Psoriasiste Topikal Retinoidler
Özet
Topikal retinoidlerden tazarotenin gerek tek başına gerekse de topikal kortikosteroidler, kalsipotriyol, darbant UVB ve PUVA gibi tedavilerle kombine olarak plak psoriasis tedavisinde başarılı bir şekilde kullanıldığını bildiren çok sayıda çalışma vardır. Ülkemizde de %0,1 jel ve krem formundaki ilaçlar ruhsat almıştır. Tazaroten tırnak ve palmoplantar psoriasis gibi klinik tiplerde de kullanılmaktadır. Beksarotenin psoriasiste etkili olduğunu gösteren çalışmalar olmakla beraber psoriasiste endikasyon ruhsatı bulunmamaktadır.
Referanslar
Tazorac (tazarotene) cream, 0.05% and 0.1%, for topical use. Irvine, CA: Allergan; 2017. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/ 021184s009lbl.pdf.
Avage (tazarotene) cream, 0.1% U.S. Irvine CA Allergan. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021184s009lbl.pdf.
Duobrii (halobetasol propionate and tazarotene). Bausch Health Companies Inc. U.S. Food and Drug Administration website. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209354s000lbl.pdf
Zorante (tazaroten) krem %0,1 jel. Farmatek. Available at: https://titck.gov.tr/storage/Archive/2019/kubKtAttachments/T%C4%B0TCK%20Onayl%C4%B1%20K%C3%9CB%20ZORANTE.pdf_21615cb0-2956-49a1-9947-3b8e42040284.pdf
Zorante (tazaroten) krem %0,1 krem. Farmatek. Available at: https://titck.gov.tr/storage/kubKtAttachments/EQMUzEJcRE3R1.pdf
Smit JV, de Jong EM, van Hooijdonk CA, Otero ME, Boezeman JB, van de Kerkhof PC. Systemic treatment of psoriatic patients with bexarotene decreases epidermal proliferation and parameters for inflammation and improves differentiation in lesional skin. J Am Acad Dermatol. 2004 Aug;51(2):257-64.
Breneman D., Sheth P., Berger V., Naini V., Stevens V. Phase II clinical trial of bexarotene gel 1% in psoriasis. J Drugs Dermatol. 6(5); 2007:501-506.
Saka R., Jain H., Kommineni N., Chella N., Khan W. Enhanced penetration and improved therapeutic efficacy of bexarotene via topical liposomal gel in imiquimod induced psoriatic plaque model in BALB/c mice. J Drug Deliv Sci Technol. 2020; 58:101691.
Magliocco M. A., Pandya K., Dombrovskiy V., Christiansen L., Wong Y., Gottlieb A. A randomized, double-blind, vehicle-controlled, bilateral comparison trial of bexarotene gel 1% versus vehicle gel in combination with narrowband UVB phototherapy for moderate to severe psoriasis vulgaris. J Am Acad Dermatol. 2006;54(1): 115-118.
Beksar (Beksaroten) jel % 0,1. Nobel İlaç. Available at: https://titck.gov.tr/storage/Archive/2020/kubKtAttachments/beksar%20kub- UYGUN.pdf_6261577e-c672-4690-8d64-c5abe6501373.pdf
Weinstein GD, Koo JY, Krueger GG, Lebwohl MG, Lowe NJ, Menter MA, et al; Tazarotene Cream Clinical Study Group. Tazarotene cream in the treatment of psoriasis: Two multicenter, double-blind, randomized, vehicle-controlled studies of the safety and efficacy of tazarotene creams 0.05% and 0.1% applied once daily for 12 weeks. J Am Acad Dermatol. 2003;48(5):760-7. 12- Guenther L.C. Topical tazarotene therapy for psoriasis, acne vulgaris, and photoaging. Skin Therapy Lett. 2002;7(3):1-4.
Gaikwad J, Sanjay S, Ketan V.H. Review on Characteristics and Analytical Methods of Tazarotene: An Update. Crit Rev Anal Chem. 2020;50(1):90-96.
Lebwohl M, Ast E, Callen JP, Cullen SI, Hong SR, Kulp-Shorten CL, et al. Once-daily tazarotene gel versus twice-daily fluocinonide cream in the treatment of plaque psoriasis. J Am Acad Dermatol. 1998;38(5 Pt 1):705-11.
Sami N. Topical retinoids. Topical Immunomodulatory and Antiproliferative Drugs. In: Wolverton S., Wu J, editors. Comprehensive Dermatologic Drug Therapy. [Internet]. USA: Elsevier; 2020. PART IX. Available from: https://www.clinicalkey.com/service/content/pdf/watermarked/3-s2.0-B9780323612111000462.pdf?locale=en_US&searchIndex.
Khalil S, Bardawil T, Stephan C, Darwiche N, Abbas O, Kibbi AG, et al. Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects. J Dermatolog Treat. 2017;28(8):684-696.
Tyring S, Kircik LH, Yamauchi P, Jacobson A, Lin T. Halobetasol Propionate 0.01%/Tazarotene 0.045% Lotion for Moderate-to-Severe Psoriasis: Pooled Phase 3 Analysis of Lower Extremities. J Drugs Dermatol. 2020;19(4):389-396.
Lebwohl MG, Sugarman JL, Stein Gold L, Lin T, Israel R. Efficacy, Safety, and Tolerability of a Halobetasol 0.01% /Tazarotene 0.045% Fixed Combination in the Treatment of Severe Localized Plaque Psoriasis: Post Hoc Analysis of Two Phase III Randomized Controlled Trials. J Drugs Dermatol. 2019;18(10):1012-1018.
Kircik LH, Papp KA, Stein Gold L, Harris S, Pharm TL, Pillai R. Assessing the Synergistic Effect of a Fixed Combination Halobetasol Propionate 0.01% and Tazarotene 0.045% Lotion in Moderate-to-Severe Plaque Psoriasis. J Drugs Dermatol. 2019; 18(3):279-284.
Elmowafy E, El-Gogary RI, Ragai MH, Nasr M. Novel antipsoriatic fluidized spanlastic nanovesicles: In vitro physicochemical characterization, ex vivo cutaneous retention and exploratory clinical therapeutic efficacy. Int J Pharm. 2019; 568:118556.
Gold LS, Lebwohl MG, Sugarman JL, Pariser DM, Lin T, Martin G, et al. Safety and efficacy of a fixed combination of halobetasol and tazarotene in the treatment of moderate-to-severe plaque psoriasis: Results of 2 phase 3 randomized controlled trials. J Am Acad Dermatol. 2018; 79(2):287-293.
Sugarman JL, Weiss J, Tanghetti EA, Bagel J, Yamauchi PS, Stein Gold L, et al. Safety and Efficacy of a Fixed Combination Halobetasol and Tazarotene Lotion in the Treatment of Moderate-to-Severe Plaque Psoriasis: A Pooled Analysis of Two Phase 3 Studies. J Drugs Dermatol. 2018; 17(8):855-861.
Dayal S, Kaura R, Sahu P, Jain VK. Tazarotene gel with narrow-band UVB phototherapy: a synergistic combination in psoriasis. An Bras Dermatol. 2018 Jun;93(3):385-390.
Nasr M, Abdel-Hamid S, Moftah NH, Fadel M, Alyoussef AA. Jojoba Oil Soft Colloidal Nanocarrier of a Synthetic Retinoid: Preparation, Characterization and Clinical Efficacy in Psoriatic Patients. Curr Drug Deliv. 2017;14(3):426-432.
Huang YC, Chou CL, Chiang YY. Efficacy of pulsed dye laser plus topical tazarotene versus topical tazarotene alone in psoriatic nail disease: a single-blind, intrapatient left-to-right controlled study. Lasers Surg Med. 2013;45(2):102-7.
Rigopoulos D., Gregoriou S., Katsambas A. Treatment of psoriatic nails with tazarotene cream 0.1% vs. clobetasol propionate 0.05% cream: a double-blind study. Acta Derm Venereol. 2007;87(2):167-168.
Angelo J. S., Kar B. R., Thomas J. Comparison of clinical efficacy of topical tazarotene 0.1% cream with topical clobetasol propionate 0.05% cream in chronic plaque psoriasis: A double-blind, randomized, right-left comparison study. Indian J Dermatol Venereol Lepro. 2007;73(1):65.
Bianchi L., Soda R., Diluvio L., Chimenti S. Tazarotene 0· 1% gel for psoriasis of the fingernails and toenails: an open, prospective study. Br J Dermatol. 2003;149(1):207-209.
Bowman P. H., Maloney J. E., Koo J. Y. Combination of calcipotriene (Dovonex) ointment and tazarotene (Tazorac) gel versus clobetasol ointment in the treatment of plaque psoriasis: a pilot study. J Am Acad Dermatol. 2002;46(6):907-913.
Tzaneva S., Seeber A., Hönigsmann H., Tanew A. A comparison of psoralen plus ultraviolet A (PUVA) monotherapy, tacalcitol plus PUVA and tazarotene plus PUVA in patients with chronic plaque‐type psoriasis. Br J Dermatol. 2002;147(4);748-753.
Scher R. K., Stiller M., Zhu Y. I. Tazarotene 0.1% gel in the treatment of fingernail psoriasis: a double-blind, randomized, vehicle-controlled study. Cutis. 2001;68(5):355-358.
Schiener R., Behrens‐Williams S. C., Pillekamp H., Kaskel P., Peter, R. U., Kerscher, M. Calcipotriol vs. tazarotene as combination therapy with narrowband ultraviolet B (311 nm): efficacy in patients with severe psoriasis. Br J Dermatol. 2000;143(6):1275-1278.
Krueger G. G., Drake L. A., Elias P. M., Lowe N. J., Guzzo C., Weinstein, G, et al. The safety and efficacy of tazarotene gel, a topical acetylenic retinoid, in the treatment of psoriasis. Arch Dermatol. 1998;134(1):57-60.
Mehta BH, Amladi ST. Evaluation of topical 0.1% tazarotene cream in the treatment of palmoplantar psoriasis: an observer-blinded randomized controlled study. Indian J Dermatol. 2011; 56:40–3.
Elmets C. A., Korman N. J., Prater E. F., Wong, E. B., Rupani R. N., Kivelevitch, et al. Joint AAD-NPF Guidelines of care for the management and treatment of psoriasis with topical therapy and alternative medicine modalities for psoriasis severity measures. J Am Acad Dermatol 2021; 84: 432
