Bruselloz
Özet
Bruselloz dünyada birçok bölgede endemik olarak görülen ve insanlara sığır, keçi, domuz gibi enfekte hayvanlardan elde edilen pastörize edilmeden tüketilen süt ve süt ürünleri ile enfekte vücut sıvıları ve dokularına temas ve inhalasyon yoluyla bulaşır. Tüm yaş gruplarını etkileyen bir enfeksiyondur. Klinik olarak spesifik olmayan semptomlardan çoklu organ ve sistem tutulumuna kadar değişiklik gösterebilir. Hastalığın tanısı kan, kemik iliği veya dokulardan etkenin izolasyonu ve çeşitli serolojik testlerle doğrulama ile konulur. Önemli derecede morbiditesi olan bu enfeksiyonun tedavisi uzun süreli olup kombine antibiyotik tedavisi ile mümkün olmaktadır. Tedavi ile hastalık kontrol altına alınarak komplikasyon, sekel, nüks ve mortalitenin önüne geçilmesi amaçlanır.
Referanslar
WHO Recommended Strategies for the Prevention and Control Communicable Diseases. Brucellosis (human). WHO/CDS/CPE/SMT/2001.13; 51-52.
Centers for Disease Control (CDC) Brucellosis Reference Guide: Exposure, Testing, and Prevention. Updated February 2017. Available from: https://stacks.cdc.gov/view/cdc/46133.
Corbel MJ (2006). Brucellosis in humans and animals. WHO/CDS/EPR/2006.7.
Young EJ. Brucellosis. In: Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ (ed).Feigin and Cherry's Textbook of Pediatric Infectious Diseases. 8th Ed. Philadelphia: WB Saunders, 2019. p.1156-1159.e3.
Doganay GD, Doganay M. Brucella as a potential agnet of bioterrorism. Recent Pat Antiinfect Drug Discov 2013; 8(1): 27-33.
Pappas G, Panagopouloua P, Christoub L, et al. Brucella as a biological weapon. Cell. Mol. Life Sci. 2006; 63: 2229-2236.
Bosilkovski M, Dimzova M, Grozdanovski K. Natural history of brucellosisin an endemic region in different time periods. Acta Clin Croat.2009; 48(1): 41-46.
Jennings GJ, Hajjeha RA, Girgis FY, et al. Brucellosis as a cause of acute febrile illness in Egypt. Trans R Soc Trop Med Hyg 2007; 101(7): 707-713.
Laine CG, Johnson VE, Scott HM, et al. Global Estimate of Human Brucellosis Incidence. Emerg Infect Dis 2023; 29(9): 1789-1797.
Türkiye Halk Sağlığı Kurumu Zoonotik ve Vektörel Hastalıklar Daire Başkanlığı, Bruselloz Vakaları (Türkiye, 2008-2017). https://hsgm.saglik.gov.tr/depo/birimler/zoonotik-ve-vektorel-hastaliklar-db/Dokumanlar/Istatistikler/Web-Bruselloz.jpg.
Türkiye Halk Sağlığı Kurumu Zoonotik ve Vektörel Hastalıklar Daire Başkanlığı, Bruselloz Haritası (Türkiye, 2008-2017). https://hsgm.saglik.gov.tr/depo/birimler/zoonotik-ve-vektorel-hastaliklar-db/Dokumanlar/Istatistikler/Web_Bruselloz_haritasi.pdf.
Pappas G, Akritidis N, Bosilkovski M, et al. Brucellosis. N Engl J Med 2005; 352: 2325-2336.
Kara Ulu N, Tapısız A. Brusella. Tezer H, editör.Çocuklarda Zoonotik Hastalıklar. 1. Baskı.Ankara: Türkiye Klinikleri; 2022. p.14-24.
Roushan MRH, Baiani M, Asnafi N, et al. Outcomes of 19 pregnant women with brucellosis in Babol, northern Iran. Trans R Soc Trop Med Hyg 2011; 105: 540-542.
American Academy of Pediatrics. Brucella. In: Kimberlin DW, Banerjee R, Barnett ED,Lynfield R, Sawyer MH, eds. Red Book: 2024-2007 Report of the Committeeon Infectious Diseases. Itasca, IL:American Academy of Pediatrics; 2024. p.277-280.
Mesner O, Riesenberg K, Biliar N, et al. the Many Faces of Human-to-Human Transmission of Brucellosis: Congenital Infection and Outbreak of Nosocomial Disease Related to an Unrecognized Clinical Case. CID 2007; 45: e135-140.
Alnemri AR, Hadid A, Hussain SA, et al. Neonatal brucellosis: A case report. J Infect Dev Ctries 2017; 11(2): 199-202.
Gul HC, Erdem H. Brucellosis (Brucella Species). In: Bennet JE, Dolin R, Blaser MJ (ed). Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 9th Ed. Philadelphia, PA 19103-2899, 2020 by Elsevier, Inc. p.2753-2758.e2.
Young EJ. Brucella Species (Brucellosis). In: Long SS, Prober CG, Fischer M, Kimberlin DW (ed). Principles and Practice of Pediatric Infectious Diseases, 6th ed. Philadelphia, PA 19103-2899, 2023 by Elsevier, Inc. p.905-909.e1.
Doganay M, Aygen B. Brucellosis: an overview. Int J Infect Dis. 2003;7:173–182.
Zheng R, Xie S, Lu X, et al. A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China. Biomed Res Int 2018; 22: 2018: 5712920. doi: 10.1155/2018/5712920.
Akkoc G, Tekerek S. Osteoarticular Involvement in Childhood Brucellosis: Evaluation of Clinical, Laboratory and Radiologic Features of 185 Cases. Pediatr Infect Dis J 2023; 42(5): 381-388.
Tanir G, Tufekci SB, Tuygun N. Presentation, complications, and treatment outcome of brucellosis in Turkish children. Pediatr Int. 2009; 51: 114-119.
Teke TA, Koyuncu H, Oz FN, et al. Neurobrucellosis in children: Case series from Turkey. Pediatr Int. 2015; 57(4): 578-581.
Jin M, Fan Z, Gao R, et al. Research progress on complications of Brucellosis. Front Cell Infect Microbiol. 2023; 13: 1136674. doi: 10.3389/fcimb.2023.1136674. eCollection 2023.
Bosilkovski M, Krteva L, Dimzova M, et al. Human Brucellosis in Macedonia-10 Years of Clinical Experience in Endemic Region. Croat Med J. 2010; 51: 327-536.
Centers for Disease Control (CDC) Brucellosis (Brucella spp.) 2010 Case Definition. Last Reviewed: April 16, 2021. Available from:https://ndc.services.cdc.gov/case-definitions/brucellosis-2010/
T. C. Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu Başkanlığı Mikrobiyoloji Referans Laboratuvarları Daire Başkanlığı Ulusal Mikrobiyoloji Standartları Bulaşıcı Hastalıklar Laboratuvar Tanı Rehberi Cilt 1. Brusellozun Mikrobiyolojik Tanısı. Ulusal Mikrobiyoloji Standartları01.01.2015 / Sürüm: 1.1 / B-MT-19 / Mikrobiyolojik Tanımlama / Bakteriyoloji.
Roushan MRH, Amiri MJS. Update on Childhood Brucellosis. Recent Patents on AntiInfective Drug Discovery 2013; 8: 42-46.
Sabour S, Arzanlou M, Jeddi F, et al. Evaluating the efficiency of TaqMan real-time PCR and serological methods in the detection of Brucella spp. in clinical specimens collected from suspected patients in Ardabil, Iran. J Microbiol Methods 2020: 175: 105982.
Mohseni K, Mirnejad R, Piranfar V, et al. A Comparative Evaluation of ELISA, PCR, and Serum Agglutination Tests For Diagnosis of Brucella Using Human Serum. Iran J Pathol. 2017; 12(4): 371-376.
Yagupsky P, Morata P, Colmenero JD. Laboratory Diagnosis of Human Brucellosis. Clin Microbiol Rev 2019; 33(1): e00073-19. doi: 10.1128/CMR.00073-19.
Yousefi-Nooraie R, Mortaz-Hejri S, Mehrani M, et al. Antibiotics for treating human brucellosis. Cochrane Database Syst Rev 2012; 10(10): CD007179. Doi: 10.1002/14651858.CD007179.pub2.
Brucellosis. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/brucellosis (Accessed March 15, 2024).
Alp E, Doganay M. Current therapeutic strategy in spinal brucellosis. Int J Infect Dis 2008; 12(6): 573-577.
Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 2007; 25(3): 188-202.
Bosilkovski M. Brucellosis: Treatment and prevention. Available from: https://sso.uptodate.com/contents/brucellosis-treatment-andprevention?search=bruselloz&source=search_result&selectedTitle=2~107&usage_type=default&display_rank=2. Last updated Dec 12, 2023.
