Topikal Retinoidler: Tretinoin
Özet
A vitamininin doğal metaboliti olan tretinoin, aynı zamanda sentezlenen ilk retinoiddir. Birinci jenerasyon sentetik non-aromatik retinoidler grubunda yer alır. Tretinoin topikal olarak çeşitli dermatolojik hastalıkların tedavisinde, sistemik olarak ise akut promiyelositik lösemi tedavisinde kullanılmaktadır. Topikal tretinoinin akne vulgaris ve fotoyaşlanmaya bağlı deri değişikliklerinin tedavisinde kullanımı onaylanmıştır. Bu iki endikasyon dışında topikal tretinoin pek çok dermatolojik hastalığın (melazma, aktinik keratoz, displastik nevus, stria, skar, alopesi, siğiller, keratozis pilaris, nevus komedonikus, perforan hastalıklar, porokeratoz, vb) tedavisinde kullanılmaktadır.
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