Baş Ağrısı Patofizyolojisi

Aydın NO. Ağrı ve ağrı mekanizmalarına güncel bakış. Adnan Menderes Univ Tıp Fak Derg. 2002;3(2):37–48.

Duus P. Nöroloji: Tanıda Lokalizasyon. Oğuz Y, Özkaynak S, Önal MZ, çevirenler. Ankara: Palme Yayıncılık; 2001.

Markenson JA. Mechanisms of chronic pain. Am J Med. 1996;101(1A):6S–18S.

Yağcı Ü, Saygın M. Pain physiopathology. Med J SDU. 2019;26(2):209–220.

Walters ET, Crook RJ, Neely GG, Price TJ, Smith ESJ. Persistent nociceptor hyperactivity as a painful evolutionary adaptation. Trends Neurosci. 2023;46(3):211–227.

Wen ZH, Wu ZS, Huang SY, Lin YC, Chen WF, Wang YC, et al. Local magnesium sulfate administration ameliorates nociception, peripheral inflammation, and spinal sensitization in a rat model of incisional pain. Neuroscience. 2024;547:98–107.

Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10(9):895–926.

Goadsby PJ, Charbit AR, Andreou AP, Akerman S, Holland PR. Neurobiology of migraine. Neuroscience. 2009;161(2):327–341.

Harvey AR, editor. Lippincott’s Illustrated Reviews: Neuroscience. Baltimore: Lippincott Williams & Wilkins; 2012:407–424.

Jaffal SM. Neuroplasticity in chronic pain: insights into diagnosis and treatment. Korean J Pain. 2025;38(2):89–102.

Jayathilake NJ, Phan TT, Kim J, Lee KP, Park JM. Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach. Exp Mol Med. 2025;57(3):501–514.

Simons SH, Tibboel D. Pain perception development and maturation. Semin Fetal Neonatal Med. 2006;11(4):227–231.

James KC, Piña-Garza JE. 3. Headache. In: Fenichel’s Clinical Pediatric Neurology: A Signs and Symptoms Approach. 9th ed. Philadelphia: Elsevier; 2024:309–310.

Bogduk N. Anatomy and physiology of headache. Biomed Pharmacother. 1995;49(10):435–445. doi:10.1016/0753-3322(96)82687-4.

Robertson CE, Benarroch EE. The anatomy of head pain. In: Handbook of Clinical Neurology. Vol 198. Amsterdam: Elsevier; 2023:41–60.

Olesen J, Burstein R, Ashina M, Tfelt-Hansen P. Origin of pain in migraine: evidence for peripheral sensitisation. Lancet Neurol. 2009;8:679–690.

Penfield W. A contribution to the mechanism of intracranial pain. Assoc Res Nerv Dis Proc. 1935;15:399–416.

Marfurt CF. The central projection of trigeminal primary afferent neurons in the cat as determined by the transganglionic transport of horseradish peroxidase. J Comp Neurol. 1981;203:785–798.

Gauriau C, Bernard JF. A comparative reappraisal of projections from the superficial laminae of the dorsal horn in the rat: the forebrain. J Comp Neurol. 2004;468:24–56.

Chalus M, Villanueva L. Central nervous system networks involved in the processing of meningeal and cutaneous inputs from the ophthalmic branch of the trigeminal nerve in the rat. Cephalalgia. 2008;28:813–824.

Canpolat M, Kumandaş S. Baş ağrısıyla başvuran çocuğa yaklaşım ve akut baş ağrılarının yönetimi. In: Canpolat M, Kumandaş S, editors. Çocuk Nörolojik Acilleri. Türkiye Klinikleri Pediatri. 2018;14(1):82–98.

Unalp A, Dirik E, Kurul S. Prevalence and characteristics of recurrent headaches in Turkish adolescents. Pediatr Neurol. 2006;34(2):110–115.

Arnold M. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders. 3rd ed. Cephalalgia. 2018;38(1):1–211.

Guidetti V, Faedda N, Siniatchkin M. Migraine in childhood: biobehavioural or psychosomatic disorder? J Headache Pain. 2016;17(1):82.

Salvadori F, Gelmi V, Muratori F. Present and previous psychopathology of juvenile onset migraine: a pilot investigation by Child Behavior Checklist. J Headache Pain. 2007;8(1):35–42.

Genç Ş. Çocukluk çağında migren. In: Orhan Başer D, Çetiner İ, editors. Pediatri Polikliniklerinde Sık Görülen Vakalar. Ankara: Akademisyen Kitabevi; 2023:605–608.

Dora B. Başağrısı fizyopatolojisi. In: Köseoğlu E, editor. Nörolojik Hastalıklarda Patogenez. Türkiye Klinikleri Nöroloji. 2017;10(3):217–230.

Malick A, Jakubowski M, Elmquist JK, Saper CB, Burstein R. A neurohistochemical blueprint for pain-induced loss of appetite. Proc Natl Acad Sci U S A. 2001;98:9930–9935.

Qubty W, Patniyot I. Migraine pathophysiology. Pediatr Neurol. 2020;107:1–6.

Alemdar M, Selekler M. Migren ve kortikal yayılma depresyonu. Agri. 2006;18(4):24–30.

Boran HE, Bolay H. Pathophysiology of migraine. Noro Psikiyatr Ars. 2013;50(Suppl 1):S1–7.

Gasparini CF, Griffiths LR. The biology of the glutamatergic system and potential role in migraine. Int J Biomed Sci. 2013;9(1):1–8.

Pietrobon D, Moskowitz MA. Pathophysiology of migraine. Annu Rev Physiol. 2014;76:365–391.

Volobueva MN, Suleymanova EM, Smirnova MP, Bolshakov AP, Vinogradova LV. A single episode of cortical spreading depolarization increases mRNA levels of proinflammatory cytokines, calcitonin gene-related peptide and pannexin-1 channels in the cerebral cortex. Int J Mol Sci. 2022;24(1):85.

Kitamura E, Imai N. Molecular and cellular neurobiology of spreading depolarization/depression and migraine: a narrative review. Int J Mol Sci. 2024;25(20):11163.

Plinta A, Tretjakovs P, Svirskis S, et al. Association of body mass index, blood pressure, and interictal serum levels of cytokines in migraine with and without aura. J Clin Med. 2022;11(19):5696.

Özgör B, Güngör S. Çocukluk çağında migren. In: Kumandaş S, Canpolat M, editors. Temel Pediatrik Nöroloji: Tanı ve Tedavi. Cilt 2. Ankara: Akademisyen Kitabevi; 2022:1695–1704.

Kabbouche MA, Kacperski J, O’Brien HL, Powers SW, Hershey AD. Headache in children and adolescents. In: Swaiman KF, Ashwal S, Ferriero DM, Schor RS, editors. Swaiman’s Pediatric Neurology: Principles and Practice. 6th ed. Philadelphia: Elsevier; 2016:647–655.

Urbach A, Bruehl C, Witte OW. Microarray-based long-term detection of genes differentially expressed after cortical spreading depression. Eur J Neurosci. 2006;24(3):841–856.

Karssen AM, Her S, Li JZ, et al. Stress-induced changes in primate prefrontal profiles of gene expression. Mol Psychiatry. 2007;12(12):1089–1102.

Zhai Q, Chen Q, Zhang N, Li H, Yu Q, Pan Y. Exploring vestibulocerebellum–vestibular nuclei–spinal trigeminal nucleus causal communication and TRPV2 ion channel in a mouse model of vestibular migraine. J Headache Pain. 2025;26(1):47.

Charles AC, Baca SM. Cortical spreading depression and migraine. Nat Rev Neurol. 2013;9(11):637–644.

McLeod GA, Josephson CB, Engbers JDT, Cooke LJ, Wiebe S. Mapping the migraine: intracranial recording of cortical spreading depression in migraine with aura. Headache. 2025;65(4):658–665.

Charles AC, Goadsby PJ. The cortical spreading depression/migraine aura hypothesis: finally some definitive evidence. Headache. 2025;65(4):537–538.

Russo AF, Hay DL. CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond. Physiol Rev. 2023;103(2):1565–1644.

Tepper SJ, Rapoport AM, Sheftell FD. Mechanisms of action of the 5-HT1B/1D receptor agonists. Arch Neurol. 2002;59(7):1084–1088.

Noseda R, Kainz V, Jakubowski M, et al. A neural mechanism for exacerbation of headache by light. Nat Neurosci. 2010;13(2):239–245.

Straube A, Andreou A. Primary headaches during lifespan. J Headache Pain. 2019;20(1):35.

Üçler S. Migren ve gerilim tipi baş ağrılarında patofizyoloji. In: Selçuki D, editor. Baş Ağrısı. Türkiye Klinikleri Nöroloji. 2018;11(1):21–27.

Online Mendelian Inheritance in Man (OMIM). Familial hemiplegic migraine; FHM1 [Internet]. Baltimore (MD): Johns Hopkins University; cited 2025 Apr 13. Available from: https://www.omim.org/entry/141500

Ophoff RA, van den Maagdenberg AM, Roon KI, Ferrari MD, Frants RR. The impact of pharmacogenetics for migraine. Eur J Pharmacol. 2001;413(1):1–10.

Schaare D, Lusk L, Karlin A, et al. A longitudinal exploration of CACNA1A-related hemiplegic migraine in children using electronic medical records. Neurol Genet. 2025;11(1):e200228.

Gritz SM, Radcliffe RA. Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models. Hum Genomics. 2013;7(1):8.

Dichgans M, Freilinger T, Eckstein G, et al. Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet. 2005;366(9483):371–377.

Al-Futaisi A. Pediatric migraines: a comprehensive review and perspectives on diagnosis and treatment. Oman Med J. 2023;38(3):e499.

Grangeon L, Lange KS, Waliszewska-Prosół M, et al. Genetics of migraine: where are we now? J Headache Pain. 2023;24(1):12.

Hautakangas H, Winsvold BS, Ruotsalainen SE, et al. Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles. Nat Genet. 2022;54(2):152–160.

Gormley P, Anttila V, Winsvold BS, et al. Meta-analysis of 375,000 individuals identifies susceptibility loci for migraine. Nat Genet. 2016;48(8):856–866.

Bottini F, Celle ME, Calevo MG, et al. Metabolic and genetic risk factors for migraine in children. Cephalalgia. 2006;26(6):731–737.

Bellini B, Arruda M, Cescut A, et al. Headache and comorbidity in children and adolescents. J Headache Pain. 2013;14(1):79.

Chabriat H. Is migraine a common manifestation of CADASIL? Arguments pros. J Headache Pain. 2025;26(1):64.

Wang YF. Is migraine a common manifestation of CADASIL? Cons. J Headache Pain. 2025;26(1):65.

Chen ZH, Cui YL, Sun JT, et al. Brain structure and function abnormalities of migraineurs: a systematic review and neuroimaging meta-analysis. Front Neurol. 2022;13:1022793.

Chou BC, Lerner A, Barisano G, et al. Functional MRI and diffusion tensor imaging in migraine: a review. J Cent Nerv Syst Dis. 2023;15:11795735231205413.

Karalök ZS, Güneş A, Öztürk Z. Çocukluk çağı migreni ile subkortikal gri madde yapılarının ilişkisi. Akd Tıp Derg. 2020;6(1):106–111.

Yılmaz Ü, Çeleğen M, Yılmaz TS, Gürçınar M, Ünalp A. Childhood headaches and brain magnetic resonance imaging findings. Eur J Paediatr Neurol. 2014;18(2):163–170.

Fernández-de-las-Peñas C, Ambite-Quesada S, Rivas-Martínez I, et al. Genetic contribution of catechol-O-methyltransferase polymorphism in children with chronic tension-type headache. Pediatr Res. 2011;70(4):395–399.

Park JW, Kim JS, Lee HK, Kim YI, Lee KS. Serotonin transporter polymorphism and harm avoidance personality in chronic tension-type headache. Headache. 2004;44(10):1005–1009.

Jensen R, Stovner LJ. Epidemiology and comorbidity of headache. Lancet Neurol. 2008;7(4):354–361.

Baglioni V, Orecchio S, Esposito D, Faedda N, Natalucci G, Guidetti V. Tension-type headache in children and adolescents. Life (Basel). 2023;13(3):825.

Gupta R, Kumar V, Luthra K, Banerjee B, Bhatia MS. Polymorphism in apolipoprotein E among migraineurs and tension-type headache subjects. J Headache Pain. 2009;10(2):115–120.

Vuralli D, Boran HE, Cengiz B, Coskun O, Bolay H. Somatosensory temporal discrimination remains intact in tension-type headache whereas it is disrupted in migraine attacks. Cephalalgia. 2017;37(13):1241–1247.

Pizer JH, Hernandez KA, Aita SL, et al. Neuropsychological functioning in pediatric primary headache disorders: a meta-analysis. Pediatrics. 2025;145:e2024067838.

Kayalı Şendur N. Gerilim tipi baş ağrısı. In: Kunt R, editor. Baş Ağrısı ve Migren. Ankara: Akademisyen Kitabevi; 2022:119–142.

Sekelj Fures J, Duranovic V, Lenicek Krleza J, et al. Calcitonin gene-related peptide in migraine and tension-type headache in children during interictal period. Diagnostics (Basel). 2024;14(23):2645.

Soee AB, Thomsen LL, Kreiner S, Tornoe B, Skov L. Altered pain perception in children with chronic tension-type headache: is this a sign of central sensitisation? Cephalalgia. 2013;33(7):454–462.

Önerli Yener M. Küme baş ağrısı. In: Kunt R, editor. Baş Ağrısı ve Migren. Ankara: Akademisyen Kitabevi; 2022:143–158.

de Freitas Dias B, Robinson CL, Villar-Martinez MD, Ashina S, Goadsby PJ. Current and novel therapies for cluster headache: a narrative review. Pain Ther. 2025;14(1):1–19.

Dora B. SUNCT sendromu ve SUNA. In: Öztürk V, Bıçakcı Ş, editors. Trigeminal Otonomik Baş Ağrıları. Türkiye Klinikleri; 2024:55–61.