Aknede Topikal Retinoidler
Özet
Topikal retinoidler akne tedavisinin yapıtaşı olup hem ana tedavide hem de idame tedavide en önemli topikal tedavi seçeneğidir. Adapalen, tretinoin, izotretinoin, tazaroten ve trifaroten akne tedavisinde kullanılmaktadır. Akne etyopatogenezinde etkili olan folliküler keratinizasyon bozukluğu düzenler, inflamasyonu, pigmentasyonu ve skarı azaltır. Aknenin inflamatuvar ve noninflamatuvar tüm lezyonlarına etkili olup mikrokomedon oluşumunu azaltan tek topikal tedavidir, idame tedavide en önemli seçenektir. Kombine kullanımda benzoil peroksit ve topikal antibiyotiklerin foliküler penetrasyonunu arttırır. Tedavinin erken döneminde eritem, kuruluk, kaşıntı ve batma gibi lokal yan etkiler kullanımında güçlüğe yol açabilmektedir. İnflamatuvar ve noninflamatuvar akne lezyonlarında birinci basamak tedavi seçeneği olmasının yanısıra bakteriyal direnci artırma riski de olmadığından idame tedavide uzun süreli kullanıma uygundur.
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