İktiyoziform Dermatozlar ve Keratodermalarda Topikal Retinoidler
Özet
Retinoidler, iktiyoziform dermatozların ve keratodermaların tedavisinde kullanılan etkili ilaçlar arasındadır. Tüm vücut uygulaması için ve uzun süreli kullanım için uygun olmasalar da eller, ayaklar, bacaklar ve eklem bölgeleri gibi lokalize keratinizasyon bozukluklarında tedaviye dirençli alanlar için uygundurlar. Topikal retinoidler, tretinoin, adapalen ve özellikle tazaroten olmak üzere, konjenital iktiyozisde skuamları azaltmada, dijital kontraktürleri iyileştirmede ve ektropiyonun kısmen düzelmesinde fayda sağlarlar. Palmoplantar keratodermalarda topikal retinoidlerden, tazaroten, adapalen ve tretinoin ile tedavide başarılı sonuçlar elde edilebilir. Tüm retinoidler iritan olduklarından dolayı konsantrasyon, uygulama aralıkları ve uygulama süresi dikkatlice seçilmeli ve her kullanıldıklarında kuruluk için yağlı nemlendiriciler ile birlikte uygulanmalıdırlar.
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