Epstein-Barr Virüs Enfeksiyonları
Özet
Epstein-Barr virüsü, dünya çapında yaygın olarak bulunan ve çoğunlukla asemptomatik seyreden bir Herpes virüsüdür. Ancak, enfeksiyon, çeşitli klinik tablolar ve komplikasyonlar ortaya çıkarabilir. En bilinen klinik tablo enfeksiyöz mononükleozdur. Epstein-Barr virüsünün etkileri, bağışıklık sistemi baskılanmış hastalarda daha ciddi hale gelebilir ve malignitelere yol açabilir. Tanı; klinik belirtiler, laboratuvar testleri ve spesifik antikorların değerlendirilmesi ile konulmalıdır. Tedavi çoğunlukla destekleyici olup, komplikasyonların ortaya çıkması durumunda ise spesifik tedaviler uygulanabilir. Bağışıklık sistemi sağlam olan bireylerde iyi bir prognoza sahip olan EBV, immün yetmezliği olan hastalarda daha ciddi sonuçlar doğurabilir. Bu nedenle, EBV ile ilişkili hastalıkların erken tanısı ve tedavisi büyük önem taşır.
Referanslar
Kieff E, Rickinson AB. Epstein-Barr virüs and its replication. Fields BN, Knipe DM, Howley PM, Fields Virology. 2007. Lippincott, Williams &Wilkins Philadelphia: pp. 2603-2654.
Imadome KI, Shirakata M, Shimizu N, et al. CD40 ligand is a critical effector of Epstein-Barr virus in host cell survival and transformation. Proc Natl Acad Sci USA 2003; 100: pp. 7836-7840.
Dunmire SK, Verghese PS, Balfour HH Jr. Primary Epstein-Barr virus infection. J ClinVirol 2018; 102:84.
Balfour HH Jr, Meirhaeghe MR, Stancari AL, et al. Declining Epstein-Barr Virus Antibody Prevalence in College Freshmen Strengthens the Rationale for a Prophylactic EBV Vaccine. Vaccines (Basel) 2022; 10.
Woodman CBJ, Collins SJ, Vavrusova N, et al. Role of sexual behavior in the acquisition of asymptomatic Epstein-Barr virüs infection: a longitudinal study. Pediatr Infect Dis J 2005; 24: pp. 498-502.
Dunmire SK, Hogquist KA, Balfour HH. Infectious Mononucleosis. Curr Top Microbiol Immunol 2015; 390:211.
Luzuriaga K, Sullivan JL. Infectious mononucleosis. N Engl J Med 2010; 362:1993.
Evans AS. Infectious mononucleosis in University of Wisconsin students. Report of a five-year investigation. Am J Hyg 1960; 71:342.
Kitayama Y, Honda S, Sugimura H. Epstein-Barr virus-related gastric pseudo lymphoma in infectious mononucleosis. Gastrointest Endosc 2000; 52:290.
Bartlett A, Williams R, Hilton M. Splenic rupture in infectious mononucleosis: A systematic review of published case reports. Injury 2016; 47:531.
Dommersby H. Stangerup SE, Stangerup M, Hancke S. Hepatosplenomegaly in infectious mononucleosis, assessed by ultrasonic scanning. J LaryngolOtol 1986; 100: pp. 573-579.
Thompson DF, Ramos CL. Antibiotic-Induced Rash in Patients With Infectious Mononucleosis. Ann Pharmacother 2017; 51:154.
Chovel-Sella A, Ben Tov A, Lahav E, et al. Incidence of rash after amoxicillin treatment in children with infectious mononucleosis. Pediatrics 2013; 131:e1424.
Schissel DJ, Singer D, David-Bajar K. Azithromycin eruption in infectious mononucleosis: a proposed mechanism of interaction. Cutis 2000; 65:163.
Paily R. Quinolonedrugrash in a patient with infectious mononucleosis. J Dermatol 2000; 27:405.
LeClaire AC, Martin CA, Hoven AD. Rash associated with piperacillin/tazobactam administration in infectious mononucleosis. Ann Pharmacother 2004; 38:996.
McCloskey GL, Massa MC. Cephalexin rash in infectious mononucleosis. Cutis 1997; 59:251.
Dickerman JD, Howard P, Dopp S, et al. Infectious mononucleosis initially seen as cold-induced acrocyanosis: association with auto-anti-M and anti-I antibodies. Am J Dis Child 1980; 134: pp. 159-160.
Hudson LB, Perlman SE. Necrotizing genital ulcerations in a premenarcheal female with mononucleosis. Obstet Gynecol 1998; 92:642.
Tselis A, Duman R, Storch GA, Lisak RP. Epstein-Barr virus encephalomyelitis diagnosed by polymerase chain reaction: detection of the genome in the CSF. Neurology 1997; 48:1351.
Mayer H.B, Wanke CA, Williams M, et al. Epstein-Barr virus-induced infectious mononucleosis complicated by acute renal failure: case report and review. Clin Infect Dis 1996; 22: pp. 1009-1018.
Lee SH, Lee DG, Choi SW, et al. Acute idiopathic scrotal edema caused by Epstein-Barr virus. Pediatr Infect Dis J 2016; 35: pp. 593-594.
Penman HG. Fatal infectious mononucleosis: a critical review. J Clin Pathol 1970; 23: pp. 765-771.
Grotto I, Mimouni D, Huerta M, et al. Clinical and laboratory presentation of EBV positive infectious mononucleosis in young adults. Epidemiol Infect 2003; 131: pp. 683-689.
Cai X, Ebell MH, Haines L. Accuracy of Signs, Symptoms, and Hematologic Parameters for the Diagnosis of Infectious Mononucleosis: A Systematic Review and Meta-Analysis. J Am Board Fam Med 2021; 34:1141.
Blake J.M, Edwards JMB, Fletcher W, et al. Measurement of heterophil antibody and antibodies to EBV viral capsid antigen IgG and IgM in suspected cases of infectious mononucleosis. J Clin Pathol 1976; 29: pp. 841-847.
Rea TD, Russo JE, Katon W, et al. Prospective study of the natural history of infectious mononucleosis caused by Epstein-Barr virus. J Am Board Fam Pract 2001; 14:234.
Bruu AL, Hjetland R, Holter E, et al. Evaluation of 12 commercial tests for detection of Epstein-Barr virus-specific and heterophile antibodies. Clin Diagn Lab Immunol 2000; 7:451.
Committee on InfectiousDiseases. Epstein-Barr virüs infections (infectious mononucleosis). In: RedBook: 2018-2021 Report of the Committee on Infectious Diseases, 31st ed, Kimberlin DW, Brady MT, Jackson MA, Long SS (Eds), American Academy of Pediatrics, 2018. p.334.
Marshall-Andon T, Heinz P. How to use… the Monospot and other heterophile antibody tests. Arch Dis Child Educ Pract Ed. 2017 Aug;102(4):188-193. doi: 10.1136/archdischild-2016-311526.
Boyd K, Harrison JM, Kavanaugh MJ. False-Positive Monospot in a Returning Traveler with Dengue Fever. Mil Med 2018; 183:e235.
Lupo J, Truffot A, Andreani J, et al. Virological Markers in Epstein-Barr Virus-Associated Diseases. Viruses 2023; 15.
Weinberger B, Plentz A, Weinberger KM, et al. Quantitation of Epstein-Barr virus mRNA using reverse transcription and real-time PCR. J Med Virol 2004; 74:612.
Dunmire SK, Grimm JM, Schmeling DO, et al. The Incubation Period of Primary Epstein-Barr Virus Infection: Viral Dynamics and Immunologic Events. PLoS Pathog 2015; 11:e1005286.
Hoshino A,Takashima T, Yoshida K, et al. Dysreguklation of Epstein-Barr virüs infection in hypomorphic ZAP 70 mutation. J Infect Dis 2018; 218: pp. 825-834.
Alosaimi MF, Hoenig M, Jaber F, et al. Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency. J Allergy Clin Immunol 2019; 144: pp. 574-583.
Booth C, Gilmour KC, Veys P, et al. X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease. Blood 2011; 117: pp. 53-62.
Filipovich AH. Hemophagocytic lymphohistiocytosis (HLH) and related disorders. Hematology Am Soc Hematol Educ Program 2009; pp. 127-131.
Kimura H, Cohen JI. Chronic Active Epstein-Barr Virus Disease. Front Immunol 2017; 8:1867.
Capello D, Cerri M, Muti G, et al. Analysis of immunoglobulin heavy and light chain variable genes in post-transplant lymphoproliferative disorders. Hematol Oncol 2006; 24:212.
Styczynski J, Gil L, Tridello G, et al. Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Response to rituximab-based therapy and risk factor analysis in Epstein Barr Virus-related lymphoproliferative disorder after hematopoietic stem cell transplant in children and adults: a study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Clin Infect Dis. 2013 Sep;57(6):794-802. doi: 10.1093/cid/cit391.
