Guillain-Barré Sendromu: Nörolojik Acil Durumlarda Tanı ve Yönetim

Özet

Guillain-Barré Sendromu (GBS), genellikle enfeksiyon sonrası gelişen, akut inflamatuar bir polinöropati olup hızla ilerleyen kas güçsüzlüğü ve refleks kaybıyla karakterize edilir. Bu makalede, GBS'nin tanı kriterleri, patofizyolojisi, alt tipleri ve yönetim stratejileri ele alınmaktadır. Erken tanı ve uygun tedavi, özellikle solunum yetmezliği gibi ciddi komplikasyonların önlenmesinde önem arz etmektedir. Intravenöz immünoglobulin (IVIG) ve plazmaferez, yönetiminde temel tedavi seçenekleridir. GBS'nin etiyolojisi, özellikle enfeksiyon sonrası bağışıklık yanıtının periferik sinirlere zarar vermesi mekanizmasıyla ilişkilidir. Epidemiyolojik veriler ve yeni tedavi yaklaşımları GBS'nin anlaşılmasına katkı sağlamakta olup, multidisipliner bir rehabilitasyon süreci, uzun vadeli prognozda önemli rol oynamaktadır.

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28 Şubat 2025

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