabiano S, Spano S, Volpi T, Morosetti D, Chiaravalloti A, et al. Randomized control study of the outback LTD reentry catheter versus manual reentry for the treatment of chronic total occlusions in the superficial femoral artery. Catheterization and Cardiovascular Interventions. 2013 Sep 1;82(3):485–92. doi:10.1002/ccd.24742 PubMed PMID: 23152133.
Kokkinidis DG, Katsaros I, Jonnalagadda AK, Avner SJ, Chaitidis N, Bakoyiannis C, et al. Use, Safety and Effectiveness of Subintimal Angioplasty and Re-Entry Devices for the Treatment of Femoropopliteal Chronic Total Occlusions: A Systematic Review of 87 Studies and 4,665 Patients. Cardiovascular Revascularization Medicine. 2019 Jan 1;21(1):34–45. doi:10.1016/j.carrev.2019.03.016 PubMed PMID: 31054801.
Spinosa DJ, Harthun NL, Bissonette EA, Cage D, Leung DA, Angle JF, et al. Subintimal arterial flossing with antegrade-retrograde intervention (SAFARI) for subintimal recanalization to treat chronic critical limb ischemia. Journal of Vascular and Interventional Radiology. 2005;16(1):37–44. doi:10.1097/01.RVI.0000141336.53745.4A PubMed PMID: 15640408.
Dippel EJ, Makam P, Kovach R, George JC, Patlola R, Metzger DC, et al. Randomized Controlled Study of Excimer Laser Atherectomy for Treatment of Femoropopliteal In-Stent Restenosis Initial Results From the EXCITE ISR Trial (EXCImer Laser Randomized Controlled Study for Treatment of FemoropopliTEal In-Stent Restenosis). JACC Cardiovasc Interv [Internet]. 2015. Available from: www.clinicaltrials.gov
Tepe G, Brodmann M, Bachinsky W, Holden A, Zeller T, Mangalmurti S, et al. Intravascular Lithotripsy for Peripheral Artery Calcification: Mid-term Outcomes From the Randomized Disrupt PAD III Trial. Journal of the Society for Cardiovascular Angiography and Interventions. 2022 Jul 1;1(4). doi:10.1016/j.jscai.2022.100341
Yiu J, Tippireddy R, Biasi L, Patel S, Saha P, Saratzis A, et al. Systematic Review and Network Meta-analysis of Vessel Preparation Techniques With Plain Balloon Angioplasty, Atherectomy, or Intravascular Lithotripsy Before Application of a Drug Coated Balloon to Treat Atherosclerotic Femoropopliteal Disease. European Journal of Vascular and Endovascular Surgery. W.B. Saunders Ltd; 2025. p. 118–29. doi:10.1016/j.ejvs.2024.08.002 PubMed PMID: 39121903.
Tepe G, Schnorr B, Albrecht T, Brechtel K, Claussen CD, Scheller B, et al. Angioplasty of femoral-popliteal arteries with drug-coated balloons: 5-year follow-up of the THUNDER Trial. JACC Cardiovasc Interv. 2015 Jan 1;8(1):102–8. doi:10.1016/j.jcin.2014.07.023 PubMed PMID: 25616822.
Rosenfield K, Jaff MR, White CJ, Rocha-Singh K, Mena-Hurtado C, Metzger DC, et al. Trial of a Paclitaxel-Coated Balloon for Femoropopliteal Artery Disease. New England Journal of Medicine. 2015 Jul 9;373(2):145–53. doi:10.1056/nejmoa1406235 PubMed PMID: 26106946.
Laird JA, Schneider PA, Jaff MR, Brodmann M, Zeller T, Metzger DC, et al. Long-Term Clinical Effectiveness of a Drug-Coated Balloon for the Treatment of Femoropopliteal Lesions: Five-Year Outcomes from the IN.PACT SFA Randomized Trial. Circ Cardiovasc Interv. 2019 Jun 1;12(6). doi:10.1161/CIRCINTERVENTIONS.118.007702 PubMed PMID: 31195825.
Teichgräber U, Lehmann T, Ingwersen M, Aschenbach R, Zeller T, Brechtel K, et al. Long-Term Effectiveness and Safety of Femoropopliteal Drug-Coated Balloon Angioplasty : 5-Year Results of the Randomized Controlled EffPac Trial. Cardiovasc Intervent Radiol. 2022 Dec 1;45(12):1774–83. doi:10.1007/s00270-022-03265-1 PubMed PMID: 36088609.
Katsanos K, Spiliopoulos S, Kitrou P, Krokidis M, Karnabatidis D. Risk of death following application of paclitaxel-coated balloons and stents in the femoropopliteal artery of the leg: A systematic review and meta-analysis of randomized controlled trials. Journal of the American Heart Association. American Heart Association Inc.; 2018. doi:10.1161/JAHA.118.011245 PubMed PMID: 30561254.
Katsanos K, Spiliopoulos S, Saratzis A, Teichgräber U, Zayed H, Kitrou P, et al. Editor’s Choice – Dynamic Risk of Death following Application of Paclitaxel Coated Devices in the Femoropopliteal Artery: A Contemporary Meta-analysis of Randomised Controlled Trials. European Journal of Vascular and Endovascular Surgery. W.B. Saunders Ltd; 2026. p. 928–41. doi:10.1016/j.ejvs.2026.01.030 PubMed PMID: 41577117.
Iida O, Soga Y, Saito S, Mano T, Hayakawa N, Ichihashi S, et al. A Novel Sirolimus-Coated Balloon for the Treatment of Femoropopliteal Lesions: The SELUTION SFA Japan Trial. JACC Cardiovasc Interv. 2024 Jul 8;17(13):1547–56. doi:10.1016/j.jcin.2024.03.029 PubMed PMID: 38842992.
Dake MD, Ansel GM, Jaff MR, Ohki T, Saxon RR, Smouse HB, et al. Durable Clinical Effectiveness with Paclitaxel-Eluting Stents in the Femoropopliteal Artery: 5-Year Results of the Zilver PTX Randomized Trial. Circulation. 2016 Apr 12;133(15):1472–83. doi:10.1161/CIRCULATIONAHA.115.016900 PubMed PMID: 26969758.
Gray WA, Keirse K, Soga Y, Benko A, Babaev A, Yokoi Y, et al. A polymer-coated, paclitaxel-eluting stent (Eluvia) versus a polymer-free, paclitaxel-coated stent (Zilver PTX) for endovascular femoropopliteal intervention (IMPERIAL): a randomised, non-inferiority trial. The Lancet. 2018 Oct 27;392(10157):1541–51. doi:10.1016/S0140-6736(18)32262-1 PubMed PMID: 30262332.
Müller-Hülsbeck S, Benko A, Soga Y, Fujihara M, Iida O, Babaev A, et al. Two-Year Efficacy and Safety Results from the IMPERIAL Randomized Study of the Eluvia Polymer-Coated Drug-Eluting Stent and the Zilver PTX Polymer-free Drug-Coated Stent. Cardiovasc Intervent Radiol. 2021 Mar 1;44(3):368–75. doi:10.1007/s00270-020-02693-1 PubMed PMID: 33225377.
Bosiers MJ, De Donato G, Torsello G, Silveira PG, Scheinert D, Veroux P, et al. ZILVERPASS Study: ZILVER PTX Stent versus Prosthetic Above-the-Knee Bypass Surgery in Femoropopliteal Lesions, 5-year Results. Cardiovasc Intervent Radiol. 2023 Oct 1;46(10):1348–58. doi:10.1007/s00270-023-03549-0 PubMed PMID: 37670198.
Lammer J, Zeller T, Hausegger KA, Schaefer PJ, Gschwendtner M, Mueller-Huelsbeck S, et al. Heparin-bonded covered stents versus bare-metal stents for complex femoropopliteal artery lesions: The randomized VIASTAR trial (viabahn endoprosthesis with propaten bioactive surface [VIA] versus bare nitinol stent in the treatment of long lesions in superficial femoral artery occlusive disease). J Am Coll Cardiol. 2013 Oct 8;62(15):1320–7. doi:10.1016/j.jacc.2013.05.079 PubMed PMID: 23831445.
Bosiers M, Deloose K, Callaert J, Verbist J, Hendriks J, Lauwers P, et al. Superiority of stent-grafts for in-stent restenosis in the superficial femoral artery: Twelve-month results from a multicenter randomized trial. Journal of Endovascular Therapy. 2015 Feb 1;22(1):1–10. doi:10.1177/1526602814564385 PubMed PMID: 25775672.
Lammer J, Zeller T, Hausegger KA, Schaefer PJ, Gschwendtner M, Mueller-Huelsbeck S, et al. Sustained Benefit at 2 Years for Covered Stents Versus Bare-Metal Stents in Long SFA Lesions: The VIASTAR Trial. Cardiovasc Intervent Radiol. 2015 Dec 5;38(1):25–32. doi:10.1007/s00270-014-1024-9 PubMed PMID: 25472936.
Wu H, Liu J, Jiang Y, Huang X, Wang B, Liu Y, et al. Drug-coated balloon combined with stent versus stent alone for femoropopliteal disease: a systematic review and meta-analysis. BMC Cardiovascular Disorders. BioMed Central Ltd; 2026. doi:10.1186/s12872-026-05706-y PubMed PMID: 41820876.
Lee SJ, Kim TH, Lee JH, Ahn CM, Lee SH, Lee YJ, et al. Intravascular Ultrasound-Guided vs Angiography-Guided Drug-Coated Balloon Angioplasty in Patients With Complex Femoropopliteal Artery Disease. JACC Cardiovasc Interv. 2025 Mar 10;18(5):558–69. doi:10.1016/j.jcin.2024.10.052 PubMed PMID: 39846915.
Farber A, Menard MT, Conte MS, Kaufman JA, Powell RJ, Choudhry NK, et al. Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia. New England Journal of Medicine. 2022 Dec 22;387(25):2305–16. doi:10.1056/nejmoa2207899 PubMed PMID: 36342173.
Krankenberg H, Tübler T, Ingwersen M, Schlüter M, Scheinert D, Blessing E, et al. Drug-coated balloon versus standard balloon for superficial femoral artery in-stent restenosis: The randomized Femoral Artery In-Stent Restenosis (FAIR) trial. Circulation. 2015 Dec 8;132(23):2230–6. doi:10.1161/CIRCULATIONAHA.115.017364 PubMed PMID: 26446728.
Ott I, Cassese S, Groha P, Steppich B, Voll F, Hadamitzky M, et al. ISAR-PEBIS (Paclitaxel-Eluting Balloon Versus Conventional Balloon Angioplasty for In-Stent Restenosis of Superficial Femoral Artery): A Randomized Trial. J Am Heart Assoc. 2017;6(7). doi:10.1161/JAHA.117.006321 PubMed PMID: 28743787.
Bonaca MP, Bauersachs RM, Anand SS, Debus ES, Nehler MR, Patel MR, et al. Rivaroxaban in Peripheral Artery Disease after Revascularization. New England Journal of Medicine. 2020 May 21;382(21):1994–2004. doi:10.1056/nejmoa2000052 PubMed PMID: 32222135.