Bariatrik Cerrahide Sleeve Gastrektomi Sonrası Portal Ven Trombozu: Bir Olgu Sunumu

Özet

Sleeve gastrektomi sonrası postoperatif 12. gününde karın ağrısı, bulantı, hematemez  ve hematokezya şikayeti ile acil servise başvuran hastaya yapılan abdominal BT anjiografi ile  Porto-Mesenterik Venöz Trombozu (PMVT) tanısı konuldu. Hemodinamik olarak stabil olmayan hastaya yoğun bakımda antikoagülasyon tedavi başlandı. Septik şok ekarte edilemediğinden sıvı resüsitasyonu ve antibiyoterapi uygulandı. Hasta obez ve tromboz eğilimli olduğu için trombofili açısından ileri tetkik edildi. Klinik ve laboratuvar bulguları normale dönen hasta servis transferinden sonra evine taburcu edildi. Taburculuğun 10. gününde şiddetli karın ağrısı, bulantı ve kusma şikayetiyle acil servise başvuran hastaya abdominal BT görüntüleme yapıldı ve batında serbest hava gözlendi. Acil laporotomi uygulanan hastada barsak perforasyonu ve batın içinde intestinal içerik tespit edildi, barsak rezeksiyonu yapıldı. Ancak hastada sleeve gastrektomi sonrası postoperatif 1. ayında intestinal enfarkt ve barsak perforasyonu nedeniyle exitus gelişti. Hasta kaybedildikten sonra bildirilen trombofili panelinde heterozigot Faktör V Leiden mutasyonu beraberinde heterozigot Plasminogen Aktivatör İnhibitörü-1 polimorfizmi saptandı. Bu vaka obezite gibi yüksek riskli bir grupta trombofili eğilimini araştırmak ve tedavi seçeneklerini tartışmak için planlandı.

Referanslar

Schulman AR, Thompson CC. Complications of bariatric surgery: what you can expect to see in your GI practice. Official journal of the American College of Gastroenterology| ACG. 2017;112(11):1640-1655.

Khwaja HA, Bonanomi G. Bariatric surgery: techniques, outcomes and complications. Current Anaesthesia & Critical Care. 2010;21(1):31-38.

Gulinac M, Miteva DG, Peshevska-Sekulovska M, et al. Long-term effectiveness, outcomes and complications of bariatric surgery. World journal of clinical cases. 2023;11(19):4504.

Arterburn DE, Telem DA, Kushner RF, et al. Benefits and risks of bariatric surgery in adults: a review. Jama. 2020;324(9):879-887.

Iacobellis F, Dell’Aversano Orabona G, Brillantino A, et al. Common, Less Common, and Unexpected Complications after Bariatric Surgery: A Pictorial Essay. Diagnostics. 2022;12(11):2637.

Bjørklund G, Semenova Y, Pivina L, et al. Follow-up after bariatric surgery: A review. Nutrition. 2020;78:110831.

Kassir R, Debs T, Blanc P, et al. Complications of bariatric surgery: presentation and emergency management. LWW; 2016. p. 77-81.

Barajas-Gamboa JS, Duran V, Romero-Velez G, et al. Prevalence, Indications, and Complications of Conversional Surgery After Vertical Banded Gastroplasty: A MBSAQIP Analysis. Obesity Surgery. 2024:1-9.

Froylich D, Abramovich TS, Fuchs S, et al. Long-term (over 13 years) follow-up of vertical band gastroplasty. Obesity surgery. 2020;30:1808-1813.

Godoroja-Diarto D, Copaescu C, Rusu E, et al. The role of thromboprophylaxis in patients with portal vein thrombosis: a life-threatening complication after laparoscopic sleeve gastrectomy following 8 years of experience in a bariatric center of excellence. Diagnostics. 2022;13(1):43.

Lee CW, Kelly JJ, Wassef WY. Complications of bariatric surgery. Current opinion in gastroenterology. 2007;23(6):636-643.

Chang SH, Freeman NL, Lee JA, et al. Early major complications after bariatric surgery in the USA, 2003–2014: a systematic review and meta‐analysis. Obesity Reviews. 2018;19(4):529-537.

Collazo-Clavell ML, Shah M. Common and rare complications of bariatric surgery. Endocrinology and Metabolism Clinics. 2020;49(2):329-346.

Alligier M, Borel A-L, Savey V, et al. A series of severe neurologic complications after bariatric surgery in France: the NEUROBAR Study. Surgery for Obesity and Related Diseases. 2020;16(10):1429-1435.

Stone G, Samaan JS, Samakar K. Racial disparities in complications and mortality after bariatric surgery: a systematic review. The American Journal of Surgery. 2022;223(5):863-878.

El Ansari W, Sathian B, El-Menyar A. Venous thromboembolic events after bariatric surgery: Protocol for a systematic review and meta-analysis. International Journal of Surgery Protocols. 2020;22:10-14.

Pastori D, Cormaci VM, Marucci S, et al. A comprehensive review of risk factors for venous thromboembolism: from epidemiology to pathophysiology. International Journal of Molecular Sciences. 2023;24(4):3169.

O'Connor K, Whitlock AEG, Tewksbury C, et al. Risk factors for postdischarge venous thromboembolism among bariatric surgery patients and the evolving approach to extended thromboprophylaxis with enoxaparin. Surgery for Obesity and Related Diseases. 2021;17(6):1218-1225.

Luo L, Li H, Wu Y, et al. Portal venous system thrombosis after bariatric surgery: a systematic review and meta-analysis. Surgery. 2021;170(2):363-372.

Shoar S, Saber AA, Rubenstein R, et al. Portomesentric and splenic vein thrombosis (PMSVT) after bariatric surgery: a systematic review of 110 patients. Surgery for Obesity and Related Diseases. 2018;14(1):47-59.

Parikh M, Somoza E, Chopra A, et al. Thrombophilia prevalence in patients seeking laparoscopic sleeve gastrectomy: extended chemoprophylaxis may decrease portal vein thrombosis rate. Surgery for Obesity and Related Diseases. 2020;16(7):839-843.

Fijnheer R, Paijmans B, Verdonck LF, et al. Factor V Leiden in central venous catheter‐associated thrombosis. British journal of haematology. 2002;118(1):267-270.

Zhang Q, Jin Y, Li X, et al. Plasminogen activator inhibitor-1 (PAI-1) 4G/5G promoter polymorphisms and risk of venous thromboembolism–a meta-analysis and systematic review. Vasa. 2020.

Kollabathula A, Sharma S, Kumar N, et al. Plasminogen Activator Inhibitor-1 4G/5G Promoter Polymorphism in Adults with Splanchnic Vein Thrombosis: A Case–Control Study. Indian Journal of Hematology and Blood Transfusion. 2022;38(1):169-172.

Thomas RM, Ahmad SA. Management of acute post-operative portal venous thrombosis. Journal of Gastrointestinal Surgery. 2010;14(3):570-577.

Chawla YK, Bodh V. Portal vein thrombosis. Journal of clinical and experimental hepatology. 2015;5(1):22-40.

Carlin AM, Varban OA, Ehlers AP, et al. Independent predictors and timing of portomesenteric vein thrombosis after bariatric surgery. Surgery for Obesity and Related Diseases. 2022;18(12):1385-1391.

Sayfalar

49-66

Gelecek

24 Ocak 2025

Lisans

Lisans