Akut Romatizmal Ateş
Özet
Akut romatizmal ateş A grubu beta hemolitik streptokok enfeksiyonunun süpüratif olmayan komplikasyonlarından biridir. GABHS enfeksiyonu ve ARA 5-15 yaşları arasında sık görülür. GABHS tonsillofarenjitinden veya tropikal bölgelerden gelen hastalarda streptokokal piyodermadan sonraki 1-5 hafta içinde birkaç farklı klinik bulguyla ortaya çıkabilir. Amerikan Kalp Derneği tarafından 2015 yılında bildirilen modifiye Jones kriterleri ile tanı konulur. ARA’nın tedavisi antibiyotik tedavisi, anti-inflamatuvar tedavi, kalp yetmezliği yönetimi ve sekonder profilaksi ile yapılır. ARA’da prognozu belirleyen kapak tutulumunun olmasıdır. Kapak tutulumu olmayan hastalarda prognoz iyidir. Kapak tutulumunun ağırlığı ve birden fazla kapak tutulumu romatizmal kapak hastalığına ilerleme için risk faktörüdür. ARA çocuklarda morbiditesi yüksek bir hastalıktır. Önlemek için başta yaşam koşullarının iyileştirilmesi, streptokok farenjitinin uygun antibiyotikler ile önerilen sürede tedavi edilmesi ve ARA geçiren hastalarda tekrarı önlemek için uygun sürelerde sekonder profilaksi yapılması gerekmektedir.
Referanslar
Quinn RW. Did scarlet fever and rheumatic fever exist in Hippocrates' time? Rev Infect Dis. 1991;13(6): 1243-1244.
Saltık İL. Akut romatizmal ateşin tarihçesi. Baysal MK, editör. Çocukluk Çağında Akut Romatizmal Ateş ve Romatizmal Kalp Hastalıkları. 1. Baskı. Ankara: Türkiye Klinikleri; 2020. p.1-5.
Jones TD. The diagnosis of rheumatic fever. JAMA.1944;126: 481‑484.
Gewitz MH, Baltimore RS, Tani LY, et al. American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young. Revision of the Jones Criteria for the diagnosis of Acute rheumatic fever in the era of Doppler echocardiography: a scientific statement from the American Heart Association. Circulation. 2015; 131 (20):1806-1818.
Watkins DA, Johnson CO, Colquhoun SM, et al. Global, Regional, and National Burden of Rheumatic Heart Disease, 1990-2015. N Engl J Med. 2017;377(8): 713-722. doi: 10.1056/NEJMoa1603693.
Negi PC, Kandoria A, Asotra S, et al. Gender differences in the epidemiology of Rheumatic Fever/Rheumatic heart disease (RF/RHD) patient population of hill state of northern India; 9 years prospective hospital based, HP-RHD registry. Indian Heart J. 2020;72(6): 552-556. doi: 10.1016/j.ihj.2020.09.011.
Tibazarwa KB, Volmink JA, Mayosi BM. Incidence of Acute rheumatic fever in the world: a systematic review of population-based studies. Heart. 2008;94(12): 1534-1540.
Parnaby MG, Carapetis JR. Rheumatic fever in indigenous Australian children. J Paediatr Child Health. 2010;46(9): 527-33. doi: 10.1111/j.1440-1754.2010.01841.x.
Gürses D, Koçak G, Tutar E, Özbarlas N; Turkish ARF study group. Incidence and clinical characteristics of Acute rheumatic fever in Turkey: Results of a nationwide multicentre study. J Paediatr Child Health. 2021;57(12): 1949-1954. doi: 10.1111/jpc.15619.
Azevedo PM, Pereira RR, Guilherme L. Understanding rheumatic fever. Rheumatol Int. 2012;32(5): 1113-1120. doi: 10.1007/s00296-011-2152-z.
Guilherme L, Ramasawmy R, Kalil J. Rheumatic fever and rheumatic heart disease: genetics and pathogenesis. Scand J Immunol. 2007;66(2-3): 199-207. doi: 10.1111/j.1365-3083.2007.01974.x.
Cunningham MW. Rheumatic fever, autoimmunity, and molecular mimicry: the streptococcal connection. Int Rev Immunol. 2014;33(4): 314-329. doi: 10.3109/08830185.2014.917411.
Faé KC, da Silva DD, Oshiro SE, et al. Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease. J Immunol. 2006;176(9): 5662-5670. doi: 10.4049/jimmunol.176.9.5662.
Engel ME, Stander R, Vogel J, Adeyemo AA, Mayosi BM. Genetic susceptibility to Acute rheumatic fever: a systematic review and meta-analysis of twin studies. PLoS One. 2011;6(9): e25326. doi: 10.1371/journal.pone.0025326.
Tani LY. Rheumatic fever and rheumatic heart disease. In: Allen HD, Driscoll MD, Shaddy RE, Feltes TF, eds. Moss and Adams’ Heart Disease in Infants, Children, and Adolescents. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013. p. 1303-1330.
Wallace MR, Garst PD, Papadimos TJ, Oldfield EC 3rd. The return of Acute rheumatic fever in young adults. JAMA. 1989;262(18): 2557-2561.
Steer A, Gibofsky A. Acute rheumatic fever: Clinical manifestations and diagnosis. Sexton DJ, ed. UpToDate- Wolters Kluwer (Accessed 12/01/2025, last updated May 15, 2024- https://www.uptodate.com/contents/acute-rheumatic-fever-clinical-manifestations-and-diagnosis?search=akut%20romatizmal%20ate%C5%9F&source=search_result&selectedTitle=1~112&usage_type=default&display_rank=1#H5)
Tubridy-Clark M, Carapetis JR. Subclinical carditis in rheumatic fever: a systematic review. Int J Cardiol. 2007;119: 54–58.
Karthikeyan G, Guilherme L. Acute rheumatic fever. Lancet. 2018;392(10142): 161-174. doi: 10.1016/S0140-6736(18)30999-1.
Park MK, Salamat M. Valvular Heart Disease. Park’s Pediatric Cardiology For Practitioners 7th edition. Philadelphia: Elsevier Saunders; 2021. p. 288-296.
Erdem S, Demir F, Ayana M, et al. Acute rheumatic fever in south-east of Turkey: clinical features and epidemiological evaluation of the patients over the last 25 years. Cardiol Young. 2020;30(8): 1086-1094. doi: 10.1017/S1047951120001596.
Arvind B, Ramakrishnan S. Rheumatic Fever and Rheumatic Heart Disease in Children. Indian J Pediatr. 2020;87(4): 305-311. doi: 10.1007/s12098-019-03128-7.
Sacks L, Feinstein AR, Taranta A. A controlled psychologic study of Sydenham's chorea. J Pediatr. 1962;61: 714-722. doi: 10.1016/s0022-3476(62)80343-6.
Eshel G, Lahat E, Azizi E, Gross B, Aladjem M. Chorea as a manifestation of rheumatic fever--a 30-year survey (1960-1990). Eur J Pediatr. 1993;152(8): 645-646. doi: 10.1007/BF01955239.
Punukollu M, Mushet N, Linney M, Hennessy C, Morton M. Neuropsychiatric manifestations of Sydenham's chorea: a systematic review. Dev Med Child Neurol. 2016;58(1): 16-28. doi: 10.1111/dmcn.12786.
Karacan M, Işıkay S, Olgun H, Ceviz N. Asymptomatic rhythm and conduction abnormalities in children with Acute rheumatic fever: 24-hour electrocardiography study. Cardiol Young. 2010;20(6): 620-630. doi: 10.1017/S104795111000079X.
Agnew J, Wilson N, Skinner J, Nicholson R. Beyond first-degree heart block in the diagnosis of Acute rheumatic fever. Cardiol Young. 2019;29(6): 744-748. doi: 10.1017/S104795111900026X.
Steer AC, Smeesters PR, Curtis N. Streptococcal Serology: Secrets for the Specialist. Pediatr Infect Dis J. 2015;34(11): 1250-1252. doi: 10.1097/INF.0000000000000881.
Danchin MH, Carlin JB, Devenish W, Nolan TM, Carapetis JR. New normal ranges of antistreptolysin O and antideoxyribonuclease B titres for Australian children. J Paediatr Child Health. 2005;41(11): 583-586. doi: 10.1111/j.1440-1754.2005.00726.x.
RHD Australia (ARF/RHD writing group), National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand. Australian guideline for prevention, diagnosis and management of Acute rheumatic fever and rheumatic heart disease (2nd edition). 2012
Gerber MA, Baltimore RS, Eaton CB, et al. Prevention of rheumatic fever and diagnosis and treatment of Acute Streptococcal pharyngitis: a scientific statement from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young, the Interdisciplinary Council on Functional Genomics and Translational Biology, and the Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Academy of Pediatrics. Circulation. 2009;119(11): 1541-1551. doi: 10.1161/CIRCULATIONAHA.109.191959.
Park MK, Salamat M. Acute Rheumatic Fever. Park’s Pediatric Cardiology For Practitioners 7th edition. Philadelphia: Elsevier Saunders; 2021. p. 282-287.
Steer A, Gibofsky A. Acute rheumatic fever: Treatment and prevention. Sexton DJ, ed. UpToDate- Wolters Kluwer (Accessed 12/01/2025, last updated May 6, 2024- https://www.uptodate.com/contents/acute-rheumatic-fever-treatment-and-prevention?search=akut%20romatizmal%20ate%C5%9F&source=search_result&selectedTitle=2~112&usage_type=default&display_rank=2#H2)
Atalay S, Ramoğlu MG. Akut romatizmal ateşte medikal tedavi. Baysal MK, editör. Çocukluk Çağında Akut Romatizmal Ateş ve Romatizmal Kalp Hastalıkları. 1. Baskı. Ankara: Türkiye Klinikleri; 2020. p. 38-41.
Depietri G, Carli N, Sica A, et al. Therapeutic aspects of Sydenham's Chorea: an update. Acta Biomed. 2022;92(S4): e2021414. doi: 10.23750/abm.v92iS4.12663.