Ağrı Patofizyolojisi

Authors

Serpil Demirulus
https://orcid.org/0000-0001-7113-5912

References

Faerber G, Cornely M, Daubert C, et al. S2k guideline lipedema. J Dtsch Dermatol Ges. 2024;22(9):1303-1315. doi:10.1111/ddg.15513.

Aksoy H, Karadag AS, Wollina U. Cause and management of lipedema‐associated pain. Dermatol Ther. 2021;34(1):e14364. doi: 10.1111/dth.14364.

Pervane S, Uzun Ö. Neuropathic Pain Features in Lipedema Compared to Lymphedema: An Exploratory Cross-Sectional Study. Lymphat Res Biol. 2026; [Epub ahead of print] doi:10.1177/15578585261454778

Buso G, Depairon M, Tomson D, Raffoul W, Vettor R, Mazzolai L. Lipedema: A Call to Action! Obesity. 2019;27(10):1567–1576.

Angst F, Benz T, Lehmann S, et al. Extended overview of the longitudinal pain-depression association: A comparison of six cohorts treated for specific chronic pain conditions. J Affect Disord. 2020;273:508–516.

Kruppa P, Gohlke S, Łapiński K, et al. Lipedema stage affects adipocyte hypertrophy, subcutaneous adipose tissue inflammation and interstitial fibrosis. Front Immunol. 2023;14:1223264. doi:10.3389/fimmu.2023.1223264

Grewal T, Kempa S, Buechler C. Lipedema: A Disease Triggered by M2 Polarized Macrophages? Biomedicines. 2025;13(3):561.

Dal’Forno-Dini T, Birck MS, Saalfeld RM, Macedo CLD, Bagatin E. Lipedema: pathophysiological insights and therapeutic strategies – An update for dermatologists. An Bras Dermatol. 2026;101(1):501270.

Amato ACM. Lipedema as a Syndrome of Adipose Mast Cell Activation and Type 2 Immune Orchestration: A Testable Neuroimmune Framework [Internet]. Medicine and Pharmacology; 2026 [cited 2026 Jun 11]. Available from: https://www.preprints.org/manuscript/202605.1114/v1 doi:10.20944/preprints202605.1114.v1

Dinnendahl R, Tschimmel D, Löw V, Cornely M, Hucho T. Non-obese lipedema patients show a distinctly altered quantitative sensory testing profile with high diagnostic potential. PAIN Rep. 2024;9(3):e1155. doi:10.1097/PR9.0000000000001155

Chakraborty A, Crescenzi R, Usman TA, et al. Indications of Peripheral Pain, Dermal Hypersensitivity, and Neurogenic Inflammation in Patients with Lipedema. Int J Mol Sci. 2022;23(18):10313.

Mai L, Liu Q, Huang F, He H, Fan W. Involvement of Mast Cells in the Pathophysiology of Pain. Front Cell Neurosci. 2021;15:665066. doi:10.3389/fncel.2021.665066

Sakizli Erdal E, Haspolat M, Ergin C, Keser I. A multidimensional evaluation of pain in lipedema. Phlebology. 2026; [Epub ahead of print] doi:10.1177/02683555261427251

Published

November 5, 2026

License

License